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中医定向透药联合护理干预对COPD急性加重期患者肺功能和满意度的影响

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上海医药 2024年第6期45卷 18-20,49页

作者：邱兵黄纡寰江西省抚州市中医医院内科抚州344000

目的:研究中医定向透药联合护理干预治疗慢性阻塞性肺疾病急性加重期(AECOPD)的临床效果。方法:收集2021年1月—2022年12月江西省抚州市中医医院AECOPD患者64例,按随机数字表法分成两组各32例。对照组给予西医常规治疗和护理,干预组在... 详细信息

目的:研究中医定向透药联合护理干预治疗慢性阻塞性肺疾病急性加重期(AECOPD)的临床效果。方法:收集2021年1月—2022年12月江西省抚州市中医医院AECOPD患者64例,按随机数字表法分成两组各32例。对照组给予西医常规治疗和护理,干预组在对照组基础上加用中医定向透药疗法联合护理干预,两组均治疗2周。比较两组治疗前、治疗2周后的1秒用力呼吸容积(FEV_(1))、FEV_(1)占预计值(FEV_(1)%)、FEV_(1)与用力肺活量(FVC)比值(FEV_(1)/FVC)、临床病情控制有效率以及患者满意率。结果:治疗2周后,干预组的FEV_(1)值、FEV_(1)%值、FEV_(1)/FVC值均高于对照组(P<0.05)。干预组的临床病情控制有效率和患者满意率分别为96.88%(31/32)、96.88%(31/32),高于对照组的71.88%(23/32)和75.00%(24/32,P<0.05)。结论:中医定向透药联合护理干预治疗AECOPD效果佳,可有效改善肺功能,提高治疗效果和患者满意度。

关键词： AECOPD 中医定向透药护理干预肺功能疗效满意度

新时期乡村特色发展理论与实践初探——以京津冀乡镇为例

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小城镇建设 2024年第7期42卷 5-13页

作者：曾鹏黄雨欢孙宗耀天津大学建筑学院城乡规划系昆明理工大学建筑与城市规划学院

特色化发展是当前乡村地区由脱贫攻坚转向乡村振兴的重要要求,也是乡村持续高质量发展的动力来源。面向广域乡村地区发展的紧迫需求,梳理乡村发展脉络,更新具有现实价值的乡村特色发展理论尤为重要。本研究整理了自改革开放以来乡村发展... 详细信息

特色化发展是当前乡村地区由脱贫攻坚转向乡村振兴的重要要求,也是乡村持续高质量发展的动力来源。面向广域乡村地区发展的紧迫需求,梳理乡村发展脉络,更新具有现实价值的乡村特色发展理论尤为重要。本研究整理了自改革开放以来乡村发展的3个阶段,认为既往乡村特色发展体系遵循特色萌芽阶段、类型拓展阶段和培育强化阶段逐步深入,当前来到全面特色化的关键阶段。在此基础上,研究总结了新时期乡村特色发展的主体要求,在“精准化特色定位+统筹区域要素配置”上进行完善,提出乡村特色发展的概念与框架,以期为广域乡村空间优势挖潜和特色激活提供理论支撑。最后以京津冀乡镇为案例,根据特色发展理论框架展开实证研究,初步完成了从特色识别到特色培育的全流程研究,讨论了其中的方法创新和期待未来能解决的诸多科学问题。

关键词：乡村特色发展演进阶段特色定位特色培育京津冀

刘敏如教授治疗多囊卵巢综合征胞中脂膜壅塞诸证的用药规律

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中国实验方剂学杂志 2024年第20期30卷 169-176页

作者：何鑫波胡翔刘敏如李馥竹黄玉环成都中医药大学附属医院成都610032 成都中医药大学成都610075 上海道生医疗科技有限公司上海201203

目的:分析总结刘敏如教授治疗多囊卵巢综合征胞中脂膜壅塞诸证的用药规律及核心处方,探索其潜在作用机制。方法:运用双平台开展数据挖掘,分析刘教授治疗本病的处方用药规律,提取核心处方;以网络药理学方法获取核心处方有效成分,构建中药... 详细信息

目的:分析总结刘敏如教授治疗多囊卵巢综合征胞中脂膜壅塞诸证的用药规律及核心处方,探索其潜在作用机制。方法:运用双平台开展数据挖掘,分析刘教授治疗本病的处方用药规律,提取核心处方;以网络药理学方法获取核心处方有效成分,构建中药-有效成分-靶点网络,分析其潜在作用机制。结果:纳入医案处方321张,涉及178味中药,成方颗粒28种。药物主归肝、肾经,味以甘、辛、苦为主,性多温、平、微寒;常用药对包括山药-熟地黄、川芎-当归、柴胡-枳壳、皂角刺-莪术等,常用血府逐瘀汤、四物汤、养精种玉汤、左归丸、四逆散组方。核心处方由当归、白芍、皂角刺、淫羊藿等12味药物组成,含74个有效成分,核心成分有槲皮素、木犀草素、山柰酚、非瑟酮、β-谷甾醇等;发现关键靶点37个,涉及磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)、丝裂原活化蛋白激酶(MAPK)、Janus酪氨酸蛋白激酶(JAK)/信号转导与转录激活因子(STAT)等信号通路。结论:该病虚实错杂,刘教授围绕“肾虚为本,痰瘀为标”的核心病机,在“肾气为根,保阴为本”“育阴涵阳”的学术思想指导下,平补肾中阴阳,养精血顾其本,散结、活血理气治其标;遣药组方思路严谨,核心处方具有多成分、多靶点、多通路综合调控的特点。

关键词：多囊卵巢综合征胞中脂膜壅塞诸证数据挖掘网络药理学国医大师刘敏如

注射用鼠神经生长因子联合高压氧辅助治疗早产儿脑损伤的效果

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中国药物滥用防治杂志 2024年第7期30卷 1260-1263页

作者：张磊黄玉焕李莹南阳市第一人民医院新生儿重症监护科河南南阳473000

目的:研究注射用鼠神经生长因子联合高压氧对早产脑损伤患儿新生儿神经行为(NABA)评分及Tau蛋白、Toll样受体9(TLR9)mRNA相对表达水平的影响。方法:以2021年10月—2022年10月我院收治的99例早产脑损伤患儿为研究对象,采用随机数字表法... 详细信息

目的:研究注射用鼠神经生长因子联合高压氧对早产脑损伤患儿新生儿神经行为(NABA)评分及Tau蛋白、Toll样受体9(TLR9)mRNA相对表达水平的影响。方法:以2021年10月—2022年10月我院收治的99例早产脑损伤患儿为研究对象,采用随机数字表法分为对照组(49例)和联合组(50例)。对照组采用高压氧治疗,联合组采用注射用鼠神经生长因子联合高压氧治疗。比较两组临床疗效、NABA评分、大脑中动脉血流动力学指标[收缩期峰值流速(PSFV)、舒张末期血流速度(EDFV)、平均血流速度(Vm)、阻力指数(RI)]、血清指标[髓鞘碱性蛋白(MBP)、S100钙结合蛋白β(S100β)、Tau蛋白及TLR9 mRNA相对表达水平]、不良反应发生率。结果:联合组临床总有效率高于对照组(P0.05)。结论:采用注射用鼠神经生长因子与高压氧联合治疗早产脑损伤患儿可提高临床疗效,减轻患儿神经行为异常,促进脑血流动力学及神经功能改善。

关键词：注射用鼠神经生长因子高压氧早产儿脑损伤新生儿神经行为评分

自拟钩草平肝汤治疗椎基底动脉供血不足引起的眩晕的临床效果

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中国当代医药 2024年第11期31卷 168-171页

作者：邱兵黄纡寰胡小花江西省抚州市中医医院内科江西抚州344000

目的评估自拟钩草平肝汤联合护理干预在治疗椎基底动脉供血不足引起的眩晕中的临床效果。方法选择2022年1月至2023年2月抚州市中医医院内科收治的80例符合椎基底动脉供血不足引起眩晕的患者作为研究对象,采用随机数字表法分为对照组(40... 详细信息

目的评估自拟钩草平肝汤联合护理干预在治疗椎基底动脉供血不足引起的眩晕中的临床效果。方法选择2022年1月至2023年2月抚州市中医医院内科收治的80例符合椎基底动脉供血不足引起眩晕的患者作为研究对象,采用随机数字表法分为对照组(40例)和观察组(40例)。对照组采用常规治疗和护理干预,观察组在对照组的基础上增加口服自拟钩草平肝汤。比较两组治疗前后的眩晕情况、生活质量、心理状态。结果观察组患者治疗后的眩晕障碍量表(DHI)评分低于对照组,生活质量综合评定问卷(GQOL-74)评分高于对照组,差异有统计学意义(P<0.05)。观察组治疗后抑郁自评量表(SDS)评分和焦虑自评量表(SAS)评分均低于对照组,差异均有统计学意义(P<0.05)。结论本研究结果表明自拟钩草平肝汤联合护理干预能够有效改善椎基底动脉供血不足引起的眩晕的临床症状。

关键词：钩草平肝汤护理干预椎基底动脉供血不足眩晕

钩草平肝汤联合针刺治疗肝阳上亢型后循环缺血性眩晕临床观察

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中国中医药现代远程教育 2024年第6期22卷 133-135,154页

作者：胡小花黄纡寰段小林抚州市中医院内二科江西抚州344000

目的观察自拟钩草平肝汤联合针刺治疗肝阳上亢型后循环缺血性眩晕的临床效果。方法采用随机对照原则,将符合纳入标准的60例肝阳上亢型后循环缺血性眩晕患者分为对照组、观察组,各30例。对照组用盐酸倍他司汀注射液静脉滴注治疗,观察组... 详细信息

目的观察自拟钩草平肝汤联合针刺治疗肝阳上亢型后循环缺血性眩晕的临床效果。方法采用随机对照原则,将符合纳入标准的60例肝阳上亢型后循环缺血性眩晕患者分为对照组、观察组,各30例。对照组用盐酸倍他司汀注射液静脉滴注治疗,观察组在对照组基础上加自拟钩草平肝汤口服及针刺治疗,2组疗程均为10 d。比较2组患者的中医证候疗效、经颅多普勒(TCD)血流检查指标等。结果治疗后,观察组的总有效率为96.67%(29/30),高于对照组的76.67%(23/30),差异有统计学意义(P<0.05)。2组患者的TCD各项指标平均血流速度(Vm)较治疗前均有明显提高,且观察组的左、右椎动脉及基底动脉的Vm明显高于对照组,差异均有统计学意义(P<0.05)。结论自拟钩草平肝汤联合针刺治疗后循环缺血性眩晕效果显著,可明显改善患者的眩晕症状,值得临床进一步推广。

关键词：眩晕后循环缺血性眩晕肝阳上亢证钩草平肝汤针刺疗法中医综合疗法

Distribution characteristics of lipids in hadal sediment in the Yap Trench

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Journal of Oceanology and Limnology 2020年第3期38卷 634-649页

作者： YAN Yixin SUN Chengjun huang yuhuan CAO Wei JIANG Fenghua YANG Guipeng DING Haibing Key Laboratory of Marine Chemistry Theory and Technology Ocean University of ChinaQingdao 266100China College of Chemistry and Chemical Engineering Ocean University of ChinaQingdao 266100China Key Laboratory of Marine Eco-environmental Science and Technology Marine Bioresource and Environment Research CenterFirst Institute of OceanographyMinistry of Natural ResourcesQingdao 266061China Qingdao National Laboratory for Marine Science and Technology Qingdao 266237China Qingdao Collaborative Innovation Center of Marine Science and Technology Qingdao 266100China

In this study,cored sediment samples collected by the Jiaolong Submersible at 6779 m depth from the hadal zone of the Yap Trench in May 2016 were sliced in 1-cm interval from top to bottom,and lipids in each sediment layer were quantitatively and qualitatively *** vertical distribution profiles of the lipids in the sediment sample,their main existing forms,and their possible sources were *** results show that the concentration of lipid in the surface sediment was the highest with the carbon number from 12 to 27,dominated by medium and short-chain *** total concentration of fatty acids in surface sediment was much higher than those in the offshore and deep-sea areas,being up to 325.77μg/g due to the funnel effect caused by the“V”terrain of the *** acid 18:0 was the most abundant lipids in the sediment *** high concentrations of fatty acid 18:1ω7 and alkanes indicated the existence of hydrothermal fluids in the study *** addition,saturated fatty acids and monounsaturated fatty acids existed mainly in free form,and polyunsaturated fatty acids existed mainly in bound *** of the alkanes were in bound form,and their major source was autochthounous *** carbon number of alcohols in the sediment sample ranged from 12 to 20,mainly existed in bound *** source of fatty acids was mainly autochthonous input,and the neutral lipids had both marine and terrestrial *** is the first study of lipids in hadal sediment of the Yap *** results will promote deeper understanding of organic carbon cycle in marine environment.

关键词： hadal zone the Yap Trench lipids fatty acids sediment

Characteristics of vertical distributions of methane and dimethylsulphoniopropionate in the southern Yap Trench

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Journal of Oceanology and Limnology 2023年第6期41卷 2101-2116页

作者： yuhuan huang Chengjun SUN Lina Lü Neal Xiangyu DING Liangmin YU Guipeng YANG Haibing DING Frontier Science Center for Deep Ocean Multispheres and Earth System and Key Laboratory of Marine Chemistry Theory and TechnologyMinistry of EducationOcean University of ChinaQingdao 266100China Marine Ecology and Environmental Science Laboratory Laoshan Laboratory(Qingdao)Qingdao 266237China Marine Bioresource and Environment Research Center the First Institute of OceanographyMinistry of Natural ResourcesQingdao 266061China College of Chemistry and Chemical Engineering Ocean University of ChinaQingdao 266100China Key Laboratory of Tropical Marine Bio-resources and Ecology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China College of Agriculture and Life Sciences Cornell UniversityIthacaNY 14853USA

Methane(CH_(4) )and dimethylsulphoniopropionate(DMSP)are major carbon and sulfur sources for bacterioplankton in the *** investigated the characteristics of CH_(4) and DMSP in the southern Yap Trench from sea surface to hadal zone in June *** found that concentrations of CH_(4) varied from 1.5 to 4.5 nmol/L with saturation between 94% and 204% in the euphotic *** of dissolved DMSP(DMSPd)ranged from 0.5 to 3.7 nmol/L with higher values in surface water and decreased with *** of particulate DMSP(DMSPp)varied from 0 to 13.6 nmol/*** of total DMSP(DMSPt)ranged 2.0-15.2 nmol/*** concentrations decreased slightly and reached consistent levels in 200-3000-m depth due probably to heterotrophic bacterial production in marine aphotic and high-pressure *** exception occurred around 4000-m depth where their concentrations increased considerably and then decreased in deeper *** previously unrecognized phenomenon sheds light on the elevated concentrations of DMSP in the abyssal layer that might be affected by the Lower Circumpolar Deep Water(LCPW).Concentrations of CH_(4) in seawater of the Benthic Boundary Layer of the southern Yap Trench were slightly higher than those in the water column at approximate depth,and concentrations of DMSP in seawater of the Benthic Boundary Layer of the southern Yap Trench were not much higher than those in the water column at the approximate depth,indicating that sediment was a weak source of CH_(4) but was not a source of DMSP for seawater in the study *** study presented clear correlations between CH_(4) and DMSP from sea surface to sea bottom,proving that DMSP might be a potential substrate for CH_(4) not only in oxic surface seawater but also in deep water.

关键词： methane dimethylsulphoniopropionate(DMSP) hadal zone Jiaolong submersible Yap Trench oceanic methane paradox

Understanding the Behavioral Differences Between American and German Users: A Data-Driven Study

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Big Data Mining and Analytics 2018年第4期1卷 284-296页

作者： Chenxi Yang Yang Chen Qingyuan Gong Xinlei He Yu Xiao yuhuan huang Xiaoming Fu School of Computer Science Fudan UniversityShanghai 200433China Engineering Research Center of Cyber Security Auditing and Monitoring Ministry of EducationShanghai 200433China Department of Communications and Networking Aalto University02150 EspooFinland Faculty of European Languages and Cultures Guangdong University of Foreign StudiesGuangzhou 510420China Institute of Computer Science University of Gottingen37077 GottingenGermany

Given that the USA and Germany are the most populous countries in North America and Western Europe,understanding the behavioral differences between American and German users of online social networks is *** this work,we conduct a data-driven study based on the Yelp Open *** demonstrate the behavioral characteristics of both American and German users from different aspects,i.e.,social connectivity,review styles,and spatiotemporal *** addition,we construct a classification model to accurately recognize American and German users according to the behavioral *** model achieves high classification performance with an F1-score of 0.891 and AUC of 0.949.

关键词： behavioral difference online social networks Yelp machine learning