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Visible light cross-linking and bioactive peptides loaded integrated hydrogel with sequential release to accelerate wound healing complicated by bacterial infection

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Nano Research 2024年第3期17卷 1737-1747页

作者： Guiyan wang Ning Yuan Jun Zhang Man Qin Suwei Dong yuguang wang Department of Pediatric Dentistry Peking University School and Hospital of StomatologyBeijing 100081China State Key Laboratory of Natural and Biomimetic Drugs Chemical Biology Centerand School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Department of Prosthodontics Peking University School and Hospital of StomatologyBeijing 100081China

The effective management of bacterial infections that are resistant to multiple drugs remains a substantial clinical challenge.The eradication of drug-resistant bacteria and subsequent promotion of angiogenesis are imperative for the regeneration of the infected wounds.Here,a novel and facile peptide containing injectable hydrogel with sustained antibacterial and angiogenic capabilities is developed.The antibacterial peptide that consists of 11 residues(CM11,WKLFKKILKVL)is loaded onto acrylate-modified gelatin through charge interactions.A vascular endothelial growth factor mimetic peptide KLT(KLTWQELYQLKYKGI)with a GCG(Gly-Cys-Gly)modification at the N-terminal is covalently coupled through a visible light-induced thiol-ene reaction.In this reaction,the acrylate gelatin undergoes cross-linkage within seconds.Based on the physical/chemical double crosslinking strategy,the bioactive peptides achieve sustained and sequential release.The results show that the hydrogel significantly inhibits methicillin-resistant Staphylococcus aureus(MRSA)growth through the rapid release of CM11 peptides at early stage;it forms obvious growth inhibition zones against pathogenic bacterial strains.Moreover,cell counting kit-8 assay and scratch test confirm that the CM11/KLT-functionalized hydrogels promote cell proliferation and migration through the later release of KLT peptides.In a mouse skin wound infected with self-luminous MRSA,the CM11/KLT-functionalized hydrogels enhance wound healing,with rapidly bacterial infection reduction,lower expression of inflammatory factors,and neovascularization promotion.These results suggest that the rationally designed,sustained and sequential release CM11/KLT-functionalized hydrogels have huge potential in promoting the healing of multi-drug resistant bacterial infected wounds.

关键词： antimicrobial peptide vascular endothelial growth factor(VEGF)mimetic peptide sequential release visible-light crosslinking hydrogel wound therapy

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A stepwise-responsive editor integrated with three copper ions for the treatment of oral squamous cell carcinoma

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Nano Research 2024年第6期17卷 5424-5434页

作者： Jinna Ren Jingying Hu Fan Dong Yan Xu Yang Peng Yuping Qian Guanmeng Zhang Min wang yuguang wang Department of Prosthodontics Hospital of StomatologyJilin UniversityChangchun 130021China Department of General Dentistry II Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China Center of Digital Dentistry Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China Department of Nursing Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China The VIP Department School and Hospital of StomatologyChina Medical UniversityLiaoning Provincial Key Laboratory of Oral DiseasesShenyang 110002China

Cuprotosis,a new type of cell death,provides great opportunities for the treatment of oral squamous cell carcinoma,as nanocarriers of copper ions can induce cuprotosis and immunogenic death.Here,we studied an editor that enables production of a nanoparticle“storm”in oral squamous cell carcinoma,maximizing the toxic effect of these particles and reprogramming the tumor microenvironment;as a result,T cells and natural killer(NK)cells can infiltrate the tumor microenvironment to activate an antitumor immune response.On this basis,the editor can be combined with optical therapy to improve patient prognosis.In this study,the metal ratio was regulated in response to the nanocarrier of acid response type.Thus,in the presence of a specific copper ion content,the nanocarrier could change the permeability of the tumor cell membrane.Based on these results,the nanoparticles were cracked in an acidic environment and then released copper ions.Finally,the nanoparticles contributed to cuprotosis and immunogenic death.In addition,the editor could inhibit murine oral cancer 1(MOC1)tumors in C57BL/6 without toxicity.The rate of tumor growth inhibition was as high as approximately 80%.This strategy provides a new idea for immunotherapy.Moreover,it can improve the interaction between immunotherapy and the copper-induced death of oral squamous cell carcinoma.Above all,this study will provide a new opportunity for the effective treatment of oral squamous cell carcinoma.

关键词： cuprotosis immunogenic death photothermal therapy tumor microenvironment immunotherapy

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Bioinspired surface functionalization of biodegradable mesoporous silica nanoparticles for enhanced lubrication and drug release

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Friction 2023年第7期11卷 1194-1211页

作者： Xiaowei MAO Kexin CHEN Yanlong ZHAO Chunrong Xiong Jing LUO yuguang wang Bo wang Hongyu ZHANG School of Chemical Engineering and Technology Hainan UniversityHaikou 570228China State Key Laboratory of Tribology Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China Peking University School of Nursing&National Engineering Laboratory for Digital and Material Technology of Stomatology Beijing 100191China Beijing Research Institute of Automation for Machinery Industry Co. Ltd.Beijing 100120China Center of Digital Dentistry Peking University School and Hospital of Stomatology&NHC Research Center of Engineering and Technology for Computerized DentistryBeijing 100081China College of Chemical and Biological Engineering Shandong University of Science and TechnologyQingdao 266590China

Osteoarthritis is associated with the significantly increased friction of the joint,which results in progressive and irreversible damage to the articular cartilage.A synergistic therapy integrating lubrication enhancement and drug delivery is recently proposed for the treatment of early-stage osteoarthritis.In the present study,bioinspired by the self-adhesion performance of mussels and super-lubrication property of articular cartilages,a biomimetic self-adhesive dopamine methacrylamide-poly(2-methacryloyloxyethyl phosphorylcholine)(DMA-MPC)copolymer was designed and synthesized via free radical polymerization.The copolymer was successfully modified onto the surface of biodegradable mesoporous silica nanoparticles(bMSNs)by the dip-coating method to prepare the dual-functional nanoparticles(bMSNs@DMA-MPC),which were evaluated using a series of surface characterizations including the transmission electron microscope(TEM),Fourier transform infrared(FTIR)spectrum,thermogravimetric analysis(TGA),X-ray photoelectron spectroscopy(XPS),etc.The tribological test and in vitro drug release test demonstrated that the developed nanoparticles were endowed with improved lubrication performance and achieved the sustained release of an anti-inflammatory drug,i.e.,diclofenac sodium(DS).In addition,the in vitro biodegradation test showed that the nanoparticles were almost completely biodegraded within 10 d.Furthermore,the dual-functional nanoparticles were biocompatible and effectively reduced the expression levels of two inflammation factors such as interleukin-1β(IL-1β)and interleukin-6(IL-6).In summary,the surface functionalized nanoparticles with improved lubrication and local drug release can be applied as a potential intra-articularly injected biolubricant for synergistic treatment of early-stage osteoarthritis.

关键词： surface functionalization phosphorylcholine coating mesoporous silica nanoparticles hydration lubrication osteoarthritis

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The Political Cause of the Movement of RMB Exchange Rate： A Research Based on the Spillover Effects of US Political Cycle

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Frontiers of Economics in China-Selected Publications from Chinese Universities 2016年第4期11卷 694-731页

作者： Mengnan Zhu Qian Zhao yuguang wang School of Economics Xiamen University Xiamen 361005 China

Movement of the renminbi （RMB） exchange rate is not only affected by economic factors, but also by political factors home and aboard. This paper analyzes the transmission mechanism of political cycles on the RMB exchange rate first, and then sets up a ＂political cycle spillover effect model＂ followed by an empirical analysis. We find that：（1） the US political cycle has a direct effect on the RMB exchange rate in the short run, which is mainly transmitted by capital flows and China＇s exchange rate policy control; （2） the RMB exchange rate changes periodically in accordance with the US presidential election and midterm election cycle, with the appreciation ratio significantly lower in the first year of the election cycle, while significantly higher in the year after the midterm election; （3） The effect of the political cycle will not be affected by which party holds power, though it will be affected if the president and parliament are ruled by the same party. This paper not only extends the research of the influencing factors of the RMB exchange rate to the political field, but also sets up a use theoretical model to analyze the impact of political issues on the RMB exchange rate, providing a new perspective to fully understand the external environment of RMB exchange rate reform.

关键词： political cycle spilIover effect RMB exchange rate

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Advances in quantitative proteomics

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Frontiers in Biology 2010年第3期5卷 195-203页

作者： yuguang wang Haiying LI Sixue CHEN College of Life Sciences Heilongjiang UniversityHarbin 150080China Department of Biology Genetics InstituteThe Plant Molecular and Cellular Biology ProgramInterdisciplinary Center for Biotechnology ResearchUniversity of FloridaGainesvilleFL 32611USA

Large-scale protein quantification has become a major proteomics application in many areas of biological and medical research.During the past years,different techniques have been developed,including gel-based such as differential in-gel electrophoresis(DIGE)and liquid chromatography-based such as isotope labeling and labelfree quantification.These quantitative proteomics tools hold significant promise for biomarker discovery,diagnostic and therapeutic applications.They are also important for research in functional genomics and systems biology towards basic understanding of molecular networks and pathway interactions.In this review,we summarize current technologies in quantitative proteomics and discuss recent applications of the technologies.

关键词： two dimensional gel liquid chromatographymass spectrometry(LC-MS) stable isotope quantification application

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An 84-month observational study of the changes in CD4 T-lymphocyte cell count of 110 HIV/AIDS patients treated with traditional Chinese medicine

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Frontiers of Medicine 2014年第3期8卷 362-367页

作者： Jian wang Biyan Liang Xiaoping Zhang Liran Xu Xin Deng Xiuhui Li Lu Fang Xinghua Tan Yuxiang Mao Guoliang Zhang yuguang wang TCM Center for AIDS Prevention and Treatment China Academy of Chinese Medical Sciences Beijing 100700 China The First Affiliated Hospital of Henan University of Traditional Chinese Medicine Zheng hou 450000 China Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine Nanning 530011 China Beijing You 'an Hospital Beijing 100054 China Yunnan Provinical Academy of Traditional Chinese Medicine Kunming 650031 China Guangzhou Eighth People's Hospital Guangzhou 510060 China Hebei Hospital of Traditional Chinese Medicine Shijiazhuang 050011 China Anhui Hospital of Traditional Chinese Medicine Hefei 230000 China Beijing Ditan Hospital Beijing 100015 China

This study aimed to evaluate the therapeutic effect of traditional Chinese medicine （TCM） by observing the changes in CD4 T-lymphocyte cell count of 110 cases with human immunodeficiency virus （HIV）/acquired immunodeficiency syndrome （AIDS） treated continuously with TCM for 84 months. Information of 110 HIV/AIDS patients from 19 provinces and cities treated with TCM from 2004 to 2013 was collected. Changes in the indexes of CD4 counts （ ~〈 200, 201-350, 351-500 and 〉 500 cells/mm3） at five time points （0, 12, 36, 60 and 84 months） and different treatments [TCM and TCM plus antiretroviral therapy （ART）] were compared. Repeated measures test indicated no interaction between group and time （P 〉 0.05）. Degrees of increasing and decreasing CD4 count of the two groups at four different frames were statistically significant compared with the baseline. The CD4 count between the two groups was not statistically significant. For CD4 count of ~〈 200 cells/ram3, the mean CD4 count changes were 21 and 28 cells/mm3 per year for the TCM group and TCM plus ART group, respectively. For CD4 count of 201-350 celis/mm3, the mean CD4 count changes were 6 and 25 cells/mm3 per year for the TCM group and TCM plus ART group, respectively. For CD4 count of 351 500 cells/mm3, the mean CD4 count changes were 13 and -7 cells/mm3 per year for the TCM group and TCM plus ART group, respectively. For CD4 count of 〉 500 cells/mm3, the mean CD4 count changes were -34 and -17 cells/mm3 per year for the TCM group and TCM plus ART group, respectively. Long-term use of TCM could maintain or slow the pace of declining CD4 counts in patients with HIV/AIDS, and may achieve lasting effectiveness.

关键词： AIDS HIV CD4 traditional Chinese medicine linear models

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B型地铁车辆转向架构架载荷特征研究

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城市轨道交通研究 2024年第7期27卷 204-210,217页

作者：王玉光王文静李爽杨广雪中车青岛四方机车车辆股份有限公司青岛266111 北京交通大学机械与电子控制工程学院北京100044 中车青岛四方车辆研究所有限公司青岛266031

[目的]我国地铁车辆在设计和校核中所采用的国际标准不完全符合车辆实际运营条件,导致一些地铁车辆转向架构架在未达到规定的运营里程时就出现了疲劳裂纹现象,开展实际运营条件下地铁车辆转向架构架载荷研究十分必要。[方法]基于B型地... 详细信息

[目的]我国地铁车辆在设计和校核中所采用的国际标准不完全符合车辆实际运营条件,导致一些地铁车辆转向架构架在未达到规定的运营里程时就出现了疲劳裂纹现象,开展实际运营条件下地铁车辆转向架构架载荷研究十分必要。[方法]基于B型地铁车辆长期跟踪测试试验实测数据,采用统计计算与STFT(短时傅里叶变换)分析相结合的方法,从线路状况、车辆运行状态和载客量3个方面研究构架载荷变化规律。[结果及结论]构架主体载荷和线路条件高度相关,构架局部载荷和车辆运行状态高度相关;减振器载荷和载客量之间有较为明显的负线性相关性,除侧滚载荷外的其他构架载荷与载客量呈正线性相关。

关键词：地铁车辆转向架构架载荷特征

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报废政策视角下耐用品制造商决策研究

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商业经济 2024年第7期 142-145,192页

作者：李任王裕光新疆理工学院经济贸易与管理学院新疆阿克苏843000

本研究分析了引导性报废政策和强制性报废政策对耐用品制造商的影响,构建了制造商最优定价和产品设计决策模型。结果显示:强制报废政策下,制造商不会生产超过报废年限的产品,适当补贴可增加需求但价格下降;引导报废政策下,产品设计寿命... 详细信息

本研究分析了引导性报废政策和强制性报废政策对耐用品制造商的影响,构建了制造商最优定价和产品设计决策模型。结果显示:强制报废政策下,制造商不会生产超过报废年限的产品,适当补贴可增加需求但价格下降;引导报废政策下,产品设计寿命常超出自定年限,适当补贴能提升价格和需求,但可能导致资源浪费。补贴缺失时,强制报废政策会使制造商利润降低,而引导报废政策可通过价格和设计调整保持利润。强制报废为防止产品超期服役设定期限,但在相同补贴下,引导报废政策在提升消费者剩余和社会福利方面更有效。

关键词：报废政策经济分析耐用品效用理论

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基于《治肝三十法》探析从肝论治间质性肺疾病咳嗽

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吉林中医药 2024年第6期44卷 637-640页

作者：李睿王玉光北京中医药大学研究生院北京100105 首都医科大学附属北京中医医院呼吸科北京100010

清代医家王旭高以肝气、肝火、肝风、肝虚为纲,总结创立了《治肝三十法》。以《治肝三十法》为立足点探析肝气、肝火、肝风、肝虚的源流及内涵,并探讨间质性肺疾病的病机变化与其相似之处,从而提出从肝论治间质性肺疾病咳嗽,分析并探索... 详细信息

清代医家王旭高以肝气、肝火、肝风、肝虚为纲,总结创立了《治肝三十法》。以《治肝三十法》为立足点探析肝气、肝火、肝风、肝虚的源流及内涵,并探讨间质性肺疾病的病机变化与其相似之处,从而提出从肝论治间质性肺疾病咳嗽,分析并探索间质性肺疾病相关咳嗽的临床用药规律及有效方剂,并应用典型案例验证其临床疗效,希望能对中医辨治间质性肺疾病相关咳嗽提供新的思路及方法。

关键词：《治肝三十法》间质性肺疾病久咳辨证论治

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云南边疆民族地区体育旅游资源开发的问题与思考

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凯里学院学报 2024年第2期42卷 37-42页

作者：王玉光邓阿岚云南师范大学云南昆明650500

云南省地处中国西南边疆,是世界上少有的多民族群体、多文化形态共生带,体育旅游资源具有鲜明的民族性、地域性、多样性和群体性。其基本特性与体育旅游的“具身性”本质相吻合,富有旅游开发价值。但是,在实际开发中仍存在整体开发不够... 详细信息

云南省地处中国西南边疆,是世界上少有的多民族群体、多文化形态共生带,体育旅游资源具有鲜明的民族性、地域性、多样性和群体性。其基本特性与体育旅游的“具身性”本质相吻合,富有旅游开发价值。但是,在实际开发中仍存在整体开发不够充分、与已成形资源匹配不佳、产品缺乏文化内涵和市场引导不足等问题。需要立足边疆民族体育文化特性进行深度开发,不断提升边疆民族体育旅游产品文化附加值,形成具有持久生命力、竞争力的体育旅游品牌。

关键词：云南边疆民族地区体育旅游资源具身性浅表化整体开发

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