检索结果-南通市图书馆

Comparative study on virus shedding patterns in nasopharyngeal and fecal specimens of COVID-19 patients

Science China(Life Sciences) 2021年第3期64卷 486-488页

作者： Ning Zhang yuhuan gong Fanping Meng Yi Shi Jun Wang Panyong Mao Xia Chuai Yuhai Bi Penghui Yang Fusheng Wang CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyCenter for Influenza Research and Earlywarning(CASCIRE)CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID)Chinese Academy of SciencesBeijing 100101China Institutes of Physical Science and Information Technology Anhui UniversityHefei 230601China The Fifth Medical Center of PLA General Hospital National Clinical Research Center for Infectious DiseasesBeijing 100039China Department of Pathogenic Biology Hebei Medical UniversityShijiazhuang 050017China Shenzhen Key Laboratory of Pathogen and Immunity Second Hospital Affiliated to Southern University of Science and TechnologyShenzhen Third People’s HospitalShenzhen 518112China University of Chinese Academy of Sciences Beijing 101408China

Dear Editor,An acute viral pneumonia(COVID-19),caused by the novel coronavirus known as SARS-CoV-2,was first identified during December 2019 in China(Zhu et al.,2020).SARSCoV-2 was found to be highly transmissible in humans(Wang et al.,2020)and is now a pandemic spreading to over 140 countries and causing over 150,000 infections and 6,000 deaths as of March 15,*** is critical for confirmation and treatment of *** the primary criterion for diagnosis of COVID-19 is viral RNA detection for respiratory ***,two studies on virus loads in clinical samples reported that viral loads in nasal and throat swabs and sputum specimens peaked at 3–7 days after illness onset(d.a.o.)and virtually disappeared before 15 d.a.o.(Pan et al.,2020;Zou et al.,2020).Another study showed that the median duration of virus shedding in throat swabs was 20 *** survivors and was detectable until death in non-survivors(Zhou et al.,2020).Additionally,live viruses have been isolated in the feces and urine samples of COVID-19 ***,the viral dynamics in these types of specimens has not yet been clearly elucidated,as well as comparative studies on virus shedding in the upper respiratory,intestinal,and urinary tracts.

关键词： patients diagnosis urine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Co-existence and co-infection of influenza A viruses and coronaviruses: Public health challenges

引用

The Innovation 2022年第5期3卷 38-47页

作者： Jing Yang yuhuan gong Chunge Zhang Ju Sun Gary Wong Weifeng Shi Wenjun Liu George FGao Yuhai Bi CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyCenter for Influenza Research and Early-warning(CASCIRE)CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID)Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Institut Pasteur of Shanghai Chinese Academy of SciencesShanghai 200031China Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong Shandong First Medical University&Shandong Academy of Medical SciencesTaian 271016China

Since the 20th century,humans have lived through five pandemics caused by influenza A viruses(IAVs)(H1N1/1918,H2N2/1957,H3N2/1968,and H1N1/2009)and the coronavirus(CoV)severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).IAVs and CoVs both have broad host ranges and share multiple *** co-circulation and even co-infections facilitate genetic reassortment among IAVs and recombination among CoVs,further altering virus evolution dynamics and generating novel variants with increased cross-species transmission ***,SARS-CoV-2 may maintain longterm circulation in humans as seasonal ***-existence and co-infection of both viruses in humans could alter disease transmission patterns and aggravate disease ***,we demonstrate how virus-host ecology correlates with the co-existence and co-infection of IAVs and/or CoVs,further affecting virus evolution and disease dynamics and burden,calling for active virus surveillance and countermeasures for future public health challenges.

关键词： infection maintain generating

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

从大学衍生企业看学术价值与商业价值的冲突及其化解

引用

科技管理研究 2006年第12期26卷 215-217页

作者：龚玉环黑龙江科技学院人文社会科学学院黑龙江哈尔滨150027

本文从场域的视角阐明了大学衍生企业引发的价值冲突的实质和形式,在此基础上,从办学理念、功能定位、制度安排、衍生企业发展模式以及价值冲突防范等方面对麻省理工学院进行了详细分析,揭示了明确的学术价值目标、严明的教学科研制度... 详细信息

本文从场域的视角阐明了大学衍生企业引发的价值冲突的实质和形式,在此基础上,从办学理念、功能定位、制度安排、衍生企业发展模式以及价值冲突防范等方面对麻省理工学院进行了详细分析,揭示了明确的学术价值目标、严明的教学科研制度保障是大学发展衍生企业、化解价值冲突的关键。

关键词：大学衍生企业科学场域经济场域学术价值商业价值

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Anti-infection effects of heparin on SARS-CoV-2 in a diabetic mouse model

引用

Zoological Research 2023年第6期44卷 1003-1014页

作者： Zhongyun Zhang Ning Zhang Xuancheng Lu Min Zhou Xiaoxiang Yan Weiqiong Gu Jingru Yang Qin Zhang Cheng Zhang yuhuan gong Mingjun Jia Xiaoyu Zhang Peng Ning Mei Liu Xiaoyan Li Xiaomeng Shi Wenjun Liu George FGao Guang Ning Jiqiu Wang Yuhai Bi Department of Endocrinology and Metabolism Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR ChinaShanghai National Center for Translational MedicineShanghai 200025China CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyCenter for Influenza Research and Early-warning(CASCIRE)CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID)Chinese Academy of SciencesBeijing 100101China Laboratory Animal Center Chinese Center for Disease Control and Prevention(China CDC)Beijing 102206China Department of Respiratory and Critical Care Medicine Institute of Respiratory DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Cardiology Institute of Cardiovascular DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China School of Laboratory Medicine and Life Sciences Wenzhou Medical UniversityWenzhouZhejiang 325000China University of Chinese Academy of Sciences Beijing 100049China

Severe acute respiratory syndrome coronavirus 2(SARSCo V-2)infection can result in more severe syndromes and poorer outcomes in patients with diabetes and ***,the precise mechanisms responsible for the combined impact of coronavirus disease 2019(COVID-19)and diabetes have not yet been elucidated,and effective treatment options for SARS-Co V-2-infected diabetic patients remain *** investigate the disease pathogenesis,K18-h ACE2 transgenic(h ACE2^(Tg))mice with a leptin receptor deficiency(h ACE2-Lepr^(-/-))and high-fat diet(h ACE2-HFD)background were *** two mouse models were intranasally infected with a 5×10^(5) median tissue culture infectious dose(TCID_(50))of SARSCo V-2,with serum and lung tissue samples collected at 3days *** h ACE2-Lepr^(-/-)mice were then administered a combination of low-molecular-weight heparin(LMWH)(1 mg/kg or 5 mg/kg)and insulin via subcutaneous injection prior to intranasal infection with1×10^(4) TCID_(50)of SARS-Co *** drug administration continued until the euthanasia of the *** of viral RNA loads,histopathological changes in lung tissue,and inflammation factors were *** demonstrated similar SARS-Co V-2 susceptibility in h ACE2^(Tg)mice under both lean(chow diet)and obese(HFD)***,compared to the h ACE2-Lepr^(+/+)mice,h ACE2-Lepr^(-/-)mice exhibited more severe lung injury,enhanced expression of inflammatory cytokines and hypoxia-inducible factor-1α(HIF-1α),and increased ***,combined LMWH and insulin treatment effectively reduced disease progression and severity,attenuated lung pathological changes,and mitigated inflammatory *** conclusion,preexisting diabetes can lead to more severe lung damage upon SARS-Co V-2 infection,and LMWH may be a valuable therapeutic approach for managing COVID-19patients with diabetes.

关键词： SARS-CoV-2 Diabetes Mouse model Heparin Antiviral therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于多状态系统理论的大规模创新网络风险评价

引用

科技管理研究 2010年第4期30卷 42-44页

作者：龚玉环莫毓昌浙江师范大学行知学院浙江师范大学数理信息学院浙江金华321004

针对大规模创新网络风险评价问题,建立创新网络的结构模型P,在识别出网络风险集R的基础上建立风险模型F;然后尝试把多状态系统理论和创新网络风险评价联系起来,一方面介绍如何把多状态系统理论中决策图分析方法应用到创新网络风险分析中... 详细信息

针对大规模创新网络风险评价问题,建立创新网络的结构模型P,在识别出网络风险集R的基础上建立风险模型F;然后尝试把多状态系统理论和创新网络风险评价联系起来,一方面介绍如何把多状态系统理论中决策图分析方法应用到创新网络风险分析中;另一方面针对创新网络风险评价这一新的课题总结多状态理论的未来研究方向。

关键词：风险分析创新网络多状态系统

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

科研合作复杂网络及其创新能力分析

引用

科技管理研究 2008年第12期28卷 30-32,36页

作者：龚玉环卜琳华黑龙江科技学院人文社会科学学院黑龙江哈尔滨150027 哈尔滨工业大学黑龙江哈尔滨150001

建立了引文网、合著网、机构合作网三维网络模型,从小世界特征、无尺度特征两个角度对我国科研合作复杂网络进行结构分析与考察。提出我国科研合作复杂网络处于从成长期向成熟期过渡的阶段;大力发展科研合作复杂网络是为了增强知识创新... 详细信息

建立了引文网、合著网、机构合作网三维网络模型,从小世界特征、无尺度特征两个角度对我国科研合作复杂网络进行结构分析与考察。提出我国科研合作复杂网络处于从成长期向成熟期过渡的阶段;大力发展科研合作复杂网络是为了增强知识创新的速度,保证知识创新的可持续性;应建立风险预警机制以规避科研合作复杂网络发展过程中可能出现的锁定效应和网络脆弱性。

关键词：科研合作复杂网络无尺度小世界知识创新

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Platinum oxide redefined: a thermally stable two-dimensional crystallineform

引用

Science China Materials 2025年第2期68卷 683-684页

作者： Bixuan Li Yongji gong Tianmushan Laboratory Hangzhou 310023China School of Materials Science and Engineering Beihang UniversityBeijing 100191China

Catalysis,as a core technology in the chemical industry,plays a pivotal role in numerous fields,including energy,environmental science,and materials ***(Pt),a ubiquitous and indispensable catalyst,has been extensively employed in diverse applications,including industrial chemical transformations and automotive emission control systems[1].However,it was believed to suffer from deactivation under severe operating conditions,particularly in high-temperature and oxidizing *** concept suggests that platinum oxides,decompose or sublimate at elevated temperatures,typically above 700 K[2].Consequently,researchers frequently employ encapsulation techniques for metal particles,utilizing materials such as mesoporous silica[3],zeolites[4],two-dimensional(2D)layered materials[5],and various other protective *** approach necessitates a delicate balance between activity and stability,often resulting in enhanced stability at the expense of catalytic efficiency.

关键词： stability crystalline utilizing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

复杂网络结构视角下中关村产业集群创新能力分析

引用

科学学与科学技术管理 2009年第5期30卷 56-60页

作者：龚玉环卜琳华孟庆伟黑龙江科技学院人文社会科学学院哈尔滨150027 哈尔滨工业大学哈尔滨150001 哈尔滨工业大学人文与社会科学学院哈尔滨150001

通过复杂网络结构分析发现,中关村产业集群具有短平均路径、高异质性度分布、高集聚系数的结构特征。这使中关村产业集群创新能力处于风险运行状态:企业技术创新出现"等靠要"现象;集群创新能力高度依赖于少数大企业;网络呈锁定趋势。建... 详细信息

通过复杂网络结构分析发现,中关村产业集群具有短平均路径、高异质性度分布、高集聚系数的结构特征。这使中关村产业集群创新能力处于风险运行状态:企业技术创新出现"等靠要"现象;集群创新能力高度依赖于少数大企业;网络呈锁定趋势。建议:完善知识产权保护机制,分散集散节点的资源与社会连接,进行集群外联,使中关村产业集群拥有合适的平均路径、度分布、集聚系数,进而使中关村产业集群创新能力回归正常运行状态。

关键词：中关村产业集群创新复杂网络结构

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Quantile-based optimization under uncertainties for complex engineering structures using an active learning basis-adaptive PC-Kriging model

引用

Chinese Journal of Aeronautics 2025年第1期38卷 340-352页

作者： Yulian gong Jianguo ZHANG Dan XU Ying HUANG School of Reliability and Systems Engineering Beihang UniversityBeijing 100191China

The Reliability-Based Design Optimization(RBDO)of complex engineering structures considering uncertainties has problems of being high-dimensional,highly nonlinear,and timeconsuming,which requires a significant amount of sampling simulation *** this paper,a basis-adaptive Polynomial Chaos(PC)-Kriging surrogate model is proposed,in order to relieve the computational burden and enhance the predictive accuracy of a *** active learning basis-adaptive PC-Kriging model is combined with a quantile-based RBDO ***,five engineering cases have been implemented,including a benchmark RBDO problem,three high-dimensional explicit problems,and a high-dimensional implicit *** with Support Vector Regression(SVR),Kriging,and polynomial chaos expansion models,results show that the proposed basis-adaptive PC-Kriging model is more accurate and efficient for RBDO problems of complex engineering structures.

关键词： Reliability-based design optimization Quantile-based Basis-adaptive PC-Kriging Complex engineering structures Active learning Uncertainty

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Distinct durability of IgM/IgG antibody responses in COVID-19 patients with differing severity

引用

Science China(Life Sciences) 2022年第1期65卷 223-226页

作者： Junyan Han Ning Zhang Danying Chen yuhuan gong Guoli Li Yaxian Kong Lin Pu Chen Chen Jingyuan Liu Qi Wang Ju Zhang Xuesen Zhao Juan Du Kai Han Chuan Song Linghang Wang Mingxi Hua Yu Hao Rui Song Yangzi Song Fengting Yu Siyuan Yang Haofeng Xiong Wei Zhang George F.Gao Fujie Zhang Ang Li Hui Zeng Yuhai Bi Beijing Key Laboratory of Emerging Infectious Diseases Institute of Infectious DiseasesBeijing Ditan HospitalCapital Medical UniversityBeijing 100015China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyCenter for Influenza Research andEarly-warning(CASCIRE)CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID)Chinese Academy of SciencesBeijing 100101China Institutes of Physical Science and Information Technology Anhui UniversityHefei 230601China Intensive Care Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Center of Liver Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Laboratory of Infectious Diseases Center of Beijing Ditan Hospital Capital Medical UniversityBeijing 100015China The Infectious Disease Diagnostic Therapeutic and Research CentersBeijing Ditan HospitalCapital Medical UniversityBeijing 100015China Clinical Center for HIV/AIDS Clinical and Research Center of Infectious DiseasesBeijing Ditan HospitalCapital Medical UniversityBeijing 100015China University of Chinese Academy of Sciences Beijing 100049China

Dear Editor,The coronavirus disease 2019(COVID-19)pandemic is generating a demand for simultaneous vaccine development,which is expected to prevent future outbreaks by eliciting sufficient and protective immunity.

关键词： protective vaccine severity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：