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神经生长因子与被动运动对失神经大鼠骨代谢指标的影响

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中国医药科学 2022年第1期12卷 35-38页

作者：王枫赵立奇姬宇辉蒋维海张佳月深圳市萨米医疗中心骨科广东深圳518118

目的探究神经生长因子与被动运动对失神经大鼠骨代谢指标的影响。方法采用随机抽签法将60只大鼠随机分为假手术组(SHAM组)、去神经组(DN组)、神经生长因子组(NGF组)、被动运动组(PM组)、神经生长因子及被动运动联合组(NGF+PM组)共5组,S... 详细信息

目的探究神经生长因子与被动运动对失神经大鼠骨代谢指标的影响。方法采用随机抽签法将60只大鼠随机分为假手术组(SHAM组)、去神经组(DN组)、神经生长因子组(NGF组)、被动运动组(PM组)、神经生长因子及被动运动联合组(NGF+PM组)共5组,SHAM组无需将坐骨神经及股神经切除,其他4组将大鼠右侧坐骨神经及股神经切除,建立SD大鼠右侧后肢去神经模型,给予被动运动及外源生长因子干预,比较各组大鼠血清骨钙素(BGP)、抗酒石酸酸性磷酸酶(TRACP)水平。结果术后2周大鼠体重均有所增加,术后3周DN组、NGF+PM组、SHAM组体重均明显高于PM组与NGF组,术后4周DN组最轻,SHAM组最重,差异有统计学意义(P<0.05);DN组大鼠血清BGP明显低于SHAM组,血清TRACP水平高于SHAM组,差异有统计学意义(P<0.05);NGF组、NGF+PM组血清BGP水平高于DN组,血清TRACP水平低于DN组,差异有统计学意义(P<0.05);PM组血清TRACP水平明显低于DN组,差异有统计学意义(P<0.05)。结论大鼠下肢丧失神经支配后会出现肌肉萎缩及骨代谢破坏,给予神经生长因子及被动运动干预,有利于改善血清BGP与TRACP水平,预防骨质疏松的发生。

关键词：大鼠神经生长因子被动运动骨代谢指标血清骨钙素血清抗酒石酸酸性磷酸酶

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Influence of metal-contamination on distribution in subcellular fractions of the earthworm (Metaphire californica) from Hunan Province, China

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Journal of Environmental Sciences 2018年第11期30卷 127-137页

作者： Kun Wang yuhui Qiao Huiqi Zhang Shizhong Yue Huafen Li Xionghui ji Longsheng Liu College of Resources and Environmental Science China Agricultural University Beijing 100193 China Hunan Academy of Agricultural Sciences Changsha 410125 China Hengyang Academy of Agricultural Sciences Hengyang 421151 China

Earthworms have the ability to accumulate of heavy metals, however, there was few studies that addressed the metals in earthworm at subcellular levels in fields. The distributions of metals （Cd, Cu, Zn, and Pb） in subcellular fractions （cytosol, debris, and granules） of earthworm Metaphire californica were investigated. The relationship between soil metals and earthworms were analyzed to explain its high plasticity to inhabit in situ contaminated soil of Hunan Province, south China. The concentration of Cd in subcellular compartments showed the same pattern as Cu in the order of cytosol 〉 debris 〉 granules. The distribution of Zn and Pb in earthworms indicated a similar propensity for different subcellular fractions that ranked as granules 〉 debris 〉 cytosol for Zn, and granules 〉 cytosol 〉 debris for Pb. The internal metal concentrations in earthworms increased with the soil metals （p 〈 0.05）. Significant positive correlations were found between soil Cd and Cd concentrations in cytosol and debris （p 〈 0.01）. Moreover, the soil Pb concentration significantly influenced the Pb concentrations in cytosol and debris （p 〈 0.01）, similar to that of Cd. The soil Cu concentrations was only associated with the Cu in granules （p 〈 0.05）. Soil Zn concentrations correlated with the Zn concentrations in each subcellular fraction （p 〈 0.05）. Our results provide insights into the variations of metals partitioning in earthworms at subcellular levels and the relationships of soil metals, which could be one of the detoxiflcation strategies to adapt the long-term contaminated environment.

关键词： Heavy metals Metaphire californica Subcellular fractions South China

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不同肥料投入对有机菜田土壤质量的影响

中国农业大学学报 2024年第6期29卷 197-205页

作者：王相宜黄红心鞠鲤懋汤耀中朱秀妹李季乔玉辉中国农业大学资源与环境学院北京100193 江苏省昆山市果蔬科技小院江苏苏州215300 中国农业大学有机循环研究院(苏州) 江苏苏州215100 山东省青岛市即墨区农业农村局山东青岛266200 昆山悦丰岛有机农副产品基地有限公司江苏苏州215300

为探究不同肥料投入对有机菜田土壤质量的影响,以有机菜田为研究对象,设置商品有机肥(OF)、餐厨有机肥(KOF)、绿肥(G)和种植绿肥配施菌剂(MG)4个处理,以不施用肥料为对照(CK),测定不同肥料投入后有机菜田土壤的pH、有机质含量、阳离子... 详细信息

为探究不同肥料投入对有机菜田土壤质量的影响,以有机菜田为研究对象,设置商品有机肥(OF)、餐厨有机肥(KOF)、绿肥(G)和种植绿肥配施菌剂(MG)4个处理,以不施用肥料为对照(CK),测定不同肥料投入后有机菜田土壤的pH、有机质含量、阳离子交换量等15个指标,利用相关性分析、聚类分析以及主成分分析等方法建立有机菜田土壤质量评价最小数据集,并根据非线性参数方程及权重计算出不同肥料投入对土壤质量的综合影响指数。结果表明:与CK相比,施加OF和KOF均可以显著提高土壤pH、速效磷含量、电导率、钠离子含量(P<0.05),施加KOF可使土壤有机质增加18.52%(P<0.05)。相较于CK,施用有机肥和种植绿肥均可以提升土壤质量,但KOF的施用对土壤质量提升效果最为显著,综合土壤质量评价指数较CK升高30.23%。在筛选出的8个土壤评价最小数据集指标中,土壤有机质对土壤质量影响最大。综上,施加餐厨有机肥比商品有机肥和绿肥更有利于提升有机菜田的土壤质量。

关键词：有机肥绿肥土壤性质最小数据集土壤质量评价

汽轮发电机转子绕组匝间短路故障恶化的影响因素研究

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大电机技术 2024年第4期 43-50页

作者：武玉才张宇航纪璇白雨卉华北电力大学电力工程系河北保定071003

转子绕组匝间短路是大型同步发电机的常见故障,在发电机的电气故障中占据了较高的比例,也是影响机组安全运行的主要原因之一。本文针对转子绕组匝间短路伴随的局部过热问题,分别研究了短路点过渡电阻、短路点电流集束效应以及短路点的... 详细信息

转子绕组匝间短路是大型同步发电机的常见故障,在发电机的电气故障中占据了较高的比例,也是影响机组安全运行的主要原因之一。本文针对转子绕组匝间短路伴随的局部过热问题,分别研究了短路点过渡电阻、短路点电流集束效应以及短路点的反复通断过程对其的影响。以一台300MW汽轮发电机为例,仿真获取了短路回路电流和功率损耗、短路点附近励磁电流密度以及被短路回路的暂态电压规律。本研究为确定转子绕组匝间短路故障的过热现象原因奠定了理论基础,也为进一步研究故障演化过程提供了分析思路。

关键词：汽轮发电机励磁电流匝间短路过渡电阻功率损耗集束效应暂态电压

An OP-TEE Energy-Efficient Task Scheduling Approach Based on Mobile Application Characteristics

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Intelligent Automation & Soft Computing 2023年第8期37卷 1621-1635页

作者： Hai Wang Xuan Hao Shuo ji jie Zheng yuhui Ma jianfeng Yang State-Province Joint Engineering and Research Center of Advanced Networking and Intelligent Information Services School of Information Science and TechnologyNorthwest UniversityXi’an710127China

Trusted Execution Environment(TEE)is an important part of the security architecture of modern mobile devices,but its secure interaction process brings extra computing burden to mobile *** paper takes open portable trusted execution environment(OP-TEE)as the research object and deploys it to Raspberry Pi 3B,designs and implements a benchmark for OP-TEE,and analyzes its program ***,the application execution time,energy consumption and energy-delay product(EDP)are taken as the optimization objectives,and the central processing unit(CPU)frequency scheduling strategy of mobile devices is dynamically adjusted according to the characteristics of different applications through the combined *** experimental result shows that compared with the default strategy,the scheduling method proposed in this paper saves 21.18%on average with the Line Regression-Decision Tree scheduling model with the shortest delay as the optimization *** Decision Tree-Support Vector Regression(SVR)scheduling model,which takes the lowest energy consumption as the optimization goal,saves 22%energy on *** Decision Tree-K-Nearest Neighbor(KNN)scheduling model with the lowest EDP as the optimization objective optimizes about 33.9%on average.

关键词： Trusted execution environment energy efficiency optimization CPU scheduling governor machine learning

大倾角下分层破碎顶板综采工作面安全管理研究

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山东煤炭科技 2024年第5期42卷 185-188,193页

作者：吕星毛玉辉中国平煤神马控股集团有限公司河南平顶山467000 平顶山天安煤业股份有限公司安全技术培训中心河南平顶山467000

大倾角下分层破碎顶板综采工作面主要面临设备稳定性差、煤矸易滚落、顶板破碎、伪倾斜不易控制等问题,回采过程中设备防倒防滑管理、顶板管理以及防滚矸管理等都制约着工作面实现安全高效生产。通过分析平煤股份香山矿己组西翼复采工... 详细信息

大倾角下分层破碎顶板综采工作面主要面临设备稳定性差、煤矸易滚落、顶板破碎、伪倾斜不易控制等问题,回采过程中设备防倒防滑管理、顶板管理以及防滚矸管理等都制约着工作面实现安全高效生产。通过分析平煤股份香山矿己组西翼复采工作面回采过程中遇到的上述技术和管理难题,确定了设备选型和开采方案,制定了采煤机和液压支架防倒防滑措施、破碎顶板加强管理措施、工作面防滚矸措施等,避免了生产过程中出现支架倾倒、运输机下滑、顶板冒漏及滚矸伤人等问题,实现了工作面安全高效生产。

关键词：大倾角下分层综采安全管理

A paradigm for high-throughput screening of cell-selective surfaces coupling orthogonal gradients and machine learning-based cell recognition

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Bioactive Materials 2023年第10期28卷 1-11页

作者： Hongye Hao Yunfan Xue yuhui Wu Cong Wang Yifeng Chen Xingwang Wang Peng Zhang jian ji MOE Key Laboratory of Macromolecule Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027PR China International Research Center for X Polymers International CampusZhejiang UniversityHaining314400PR China

The combinational density of immobilized functional molecules on biomaterial surfaces directs cell behaviors. However, limited by the low efficiency of traditional low-throughput experimental methods, investigation and optimization of the combinational density remain daunting challenges. Herein, we report a high-throughput screening set-up to study biomaterial surface functionalization by integrating photo-controlled thiol-ene surface chemistry and machine learning-based label-free cell identification and statistics. Through such a strategy, a specific surface combinational density of polyethylene glycol (PEG) and arginine-glutamic acid-aspartic acid-valine peptide (REDV) leads to high endothelial cell (EC) selectivity against smooth muscle cell (SMC) was identified. The composition was translated as a coating formula to modify medical nickel-titanium alloy surfaces, which was then proved to improve EC competitiveness and induce endothelialization. This work provided a high-throughput method to investigate behaviors of co-cultured cells on biomaterial surfaces modified with combinatorial functional molecules.

关键词： alloy coating high

“分合协同”药学硕士专业学位研究生创新人才培养途径探索

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药学教育 2024年第4期40卷 6-10,37页

作者：金阳季勇韩峰李歆辛洪亮林瑜辉都述虎南京医科大学药学院南京211166

针对“新医科”建设背景下药学硕士专业学位研究生培养要求,南京医科大学秉持采用“需求-培养-发展”培养理念,从培养体系、培养环境和培养手段等方面,探索药学硕士专业学位研究生“分合协同”培养途径,在践行药学硕士专业学位研究生培... 详细信息

针对“新医科”建设背景下药学硕士专业学位研究生培养要求,南京医科大学秉持采用“需求-培养-发展”培养理念,从培养体系、培养环境和培养手段等方面,探索药学硕士专业学位研究生“分合协同”培养途径,在践行药学硕士专业学位研究生培养过程中取得了一定成效。

关键词：药学硕士专业学位研究生分合协同培养途径

Perfection of Perovskite Grain Boundary Passivation by Rhodium Incorporation for Efficient and Stable Solar Cells

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Nano-Micro Letters 2020年第9期12卷 203-213页

作者： Wei Liu Nanjing Liu Shilei ji Hongfeng Hua yuhui Ma Ruiyuan Hu jian Zhang Liang Chu Xing’ao Li Wei Huang Institute of Advanced Materials and New Energy Technology Engineering Laboratory of jiangsu Province Nanjing University of Posts and Telecommunications(NUPT)Nanjing 210023People’s Republic of China Shaanxi Institute of Flexible Electronics Northwestern Polytechnical UniversityXi’an 710072People’s Republic of China Guangdong Provincial Key Lab of Nano‑Micro Materials Research School of Chemical Biology and BiotechnologyPeking University Shenzhen Graduate SchoolShenzhen 518055People’s Republic of China

Organic cation and halide anion defects are omnipresent in the perovskite films,which will destroy perovskite electronic structure and downgrade the properties of *** passivation in halide perovskites is crucial to the application of solar ***,tiny amounts of trivalent rhodium ion incorporation can help the nucleation of perovskite grain and passivate the defects in the grain boundaries,which can improve efficiency and stability of perovskite solar *** first-principle calculations,rhodium ion incorporation into the perovskite structure can induce ordered arrangement and tune *** experiment,rhodium ion incorporation with perovskite can contribute to preparing larger crystalline and uniform film,reducing trap-state density and enlarging charge carrier *** optimizing the content of 1% rhodium,the devices achieved an efficiency up to 20.71% without obvious hysteresis,from 19.09% of that pristine *** addition,the unencapsulated solar cells maintain 92% of its initial efficiency after 500 h in dry *** work highlights the advantages of trivalent rhodium ion incorporation in the characteristics of perovskite solar cells,which will promote the future industrial application.

关键词： Perovskite solar cells Grain boundary passivation Rhodium incorporation