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Neutrophil peptide 1 accelerates the clearance of degenerative axons during Wallerian degeneration by activating macrophages after peripheral nerve crush injury

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Neural Regeneration Research 2024年第8期19卷 1822-1827页

作者： yuhui kou Yusong Yuan Qicheng Li Wenyong Xie Hailin Xu Na Han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina National Center for Trauma Medicine BeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina Department of Central Laboratory and Institute of Clinical Molecular Biology Peking University People’s HospitalBeijingChina

Macrophages play an important role in peripheral nerve regeneration,but the specific mechanism of regeneration is still *** preliminary findings indicated that neutrophil peptide 1 is an innate immune peptide closely involved in peripheral nerve ***,the mechanism by which neutrophil peptide 1 enhances nerve regeneration remains *** study was designed to investigate the relationship between neutrophil peptide 1 and macrophages in vivo and in vitro in peripheral nerve crush *** functions of RAW 264.7 cells we re elucidated by Cell Counting Kit-8 assay,flow cytometry,migration assays,phagocytosis assays,immunohistochemistry and enzyme-linked immunosorbent *** debris phagocytosis was observed using the CUBIC(Clear,Unobstructed Brain/Body Imaging Cocktails and Computational analysis)optical clearing technique during Wallerian *** inflammatory factor expression in different polarization states was detected using a protein *** results showed that neutrophil peptide 1 promoted the prolife ration,migration and phagocytosis of macrophages,and CD206 expression on the surfa ce of macrophages,indicating M2 *** axonal debris clearance rate during Wallerian degeneration was enhanced after neutrophil peptide 1 *** peptide 1 also downregulated inflammatory factors interleukin-1α,-6,-12,and tumor necrosis factor-αin invo and in ***,the results suggest that neutrophil peptide 1 activates macrophages and accelerates Wallerian degeneration,which may be one mechanism by which neutrophil peptide 1 enhances peripheral nerve regeneration.

关键词： axonal debris inflammatory factors macrophages neutrophil peptide 1 peripheral nerve injury peripheral nerve regeneration RAW 264.7 cells sciatic nerve Wallerian degeneration

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FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival

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Neural Regeneration Research 2025年第7期20卷 2108-2115页

作者： yuhui kou Zongxue Jin Yusong Yuan Bo Ma Wenyong Xie Na Han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina National Center for Trauma Medicine Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Trauma Medicine Center Peking University People’s HospitalBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina

FK506(Tacrolimus)is a systemic immunosuppressant approved by the *** and Drug ***506 has been shown to promote peripheral nerve regeneration,however,its precise mechanism of action and its pathways remain *** this study,we established a rat model of sciatic nerve injury and found that FK506 improved the morphology of the injured sciatic nerve,increased the numbers of motor and sensory neurons,reduced inflammatory responses,markedly improved the conduction function of the injured nerve,and promoted motor function *** findings suggest that FK506 promotes peripheral nerve structure recovery and functional regeneration by reducing the intensity of inflammation after neuronal injury and increasing the number of surviving neurons.

关键词： FK506 inflammation motor neurons nerve regeneration neuron peripheral nerve injury sensory neurons

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Synthesis and host-guest properties of pillar[6]arenes

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Science China Chemistry 2012年第2期55卷 223-228页

作者： TAO HongQi CAO DeRong LIU LuZhi kou yuhui WANG LingYun MEIER Herbert School of Chemistry and Chemical Engineering South China University of Technology Guangzhou 510640 China State Key Laboratory of Luminescent Materials and Devices South China University of Technology Guangzhou 510640 China Institute of Organic Chemistry University of Mainz 55099 Mainz Germany

A facile method for the synthesis of pillar[6]arenes was developed. A series of pillar[6]arenes were prepared with FeC13 as catalyst and chloroform as solvent at room temperature in moderate yields （30%-40%）. Their host-guest properties with n-cetyltrimethyl ammonium bromide were investigated by 1 HNMR. The results showed that high selectivity in the host-guest relationship became apparent between pillar[6]arenes and pillar[5]arenes based on the different size of the inner cavity.

关键词： calixarene pillararene FeCl3 supramolecular chemistry host-guest property

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Crystal Structure and Host-Guest Binding Ability of Three Types of Pillar[5]arenes

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中国化学:英文版 2015年第3期33卷 346-350页

作者： Luzhi Liu Wengui Duan yuhui kou Lingyun Wang Herbert Meier Derong Cao School of Chemistry and Chemical Engineering South China University of TechnologyGuangzhouGuangdong 510640China School of Chemistry and Chemical Engineering Guangxi UniversityNanningGuangxi 530004China Institute of Organic Chemistry University of MainzMainz 55099Germany

A systematic research of the structural characterization and the host-guest binding abilities between three types of pillar[5]arenes 3-5(3 for Structure Type I,4 for Structure Type II and 5 for Structure Type III)is carried out by 1H NMR measurements and X-ray *** results show that the configurations or symmetry of their cavities not only have large difference in these three types of pillar[5]arenes,but also have more or less variations even in the same structure type or the same host locked different guests such as crystals of 3a-3b,*** the other hand,the complexation behavior of pillar[5]arenes with 1,4-dibromobutane(DBB)is affected by the different symmetri-cal structure or substituents on the rings.

关键词： pillararenes crystal structure configuration complexation behavior

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Perceiving the connection between the bone healing process and biodegradation of biodegradable metal implants through precise bioadaptability principle

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Journal of Materials Science & Technology 2023年第16期147卷 132-144页

作者： Yufeng Zheng Xiao Liu Danni Shen Wenting Li Yan Cheng Ming Yang yuhui kou Baoguo Jiang Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China School of Materials Science and Engineering Peking UniversityBeijing 100871China International Research Organization for Advanced Science and Technology(IROAST) Kumamoto UniversityKumamoto 860-8555Japan Department of Orthopaedics and Traumatology Peking University People’s HospitalBeijing 100044China Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijing 100044China National Center for Trauma Medicine Beijing 100044China

The implants made of metallic biomaterials help healing the bone fracture but also affect the bone repair *** proposed in Matter 4(2021)2548–2650 by Wang et al.,a precisely adaptable biomaterial ought to recapitulate the targeted tissue with spatiotemporal precision and hierarchical accuracy,ranging from atoms and molecules(genes,proteins,etc.)to cells(including organelles)and to tissues and *** comparison to traditional bio-inert metallic bone implants such as Co-based alloys and Ti alloys,biodegradable metal(Mg and Zn alloys)bone implants had been developed and might arise many unexpected variables in the bone repair,due to their bioactive *** this paper,the bone repair without and with the presence of metallic implants is ***,the perspectives concerning the interactions between the bone tissues and biodegradable metal implants are put forward,and how to better mimic in vivo biodegradation by in vitro experiments is proposed for further research and development of biodegradable metals.

关键词： Biodegradable metals Magnesium Zinc Bone healing Precise bioadaptability

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神经源性异位骨化发病机制的研究进展

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中华创伤杂志 2020年第9期36卷 853-858页

作者：刘以俊寇玉辉张殿英姜保国北京大学人民医院创伤骨科创伤与神经再生研究所100044 北京大学滨海医院骨科天津300450

神经源性异位骨化(NHO)是在软组织中出现新生骨组织的现象,与中枢神经损伤相关,可引起肢体活动障碍、剧烈疼痛和皮肤溃疡等严重并发症,其发病机制尚不明确。近年针对NHO的发病机制有了更深入的研究,并据此提出了新的监测和治疗靶点。笔... 详细信息

神经源性异位骨化(NHO)是在软组织中出现新生骨组织的现象,与中枢神经损伤相关,可引起肢体活动障碍、剧烈疼痛和皮肤溃疡等严重并发症,其发病机制尚不明确。近年针对NHO的发病机制有了更深入的研究,并据此提出了新的监测和治疗靶点。笔者从促进成骨诱导因素、成骨前体细胞、成骨微环境三个方面对NHO的发病机制进行综述,为临床诊疗提供依据。

关键词：骨化,异位性骨形态发生蛋白质类间充质干细胞

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Na-MMT/醋丙复合乳液的制备及其性能研究

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广东化工 2013年第9期40卷 46-47页

作者：寇玉辉百奥泰生物科技(广州)有限公司广东广州510530

在剥离态钠基蒙脱土悬(Na-MMT)浮液中,通过原位乳液聚合法制备Na-MMT/醋丙(PVA)复合乳液,研究了Na-MMT含量对复合乳液聚合稳定性和存稳定性的影响,通过吸水率和紫外光老化等方法分别表征Na-MMT/PVA复合乳液的抗水性和抗老化性能,并通过... 详细信息

在剥离态钠基蒙脱土悬(Na-MMT)浮液中,通过原位乳液聚合法制备Na-MMT/醋丙(PVA)复合乳液,研究了Na-MMT含量对复合乳液聚合稳定性和存稳定性的影响,通过吸水率和紫外光老化等方法分别表征Na-MMT/PVA复合乳液的抗水性和抗老化性能,并通过透射电镜观察复合乳胶粒的形貌。实验结果表明:Na-MMT含量在2.0%以内有利于制备得到稳定性良好的复合乳液,复合乳液乳胶粒粒径和复合乳液涂膜吸水率均先减小后增大;复合乳液呈现层状与球状结合的复合结构,Na-MMT/PVA复合乳液涂层具有更好的耐水性和抗紫外老化性能。

关键词： Na-MMT 剥离抗水性

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杯芳烃手性识别在核磁中的检测

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有机化学 2011年第7期31卷 964-972页

作者：刘陆智寇玉辉汪凌云曹德榕华南理工大学化学与化工学院广州510640

杯芳烃是一类重要的主体化合物,在主-客体识别分析中有着广泛的用途.手性杯芳烃因其良好的手性识别、对映体分离和不对称催化等特点,成为杯芳烃化学中最令人瞩目的研究热点之一.在手性识别的研究中,核磁因其检测方便、直观、效果显著等... 详细信息

杯芳烃是一类重要的主体化合物,在主-客体识别分析中有着广泛的用途.手性杯芳烃因其良好的手性识别、对映体分离和不对称催化等特点,成为杯芳烃化学中最令人瞩目的研究热点之一.在手性识别的研究中,核磁因其检测方便、直观、效果显著等优点,成为检测手性化合物的对映体ee值和绝对构型中最为广泛的方法.综述了近年来以杯芳烃为分子骨架的手性受体的合成及其在核磁中的手性识别,最后对手性杯芳烃的发展前景作了展望.

关键词：手性识别杯芳烃对映体检测核磁

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Long-term bone and lung consequences associated with hospital-acquired severe acute respiratory syndrome:a 15-year follow-up from a prospective cohort study

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Bone Research 2020年第1期8卷 107-114页

作者： Peixun Zhang Jia Li Huixin Liu Na Han Jiabao Ju yuhui kou Lei Chen Mengxi Jiang Feng Pan Yali Zheng Zhancheng Gao Baoguo Jiang Department of Orthopedics and Trauma Peking University People’s HospitalBeijingChina Department of Respiratory Medicine Peking University People’s HospitalBeijingChina Department of Clinical Epidemiology and Biostatistics Peking University People’s HospitalBeijingChina Department of Central Laboratory Peking University People’s HospitalBeijingChina Department of Education Peking University People’s HospitalBeijingChina Department of Radiology Peking University People’s HospitalBeijingChina

The most severe sequelae after rehabilitation from SARS are femoral head necrosis and pulmonary fibrosis. We performed a 15-year follow-up on the lung and bone conditions of SARS patients. We evaluated the recovery from lung damage and femoral head necrosis in an observational cohort study of SARS patients using pulmonary CT scans, hip joint MRI examinations, pulmonary function tests and hip joint function questionnaires. Eighty medical staff contracted SARS in 2003. Two patients died of SARS, and78 were enrolled in this study from August 2003 to March 2018. Seventy-one patients completed the 15-year follow-up. The percentage of pulmonary lesions on CT scans diminished from 2003(9.40 ± 7.83)% to 2004(3.20 ± 4.78)%(P < 0.001) and remained stable thereafter until 2018(4.60 ± 6.37)%. Between 2006 and 2018, the proportion of patients with interstitial changes who had improved pulmonary function was lower than that of patients without lesions, as demonstrated by the one-second ratio(FEV1/FVC%, t = 2.21, P = 0.04) and mid-flow of maximum expiration(FEF25%–75%, t = 2.76, P = 0.01). The volume of femoral head necrosis decreased significantly from 2003(38.83 ± 21.01)% to 2005(30.38 ± 20.23)%(P = 0.000 2), then declined slowly from 2005 to 2013(28.99 ± 20.59)% and plateaued until 2018(25.52 ± 15.51)%. Pulmonary interstitial damage and functional decline caused by SARS mostly recovered, with a greater extent of recovery within 2 years after rehabilitation. Femoral head necrosis induced by large doses of steroid pulse therapy in SARS patients was not progressive and was partially reversible.

关键词： doses consequences slowly

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创伤性异位骨化形成的细胞及分子机制研究进展

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中华创伤杂志 2020年第4期36卷 366-371页

作者：张天宇寇玉辉张殿英姜保国北京大学人民医院创伤骨科 100044 北京大学人民医院创伤与神经再生研究所 100044 北京大学滨海医院骨科天津300450

创伤性异位骨化为创伤后骨外成骨。不同的损伤因素常诱导多种前体细胞参与这一过程。多种细胞因子如骨形态发生蛋白、缺氧诱导因子1-α、炎症、纤维蛋白沉积等会影响这一过程。异位骨化的形成常导致患肢功能受限及疼痛,而预防与治疗异... 详细信息

创伤性异位骨化为创伤后骨外成骨。不同的损伤因素常诱导多种前体细胞参与这一过程。多种细胞因子如骨形态发生蛋白、缺氧诱导因子1-α、炎症、纤维蛋白沉积等会影响这一过程。异位骨化的形成常导致患肢功能受限及疼痛,而预防与治疗异位骨化又常带来骨不愈合并伴随高复发率。何种治疗方法能够在抑制异位骨化形成的同时,又不影响骨折愈合成为目前临床医师所关注的问题。这就需要探究异位骨化的形成机制并从中寻找有效且安全的治疗方法。笔者对参与创伤性异位骨化形成的细胞及分子机制进行综述,旨在对影响异位骨化形成的因素有更多了解,为新的治疗方式提供参考。

关键词：骨化,异位性肌炎,骨化性骨形态发生蛋白质类缺氧诱导因子1

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