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The 2009 pandemic A/Wenshan/01/2009 H1N1 induces apoptotic cell death in human airway epithelial cells

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分子细胞生物学报:英文版 2011年第4期3卷 221-229页

作者： Ning Yang Xiaoxu Hong Penghui Yang Xiangwu Ju yuguo wang Jun Tang Chenggang Li Quanshui Fan Fuqiang Zhang Zhongwei Chen Li Xing Zhongpeng Zhao Xiao Gao Guoyang Liao Qihan Li Xiliang wang Dangsheng Li Chengyu Jiang State Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesPeking Union Medical CollegeTsinghua UniversityChinese Academy of Medical SciencesBeijing 100005China Department of Viral Immunology Institute of Medical BiologyChinese Academy of Medicine SciencePeking Union Medical CollegeKunming 650118China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China Centre for Disease Prevention and Control Cheng Du Military RegionKunming 650032China Shanghai Institutes for Biological Sciences Chinese Academy of SciencesShanghai 200031China

In 2009,a novel swine-origin H1N1 influenza virus emerged in Mexico and quickly spread to other countries,including *** 2009 pandemic H1N1 can cause human respiratory disease,but its pathogenesis remains poorly ***,we studied the infection and pathogenesis of a new 2009 pandemic strain,A/Wenshan/01/2009 H1N1,in China in human airway epithelial cell lines compared with contemporary seasonal H1N1 influenza *** results showed that viral infection by the A/Wenshan H1N1 induced significant apoptotic cell death in both the human nasopharyngeal carcinoma cell line CNE-2Z and the human lung adenocarcinoma cell line *** A/Wenshan H1N1 virus enters both of these cell types more efficiently than the seasonal influenza *** entry in both cell lines was shown to be mediated by clathrin-and dynamin-dependent ***,we discovered that the 2009 pandemic H1N1 strain,A/Wenshan/01/2009,can induce apoptotic cell death in epithelial cells of the human respiratory tract,suggesting a molecular pathogenesis for the 2009 pandemic H1N1.

关键词： apoptosis respiratory S-OIV H1N1 influenza virus

Size and Temperature Dependence of Dielectric Constant of Ultrafine PbTiO_(3) Particles

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Chinese Physics Letters 1994年第8期11卷 514-517页

作者： QU Baodong JIANG Bin wang yuguo ZHANG Peilin ZHONG Weilie Department of Physics Shandong UniversityJinan 250100

Using sol-gel method,we prepared ferroelectric PbTiO_(3) fine particles with particle size covering the range 20-200nm;the dielectric properties of powder compact were studied in the present *** room temperature dielectric constant increases with the decrease in particle size and reaches a maximum value at the size of about *** temperature dependence of dielectric constant involving the evolution of particle size during the measurement is discussed.

关键词： dielectric size particle

Enhanced piezoelectricity of Cu-doped K(Ta,Nb)O_(3) single crystals

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Journal of Materiomics 2024年第5期10卷 1017-1025页

作者： Fulin Zhang Songtao Fan Yingxu Zhu Wendie Chen Bing Liu yuguo Yang Limei Zheng Yuanyuan Zhang Xianshun Lv Xuping wang Advanced Materials Institute Qilu University of Technology(Shandong Academy of Sciences)Jinan250014China Qilu University of Technology(Shandong Academy of Sciences) Advanced Materials InstituteKey Laboratory of Light Conversion Materials and Technology of Shandong Academy of SciencesJinan250014China School of Physics Shandong UniversityJinan250100China

As a class of solid solution material,K(Ta,Nb)O3(KTN)single crystals have attracted significant interest due to their excellent piezoelectric and electro-optic *** this study,the piezoelectric properties of KTN were improved through Cu *** the advantages of composition-regulating phase transition,a large,high-quality Cu:KTN crystal measuring 30 mm×25 mm×20 mm in size was grown using the improved top seeded solution growth ***-doped KTN exhibited better piezoelectric properties than pure KTN,and the full matrix parameters were *** dielectric,piezoelectric,and electromechanical coupling responses(ε^(T)_(11)-2,136,d_(33)∼303 pC/N,k_(t)∼0.515,and k33∼0.672)were successfully *** realize the optimized orientation of the piezoelectric properties,the orientation dependence of the single domain properties was investigated,and the mechanism of Cu doping to improve piezoelectric properties was *** found that 0.36%(in mass)Cu doped crystal consisted of A-site substitution,following ferroelectric and domain *** small ferroelectric domain sizes led to a large domain wall mobility rate and high domain wall density,which contributed to high piezoelectric *** work revealed the effect of A-position doping on piezoelectric properties and provided a theoretical and experimental foundation for the performance optimization of KTN-based materials.

关键词： Solid solution material Lead-free piezoelectric Enhanced piezoelectricity

个体记忆与台湾光复接收论述——兼论个体记忆与集体记忆

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台湾研究集刊 2017年第4期 78-86页

作者：王玉国两岸关系和平发展协同创新中心福建厦门361005 厦门大学台湾研究中心福建厦门361005

个人的日记、自传、回忆录及口述历史等,是"个体记忆"的重要载体,是档案及报刊资料的有益补充,从中可以更清楚看到台湾光复与接收的相关细节:绝大多数民众对日本战败表现兴奋,也有部分民众表现失望;台湾民众对国军军容不整失望的同时,... 详细信息

个人的日记、自传、回忆录及口述历史等,是"个体记忆"的重要载体,是档案及报刊资料的有益补充,从中可以更清楚看到台湾光复与接收的相关细节:绝大多数民众对日本战败表现兴奋,也有部分民众表现失望;台湾民众对国军军容不整失望的同时,也给予理解与宽容;台湾光复后的所谓自来水龙头事件,甚至有截然相反的两种"个体记忆"。因亲历者、旁观者、听说者对台湾光复接收的接触程度不同,导致"个体记忆"也存在差异,但这些"个体记忆"都丰富了台湾光复与接收的"集体记忆"。

关键词：台湾光复个体记忆集体记忆

台湾地区大陆同乡会数量、成立时间及刊物的考订

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台湾研究集刊 2018年第2期 77-86页

作者：王玉国两岸关系和平发展协同创新中心福建厦门361005 厦门大学台湾研究中心福建厦门361005

台湾光复后,陆续有13家大陆同乡会在台湾成立。1949年后,随国民党迁台人员纷纷在台湾组设大陆同乡会。台湾地区大陆同乡会数量多、分布广、时间久,至今仍有486家大陆同乡会存在,在两岸经济文化交流中发挥重要作用。大陆同乡会一度因应... 详细信息

台湾光复后,陆续有13家大陆同乡会在台湾成立。1949年后,随国民党迁台人员纷纷在台湾组设大陆同乡会。台湾地区大陆同乡会数量多、分布广、时间久,至今仍有486家大陆同乡会存在,在两岸经济文化交流中发挥重要作用。大陆同乡会一度因应国民党当局政策凸显其政治功能,亦发挥经济功能、社会功能及文化功能,创办至少181种刊物,维系了同乡感情,保存了故乡文献。大陆同乡会组设时间不同,其宗旨也存在差异,因此不能简单强调其政治归属性。

关键词：台湾地区大陆同乡会刊物

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保险洪灾损失预测模型

计算机辅助设计与图形学学报 2005年第11期17卷 2523-2529页

作者：杨立左春王裕国中国科学院软件研究所北京100080

提出并实现了一种基于地形条件和领域知识的保险洪灾损失预测模型,根据数字高程模型生成地形及排水能力因子,利用神经网络模型的非线性映射能力进行仿真建模,并给出了在该模型中融合领域知识的方法.实验证明,该模型可得出动态的预测结... 详细信息

提出并实现了一种基于地形条件和领域知识的保险洪灾损失预测模型,根据数字高程模型生成地形及排水能力因子,利用神经网络模型的非线性映射能力进行仿真建模,并给出了在该模型中融合领域知识的方法.实验证明,该模型可得出动态的预测结果并具有较强的泛化能力,为保险及相关行业提供了一个可操作的洪灾损失预测处理平台.

关键词：洪灾损失预测模型地形条件领域知识数字高程模型神经网络

Effect of Modified Xijiao Dihuang Decoction (犀角地黄汤) on intestinal microecology and pro-inflammatory factors after acute intestinal mucosal radiation injury in rats

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Journal of Traditional Chinese Medicine 2021年

作者： Feng Jian Dou Yongqi wang yuguo Zhao Sen Feng Jian， Dou Yongqi， wang yuguo， Zhao Sen， Institute of traditional Chinese medicine of PLA General Hospital

Objective: To evaluate the effects of Modified Xijiao Dihuang Decoction (犀角地黄汤， MXDD) on the intestinal microbiota and circulating concentrations of proinflammatory factors. Methods: One hundred and thirty male Sprague Dawley rats were randomly allocated to control (CON， n=10)， model (MOD)， glutamine (GU)， Golden Bifid (JIN)， and high-， medium-， and low-dose MXDD (ZHH， ZHM， and ZHL， respectively， n=20 each) groups. All the groups except the CON group were administered a single dose of 12 Gy abdominal irradiation. Excluding the CON group， five rats were randomly selected on days 4， 8， and 12， their ileal contents were collected for analysis of the intestinal microbiota， and the serum concentrations of TNF-α， IL-6， IFN-γ， and IL-10 were measured. Results: The 2-week survival rate of the MOD group was 45%， the survival rates of rats in the treatment groups were better， especially in the ZHH and ZHM groups (70%). The intestinal epithelia of the ZHH and ZHM groups was relatively intact， the crypt structure was relatively normal， and inflammatory cell infiltration was less severe. The concentrations of pro-inflammatory factors were lower in all the treatment groups than in the MOD group. Those of TNF-α， IL-6， and IFN-γ were lower in the Gu， ZHH， and ZHM groups on day 4 (P<0.05)， and that of IL-10 was higher in the Gu， ZHM， and ZHL groups on day 4 (P<0.05). The abundance of Escherichia-Shigella was lower in the treatment groups， and especially in the Gu and ZHM groups (P<0.01)， on day 4. Escherichia-Shigella were less abundant in the JIN (P<0.01)， ZHH， and ZHL (P<0.05) groups on day 8. Escherichia-Shigella， were less abundant in the JIN (P<0.01)， ZHH， and ZHL (P<0.05) groups than in the MOD group on day 12. Conclusion: MXDD promotes the recovery of the richness and diversity of the intestinal microbiota， reduces the proportion of Escherichia-Shigella， and rebalances the expression of the proinflammatory factors TNF-α， IL-6， IFN-γ， and IL-10.

关键词： Modified Xijiao Dihuang Decoction radiation enteritis intestinal flora TNF-α IL-6 IFN-γ IL-10. traditional Chinese medicine

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关于推进消费经济学科建设的几个问题

消费经济 2005年第4期21卷 22-26页

作者：王裕国西南财经大学消费经济研究所四川成都610074

消费经济学在构筑基础理论范畴、坚持应用特色、拓展研究方法、探究现实问题上已取得显著的成绩。当前,应进一步加强基础理论研究。要有历史的眼光,探究消费问题产生的历史背景和历史条件;要有发展的眼光,深入把握社会经济发展脉络,深... 详细信息

消费经济学在构筑基础理论范畴、坚持应用特色、拓展研究方法、探究现实问题上已取得显著的成绩。当前,应进一步加强基础理论研究。要有历史的眼光,探究消费问题产生的历史背景和历史条件;要有发展的眼光,深入把握社会经济发展脉络,深刻理解目前我国消费经济学科的科学性、局限性及其发展趋势;要有比较的眼光,善于从古今中外的消费理论研究中,总结出具有共同性的规律;要有综合的眼光,注重与其他学科的交融,在跨学科的研究中全面而深入地把握消费需要理论的产生、演变及发展,进一步构筑成熟的消费经济学科体系。

关键词：消费经济学科理论方法

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近代中日政府教育投资简析

历史教学 2005年第4期 30-33页

作者：王玉国南开大学经济研究所，天津300071

近代中国和日本两国政府都积极进行教育投资,取得一定效果.受社会、政治、经济、军事等因素影响,两国对于教育投资的效果存在差异.

关键词：近代中国政府日本政府教育投资