检索结果-南通市图书馆

Harnessing innate immune pathways for therapeutic advancement in cancer

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第4期9卷 1506-1564页

作者： Ankang Hu Li Sun Hao Lin yuheng liao Hui Yang Ying Mao Department of Neurosurgery Huashan HospitalFudan UniversityShanghaiP.R.China Institute for Translational Brain Research Shanghai Medical CollegeFudan University ShanghaiPR.China National Center for Neurological Disorders Huashan HospitalShanghai Medical CollegeFudan UniversityShanghaiP.R.China Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration Shanghai Clinical Medical Center of NeurosurgeryNeurosurgical Institute of Fudan UniversityHuashan HospitalShanghai Medical CollegeFudan UniversityShanghaiP.R.China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science and MOE Frontiers Center for Brain Science Institutes of Brain ScienceShanghai Medical CollegeFudan UniversityShanghaiP.R.China Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology)and Key Laboratory of Metabolism and Molecular Medicine(Ministry of Education)and Molecular and Cell Biology LabInstitutes of Biomedical SciencesShanghai Medical College of Fudan UniversityShanghaiP.R.China

The innate immune pathway is receiving increasing attention in cancer *** pathway is ubiquitous across various cell types,not only in innate immune cells but also in adaptive immune cells,tumor cells,and stromal *** targeting the innate immune pathway have shown profound changes in the tumor microenvironment(TME)and improved tumor prognosis in preclinical ***,to date,the clinical success of drugs targeting the innate immune pathway remains ***,recent studies have shown that activation of the innate immune pathway can paradoxically promote tumor *** uncertainty surrounding the therapeutic effectiveness of targeted drugs for the innate immune pathway is a critical issue that needs immediate *** this review,we observe that the role of the innate immune pathway demonstrates heterogeneity,linked to the tumor development stage,pathway status,and specific cell *** propose that within the TME,the innate immune pathway exhibits multidimensional *** diversity is fundamentally rooted in cellular heterogeneity and is manifested as a variety of signaling *** pro-tumor effect of innate immune pathway activation essentially reflects the suppression of classical pathways and the activation of potential pro-tumor alternative *** our understanding of the tumor's innate immune pathway network and employing appropriate targeting strategies can enhance our ability to harness the anti-tumor potential of the innate immune pathway and ultimately bridge the gap from preclinical to clinicalapplication.

关键词： drugs therapeutic innate

Triplex-structure based DNA circuits with ultra-low leakage and high signal-to-noise ratio

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第1期35卷 465-470页

作者： Huan Liu Zhihao Ming Yuanpeng Zhang Qidong Xia Hao Hu Ruijie Liu yuheng liao Yizhou Liu Xiao Liu Xiaoping Zhang Longjie Li Shaogang Wang Xianjin Xiao Institute of Reproductive Health Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department and Institute of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department and Institute of Urology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China School of Life Science and Technology Wuhan Polytechnic UniversityWuhan 430030China Department of Laboratory Medicine Tongji hospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

DNA circuits are powerful tools in various applications such as logical computation,molecular diagnosis and synthetic *** is a major problem in constructing complex DNA *** directly affects the output signal and harms the circuit’s performance *** the traditional DNA circuits,the gate complex is a duplex *** are insufficient energy barriers to prevent spontaneous detachment of strands,resulting in a leak ***,we have developed triplex-structure based DNA circuit with ultra-low leakage and high signal-to-noise ratio(SNR).The triplex structure improves the stability in the absence of *** the same time,the driving force of the strand displacement cascades reduces the influence of the triplex structure on the desired *** SNR of the DNA circuit was increased to 695,while the desired reaction rate remained 90%of the conventional translator *** triplex-structure mediated leakage prevention strategy was further tested at different temperatures and in DNA translator and seesaw *** also constructed modular basic logic gates with a high efficiency and low *** this basis,we further constructed triplex-structure based tertiary DNA logic circuits,and the SNR reached 295,which,to the best of our knowledge,was among the highest of the *** believe that our scheme provides a novel,valid,and general tool for reducing leakages,and we anticipate that it will be widely adopted in DNA nanotechnology.

关键词： Leakage DNA strand displacement cascades Triplex DNA circuits Molecular programming

强风化长雨季条件下矿山GNSS与合成孔径雷达技术的适用性研究

在线全文

学校读者我要写书评

暂无评论

矿产勘查 2024年第S1期15卷 235-242页

作者：刘城成尹永明廖煜恒王宝亮罗刚中安国泰(北京)科技发展有限公司北京100012 中国安全生产科学研究院北京100012 广州珠江水泥有限公司广东广州510460

中国南部地区特别容易发生滑坡事故,主要由于表土风化和强降雨引发,对矿业生产带来不良影响。因此,急需采取有效监测和预警措施。近年来,合成孔径雷达技术迅速发展,并已应用于替代GNSS对矿山边坡进行表面位移监测。本研究以珠江水泥石... 详细信息

中国南部地区特别容易发生滑坡事故,主要由于表土风化和强降雨引发,对矿业生产带来不良影响。因此,急需采取有效监测和预警措施。近年来,合成孔径雷达技术迅速发展,并已应用于替代GNSS对矿山边坡进行表面位移监测。本研究以珠江水泥石灰石矿山为例,验证了在强风化长雨季条件下,GNSS与合成孔径雷达技术在矿山边坡监测方面的适用性。对比分析结果显示:两者记录的边坡位移变形趋势一致,为滑坡演化提供了关键信息;然而,GNSS需要更密集的本地观测网络以提供更准确的位移评估和滑坡风险控制;合成孔径雷达技术在特殊气象和地理环境下的应用需要特定的处理工具进行一定程度的校正。

关键词：露天矿山恶劣环境 GNSS 合成孔径雷达变形监测

Inhibitory impacts of essential oil(Zanthoxylum schinifolium *** Zucc)on the growth of Staphylococcus epidermidis

在线全文

学校读者我要写书评

暂无评论

Food Bioscience 2022年第5期49卷 606-615页

作者： Shenglan liao Gang Yang yuheng Ou Shan Huang Bin Li Aijun Li Jianquan Kan College of Food Science Southwest University2#Tiansheng RoadBeibeiChongqing400715PR China Chinese-Hungarian Cooperative Research Centre for Food Science Chongqing400715PR China Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing Chongqing400715PR China Laboratory of Quality&Safety Risk Assessment for Agro-products on Storage and Preservation(Chongqing) Ministry of AgricultureChongqing400715PR China

Staphylococcus epidermidis is an important pathogenic microorganism with the ability to cause food contamination and clinical ***,finding a green,safe and effective antimicrobial therapy will benefit food safety and public *** this study,essential oil extracted from Zanthoxylum schinifolium *** Zucc was used to combat *** schinifolium *** Zucc essential oil(ZEO)showed excellent antibacterial activity with a minimum inhibitory concentration(MIC)of 2.5 mg/mL and a minimum bactericidal concentration(MBC)of 5.0 mg/***,single component antibacterial test results showed that the MIC values of the major components in ZEO,including linalool,dihydrolinalol,β-ocimene and nerolidol,ranged from 2.5 to 10 mg/*** of membrane permeability and integrity demonstrated that the pathogen had membrane damage and normal physiological function was *** membrane potential and cell membrane fluidity analyses further revealed that ZEO induced increase in surface Zeta potential and cell membrane depolarization via electrostatic interactions with cell membrane;meanwhile,ZEO disordered lipid acyl chains and increased cell membrane fluidity to induce cell *** addition,oxidative stress testing showed that ZEO can disrupt homeostasis of reactive oxygen species(ROS),causing ROS accumulation and increasing oxidative damage to *** destruction of cell morphology and ultrastructure by ZEO was further confirmed by electron *** results indicate that ZEO has the potential for development as an antibacterial agent to control the growth of *** and prevent related infections.

关键词： Essential oil Pathogens Antibacterial activity Cell membrane depolarization Reactive oxygen species

炭黑对环氧树脂复合材料的非等温固化动力学的影响

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

化工时刊 2021年第7期35卷 7-11页

作者：梅凯文李嘉炜廖宇恒李世龙张鹤馨郝文涛王文平合肥工业大学化工学院安徽合肥230009

本研究运用非等温固化动力学探究炭黑对环氧树脂/DDM复合材料固化的影响。将混有不同质量分数炭黑的环氧树脂/DDM在DSC热分析仪里分别在5、10、20、40℃/min的升温速率下发生固化,采集加热过程中的热焓值变化数据。分别运用Kissinger方... 详细信息

本研究运用非等温固化动力学探究炭黑对环氧树脂/DDM复合材料固化的影响。将混有不同质量分数炭黑的环氧树脂/DDM在DSC热分析仪里分别在5、10、20、40℃/min的升温速率下发生固化,采集加热过程中的热焓值变化数据。分别运用Kissinger方程和Coat-Redfern方程对得到的数据进行处理,得到固化反应的活化能。分析结果表明:炭黑对环氧树脂的固化起阻碍作用,这种阻碍作用在炭黑质量分数为3%时最大;CB/环氧树脂复合体系的活化能随着转化率的增大先下降再上升。

关键词：环氧树脂固化动力学炭黑

Efficiency-loss analysis of monolithic perovskite/silicon tandem solar cells by identifying the patterns of a dual two-diode model’s current-voltage curves

在线全文

学校读者我要写书评

暂无评论

Journal of Semiconductors 2023年第8期44卷 68-77页

作者： yuheng Zeng Zetao Ding Zunke Liu Wei Liu Mingdun liao Xi Yang Zhiqin Ying Jingsong Sun Jiang Sheng Baojie Yan Haiyan He Chunhui Shou Zhenhai Yang Jichun Ye Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China University of Chinese Academy of Sciences Beijing 100049China Zhejiang Engineering Research Center for Energy Optoelectronic Materials and Devices Ningbo Institute of Materials Technology&EngineeringCASNingbo 315201China Zhejiang Energy Group R&D Hangzhou 310003China

In this work,we developed a simple and direct circuit model with a dual two-diode model that can be solved by a SPICE numerical simulation to comprehensively describe the monolithic perovskite/crystalline silicon(PVS/c-Si)tandem solar *** are able to reveal the effects of different efficiency-loss mechanisms based on the illuminated current density-voltage(J-V),semi-log dark J-V,and local ideality factor(m-V)*** effects of the individual efficiency-loss mechanism on the tandem cell’s efficiency are discussed,including the exp(V/VT)and exp(V/2VT)recombination,the whole cell’s and subcell’s shunts,and the Ohmic-contact or Schottky-contact of the intermediate *** can also fit a practical J-V curve and find a specific group of parameters by the trial-and-error *** the fitted parameters are not a unique solution,they are valuable clues for identifying the efficiency loss with the aid of the cell’s structure and experimental *** method can also serve as an open platform for analyzing other tandem solar cells by substituting the corresponding circuit *** summary,we developed a simple and effective methodology to diagnose the efficiency-loss source of a monolithic PVS/c-Si tandem cell,which is helpful to researchers who wish to adopt the proper approaches to improve their solar cells.

关键词： monolithic perovskite/silicon tandem solar cell efficiency-loss analysis dual two-diode model SPICE numerical simula-tion

双功能二氧化硫替代物在合成磺酰类化合物中的研究进展

在线全文

学校读者我要写书评

暂无评论

有机化学 2023年第11期43卷 3713-3727页

作者：吴宇恒颜岩寮渭巍吉林大学化学学院长春130012

近年来通过二氧化硫插入合成磺酰类化合物的合成方法受到了研究者的关注.多种二氧化硫替代物参与的磺酰化反应被相继报道,并成功用于多种磺酰类化合物如砜、磺酰氟和磺酰胺等的合成.其中部分二氧化硫替代物展现出了双功能的作用——既... 详细信息

近年来通过二氧化硫插入合成磺酰类化合物的合成方法受到了研究者的关注.多种二氧化硫替代物参与的磺酰化反应被相继报道,并成功用于多种磺酰类化合物如砜、磺酰氟和磺酰胺等的合成.其中部分二氧化硫替代物展现出了双功能的作用——既作为二氧化硫源用于构建磺酰基,又作为体系中的还原剂.具有还原性的二氧化硫阴离子自由基在这些反应中起到了关键作用,提高了磺酰化反应的效率和原子经济性.重点介绍了近年来这类双功能二氧化硫替代物在磺酰类化合物合成中的研究进展.

关键词： SO_(2)插入 SO_(2)阴离子自由基双功能试剂磺酰化

基于光纤布拉格光栅的柔性触滑觉复合传感研究

在线全文

学校读者我要写书评

暂无评论

仪器仪表学报 2020年第2期41卷 40-46页

作者：孙世政龙雨恒李洁蒙志强廖超重庆交通大学机电与车辆工程学院重庆400074 重庆邮电大学移通学院智能工程学院重庆401520

针对仿生皮肤柔性触滑觉复合传感问题,提出了一种基于光纤布拉格光栅的双层分布式传感单元。首先,研究了光纤布拉格光栅的传感机理,推导了基于参考光栅的温度补偿原理;然后,利用聚合物弹性材料对光纤布拉格光栅传感阵列进行保护性和增... 详细信息

针对仿生皮肤柔性触滑觉复合传感问题,提出了一种基于光纤布拉格光栅的双层分布式传感单元。首先,研究了光纤布拉格光栅的传感机理,推导了基于参考光栅的温度补偿原理;然后,利用聚合物弹性材料对光纤布拉格光栅传感阵列进行保护性和增敏性封装,设计了双层"十字型"的分布式传感阵列单元,并对传感阵列单元压力灵敏度进行了仿真分析研究;最后,搭建实验系统平台,对柔性复合传感器进行了温度、触觉和滑觉传感实验。仿真和实验结果表明,该柔性触滑觉传感器具有良好的线性度和响应速度,温度灵敏度为13 pm/℃,是裸光纤布拉格光栅的1.31倍;正向压力灵敏度为7.289 nm/MPa,x正向和x负向剪切力灵敏度分别为0.060 2和0.063 6 nm/N;由滑觉传感特征信号可以获取物体的滑移信息。该传感器有望表贴或埋置于仿生手内部,对实现仿生手触滑觉信息感知具有一定的应用价值。

关键词：光纤布拉格光栅柔性传感器触滑觉复合传感温度补偿

深度贫困地区农户脱贫稳定性测度及影响机理研究

在线全文

学校读者我要写书评

暂无评论

地理科学进展 2022年第8期41卷 1378-1388页

作者：潘卓李玉恒刘愿理廖和平朱琳西南大学地理科学学院重庆400715 中国科学院地理科学与资源研究所北京100101 西南大学精准扶贫与区域发展评估研究中心重庆400715 重庆工商大学工商管理学院重庆400067 西南大学国家治理学院重庆400715

农户脱贫稳定性研究可为深度贫困地区巩固脱贫攻坚成果和乡村振兴有效衔接提供重要的理论依据。论文基于可持续生计视角进一步厘定了“农户脱贫稳定性”概念,从自然资本、物质资本、社会资本、人力资本和金融资本5个维度构建了农户脱贫... 详细信息

农户脱贫稳定性研究可为深度贫困地区巩固脱贫攻坚成果和乡村振兴有效衔接提供重要的理论依据。论文基于可持续生计视角进一步厘定了“农户脱贫稳定性”概念,从自然资本、物质资本、社会资本、人力资本和金融资本5个维度构建了农户脱贫稳定性评价指标体系,选取地处深度贫困地区的贵州省天柱县为研究区,测算1295户样本农户脱贫稳定性指数,基于不同方法共同识别影响因素并探究影响机理,提出构建稳定脱贫的长效机制。结果表明:(1)研究区农户脱贫稳定性指数整体水平偏高,脱贫稳定性较强,但农户个体差异性显著,其中物质资本和自然资本维度的脱贫稳定性较高,金融资本其次,人力资本和社会资本维度的脱贫稳定性较低,返贫风险较大;(2)农户脱贫稳定性类型主要以一般型或稳定型为主,脱贫稳定性综合指数中各类型占比分布从高到低大致呈“水滴”特征,有12.44%的样本农户处于临界型,返贫风险较大;(3)技能培训、外出务工人口占比、土地流转、转移性收入占比、到乡镇政府距离和到主干道距离是影响研究区农户脱贫稳定性的主要影响因素;(4)构建了能力提升、产业培育、激发动力、完善基础设施和拓展就业“五位一体”的深度贫困地区农户脱贫稳定性长效机制。

关键词：脱贫稳定性深度贫困地区农户长效机制贵州省天柱县