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Liver Research 2023年第3期7卷 165-176页

作者： yuhua gao Jun Lin Chuan Ye Siqi Guo Changtao Jiang Department of Physiology and Pathophysiology School of Basic Medical SciencesPeking Universityand the Key Laboratory of Molecular Cardiovascular Science(Peking University)Ministry of EducationBeijingChina Center of Basic Medical Research Institute of Medical Innovation and ResearchThird HospitalPeking UniversityBeijingChina Center for Obesity and Metabolic Disease Research School of Basic Medical SciencesPeking UniversityBeijingChina

Bile acids(BAs)play important roles in the digestion of dietary fats and molecular signal transduction,and modulation of the BA composition usually affects the progression of metabolic diseases.While the liver produces primary BAs,the gut microbiota modifies these products into various forms that greatly increase their diversity and biological functions.Mechanistically,BAs can regulate their own metabolism and transport as well as other key aspects of metabolic processes via dedicated BA receptors.Disruption of BA transport and homeostasis leads to the progression of liver diseases,including metabolic dysfunction-associated steatotic liver disease(MASLD)and hepatocellular carcinoma(HCC).Here,we summarize the microbial transformations of BAs and their downstream signaling in the development of metabolic diseases and present new insights into novel therapeutic strategies targeting BA pathways that may contribute to these diseases.

关键词： Bile acids(BAs) Gut microbiota Metabolic dysfunction-associated steatotic liver disease(MASLD) Metabolic dysfunction-associated steatohepatitis(MASH) Hepatocellular carcinoma(HCC) Farnesoid X receptor(FXR) G protein-coupled bile acid receptor 1(TGR5)

中国运动训练学话语体系中的核心概念及其建构

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体育学研究 2024年第2期38卷 28-38页

作者：夏力高玉花谢云熊焰广州体育学院运动训练学院广东广州510500 天津体育学院运动训练学院天津301617 广东白云学院体育学院广东广州510450

核心概念是话语体系建设中最为重要的表达工具和最小的分析单位,代表着一门学科、一种学说或一个学派的身份、思想与价值。采用文献资料、逻辑分析等方法,以中国运动训练学话语体系中的核心概念为研究起点,对核心概念的逻辑筛选、话语... 详细信息

核心概念是话语体系建设中最为重要的表达工具和最小的分析单位,代表着一门学科、一种学说或一个学派的身份、思想与价值。采用文献资料、逻辑分析等方法,以中国运动训练学话语体系中的核心概念为研究起点,对核心概念的逻辑筛选、话语特征、话语现状以及建构路径进行系统梳理和科学探索。研究认为:中国《运动训练学》教材历经40年发展,形成了具有中国特色的理论体系和话语表述,中国运动训练学者们围绕3W2H等问题建立了以“运动成绩”“竞技能力”“项群训练”“训练原则”“训练方法”“训练负荷”“训练计划”“竞技状态”为主体内容的核心概念集,呈现出原创性、逻辑性、相对性、扩展性等话语特征。面对欧美运动训练理论实证概念的引进和传播,受历史之情、现实之需、未来之势影响,中国运动训练学核心概念需要持续回应概念引用的适应性不高、概念转化的价值性不强、概念融通的对话性不足等话语难点;亟需从历史资源中梳理、运动实践中挖掘、学科融合中提炼、科学技术中创新,立足中国本土化,以此实现中国运动训练学话语体系中的核心概念建构以及内涵的新界定。

关键词：运动训练学话语体系核心概念竞技能力训练方法训练计划运动成绩

子宫颈腺癌预后列线图的建立及优选治疗方式的探讨基于SEER数据库及中国单中心数据的回顾性研究

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中华妇产科杂志 2024年第4期59卷 307-319页

作者：李响高玉华杨卓马悦刘畅刘光聪王丹波大连理工大学附属肿瘤医院辽宁省肿瘤医院妇科沈阳110801

目的基于美国国立癌症研究所的监测、流行病学及最终结果(SEER)数据库及中国单中心数据建立并验证预测子宫颈腺癌患者预后的列线图,探讨子宫颈腺癌的优选治疗方式。方法本研究从SEER数据库筛选出2478例子宫颈腺癌患者作为训练队列,并选... 详细信息

目的基于美国国立癌症研究所的监测、流行病学及最终结果(SEER)数据库及中国单中心数据建立并验证预测子宫颈腺癌患者预后的列线图,探讨子宫颈腺癌的优选治疗方式。方法本研究从SEER数据库筛选出2478例子宫颈腺癌患者作为训练队列,并选择辽宁省肿瘤医院收治的195例子宫颈腺癌患者作为外部验证队列,收集两个队列患者的临床病理资料及随访数据;放疗组为同步放化疗为主的综合治疗,手术组为根治性手术为主的综合治疗。采用log-rank检验和Cox回归方法分析影响子宫颈腺癌患者预后的相关因素,建立预测子宫颈腺癌患者3年、5年总生存率的列线图,并进行SEER数据库训练队列的内部验证及本院数据验证队列的外部验证。结果(1)SEER数据库训练队列中,放疗组385例(15.54%,385/2478),手术组2093例(84.46%,2093/2478);放疗组患者的总生存时间为(55.8±51.3)个月,手术组为(94.4±61.7)个月,两组比较,差异有统计学意义(χ^(2)=256.44,P50岁)、单身状态、肿瘤最大径(>4 cm)、病理分级高(G2、G3)及FIGO分期晚(≥Ⅱa2期)均为影响子宫颈腺癌患者总生存时间的独立危险因素(P均4~4~4~<6 cm的局部晚期(Ⅰb3、Ⅱa2期)、Ⅲc期(T1、T2期)子宫颈腺癌患者能从以根治性手术为主的综合治疗中获益更多。本研究建立的列线图经内部及外部验证,对子宫颈腺癌患者具有良好的预后预测效能。

关键词：宫颈肿瘤腺癌子宫切除术化放疗列线图预后回顾性研究

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接枝交联双重改性淀粉IStD絮凝性能研究

工业水处理 2024年第2期44卷 133-138页

作者：李海花高玉华郑玉轩李娜张利辉刘振法河北省科学院能源研究所河北石家庄050081 河北省工业节水技术创新中心河北石家庄050081 河北桑沃特水处理有限责任公司河北石家庄050081

以玉米淀粉(St)为原料,环氧氯丙烷(EPI)为交联剂,甲基丙烯酰氧乙基三甲基氯化铵(DMC)为接枝单体,两步法合成了接枝交联双重改性淀粉基絮凝剂IStD。测试了投药量、pH、高岭土质量分数、絮凝温度和絮凝时间对IStD絮凝性能的影响。结果表明... 详细信息

以玉米淀粉(St)为原料,环氧氯丙烷(EPI)为交联剂,甲基丙烯酰氧乙基三甲基氯化铵(DMC)为接枝单体,两步法合成了接枝交联双重改性淀粉基絮凝剂IStD。测试了投药量、pH、高岭土质量分数、絮凝温度和絮凝时间对IStD絮凝性能的影响。结果表明,当高岭土质量分数为2%,投药质量浓度为14 mg/L,pH=7,絮凝温度为25℃,絮凝时间为1 h时,上清液的透光率可达91.7%。通过观察投药前后水体中高岭土颗粒的分散状态,初步探讨了IStD的絮凝机理。结果表明在絮凝过程中,同时存在电中和与吸附架桥作用,以电中和作用为主。当IStD和CPAM复配用于处理生活废水时,透光率和COD去除率都能达到90%以上,具有一定的实用价值。

关键词：改性淀粉甲基丙烯酰氧乙基三甲基氯化铵絮凝

淀粉基水凝胶St/CMC-g-PAA对Cu^(2+)的吸附性能研究

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水处理技术 2024年第2期50卷 26-30,37页

作者：李海花高玉华郑玉轩李娜张利辉刘振法河北省科学院能源研究所河北省工业节水工程技术研究中心河北桑沃特水处理有限责任公司河北石家庄050081

以玉米淀粉(St)、羧甲基纤维素钠(CMC)为原料,丙烯酸(AA)为接枝单体,通过接枝和交联反应合成了淀粉基水凝胶St/CMC-g-PAA。考察了投药量、pH、Cu^(2+)初始浓度(ρ0)、吸附时间对吸附效果的影响。结果表明,当ρ0=40 mg/L,投药量为300 mg/... 详细信息

以玉米淀粉(St)、羧甲基纤维素钠(CMC)为原料,丙烯酸(AA)为接枝单体,通过接枝和交联反应合成了淀粉基水凝胶St/CMC-g-PAA。考察了投药量、pH、Cu^(2+)初始浓度(ρ0)、吸附时间对吸附效果的影响。结果表明,当ρ0=40 mg/L,投药量为300 mg/L,pH=5.2时,Cu^(2+)的去除率可达92.7%。实验数据拟合结果表明,水凝胶对Cu^(2+)的吸附过程符合Langmuir吸附模型和准二级动力学模型,属于单分子层的化学吸附过程。在25℃时,水凝胶对Cu^(2+)的饱和吸附容量qm=142.86 mg/g。水凝胶再生性能较好,经过4次吸附-脱附循环后,Cu^(2+)去除率仍可达到82.1%。

关键词：淀粉水凝胶吸附吸附机理重金属离子

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柴汶河袭夺地区流域地貌发育阶段研究

海洋湖沼通报 2024年第1期46卷 176-181页

作者：姜瑾斐褚忠信朱晓洁孙家高于广科姜悦高玉花中国海洋大学海洋地球科学学院山东青岛266100 海底科学与探测技术教育部重点实验室山东青岛266100 山东省物化探勘察院山东济南250013

本文基于数字高程模型和空间分析技术,对山东沂源柴汶河袭夺地区的流域地貌进行研究,划分流域地貌的发育阶段。分别计算了柴汶河源头——恶沟和沂河源头——大张庄河流域的水系分形维数、面积-高程积分和地貌信息熵并划分流域地貌发育阶... 详细信息

本文基于数字高程模型和空间分析技术,对山东沂源柴汶河袭夺地区的流域地貌进行研究,划分流域地貌的发育阶段。分别计算了柴汶河源头——恶沟和沂河源头——大张庄河流域的水系分形维数、面积-高程积分和地貌信息熵并划分流域地貌发育阶段,认为面积-高程积分和地貌信息熵值的划分结果较为准确。恶沟流域处于流域地貌发育的壮年期,大张庄河流域处于老年期;河流袭夺事件使恶沟(袭夺河)侵蚀能力增强,大张庄河(被夺河)侵蚀能力减弱。

关键词：河流袭夺水系分形维数面积-高程积分地貌信息熵流域地貌发育

IgG4相关性疾病患者临床特征和血清炎症免疫八项结果回顾性分析

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河南医学研究 2024年第7期33卷 1211-1215页

作者：刘夏楠吕亚平高玉华王雪玢常谦张世杰郑州大学第一附属医院检验科河南省检验医学重点实验室河南郑州450052 上海交通大学医学院附属仁济医院检验科上海200000

目的探讨IgG4相关性疾病(IgG4-RD)患者的临床特征及血清炎症免疫八项[C-反应蛋白(CRP)、血沉(ESR)、补体C3(C3)、补体C4(C4)、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、免疫球蛋白E(IgE)]在IgG4-RD中的检测价值。方法回... 详细信息

目的探讨IgG4相关性疾病(IgG4-RD)患者的临床特征及血清炎症免疫八项[C-反应蛋白(CRP)、血沉(ESR)、补体C3(C3)、补体C4(C4)、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、免疫球蛋白E(IgE)]在IgG4-RD中的检测价值。方法回顾性分析2020年1月至2022年7月郑州大学第一附属医院收治的52例IgG4-RD患者的临床资料和实验室检查数据,以同期年龄、性别相匹配的56例健康体检者为健康对照组。比较两组炎症免疫八项结果。通过Pearson相关性分析评估各指标间的关系。结果52例IgG4-RD患者中,胰腺-胆囊-肝脏为最常见的累及部位,其次为眼、泪腺、唾液腺。40例(76.9%)患者表现为≥2个器官受累,12例(23.1%)患者表现为单一器官受累。血清CRP、ESR、C3、C4、IgG、IgE异常占比分别为44.9%、67.4%、47.5%、32.5%、62.5%、83.3%。与健康对照组相比,IgG4-RD组血清CRP、ESR、IgG、IgE水平升高(P0.05)。相关性分析发现IgE与IgG4水平呈正相关(r=0.433,P=0.034),与C4水平呈负相关(r=-0.457,P=0.028)。结论IgG4-RD患者临床表现缺乏特异性,常累及多个器官。血清炎症免疫八项检测对IgG4-RD诊断有一定参考价值,IgE或与IgG4-RD发生发展密切相关。

关键词： IgG4相关性疾病临床特征血清IgG4 免疫球蛋白E 补体C3 补体C4

Resolving the hydrothermal signature by sequential leaching studies of sediments from the middle of the Okinawa Trough

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Science China Earth Sciences 2012年第3期55卷 665-674页

作者： YU ZengHui gao yuhua ZHAI ShiKui LIU FeiFei Key Laboratory of Submarine Geosciences and Prospecting Techniques College of Marine GeosciencesOcean University of ChinaQingdao 266100China Shandong Institute of Geophysical and Geochemical Exploration Jinan 250013China

A sediment core H9 collected from the middle of the Okinawa Trough was studied by sequential leaching to indentify the hydrothermal component from the various other components such as detrital,biogenic,and so on.The elements were partitioned into five fractions:exchangeable,bound to carbonates,bound to iron and manganese oxides,bound to organic matter,and residual.The contents of elements Al,Ti,K,Fe,Mn,Pb,Co,Cu,Ni,and V in each fraction were determined and their percentages were calculated.Residual fraction is a dominant speciation for most studied elements except for Mn and Pb in the core sediments.For the elements Al,Ti,and K,residual fraction accounts for more than 95% of the total metal concentration.The concentrations of all studied elements in the exchangeable fraction,carbonate fraction,and organic fraction are relatively low.The metal levels in the iron and manganese oxide fraction are relatively high and this fraction represents another prevalent speciation.Also in this fraction,the metal concentrations and percentages are higher in the core section above 80 cm than those below 80 cm.Especially for Mn and Pb,the fractions bound to iron and manganese oxides account for more than 50% of the total metal concentration for the upper 80 cm section.Hydrothermal components mainly occur in this fraction.And the downcore variations of metal contents and percentages reflect the variations of hydrothermal inputs to the sediments.The high metal levels in the upper core indicate the enhancing influence of hydrothermal activities around on the core H9 during its late stage of sedimentation.The accumulation rates of hydrothermally derived Fe,Mn,Pb,Co,Cu,Ni,and V were evaluated based on their concentrations in the iron and manganese oxide fractions in this study.The results show that the accumulation rate of hydrothermally derived Mn is similar to those obtained from the Mid-ocean Ridges and Lau Basin.However,hydrothermally derived Fe and Cu present a relatively lower level.

关键词：热液活动冲绳海槽沉积物碳酸盐结合态金属离子浓度锰氧化物金属含量签名

All-trans retinoic acid promotes nerve cell differentiation of yolk sac-derived mesenchymal stem cells

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All-trans retinoic acid promotes nerve cell differentiation ...

Scientific objectives and payload configuration of the Chang'E-7 mission

2015中国遗传学会大会

作者： yuhua gao Ji Meng Caiyun Ma Weijun Guan Institute of Animal Sciences Chinese Academy of Agricultural Sciences

The yolk sac is a membranous sac attached to an embryo,providing early nourishment in the form of yolk in bony fishes,sharks,reptiles,birds,and primitive mammals.It functions as the developmental circulatory system of the human embryo,before internal circulation begins.It was known that the yolk sac is the first site of hematopoiesis during mammalian development.The yolk sac is also the first site of blood vessel development.The ontogeny of haemopoiesis during fetal life and the differentiation of blood cells in life depend upon a fully competent microenvironment to provide appropriate growth factors and cell contact interactions.The cellular constituents of the microenvironment,also defined as the haemopoietic niche,largely derive from a common progenitor of mesenchymal origin-yolk sac mesenchymal stem cell(YS-MSCs)Mesenchymal stem cells(MSCs),initially identified in adult bone marrow,are defined as a group of multipotent stem cells that can functionally differentiate into at fat cells,osteoblasts,myoblasts.And even neurons in vitro and in vivo.Appropriate culture conditions,MSCs are readily amplified in vitro for several passages without signs of senescence and differentiation.All-trans retinoic acid increases the expression of neural growth factor and its receptor participating in translation pathways.Vitamin A(retinol)and its metabolites are required for vision,reproduction,growth and differentiation in mammals and birds.The vitamin A metabolite,retinoic acid(RA)is formed irreversibly by the sequential oxidation of retinol and retinal.There is mounting evidence that RA plays an important role in cellular differentiation and pattern formation in normal vertebrate embryogenesis,including development of the nervous.Because MSCs rapidly proliferate in vitro,have low immunogenicity,and it is easy to transfect foreign genes into them,they would appear to be the ideal substitute cells for tissue engineering.As an animal model,the chicken possesses abundant dermal tissues.Furthermore,the chicken is an economical anim

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National Science Review 2024年第2期11卷 285-300页

作者： Chi Wang Yingzhuo Jia Changbin Xue Yangting Lin Jianzhong Liu Xiaohui Fu Lin Xu Yun Huang Yufen Zhao Yigang Xu Rui gao Yong Wei yuhua Tang Dengyun Yu Yongliao Zou China Aerospace Science and Technology Corporation State Key Laboratory of Space Weather National Space Science Center Chinese Academy of Sciences National Space Science Center Chinese Academy of Sciences Institute of Geology and Geophysics Chinese Academy of Sciences Institute of Geochemistry Chinese Academy of Sciences Shandong Provincial Key Laboratory of Optical Astronomy and Solar-Terrestrial Environment School of Space Science and Physics Institute of Space SciencesShandong University Institute of Drug Discovery Technology Ningbo University State Key Laboratory of Isotope Geochemistry Guangzhou Institute of Geochemistry Chinese Academy of Sciences School of Earth Science and Engineering Sun Yat-sen University Lunar Exploration and Space Engineering Center

As the cornerstone mission of the fourth phase of the Chinese Lunar Exploration Program, Chang'E-7(CE-7) was officially approved, and implementation started in 2022, including a main probe and a communication relay satellite. The main probe, consisting of an orbiter, a lander, a rover and a mini-flying probe, is scheduled to be launched in 2026. The lander will land on Shackleton crater's illuminated rim near the lunar south pole, along with the rover and mini-flying probe. The relay satellite(named Queqiao-2) will be launched in February 2024 as an independent mission to support relay communication during scientific exploration undertaken by Chang'E-4, the upcoming Chang'E-6 in 2024 and subsequent lunar missions.The CE-7 mission is mainly aimed at scientific and resource exploration of the lunar south pole. We present CE-7's scientific objectives, the scientific payloads configuration and the main functions for each scientific payload with its key technical specifications.

关键词： Chang’ E-7 scientific objectives scientific payloads