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Apoptosis-inducing activity of endocrine-disrupting chemicals in cultured PC12 cells

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Advances in Biological Chemistry 2012年第2期2卷 92-105页

作者： Harue Sasaya Kazuya Yasuzumi Hiroki Maruoka Ayumi Fujita yuichi kato Taiki Waki Koji Shimoke Toshihiko Ikeuchi Department of Life Science and Biotechnology Faculty of Chemistry Materials and Bioengineering and Strategic Research Base Kansai University Osaka Japan Technology Research Laboratory Kurabo Industries Ltd. Osaka Japan

Endocrine-disrupting chemicals (EDCs) are known to exert estrogen-like effects that are similar to those made by naturally produced hormones or by inhibition of the receptors in the cell receiving the hormones. Recently, several reports have indicated that EDCs can affect the developing central nervous system. In our current study, we report that some EDCs induce apoptosis in cultured PC12 cells and can be classified into three groups. Bisphenol A (BPA), p-nonylphenol (NP) and tributyltin chloride (TBT) were found to induce endoplasmic reticulum (ER) stress-associated apoptosis and activate the unfolded protein response (UPR) system, whereas benomyl (beno) induced non-ER stress-associated apoptosis. The half-maximal apoptosis-inducing concentrations (IC50) of these EDCs were 160 μM for BPA, 25.6 μM for NP, 640 nM for TBT and 48 μM for beno. Although these concentrations are higher than those found in the environment, some EDCs may have apoptotic effects on various cells in the body, including neurons, through their accumulation in the body over time or condensation through the food chain. On the other hand, benzopyrene, fenvalerate, styrene monomer and bis(2-ethylhexyl)phthalate did not induce apoptosis in PC12 cells. We analyzed also whether apoptosis-inducing EDCs had an estrogen-like effect on cultured PC12 cells transfected with a luciferase reporter plasmid, the activity of which is dependent on estrogen receptor α. We found that BPA had an estrogen-like effect (EC50 = 5.9 μM) but that NP, TBT and beno did not in transfected PC12 cells. These results suggest that BPA may predomi-nantly exert estrogenic effects, but others may pre-dominantly have apoptosis-inducing effects on cells in the body exposed to a polluted environment.

关键词： Endocrine-Disrupting Chemicals ER Stress Apoptosis Estrogen Receptor PC12 Cells

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东日本大震灾灾后重建规划进展缓慢原因分析

结构工程师 2015年第2期31卷 57-66页

作者：郗皎如加藤優一佃悠小野田泰明薛松涛东北大学都日本仙台980-8579 同济大学结构工程与防灾研究所上海200092 东北工业大学建筑系日本仙台982-8577

日本作为自然灾害频发的国家,在历次大规模自然灾害应对经验的基础上形成了较为完善的防灾减灾法律及对策体制。但迄今为止,距2011年东日本大震灾发生已三年半有余,其灾后重建规划工作,以灾后重建规划的制定为主,进展仍旧缓慢。分析归... 详细信息

日本作为自然灾害频发的国家,在历次大规模自然灾害应对经验的基础上形成了较为完善的防灾减灾法律及对策体制。但迄今为止,距2011年东日本大震灾发生已三年半有余,其灾后重建规划工作,以灾后重建规划的制定为主,进展仍旧缓慢。分析归纳了其原因,总结得出重建规划进展缓慢的四个因素如下:受灾地的地域特性;城镇尺度的大规模重建事业,包括以海啸模拟计算为基础的避难计划及四种灾后重建模式两个方面;复杂的灾后重建规划制定流程,包括防灾集团移转促进事业及土地区画整理事业两个主要环节;人力及重建资源不足。

关键词：东日本大震灾灾后重建规划地域特性城镇尺度的规模规划制定流程重建资源

Communication Scheduling with Diversity for Unmanned Aircraft Systems Using Local 5G

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Journal of Communications and Information Networks 2020年第1期5卷 50-61页

作者： Takeru Kitagawa yuichi Kawamoto Nei kato Graduate School of Information Sciences Tohoku University Aramaki-Aoba 6-3-09Aoba-kuSendai980-8579Japan

The use of unmanned aircraft systems(UAS)for critical public service missions by public organizations,local governments,and social users is *** radio transmission by unmanned aerial vehicles(UAVs)is indispensable in these *** of the standards suitable for UAV wireless communications is local ***,to introduce local 5G into a UAS,several problems specific to UASes must be *** include the deterioration of the signal-to-noise ratio due to topography and obstacles,the uncertainty of the communication environment due to the movement of multiple UAVs,and the limitation of the frequency *** address these problems and to introduce local 5G into the UAS,we propose a novel communication scheduling *** method incorporates transmission modes with *** evaluations shows that total data volumes increase by 1.9~3 times with the proposed scheduling method compared with transmission without diversity or efficient scheduling.

关键词： unmanned aircraft system(UAS) unmanned aerial vehicle(UAV) local 5G diversity scheduling LTE sidelink time division multiple access(TDMA)

Effects of slope gradient on runoff from bare-fallow purple soil in China under natural rainfall conditions

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Journal of Mountain Science 2018年第4期15卷 738-751页

作者： KOMATSU Yoshitaka kato Hiroaki ZHU Bo WANG Tao YANG Fan RAKWAL Randeep ONDA yuichi Graduate School of Life and Environmental Sciences University of Tsukuba Center for Research in Isotopes and Environmental Dynamics University of Tsukuba Institute of Mountain Hazards and Environment Chinese Academy of Sciences Faculty of Health and Sport Sciences University of Tsukuba

Purple soil is highly susceptible for overland flow and surface erosion, therefore understanding surface runoff and soil erosion processes in the purple soil region are important to mitigate flooding and erosion hazards. Slope angle is an important parameter that affects the magnitude of runoff and thus surface erosion in hilly landscapes or bare land area. However, the effect of slope on runoff generation remains unclear in many different soils including Chinese purple soil. The aim of this study was to investigate the relationship between different slope gradients and surface runoff for bare-fallow purple soil, using 5 m × 1.5 m experimental plots under natural rainfall conditions. Four experimental plots(10°, 16°, 20° and 26°) were established in theYanting Agro-ecological Experimental Station of Chinese Academy of Science in central Sichuan Basin. The plot was equipped with water storage tank to monitor water level change. Field monitoring from July 1 to October 31, 2012 observed 42 rainfall events which produced surface runoff from the experimental plots. These water level changes were converted to runoff. The representative eight rainfall events were selected for further analysis, the relationship between slope and runoff coefficient were determined using ANOVA, F-test, and z-score analysis. The results indicated a strong correlation between rainfall and runoff in cumulative amount basis. The mean value of the measured runoff coefficient for four experimental plots was around 0.1. However, no statistically significant relationship was found between slope and runoff coefficient. We reviewed the relationship between slope and runoff in many previous studiesand calculated z-score to compare with our experimental results. The results of z-score analysis indicated that both positive and negative effects of slope on runoff coefficient were obtained, however a moderate gradient(16°-20° in this study) could be a threshold of runoff generation for many different soils

关键词： Surface runoff Slope gradient Natural rainfall Purple soil Runoff plot

Effect of forest thinning on hydrologic nitrate exports from a Nsaturated plantation

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Journal of Forestry Research 2020年第2期31卷 387-395页

作者： Masaaki Chiwa Hirokazu Haga Tamao Kasahara Makiko Tateishi Takami Saito Hiroaki kato Kyoichi Otsuki yuichi Onda Kyushu University Forest Kyushu UniversityFukuoka 811-2415Japan Faculty of Agriculture Tottori UniversityTottori 680-8553Japan Faculty of Agriculture Kyoto UniversityKitashirakawa Oiwake-choSakyo-kuKyoto 606-8502Japan Department of Plant Ecology Forestry and Forest Product Research InstituteForest Research and Management OrganizationTsukuba 305-8687Japan Graduate School of Life and Environmental Sciences University of TsukubaTsukuba 305-8572Japan

Although several studies have assessed the effects of thinning on water quality,including nitrogen(N)exports,few have examined N-saturated *** study assessed the short-term effect of thinning on N exports from a N-saturated plantation forest in northern Kyushu,western Japan,that was thinned(43%of basal area)during January-March *** levels at the gauging station were continually measured,and streamwater baseflow and stormflow samples were collected before(2011)and after(2013)forest *** precipitation before(2469 mm)and after(2418 mm)forest thinning differed little,and annual water discharge after thinning(1641 mm)was similar to that before thinning(1609 mm).However,direct flow during stormflow periods was higher after thinning(260 mm)than before(153 mm).The concentrations of major ions in stream water did not differ before and after *** a result,the high annual dissolved inorganic N(DIN)exports differed little before(35.8 kg N ha^-1 a^-1)and after(36.5 kg N ha^-1 a^-1)forest *** exports during stormflow periods were slightly higher after(12.2 kg N ha^-1 a^-1)than before thinning(10.5 kg N ha^-1 a^-1)and were proportional to the increased direct flow after thinning(561 mm after vs.470 mm before thinning).We concluded that thinning does not affect annual N exports from the N-saturated plantation forest,but it can increase the proportion of N exported during stormflow periods in proportion to increased water volume of direct flow after thinning.

关键词： Thinning Nitrogen saturation Nitrogen export Direct flow Baseflow

Laparoscopic appendectomy for acute appendicitis: How to discourage surgeons using inadequate therapy

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World Journal of Gastroenterology 2017年第32期23卷 5849-5859页

作者： tomohide hori takafumi machimoto yoshio kadokawa toshiyuki hata tatsuo ito shigeru kato daiki yasukawa yuki aisu yusuke kimura maho sasaki yuichi takamatsu taku kitano shigeo hisamori tsunehiro yoshimura department of gastrointestinal surgery tenriyorodusoudanjyo hospital

Acute appendicitis(AA) develops in a progressive and irreversible manner, even if the clinical course of AA can be temporarily modified by intentional medications. Reliable and real-time diagnosis of AA can be made based on findings of the white blood cell count and enhanced computed tomography. Emergent laparoscopic appendectomy(LA) is considered as the first therapeutic choice for AA. Interval/delayed appendectomy at 6-12 wk after disease onset is considered as unsafe with a high recurrent rate during the waiting time. However, this technique may have some advantages for avoiding unnecessary extended resection in patients with an appendiceal mass. Nonoperative management of AA may be tolerated only in children. Postoperative complications increase according to the patient's factors, and temporal avoidance of emergent general anesthesia may be beneficial for high-risk patients. The surgeon's skill and cooperation of the hospital are important for successful LA. Delaying appendectomy for less than 24 h from diagnosis is safe. Additionally, a semi-elective manner(i.e., LA within 24 h after onset of symptoms) may be paradoxically acceptable, according to the factors of the patient, physician, and institution. Prompt LA is mandatory for AA. Fortunately, the Japanese government uses a universal health insurance system, which covers LA.

关键词： Laparoscopic appendectomy Acute appendicitis Interval appendectomy Surgery Delayed appendectomy

Survival from cardiac arrest due to sushi suffocation

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World Journal of Emergency Medicine 2014年第2期5卷 154-156页

作者： Toru Hifumi Nobuaki Kiriu Hiroshi kato yuichi Koido Yasuhiro Kuroda Emergency Medical Center Kagawa University Hospital Division of Critical Care Medicine and Trauma National Hospital Organization Disaster Medical Center

BACKGROUND: Sushi suffocation is relatively uncommon, and it is an unignorable cause of sudden death; however, no reports on sushi suffocation have been ***: A 60-year-old man was referred to our hospital for post resuscitative intensive care. He had choked on sushi and collapsed in the dining room of a mental hospital. A nursing assistant summoned a physician who attempted to extract the sushi. External cardiac massage was initiated after 7 minutes had elapsed and followed by endotracheal intubation. Return of spontaneous circulation was achieved after 7 minutes of resuscitation. A bronchoscopy demonstrated a large amount of shari in the trachea and right bronchus, which was removed with alligator forceps and a wire ***: Neurological recovery was evident on day 2 of admission. He was transferred back to the mental hospital with no neurological ***: Emergency physicians should consider sushi suffocation, including its clinical features and management.

关键词： Food suffocation Sushi Cardiopulmonary arrest

Parallel Tolerance Analysis of a Power Electronic Converter by the Genetic Algorithm with the Island Model

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Parallel Tolerance Analysis of a Power Electronic Converter ...

Evaluation of small bowel blood flow in healthy subjects receiving low-dose aspirin

第4届国际电力电子及运动控制国际会议

作者： Toshiji kato Kaoru Inoue yuichi Yano Shintaro Oshio Department of Electrical Engineering Doshisha University KyotanabeKyoto610-0321JAPAN Department of Electrical Engineering Doshisha University KyotanabeKyoto610-0321JAPAN Department of Electrical Engineering Doshisha University KyotanabeKyoto610-0321JAPAN Department of Electrical Engineering Doshisha University KyotanabeKyoto610-0321JAPAN

＜正＞ It is necessary to consider variations of circuit element values for a power electronic converter design to satisfy a given specification. This analysis is so-called tolerance or worst-case analysis. The analysis is a sort of nonlinear minimum and maximum （min/max） problem with respect to circuit parameters. However its computation cost is large and practically the problem is converted to a simpler and easier one with various techniques. This paper proposes an approximate method which finds a quasi-min/max solution by applying the Genetic Algorithm （GA）. The GA models an evolution process of life forms for an engineering use and it is mainly applied to an optimization problem to utilize its selection process. This paper proposes the GA method which is based on the island model and suitable for the parallel tolerance analysis to find quasi-optimal solutions. Output voltage variations, for example, of a Cuk converter for element parameter variations are analyzed.

关键词： tolerance analysis power converters genetic algorithm parallel processing DGA

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World Journal of Gastroenterology 2011年第2期17卷 226-230页

作者： Urara Nishida Mototsugu kato Mutsumi Nishida Go Kamada Takeshi Yoshida Shouko Ono yuichi Shimizu Masahiro Asaka Department of Gastroenterology Hokkaido University Graduate School of Medicine Division of Endoscopy Hokkaido University Hospital Department of Clinical Laboratory and Transfusion Hokkaido University Hospital

AIM:To investigate the relationship between low-dose aspirin-induced small bowel mucosal damage and blood flow,and the effect of rebamipide. METHODS:Ten healthy volunteers were enrolled in this *** subjects were divided into two groups:a placebo group given low-dose aspirin plus placebo and a rebamipide group given low-dose aspirin plus rebamipide for a period of 14 *** endoscopy and contrast-enhanced ultrasonography were performed before and after administration of *** under the curves and peak value of time-intensity curve were calculated. RESULTS:Absolute differences in areas under the curves were-1102.5(95%CI:-1980.3 to-224.7,P=0.0194) in the placebo group and-152.7(95%CI:-1604.2 to 641.6,P=0.8172) in the rebamipide group. Peak values of time intensity curves were-148.0(95% CI:-269.4 to-26.2,P=0.0225) in the placebo group and 28.3(95%CI:-269.0 to 325.6,P=0.8343) in the rebamipide *** endoscopy showed mucosal breaks only in the placebo group. CONCLUSION:Short-term administration of low-dose aspirin is associated with small bowel injuries and blood flow.

关键词： Small-intestine Capsule endoscopy Lowdose aspirin Contrast-enhanced ultrasonography Rebamipide