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Metformin:A promising clinical therapeutical approach for BPH treatment via inhibiting dysregulated steroid hormones-induced prostatic epithelial cells proliferation

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Journal of Pharmaceutical Analysis 2024年第1期14卷 52-68页

作者： Tingting Yang Jiayu Yuan Yuting Peng Jiale Pang Zhen Qiu Shangxiu Chen yuhan huang Zhenzhou Jiang Yilin Fan Junjie Liu Tao Wang Xueyan Zhou Sitong Qian Jinfang Song Yi Xu Qian Lu Xiaoxing Yin Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical UniversityXuzhouJiangsu221004China Department of Pharmacy Affiliated Lianyungang Hospital of Xuzhou Medical UniversityLianyungangJiangsu222061China Department of Pharmacy The Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu221006China New Drug Screening Center Jiangsu Center for Pharmacodynamics Research and EvaluationChina Pharmaceutical UniversityNanjing210009China School of Life Sciences University of EssexEssex CO43SQUnited Kingdom Department of Urology The Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu221006China Department of Pharmacy Affiliated Hospital of Jiangnan UniversityWuxiJiangsu214000China

The occurrence of benign prostate hyperplasia(BPH)was related to disrupted sex steroid hormones,and metformin(Met)had a clinical response to sex steroid hormone-related gynaecological disease.However,whether Met exerts an antiproliferative effect on BPH via sex steroid hormones remains unclear.Here,our clinical study showed that along with prostatic epithelial cell(PEC)proliferation,sex steroid hormones were dysregulated in the serum and prostate of BPH patients.As the major contributor to dysregulated sex steroid hormones,elevated dihydrotestosterone(DHT)had a significant positive relationship with the clinical characteristics of BPH patients.Activation of adenosine 5'-monophosphate(AMP)-activated protein kinase(AMPK)by Met restored dysregulated sex steroid hormone homeostasis and exerted antiproliferative effects against DHT-induced proliferation by inhibiting the formation of androgen receptor(AR)-mediated Yes-associated protein(YAP1)-TEA domain transcription factor(TEAD4)heterodimers.Met’s anti-proliferative effects were blocked by AMPK inhibitor or YAP1 overexpression in DHT-cultured BPH-1 cells.Our findings indicated that Met would be a promising clinical therapeutic approach for BPH by inhibiting dysregulated steroid hormone-induced PEC proliferation.

关键词： Metformin Benign prostatic hyperplasia Sex steroid hormones homeostasis Proliferation DHT YAP1-TEAD4 heterodimer

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Quantum spectral clustering algorithm for unsupervised learning

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Science China(Information Sciences) 2022年第10期65卷 43-52页

作者： Qingyu LI yuhan huang Shan JIN Xiaokai HOU Xiaoting WANG Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China

Clustering is one of the most crucial problems in unsupervised learning, and the well-known k-means algorithm can be implemented on a quantum computer with a significant speedup. However, for the clustering problems that cannot be solved using the k-means algorithm, a powerful method called spectral clustering is used. In this study, we propose a circuit design to implement spectral clustering on a quantum processor with substantial speedup by initializing the processor into a maximally entangled state and encoding the data information into an efficiently simulatable Hamiltonian. Compared to the established quantum kmeans algorithms, our method does not require a quantum random access memory or a quantum adiabatic process. It relies on an appropriate embedding of quantum phase estimation into Grover's search to gain the quantum speedup. Simulations demonstrate that our method effectively solves clustering problems and is an important supplement to quantum k-means algorithm for unsupervised learning.

关键词： quantum algorithm machine learning spectral clustering quantum phase estimation Grover's search Hamiltonian simulation

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Wideband circular-polarized transmitarray for generating a high-purity vortex beam

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Frontiers of Information Technology & Electronic Engineering 2023年第6期24卷 927-934页

作者： Liangjie QIU Xiuping LI Zihang QI Wenyu ZHAO yuhan huang State Key Laboratory of Information Photonics and Optical Communications Beijing 100876China MOE Key Laboratory of Universal Wireless Communications Beijing 100876China Beijing Key Laboratory of Work Safety Intelligent Monitoring Beijing 100876China School of Electronic Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China Beijing Institute of Spacecraft System Engineering Beijing 100094China

In this correspondence,a wideband circular-polarized(CP)transmitarray(TA)in the Ka-band is presented for generating a high-purity vortex beam.The proposed element is composed of two identical combinations separated by an air layer.The subwavelength structure and double-resonance characteristics ensure the stable phase shift of the element within the 1-dB transmission bandwidth of 28.4%.A square aperture TA fed by a horn antenna is fabricated and measured.Owing to the honeycomb arrangement of elements,the mode purity of l=−1 is>0.93 in a wide band from 28.5 to 38 GHz.The measured peak gain is 22.3 dBic,and the 3-dB axial ratio bandwidth is 27.6%.The performance of the proposed antenna demonstrates its potential for high-capacity wireless communication and high-quality radar imaging.

关键词： antenna generating circular

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Genomic insights into versatile lifestyle of three new bacterial candidate phyla

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Science China(Life Sciences) 2022年第8期65卷 1547-1562页

作者： Xinxu Zhang Zongbao Liu Wei Xu Jie Pan yuhan huang Mingwei Cai Zhuhua Luo Meng Li Archaeal Biology Center Institute for Advanced StudyShenzhen UniversityShenzhen 518060China Shenzhen Key Laboratory of Marine Microbiome Engineering Institute for Advanced StudyShenzhen UniversityShenzhen 518060China Key Laboratory of Marine Biogenetic Resources Third Institute of OceanographyMinistry of Natural ResourcesXiamen 361005China School of Marine Sciences Nanjing University of Information Science&TechnologyNanjing 210044China

Metagenomic explorations of the Earth's biosphere enable the discovery of previously unknown bacterial lineages of phylogenetic and ecological significance.Here,we retrieved 11 metagenomic-assembled genomes(MAGs)affiliated to three new monophyletic bacterial lineages from the seawater of the Yap Trench.Phylogenomic analysis revealed that each lineage is a new bacterial candidate phylum,subsequently named Candidatus Qinglongiota,Candidatus Heilongiota,and Candidatus Canglongiota.Metabolic reconstruction of genomes from the three phyla suggested that they adopt a versatile lifestyle,with the potential to utilize various types of sugars,proteins,and/or short-chain fatty acids through anaerobic pathways.This was further confirmed by a global distribution map of the three phyla,indicating a preference for oxygen-limited or particle-attached niches,such as anoxic sedimentary environments.Of note,Candidatus Canglongiota genomes harbor genes for the complete WoodLjungdahl pathway and sulfate reduction that are similar to those identified in some sulfate-reducing bacteria.Evolutionary analysis indicated that gene gain and loss events,and horizontal gene transfer(HGT)play important roles in shaping the genomic and metabolic features of the three new phyla.This study presents the genomic insight into the ecology,metabolism,and evolution of three new phyla,which broadens the phylum-level diversity within the domain Bacteria.

关键词： metagenomics horizontal gene transfer fermentation anaerobic respiration evolution marine habitat

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The Development Trends and Research Fronts in Orbital Angular Momentum Technology:A Bibliometric Analysis

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China Communications 2023年第2期20卷 289-310页

作者： Saleemullah Memon Xiuping Li Kamran Ali Memon yuhan huang Junaid Ahmed Uqaili Muhammad Ishfaq School of Electronic Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China Beijing Key Laboratory of Work Safety Intelligent Monitoring Beijing University of Posts and TelecommunicationsBeijing 100876China Department of Telecommunication Engineering Quaid-e-Awam University of EngineeringScience&TechnologyPakistan

Orbital angular momentum(OAM)technology,refers to Laguerre-Gaussian(LG)beams,twisted beams,vector/vortex beams,acoustic vortex beams and fractional vortex beams.It is an emerging and promising technology to improve the communication capacity,spectral efficiency,and anti-jamming capability due to its helical phase fronts and infinite orthogonal states.Although the OAM research began in the 1990s,the developing trends,current status,issues and characteristics through a systematic observation have not yet been performed.This paper presents a knowledge-based evolution of OAM research published in the Web of Science(WoS)from 2011 to 2021 using bibliometric analysis in Citepspace.The results demonstrate that the bandwidth,efficiency,gain,divergence,phase quantization,bulky and complex feeding structures,misalignment,distortion,interferences atmospheric turbulence and diffraction were the key issues found in the OAM technology.The main research hotspots and categories,influential authors,leading journals,best institutions of OAM show a strong bias in favor of their functions and technology developments.The research on OAM was mainly performed by the counties that have developed the 5G and now moving towards 6G communications like China,USA and South Korea.This study would serve as an inclusive guide on the future research trends and status especially for the OAM researchers.

关键词： orbital angular momentum(OAM) vortex beams bibliometric analysis CiteSpace

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Correction of measurement errors on sediment concentration sampled by stirring-sampling method from traditional runoff collection tanks

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International Journal of Agricultural and Biological Engineering 2022年第6期15卷 134-142页

作者： yuhan huang Mingquan Zhao Hui Zhao Tingwu Lei Ju Tang Wei Wang Guangxi Key Laboratory of Forest Ecology and Conservation College of ForestryGuangxi UniversityNanning 530004China College of Water Resources and Civil Engineering China Agricultural UniversityBeijing 100083China Monitoring Center of Soil and Water Conservation Ministry of Water ResourcesBeijing 100053China State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau Institute of Soil and Water ConservationCAS and MWRYangling 712100China College of Resources and Environment Southwest UniversityChongqing 400716China College of Engineering China Agricultural UniversityBeijing 100083China

Stirring-sampling method is a widely adopted method to measure sediment concentrations in collection tanks of runoff plots,but with high systematic measurement errors.This research aimed to advance an approach for building correction equations to remove measurement errors in designed sediment concentration range.Experimental data of sediment measurement from the stirring-sampling method,with four representative soils,under the designed sediment concentrations(1,2,5,8,10,20,50,80,100,200,500,800,and 1000 kg/m^(3))were used to demonstrate the correction methodological process.Two correction methods(step-wise correction and universal correction)were suggested for the trial in this study based on the distribution of measurement errors.In the step-wise correction,the correction equations were made with a series of linear functions without intercept for the low concentration group(0-20 kg/m^(3)),a series of linear functions with intercept for the high(20-200 kg/m^(3))and extremely high(200-1000 kg/m^(3))concentration groups,consecutively.The correction equations were a series of power functions in the universal correction.For the step-wise correction,most of the relative errors of correction sediment concentrations were smaller than 15%and 10%under high and extremely high concentration groups,but the corrected accuracy was not good in the sediment concentration of 1,2,5 kg/m^(3)with the corrected relative errors of 0.20%-206.07%.For the universal correction,the corrected relative errors(0.19%-31.81%)of the four soils were low under the condition of extremely high sediment concentrations,but other corrected accuracies weren’t good with the corrected relative errors of 0.68%-1154.71%.The corrected accuracy of step-wise correction is higher than that of the universal correction,but the universal correction is more convenient.These results indicated that the correction equations could efficiently revise the measurement errors of the tested soils and that this method can be generalized to other soil types and was meaningful

关键词： runoff sediment concentration measurement error correction stirring-sampling method

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储能参与容量市场的国内外现状及机制思考

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电力系统自动化 2024年第6期48卷 226-239页

作者：丁涛孙嘉玮黄雨涵穆程刚黄文渊耿思敏西安交通大学电气工程学院陕西省西安市710049 中国电力科学研究院有限公司(南京) 江苏省南京市210003

在现行电力市场机制下,储能资源的容量价值和物理特性往往难以体现,且长期获利不足。在构建新型电力系统的背景下,激励储能资源参与容量市场有利于发挥储能资源的容量价值并保障电力系统长期可靠运行。因此,文中对国内外储能参与容量市... 详细信息

在现行电力市场机制下,储能资源的容量价值和物理特性往往难以体现,且长期获利不足。在构建新型电力系统的背景下,激励储能资源参与容量市场有利于发挥储能资源的容量价值并保障电力系统长期可靠运行。因此,文中对国内外储能参与容量市场的研究和实践进行了调研分析,总结了储能资源参与典型容量机制的现状。在此基础上,结合中国电力市场发展及容量机制建设现状,探讨了储能参与中国容量市场可能面临的风险与挑战,并从市场准入、技术标准、产品设计、交易机制等方面提出了相关思考。

关键词：储能容量市场容量机制容量价值交易机制

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Numerical investigation of plane Couette flow with weak spanwise rotation

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Science China(Physics,Mechanics & Astronomy) 2019年第4期62卷 71-83页

作者： yuhan huang ZhenHua Xia MinPing Wan YiPeng Shi ShiYi Chen State Key Laboratory for Turbulence and Complex Systems College of Engineering Peking University Department of Engineering Mechanics Zhejiang University Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Zhejiang University Department of Mechanics and Aerospace Engineering Southern University of Science and Technology

Direct numerical simulation of rotating plane Couette flow(RPCF) at Re_w= 1300 and Ro = 0.02 was performed with different mesh resolutions and different sizes of computation domain. Our results showed that a grid resolution in wall units with ?x^+=8.51, ?z^+= 4.26, ?y^+|_(min)= 0.0873 and ?y^+|_(max)= 3.89 is fine enough to simulate the problem at the present parameters. The streamwise length Lxand spanwise length Lzof the computational box have different impacts on the flow statistics, where the statistics were converged if Lxis longer than 8πh, while no converged results were obtained for different Lz. More importantly,our results with very long simulation time showed that a state transition would happen if L_x≥ 8πh, from a state with four pairs of roll cells to a state with three pairs of roll cells with L_z= 6πh. Each state could survive for more than 1500 h/U_w, and the flow statistics were different.

关键词： plane Couette flow span wise rotation state transition

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Transcription factor YY1 is essential for iNKT cell development

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Cellular & Molecular Immunology 2019年第6期16卷 547-556页

作者： Xijun Ou Jianxin Huo yuhan huang Yan-Feng Li Shengli Xu Kong-Peng Lam Immunology Group Bioprocessing Technology InstituteAgency for ScienceTechnology and ResearchSingapore 138668Singapore Department of Biology Southern University of Science and TechnologyShenzhen 518055China Department of Physiology National University of SingaporeSingapore 117599Singapore Department of Microbiology and Immunology National University of SingaporeSingapore 117599Singapore Department of Pediatrics Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117599Singapore School of Biological Sciences Nanyang Technological UniversitySingaporeSingapore

Invariant natural killer T(iNKT)cells develop from CD4+CD8+double-positive(DP)thymocytes and express an invariant Vα14–Jα18 T-cell receptor(TCR)α-chain.Generation of these cells requires the prolonged survival of DP thymocytes to allow for Vα14–Jα18 gene rearrangements and strong TCR signaling to induce the expression of the iNKT lineage-specific transcription factor PLZF.Here,we report that the transcription factor Yin Yang 1(YY1)is essential for iNKT cell formation.Thymocytes lacking YY1 displayed a block in iNKT cell development at the earliest progenitor stage.YY1-deficient thymocytes underwent normal Vα14–Jα18 gene rearrangements,but exhibited impaired cell survival.Deletion of the apoptotic protein BIM failed to rescue the defect in iNKT cell generation.Chromatin immunoprecipitation and deep-sequencing experiments demonstrated that YY1 directly binds and activates the promoter of the Plzf gene.Thus,YY1 plays essential roles in iNKT cell development by coordinately regulating cell survival and PLZF expression.

关键词： NKT cell PLZF YY1 Zbtb16

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红树林沉积物中多环芳烃降解菌Aquabacter sediminis P-9T的分离、鉴定及降解机制的研究

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微生物学报 2024年第6期64卷 2115-2132页

作者：李嘉谊黄雨晗刘力睿李猛深圳大学高等研究院古菌生物学研究中心广东深圳518060 深圳大学高等研究院深圳市海洋微生物组工程重点实验室广东深圳518060 深圳大学生命与海洋学院广东深圳518060

多环芳烃(polycyclic aromatic hydrocarbons,PAHs)是一类具有致畸、致癌和致突变特性的高风险有毒污染物,近年来,关于红树林生态系统受到PAHs污染的报道引起广泛关注,微生物降解被认为是处理PAHs污染的有效、经济和多功能替代方法。目... 详细信息

多环芳烃(polycyclic aromatic hydrocarbons,PAHs)是一类具有致畸、致癌和致突变特性的高风险有毒污染物,近年来,关于红树林生态系统受到PAHs污染的报道引起广泛关注,微生物降解被认为是处理PAHs污染的有效、经济和多功能替代方法。目前,研究者发现了大量细菌利用PAHs污染作为碳源和能源,然而其普遍存在降解效率偏低、降解谱系窄、对高盐环境适应性差等问题,红树林来源的PAHs降解菌的降解机理尚待充分挖掘。【目的】在红树林沉积物中定向筛选针对PAHs的高效广谱降解菌,并深入探讨其降解效能与作用机制,以期为红树林生态系统中微生物污染修复技术的创新研发提供坚实的科学基础。【方法】从深圳福田红树林沉积物筛选出一株降解PAHs的潜在新种菌株P-9T,通过形态学观察、生理生化特性检测和16S rRNA基因序列分析,对该菌株进行鉴定;基于菌株基因组测序与分析预测该菌株的PAHs代谢潜能;在不同温度(25−40℃)、不同pH(5.0−9.0)和不同底物条件下,对菌株P-9T的降解能力进行测定;利用高效液相色谱-质谱联用(HPLC-ESI-MS/MS)技术检测菌株降解PAHs的中间代谢产物,初步揭示P-9T降解PAHs的代谢机制。【结果】菌株P-9T为黄色杆菌科(Xanthobacteraceae)水杆菌属(Aquabacter)的潜在新种,暂命名为Aquabacter sediminis P-9T,也是Aquabacter属中首次发现的PAHs降解菌种;在菌株A.sediminis P-9T的基因组中则发现了一条完整的苯甲酸盐降解通路,以及参与萘和其他PAHs降解的脱氢酶、水杨酸羟化酶和细胞色素P450等关键基因。菌株P-9T可以在25−40℃和pH 5.0−8.0的条件下降解菲,并且可分别以萘、菲、芘为唯一碳源生长繁殖。在菲初始浓度为50 mg/L下培养5 d降解率达100%。利用HPLC-ESI-MS/MS技术检测发现,该菌株对萘、菲、芘降解的中间代谢产物包括1-羟基-2-萘甲酸、1,2-萘二酚和儿茶酚和1-羟基-2-萘醛。推断菌株P-9T是采用水杨酸途径降解PAHs。【结论】A.sediminis P-9T是Aquabacter属的新种,而且是该属中首次发现的PAHs降解菌,最佳降解条件为37℃和pH 7.0,可通过水杨酸途径高效降解萘、菲及芘。

关键词：红树林沉积物 Aquabacter sediminis P-9T 多环芳烃降解水杨酸降解途径

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