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Development of a convolutional neural network based geomechanical upscaling technique for heterogeneous geological reservoir

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2111-2125页

作者： Zhiwei ma Xiaoyan Ou Bo Zhang Earth and Environmental Sciences Division Los Alamos National LaboratoryLos AlamosUSA Civil and Environmental Engineering University of AlbertaEdmontonCanada

Geomechanical assessment using coupled reservoir-geomechanical simulation is becoming increasingly important for analyzing the potential geomechanical risks in subsurface geological ***,a robust and efficient geomechanical upscaling technique for heterogeneous geological reservoirs is lacking to advance the applications of three-dimensional(3D)reservoir-scale geomechanical simulation considering detailed geological ***,we develop convolutional neural network(CNN)proxies that reproduce the anisotropic nonlinear geomechanical response caused by lithological heterogeneity,and compute upscaled geomechanical properties from CNN *** CNN proxies are trained using a large dataset of randomly generated spatially correlated sand-shale realizations as inputs and simulation results of their macroscopic geomechanical response as *** trained CNN models can provide the upscaled shear strength(R^(2)>0.949),stress-strain behavior(R^(2)>0.925),and volumetric strain changes(R^(2)>0.958)that highly agree with the numerical simulation results while saving over two orders of magnitude of computational *** is a major advantage in computing the upscaled geomechanical properties directly from geological realizations without the need to perform local numerical simulations to obtain the geomechanical *** proposed CNN proxybased upscaling technique has the ability to(1)bridge the gap between the fine-scale geocellular models considering geological uncertainties and computationally efficient geomechanical models used to assess the geomechanical risks of large-scale subsurface development,and(2)improve the efficiency of numerical upscaling techniques that rely on local numerical simulations,leading to significantly increased computational time for uncertainty quantification using numerous geological realizations.

关键词： Upscaling Lithological heterogeneity Convolutional neural network(CNN) Anisotropic shear strength Nonlinear stressestrain behavior

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Ternary superhydrides for high-temperature superconductivity at low pressures

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National Science Review 2024年第7期11卷 12-14页

作者： Pengfei Shan Liang ma Jinguang Cheng Beijing National Laboratory for Condensed matter Physics and Institute of Physics Chinese Academy of Sciences School of Physical Sciences University of Chinese Academy of Sciences Key Laboratory of materials Physics Ministry of Education School of Physics and Microelectronics Zhengzhou University

The quest for room-temperature superconductivity(RTSC) has been a longstanding pursuit in physics since the discovery of superconductivity in *** to the conventional Bardeen-Cooper-Schrieffer theory, atomic metallic hydrogen holds great promise for achieving this goal due to its high Debye temperature and strong electron-phonon coupling.

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Immune checkpoint inhibition mediated with liposomal nanomedicine for cancer therapy

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Military Medical Research 2024年第1期11卷 98-114页

作者： Guang-Long ma Wei-Feng Lin Faculty of Medicine Centre for Cancer ImmunologyUniversity of SouthamptonSouthampton SO166YDUK Department of Molecular Chemistry and materials Science Weizmann Institute of Science76100 RehovotIsrael Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang UniversityBeijing 100191China

Immune checkpoint blockade(ICB)therapy for cancer has achieved great success both in clinical results and on the *** the same time,success drives more attention from scientists to improve ***,only a small portion of patients are responsive to this therapy,and it comes with a unique spectrum of side effects termed immunerelated adverse events(irAEs).The use of nanotechnology could improve ICBs’delivery to the tumor,assist them in penetrating deeper into tumor tissues and alleviate their *** nanomedicine has been investigated and used for decades,and is well-recognized as the most successful nano-drug delivery *** successful combination of ICB with liposomal nanomedicine could help improve the efficacy of ICB *** this review,we highlighted recent studies using liposomal nanomedicine(including new emerging exosomes and their inspired nanovesicles)in associating ICB therapy.

关键词： Liposome Exosome Immune checkpoint blockade(ICB)

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Lifetime-tunable circularly polarized luminescent system based on triplet-to-singlet Förster resonance energy transfer

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Science China Chemistry 2024年第9期67卷 2918-2922页

作者： Zhenyi He Zizhao Huang Xiang ma Key Laboratory for Advanced materials and Feringa Nobel Prize Scientist Joint Research Center Institute of Fine ChemicalsSchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China

Circularly polarized luminescence(CPL)materials have received widespread attention due to their remarkable performance and broad ***,current CPL material research primarily focuses on tunable color,intensity,and *** CPL with adjustable lifetime remains a significant ***,a series of CPL polymeric materials with tunable lifetime were obtained by employing phosphorescent terephthalic acid and chiral organic small molecule R/S-BNAF(a luminescent binaphthol derivative)to copolymerize with acrylamide in different *** was verified that this performance results from the different energy transfer efficiency between luminophores with varying ratios of the monomers for *** strategy to realize CPL with tunable lifetime by modulating the energy transfer efficiency will provide a new perspective to broaden the applications of CPL materials.

关键词： circularly polarized luminescence tunable lifetime Förster resonance energy transfer room temperature phosphorescence

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An adaptive energy regulation in a memristive map linearized from a circuit with two memristive channels

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Communications in Theoretical Physics 2024年第3期76卷 42-50页

作者： Feifei Yang Ping Zhou Jun ma School of Science Chongqing University of Posts and TelecommunicationsChongqing 430065China College of Electrical and Information Engineering Lanzhou University of TechnologyLanzhou 730050China Department of Physics Lanzhou University of TechnologyLanzhou 730050China

Nonlinear circuits can show multistability when a magnetic flux-dependent memristor(MFDM) or a charge-sensitive memristor(CSM) is incorporated into a one branch circuit,which helps estimate magnetic or electric field *** this paper,two different kinds of memristors are incorporated into two branch circuits composed of a capacitor and a nonlinear resistor,thus a memristive circuit with double memristive channels is *** circuit equations are presented,and the dynamics in this oscillator with two memristive terms are ***,the memristive oscillator is converted into a memristive map by applying linear transformation on the sampled time series for the memristive *** Hamilton energy function for the memristive oscillator is obtained by using the Helmholtz theorem,and it can be mapped from the field energy of the memristive *** energy function for the dual memristive map is suggested by imposing suitable weights on the discrete energy *** dynamical behaviors of the new memristive map are investigated,and an adaptive law is proposed to regulate the firing mode in the memristive *** work will provide a theoretical basis and experimental guidance for oscillator-to-map transformation and discrete map energy calculation.

关键词： Hamilton energy dual memristive map adaptive energy regulation

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Elastic wave insulation and propagation control based on the programmable curved-beam periodic structure

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Applied mathematics and Mechanics(English Edition) 2024年第10期45卷 1791-1806页

作者： Jiajia maO Hong CHENG Tianxue ma Beijing Key Laboratory of Nonlinear Vibrations and Strength of Mechanical Structures Department of MechanicsSchool of MathematicsStatistics and MechanicsBeijing University of TechnologyBeijing 100124China Department of Mechanics School of Physical Science and EngineeringBeijing Jiaotong UniversityBeijing 100044China

Curved-beams can be used to design modular multistable metamaterials(MMMs)with reprogrammable material properties,i.e.,programmable curved-beam periodic structure(PCBPS),which is promising for controlling the elastic wave *** PCBPS is theoretically equivalent to a spring-oscillator system to investigate the mechanism of bandgap,analyze the wave propagation mechanisms,and further form its geometrical and physical criteria for tuning the elastic wave *** the equivalent model,we calculate the analytical solutions of the dispersion relations to demonstrate its adjustability,and investigate the wave propagation characteristics through the *** validate the equivalent system,the finite element method(FEM)is *** is revealed that the bandgaps of the PCBPS can be turned on-and-off and shifted by varying its physical and geometrical *** findings are highly promising for advancing the practical application of periodic structures in wave insulation and propagation control.

关键词： curved-beam based periodic structure equivalent stiffness spring-oscillator system dispersion relation wave propagation

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北京市学生标化与非标化近视检出率比较

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中国学校卫生 2021年第2期42卷 195-197,202页

作者：马瑀涵王路夏志伟秦冉郭欣首都医科大学公共卫生学院北京100069 北京市疾病预防控制中心学校卫生所

目的比较标化前后北京市各区学生近视检出率的差异,为阐明标化率在基层卫生工作中的重要性和实际意义提供依据。方法研究对象来自"2018年北京市学生常见病和健康影响因素监测与干预"项目,采用整群抽样的方法,从北京市16个区的107所中小... 详细信息

目的比较标化前后北京市各区学生近视检出率的差异,为阐明标化率在基层卫生工作中的重要性和实际意义提供依据。方法研究对象来自"2018年北京市学生常见病和健康影响因素监测与干预"项目,采用整群抽样的方法,从北京市16个区的107所中小学校和35所幼儿园中抽取41 029名研究对象,所有研究对象均完成了远视力检查和屈光检测。采用2018—2019学年北京教育事业发展统计概要公布的学生构成作为标准组对北京市各区学生的近视检出率进行标化,比较标化前后各区学生近视检出率的变化。结果 2018年北京市学生近视检出率为57.3%;幼儿园学生近视检出率为12.1%,小学生为38.4%,初中生为77.2%,普通高中生为88.3%,职业高中生为73.1%。尽管标化前后均以区9学生的近视检出率最高,但检出率差异高达13.8百分点。标化前以区13学生的近视检出率最低,而标化后以区12学生的近视检出率最低。结论北京市学生的近视检出率普遍较高,且标化前后各区学生的近视检出率及排序差别较大。在实际工作中,采用标化率可以正确揭示疾病真实的流性特征。

关键词：近视患病率统计数据学生

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Influences of Graupel Microphysics on Cma-GFS Simulation of Summer Regional Precipitation

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Journal of Meteorological Research 2024年第1期38卷 27-38页

作者： Zhe LI Qijun LIU Zhanshan ma Cma Earth System Modeling and Prediction Centre China Meteorological Administration(CMA)Beijing 100081

The horizontal resolution of global numerical weather prediction models is continuously developing. However, due to the imperfect precipitation simulation/forecast of these models, the demand for considering riming particles in cloud microphysical schemes in these models is increasing. This study employed the latest versions of global atmospheric reanalysis data (ERA5), the satellite retrieval data of the Global Precipitation Observation Program (GPM),and station precipitation observations to explore the impacts of adding graupel to the cloud microphysical scheme in the China Meteorological Administration-Global Forecast System (Cma-GFS) on summer regional precipitation simulations in four Chinese climate zones. The results verify that the new graupel scheme can enable Cma-GFS to decently predict global graupel distribution, especially in tropical and midlatitude regions. The addition of graupel in the cloud microphysics increases the precipitation simulation in North China, while that in Southwest China is weakened and dispersed. Moreover, graupel scheme increases the precipitation simulations of almost all *** increase in light rain is obvious, and the absolute value of heavy rain is strengthened. This may be because graupel quickly melts into rain after falling out of the zero-temperature layer due to its large mass and fast falling speed, increasing surface precipitation. In summary, the addition of graupel in the cloud microphysical scheme can improve Cma-GFS’s underestimation of strong precipitation.

关键词： graupel cloud microphysical scheme precipitation China Meteorological Administration-Global Forecast System(Cma-GFS) climate zone

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Potential role of hippocampal neurogenesis in spinal cord injury induced post-trauma depression

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Neural Regeneration Research 2024年第10期19卷 2144-2156页

作者： Ying ma Yue Qiao Xiang Gao Spinal Cord and Brain Injury Research Group Stark Neuroscience Research InstituteIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neurology Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina

It has been reported both in clinic and rodent models that beyond spinal cord injury directly induced symptoms, such as paralysis, neuropathic pain, bladder/bowel dysfunction, and loss of sexual function, there are a variety of secondary complications, including memory loss, cognitive decline, depression, and Alzheimer's disease. The largescale longitudinal population-based studies indicate that post-trauma depression is highly prevalent in spinal cord injury patients. Yet, few basic studies have been conducted to address the potential molecular mechanisms. One of possible factors underlying the depression is the reduction of adult hippocampal neurogenesis which may come from less physical activity, social isolation, chronic pain, and elevated neuroinflammation after spinal cord injury. However, there is no clear consensus yet. In this review, we will first summarize the alteration of hippocampal neurogenesis post-spinal cord injury. Then, we will discuss possible mechanisms underlie this important spinal cord injury consequence. Finally, we will outline the potential therapeutic options aimed at enhancing hippocampal neurogenesis to ameliorate depression.

关键词： antidepressants chronic pain depression exercise hippocampal neurogenesis inflammation inhibition neuroinflammation physical activity deficits social isolation spinal cord injury

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Provenance of Conglomerate and Sandstone from Early Permian Shoushangou Formation in Xi Ujimqin,Inner Mongolia:Implications for Understanding Paleo-Asian Ocean Subduction

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Acta Geologica Sinica(English Edition) 2024年第1期98卷 10-31页

作者： ZHANG Yingli GUO Xianqing ma Shouxian MNR Key Laboratory of Metallogeny and Mineral Assessment Institute of Mineral ResourcesCAGSBeijing 100037China Chinese Academy of Geological Sciences Beijing 100037China

During the Late Carboniferous to Early Permian,a rift was formed by post-collisional extension after ocean closure or an island arc-related basin formed by Paleo-Asian Ocean(PAO)subduction in the Xi Ujimqin ***,the closure time of the PAO is still under ***,to identify the origin of the PAO,the geochemistry and U-Pb age of zircons were analyzed for the extra-large deep marine,polymict clastic boulders and sandstones in the Shoushangou Formation within the *** analyses revealed magmatic activity and tectonic *** conglomerates include megaclasts of granite(298.8±9.1 ma)and granodiorite porphyry(297.1±3.1 ma),which were deposited by muddy debris *** of this study demonstrated that the boulders of granitoids have the geochemistry of typical I-type granite,characterized by low Zr+Nb+Ce+Y and low Ga/Al *** granitoid boulders were formed in island arc setting,indicating the presence of arc magmatism in the area that is composed of the Late Carboniferous to Early Permian subduction-related granitoid in southern Xi *** diagrams for determining sedimentary provenance using major and trace elements indicate that Shoushangou sediments originated from continental island arc-related felsic *** zircon U-Pb age cluster of 330–280 ma was obtained,indicating input from granite,ophiolite,Xilin Gol complex,and Carboniferous sources to the *** basin was geographically developed behind the arc during the Early Permian period because the outcropped intrusive rocks in the Late Carboniferous to Early Permian form a volcanic *** comprehensive analyses of source areas suggest that Shoushangou sediments developed in a backarc basin in response to the northward subduction of the *** backarc basin and intrusive rocks,in addition to previously published Late Carboniferous to Early Permian magmatic rocks of arc unit in Xilin Gol,confirm the presence of an Early Permian trencharc-basin system in the region,r

关键词： provenance analysis backarc basin Shoushangou Formation Early Permian Central Asian Orogenic Belt

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