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Increased frequency of angina attacks caused by switching a brand-name vasodilator to a generic vasodilator in patients with vasospastic angina:Two case reports

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World Journal of Cardiology 2018年第3期10卷 15-20页

作者： Remi Goto-Semba yuichi fujii Tomohiro Ueda Chikage Oshita Hiroki Teragawa Department of Education and Training JR Hiroshima Hospital Department of Cardiovascular Medicine JR Hiroshima Hospital

It is well known that calcium channel blockers(CCBs) are the first line of therapy for vasospastic angina(VSA). Here, we report two cases of VSA with an increase in the frequency of angina attacks after switching from a brand-name to a generic CCB. In both cases, angina recurred upon switching from a brand-name CCB to a generic CCB during follow-up. The patients' condition improved upon switching back to the original CCB. Both cases involved a high severity of VSA, based on the results of spasm provocation testing. These findings suggest that, in some patients with severe VSA, the frequency of angina attacks increases when switching from a brand-name CCB to a generic CCB. Cardiologists should consider this factor when prescribing drugs for angina.

关键词： Vasospastic angina Acetylcholine Brandname drugs Generic drugs Refractory chest pain

Worsening of coronary spasm during the perioperative period:A case report

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World Journal of Cardiology 2014年第7期6卷 685-688页

作者： Hiroki Teragawa Kenji Nishioka yuichi fujii Naomi Idei Takaki Hata Shuji Kurushima Tomoki Shokawa Yasuki Kihara Department of Cardiovascular Medicine Hiroshima University Hospital

We present the case of a 65-year-old male with vasospastic angina(VSA)whose condition worsened during the perioperative *** had been diagnosed with VSA 10 years *** was treated with two types of vasodilators and had not experienced any chest symptoms for 5 *** this juncture,he underwent surgery for relapsed maxillary sublingual *** had taken two vasodilators one day prior to *** infusion of nitroglycerin(NTG)was initiated immediately before the surgery and continued the following *** of stopping NTG,a dermal isosorbide dinitrate tape was applied on post-operative day *** days later,a complete atrioventricular block with pulseless electrical activity *** cardiopulmonary resuscitation,emergent coronary angiography showed severe coronary spasm in both the left and right coronary *** infusion of nitroglycerin and epinephrine with percutaneous cardiopulmonary support relieved the coronary *** the perioperative period,several factors can trigger coronary vasospasm,including the discontinuation of ***,surgeons,anesthetists,and cardiologists should watch for coronary vasospasm during this period and for worsening coronary spasm when discontinuing vasodilators in patients at risk for VSA.

关键词： Coronary vasospasm Perioperative period Discontinuation of vasodilator

Case of angina pectoris at rest and during effort due to coronary spasm and myocardial bridging

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World Journal of Cardiology 2015年第6期7卷 367-372页

作者： Hiroki Teragawa yuichi fujii Tomohiro Ueda Daiki Murata Shuichi Nomura Department of Cardiovascular Medicine Hiroshima General Hospital of West Japan Railway Company

We present a case of a 71-year-old male who hadchest symptoms at rest and during effort. He had felt chest oppression during effort for 1 year,and his chest symptoms had recently worsened. One month before admission he felt chest squeezing at rest in the early morning. He presented at our institution to evaluate his chest symptoms. Electrocardiography and echocardiography failed to show any specific changes. Because of the possibility that his chest symptoms were due to myocardial ischemia,he was admitted to our institution for coronary angiography(CAG). An initial CAG showed mild atherosclerotic changes in the proximal segment of the left anterior descending coronary artery(LAD) and mid-segment of the left circumflex coronary artery. Subsequent spasm provocation testing using acetylcholine revealed a bilateral coronary vasospasm,which was relieved after the intracoronary infusion of nitroglycerin. Finally,a CAG showed myocardial bridging(MB) of the mid-distal segments of the LAD. Fractional flow reserve using the intravenous administration of adenosine triphosphate was positive at 0.77,which jumped up to 0.90 through the myocardial bridging segments when the pressure wire was pulled back. Thus,coronary vasospasm and MB might have contributed to his chest symptoms at rest and during effort. Interventional cardiologists should consider the presence of MB as a potential cause of myocardial ischemia.

关键词： Coronary spasm Myocardial bridging Myocardial squeezing Fractional flow reserve

Endovascular technique using a snare and suture for retrieving a migrated peripherally inserted central catheter in the left pulmonary artery

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World Journal of Cardiology 2013年第9期5卷 369-372页

作者： Hiroki Teragawa Takashi Sueda yuichi fujii Hiroaki Takemoto Yasushi Toyota Shuichi Nomura Keigo Nakagawa Department of Cardiovascular Medicine Hiroshima General Hospital of West Japan Railway Company Department of Internal Medicine Chuden Hospital

We report a successful endovascular technique using a snare with a suture for retrieving a migrated broken peripherally inserted central catheter(PICC)in a chemotherapy patient.A 62-year-old male received monthly chemotherapy through a central venous port implanted into his right subclavian *** patient completed chemotherapy without complications 1 mo ago;however,he experienced pain in the right subclavian area during his last chemotherapy *** tomography on that day showed migration of a broken PICC in his left pulmonary artery,for which the patient was admitted to our *** attempted to retrieve the ectopic PICC through the right jugular vein using a gooseneck snare,but were unsuccessful because the catheter was lodged in the pulmonary artery ***,a second attempt was made through the right femoral vein using a snare with triple loops,but we could not grasp the migrated ***,a string was tied to thetop of the snare,allowing us to curve the snare toward the pulmonary artery by pulling the ***,the catheter body was grasped and *** endovascular suture technique is occasionally extremely useful and should be considered by interventional cardiologists for retrieving migrated catheters.

关键词： Port catheter Catheter migration Endovascular suture technique

Extracapsular invasion as a risk factor for disease recurrence in colorectal cancer

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World Journal of Gastroenterology 2011年第15期17卷 2003-2006页

作者： Takaaki fujii yuichi Tabe Reina Yajima Satoru Yamaguchi Soichi Tsutsumi Takayuki Asao Hiroyuki Kuwano Depart ment of General Surgical Science Graduate School of Medicine Gunma University Gunma 371-8511 Japan

AIM: To evaluate the presence of extracapsular invasion (ECI) in positive nodes as a predictor of disease recurrence disease in colorectal cancer. METHODS: Two hundred and twenty-eight consecutive patients who underwent colorectal resection were identified for inclusion in this study, of which 46 had positive lymph nodes. Among 46 cases with stage Ⅲcolorectal cancer, 16 had ECI at positive nodes and 8 had disease recurrence. The clinical and pathological features of these cases were reviewed. RESULTS: In the univariate analysis, the number of positive lymph nodes and depth of tumor invasion were significantly associated with the presence of ECI at positive nodes. Multivariate analysis demonstrated that only ECI was a predictor of recurrence. The recurrence-free interval differed significantly among patients with ECI at positive ***: Our results suggest that ECI at metastatic nodes can identify which cases are at high risk of short-term disease recurrence in colorectal cancer.

关键词：复发间隔大肠癌疾病危险因素入侵 ECI 淋巴结单因素分析

Preparation of 0.055BaZrO_(3)–0.935(K_(0.45)Na_(0.5)Li_(0.05))NbO_(3)–0.01(Bi_(0.5)Na_(0.5))TiO_(3) piezoelectric thin films from precursor solution by Pechini method

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Journal of Advanced Dielectrics 2017年第2期7卷 41-44页

作者： Liqiang Liu Tomoaki Karaki Tadashi fujii yuichi Sakai Department of Intelligent Systems Design Engineering Toyama Prefectural University 5180 KurokawaImizuToyama 939-0398Japan Toyama Industrial Technology Center 150 Futagamimachi TakaokaToyama 933-0981Japan

Lead-free piezoelectric thin films of 0.055BaZrO_(3)–0.935(K_(0.45)Na_(0.5)Li_(0.05))NbO_(3)–0.01(Bi_(0.5)Na_(0.5))TiO_(3)(BZ–KNLN–BNT)were fabricated on(100)-LaNiO_(3)/SiO_(2)/Si *** Pechini(polymeric precursor)method was carried out to prepare the complicated multi-component precursor *** method was suited for controlling the complex components *** films crystallized at 700℃ showed a(100)pc-oriented perovskite structure,whose grain size was about 200 nm and thickness was about 700 *** Curie temperature Tc of the films was 292℃ that was near to that of the bulk *** preparation method used in this work provided a possibility for the application of multi-component lead-free piezoelectric films.

关键词： Lead-free piezoelectric materials thin films Pechini method sol-gel method

Factors affecting early decline of executive function after subthalamic nucleus stimulation in Parkinson’s disease

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Advances in Parkinson's Disease 2013年第3期2卷 75-80页

作者： Atsushi Umemura yuichi Oka Rika Tsuboi Sonoko fujii Yoko Shimizu Kenji Okita Noriyuki Matsukawa Kazuo Yamada Department of Neurology Nagoya City University Graduate School of Medicine Nagoya Japan Department of Neurosurgery Nagoya City University Graduate School of Medicine Nagoya Japan Department of Rehabilitation Medicine Nagoya City University Graduate School of Medicine Nagoya Japan Department of Research and Therapeutics for Movement Disorders Juntendo University School of Medicine Tokyo Japan Department of Neurosurgery Nagoya City University Graduate School of Medicine Nagoya Japan

Subthalamic nucleus deep brain stimulation (STN DBS) is an effective treatment for medically refractory Parkinson’s disease (PD). However, a minority of patients develop cognitive problems, particularly a decline of executive function in the early period after STN DBS. Although this problem is usually transient, it may cause social maladjustment. We investigated factors affecting early decline of executive function after STN-DBS. Fifty-seven patients whose preoperative global cognitive screening was normal (MMSE score;28 or more) were enrolled in this study. Executive function was evaluated with the Trail-Making Test (TMT) preoperatively and 1-month after surgery. We considered a patient to have decline in executive function if the TMT (B-A) was prolonged more than 30 seconds after STN DBS. Among 57 patients, 25 patients were categorized as having decline of executive function. Univariate analysis revealed that high preoperative UPDRS III motor score in the medication-off period and a depressive state evaluated with BDI-II correlated significantly with decline in executive function. Multiple logistic regression analysis revealed that the only significant independent variable related to early decline of executive function was the preoperative BDI-II score. Postoperative factors such as active contact location or dopaminergic medication reduction had no relation with the decline of executive function. Even in cognitively well-selected patients, STN DBS causes early decline in executive function in a significant number of patients. Preoperative simple cognitive screening alone could not predict early decline in executive function. More detailed neuropsychological evaluation, including mood status, should be undertaken before surgery.

关键词： Parkinson’s Disease Deep Brain Stimulation Subthalamic Nucleus Executive Function

Hayabusa2’s superior solar conjunction mission operations: Planning and post-operation results

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Astrodynamics 2020年第4期4卷 265-288页

作者： Stefania Soldini Hiroshi Takeuchi Sho Taniguchi Shota Kikuchi Yuto Takei Go Ono Masaya Nakano Takafumi Ohnishi Takanao Saiki yuichi Tsuda Fuyuto Terui Naoko OgawaYuya MimasuTadateru Takahashi Atsushi fujii Satoru NakazawaKent Yoshikawa Yusuke Oki Chikako Hirose Hirotaka Sawada Tomohiro Yamaguchi Makoto Yoshikawa Department of Mechanical Materials and Aerospace EngineeringUniversity of LiverpoolLiverpool L693BXUK Institute of Space and Astronautical Science Japan Aerospace Exploration AgencySagamihara 252-5210Japan Fujitsu Limited Tokyo 105-7123Japan Mitsubishi Electric Corporation Tokyo 100-8310Japan

In late 2018,the asteroid Ryugu was in the Sun's shadow during the superior solar conjunction *** the Sun-Earth-Ryugu angle decreased to below 3°,the Hayabusa2 spacecraft experienced 21 days of planned blackout in the Earth-probe communication *** was the first time a spacecraft had experienced solar conjunction while hovering around a minor *** the safety of the spacecraft,a low energy transfer trajectory named Ayu was designed in the Hill reference frame to increase its altitude from 20 to 110 *** trajectory was planned with the newly developed optNEAR tool and validated with real time *** article shows the results of the conjunction operation,from planning to fight data.

关键词： superior solar conjunction Hayabusa2 Ryugu hovering satellite mission operations