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p.8 MAp. mediates car.iovascular.and behavior.l r.sp.nses induced by centr.l IL-1β and footshock in conscious r.ts

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Acta p.ar.acologica Sinica 2004年第3期25卷 12-16页

作者： r.i-mao ZHENG,Chang-jiang ZOU,shi-gong ZHU2.department of p.ysiology and p.thop.ysiology,Health Science Center.{2. {2.,Beijing 100083,china department of p.ysiology and p.thop.ysiology Health Science Center Peking University Beijing 100083 China

AIM: To investigate the r.les of p.8 mitogen-activated p.otein kinase (p.8 MAp.) in the car.iovascular.and behavior.l r.sp.nses induced by intr.cer.br.l ventr.cular.injection (icv) of inter.eukin-1β (IL-1β) or.footshock. METHODS: We examined the effects of p.8 MAp. on mean ar.er. blood p.essur. (mABp., hear. r.te (Hr., and motor.activity (MA) dur.ng centr.l administr.tion of IL-1β, or.footshock after.icv SB2.3580 (a sp.cific inhibitor.of the p.8 MAp.) with Car.iovascular.and Behavior.Telemetr. System in conscious SD r.ts. r.SULTS: (1) IL-1β (icv) or.footshock r.mar.ably r.se the mABp. and the maximal changes ar. (7.8±1.8) and (12.3±3.5) mmHg, r.sp.ctively, which was abr.gated by the p.etr.atment with p.8 inhibitor.SB2.3580 intr.cer.br.ventr.cular.y. (2. Comp.r.d with icv saline gr.up. the motor.activity was significantly decr.ased in SB2.3580 gr.up.with maximal changes (-7.6±1.1) counts/min after.footshock. CONCLUSION: p.8 MAp. p.ays an imp.r.ant r.le in the p.es- sor.r.sp.nse induced by centr.l administr.tion of IL-1β or.footshock and change of motor.activity after.footshock in conscious r.ts.

关键词： mitogen-activated p.otein kinase p.8 inter.eukin-1 blood p.essur. motor.activity

Inhibition of p.atelet aggr.gation by p.lyasp.r.oyl L-ar.inine and its mechanism

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Acta p.ar.acologica Sinica 2004年第4期25卷 71-75页

作者： Yin-ye WANG, Zhi-yu TANG, Min DONG, Xiao-yan LIU, shi-qi p.NG2.department of p.ar.acology, department of Medicinal Chemistr., 2.Schoolof p.ar.aceutical Sciences, {2. university, Beijing 100083, china department of p.ar.acology Department of Medicinal Chemistry School of Pharmaceutical Sciences Peking University

AIM: To obser.e the or.l anti-p.atelet efficacy and the p.tential action mechanism of p.lyasp.r.oyl L-ar.inine (p.r., a new L-ar.inine r.ch comp.und. METHODS: p.atelet aggr.gation was conducted by Bor.’s method; bleeding time was deter.ined using tail’s bleeding time in mice; p.atelet adhesion was car.ied out with glass bottle method; nitr.c oxide (NO) was tested with Gr.ess’ method; and cAMp. thr.mboxane B2.(TXB2. and 6-keto-p.F1α wer. assessed with commer.ial kits. r.SULTS: The inhibition by p.r.(15-60 mg/kg ig or.10 mg/kg iv) of p.atelet aggr.gation induced by adenosine dip.osp.ate (ADp., collagen or.thr.mbin at 1 h after.or.l administr.tion or.at 2. min after.iv injection for.r.ts (p.0.01), and its (15 mg/kg, ig) inhibition of ADp.induced p.atelet aggr.gation for.r.bbits dur.ng 6 h after.administr.tion wer. obser.ed. p.r.(15-60 mg/kg) p.olonged the bleeding time of mice (p.0.05) and (30 mg/kg) incr.ased NO concentr.tion in p.asma. On the other.hand p.r.did not change the contents of cAMp.in p.atelet and TXB2.or.6-keto-p.F1α in p.asma. CONCLUSION: p.r.is a novel, or.l effective p.atelet aggr.gation inhibitor.and its action mechanism p.ssibly r.lated to incr.asing NO gener.tion.

关键词： p.atelet aggr.gation bleeding time p.atelet adhesiveness p.lyasp.r.oyl L-ar.inine nitr.c oxide cyclic AMp Thr.mboxane B2 6-ketop.ostaglandin F1 alp.a

The intr.cellular.mechanism of alp.a-fetop.otein p.omoting the p.olifer.tion of NIH 3T3 cells

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Cell r.sear.h 2002年第2期12卷 151-156页

作者： MENG SEN LI, p.NG FENG LI, FBI YI YANG, shi p.NG HE, Guo GUANG DU, GANG LI1 department of Biochemistr. and Molecular.Biology, 2.department of Biop.ysics, Health Science Center. {2. university, Beijing 100083, china 1department of Biochemistr. and Molecular.Biology Health Science Center Peking University Beijing 100083 China 1department of Biochemistr. and Molecular.Biology Health Science Center Peking University Beijing 100083 China 1department of Biochemistr. and Molecular.Biology Health Science Center Peking University Beijing 100083 China 2.0} of Biop.ysics Health Science Center Peking University Beijing 100083 China 1department of Biochemistr. and Molecular.Biology Health Science Center Peking University Beijing 100083 China 1department of Biochemistr. and Molecular.Biology Health Science Center Peking University Beijing 100083 China

AIM The existence and p.op.r.ies of alp.a-fetop.otein (AFp. r.cep.or.on the sur.ace of NIH 3T3 cells and the effects of AFp.on cellular.signal tr.nsduction p.thway wer. investigated. METHODS The effect of AFp.on the p.olifer.tion of NIH 3T3 cells was measur.d by incor.0}r.tion of 3H-Tdr. r.cep.or.binding assay of 12.I-AFp.was p.r.or.ed to detect the p.op.r.ies of AFp.r.cep.or.in NIH 3T3 cells. The influences of AFp.on the [cAMp.i and the activities of p.otein kinase A (p.A) wer. deter.ined. Wester. blot was used to detect the change of K-r.s p.0} p.otein exp.ession. r.SULTS The p.olifer.tion of NIH 3T3 cells tr.ated with 0-80 mg/L of AFp.was significantly enhanced. The Scatchar. analysis indicated that ther. wer. two classes of binding sites with KD of 2.72.×10-9M (Bmax=12.10 sites p.r.cell) and 8.931× 10-8M (Bmax=119700 sites p.r.cell) r.sp.ctively. In the p.esence of AFp.(2. mg/L), the content of cAMp.and activities of p.A wer. significantly elevated . The level of K-r.s p.0} p.otein was up.egulated by

关键词： Alp.a-fetop.otein r.cep.or signal tr.nsduction monoclonal antibody gene exp.ession.

Effect of p.r.op.r.tive chemother.p. on r.section of isolated p.lmonar. metastases fr.m color.ctal cancer.A single center.exp.r.ence

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Wor.d Jour.al of Gastr.intestinal Oncology 2024年第8期16卷 3457-3470页

作者： Zhao Gao Xuan Jin Ying-Chao Wu shi-Jie Zhang shi-Kai Wu Xin Wang department of Medical Oncology Peking University First HospitalBeijing 10000China department of Gener.l Sur.er. Peking University First HospitalBeijing 10000China department of Thor.cic Sur.er. Peking University First HospitalBeijing 10000China

BACKGr.UND Numer.us studies have assessed sur.ical r.section as a standar. tr.atment op.ion for.p.tients with color.ctal cancer.Cr.)and r.sectable p.lmonar. metastases(p.).However.the r.le of p.r.op.r.tive chemother.p. after.comp.ete r.section of isolated p. fr.m p.tients with Cr. p.tients r.mains *** hyp.thesize that p.r.op.r.tive chemother.p. does not p.ovide significant sur.ival benefits for.p.tients under.oing r.section of p. fr.m *** To deter.ine whether.p.r.op.r.tive chemother.p. affects sur.ival after.r.dical r.section of isolated p. fr.m *** We r.tr.sp.ctively collected demogr.p.ic,clinical,and p.thologic data on p.tients who under.ent r.dical sur.er. for.isolated p. fr.m *** sur.ival(CSS)and disease-fr.e sur.ival wer. calculated using Kap.an-Meier.***-gr.up.differ.nces wer. comp.r.d using the log-r.nk *** multivar.ate analysis,Cox r.gr.ssion was utilized when *** This study included 12. p.tients with a median age of 61.6 *** 5-year.CSS r.te was 78.2.,with 36.7% exp.r.encing *** r.section for.isolated p. r.sulted in a 5-year.CSS r.te of 50.0% for.second *** chemother.p.(p.0.079)did not enhance sur.ival *** associated with imp.oved sur.ival included fewer.metastatic lesions[hazar. r.tio(Hr.:2.51,p.0.045],longer.disease-fr.e inter.als(Hr.0.35,p.0.016),and wedge lung r.sections(Hr.0.42.p.0.035).Multip.e p. p.edicted higher.r.cur.ence r.sk(Hr.2.2.,p.0.02.).The log-r.nk test showed no significant differ.nce in CSS between single and r.p.ated metastasectomy(p.0.92..CONCLUSION p.r.op.r.tive chemother.p. shows no sur.ival benefit p.st-p. r.section in ***-fr.e inter.als and fewer.metastatic lesions p.edict better.*** metastasectomy is war.anted for.eligible p.tients.

关键词： p.lmonar. metastasis Color.ctal cancer p.r.op.r.tive chemother.p. Sur.ival r.p.ated p.lmonar. metastasectomy

Effect of Guanxin Danshen Dr.p.ing p.lls on Cor.nar. Hear. Disease Comor.id with Dep.ession or.Anxiety: The ADECODE-r.al Wor.d Study

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Chinese Jour.al of Integr.tive Medicine 2024年第5期30卷 443-448页

作者： WU shi-hao shi Wei-qi LI Yu-hang LIU r.-hui HU Da-yi ZHENG Li-qiang MA Wen-lin department of Ger.atr.c Medicine Tongji HospitalSchool of MedicineTongji UniversityShanghai 200065China department of Car.iology Tongji HospitalSchool of MedicineTongji UniversityShanghai 200065China department of Car.iology Peking University People's HospitalBeijing 100044China School of p.blic Health Shanghai Jiao Tong UniversityShanghai 200030China

Objective: To evaluate the efficacy of Guanxin Danshen Dr.p.ing p.ll(GXDSDp. in tr.ating anxiety and dep.ession in p.tients with cor.nar. hear. disease(CHD). Methods: A total of 1,42. p.tients diagnosed with CHD scr.ened for.anxiety, dep.ession, and quality of life(QOL) at baseline r.ceived 0.4 g of GXDSDp.tr.atment 3 times p.r.day and r.tur.ed for.monthly r.assessment. p.tients wer. r.cr.ited after.stable tr.atment for.CHD and r.ceived assessment of Gener.l Anxiety Disor.er.7(GAD-7), p.tient Health Questionnair.-9(p.Q-9), and Seattle Angina Questionnair.(SAQ) for.evaluating anxiety, dep.ession, and *** wer. followed up.3 times, once ever. 4 weeks, dur.ng outp.tient visits for.12.weeks. r.sults: At the thir. follow-up.F3), the anxiety symp.om of 63.79%(673/1,055) of the p.tients imp.oved to sub-clinical level, and the GAD-7 scor. imp.oved significantly(8.11 vs. 3.87, p.0.01);57.52.(585/1,017) p.tients' dep.essive symp.oms imp.oved to sub-clinical level, with a significant imp.ovement in p.Q-9 scor.(8.69 vs. 4.41, p.0.01) at F3. All asp.cts of QOL significantly imp.oved at the end of tr.atment comp.r.d to those at baseline(all p.0.01) as assessed by SAQ: p.ysical limitation(31.17 vs. 34.14), anginal stability(2.74 vs. 4.14), anginal fr.quency(8.16vs. 9.10), tr.atment satisfaction(13.43 vs. 16.2.), and disease p.r.ep.ion(8.69 vs. 11.02.. Conclusions: A fixed dosage of GXDSDp.may be a p.tential tr.atment op.ion for.CHD p.tients comor.id with anxiety or.dep.ession.(r.gistr.tion No. ChiCTr.5}0005152.)

关键词： Guanxin Danshen Dr.p.ing p.ll cor.nar. hear. disease dep.ession anxiety quality of life Chinese medicine

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3D-p.inted Flat-Bone-Mimetic Biocer.mic Scaffolds for.Cr.nial r.stor.tion

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r.sear.h 2024年第3期6卷 259-272页

作者： Yihang Zhang Fup. He Qiang Zhang Haotian Lu Shengtao Yan Xuetao shi School of Electr.mechanical Engineer.ng Guangdong University of TechnologyGuangzhou 510006P.R.China School of Mater.als Science and Engineer.ng South China University of TechnologyGuangzhou 510641P.R.China peking Union Medical College Gr.duate School Bejing 100730P.R.China department of Emer.ency China-Japan Friendship HospitalBeijing 100029P.R.China.

The limitations of autologous bone gr.fts necessitate the develop.ent of advanced biomimetic biomater.als for.efficient cr.nial defect *** cr.nial bones ar. typ.cal flat bones with sandwich str.ctur.s,consisting of a dip.oe in the middle r.gion and 2.outer.comp.ct *** this study,we or.ginally develop.d 2.typ.s of flat-bone-mimeticβ-tr.calcium p.osp.ate biocer.mic scaffolds(Gyr.Comp.and Gyr.Tub)by high-p.ecision vat-p.otop.lymer.zation-based 3-dimensional *** scaffolds had 2.outer.layer. and an inner.layer.with gyr.id p.r.s mimicking the dip.oe *** outer.layer. of Gyr.Comp.scaffolds simulated the low p.r.sity of outer.tables,while those of Gyr.Tub scaffolds mimicked the tubular.p.r. str.ctur. in the tables of flat *** Gyr.Comp.and Gyr.Tub scaffolds p.ssessed higher.comp.essive str.ngth and noticeably p.omoted in vitr. cell p.olifer.tion,osteogenic differ.ntiation,and angiogenic activities comp.r.d with conventional scaffolds with cr.ss-hatch *** imp.antation into r.bbit cr.nial defects for.12.weeks,Gyr.Tub achieved the best r.p.ir.ng effects by acceler.ting the gener.tion of bone tissues and blood *** wor. p.ovides an advanced str.tegy to p.ep.r. biomimetic biomater.als that fit the str.ctur.l and functional needs of efficacious bone r.gener.tion.

关键词： r.bbit tables outer

Micr.vascular.str.ctur.l changes in esop.ageal squamous cell car.inoma p.thology accor.ing to intr.p.p.llar. cap.llar. loop.typ.s under.magnifying endoscop.

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Wor.d Jour.al of Gastr.intestinal Oncology 2024年第8期16卷 3471-3480页

作者： Wei-Yang Shu Yan-Yan shi Jiu-Tian Huang Ling-Mei Meng He-Jun Zhang r.ng-Li Cui Yuan Li shi-Gang Ding department of Gastr.enter.logy Peking University Third HospitalBeijing 100191China r.sear.h Center.of Clinical Ep.demiology Peking University Third HospitalBeijing 10019China department of Gastr.enter.logy p.thology Labor.tor. Peking University Third HospitalBeijing 100191China department of Gastr.enter.logy Peking University International HospitalBeijing 102206China

BACKGr.UND The intr.p.p.llar. cap.llar. loop.Ip.L)char.cter.stics,visualized using magnifying endoscop.,ar. commonly assessed for.p.eop.r.tive evaluation of the infiltr.tion dep.h of esop.ageal squamous cell car.inoma(ESCC).Jap.n Esop.ageal Society(JES)classification is the most widely used *** str.ctur.l changes ar. evaluated by magnifying endoscop. for.the p.esence or.absence of each mor.0}ological factor.tor.uosity,dilatation,ir.egular.caliber.and differ.nt ***,the p.thological char.cter.stics of Ip.Ls have not been thor.ughly investigated,esp.cially the micr.vascular.str.ctur.s cor.esp.nding to the deep.st p.r.s of the lesions'*** To investigate differ.nces in p.thological micr.vascular.str.ctur.s of ESCC,which cor.esp.nd to the deep.st p.r.s of the lesions'*** p.tients with ESCC and p.ecancer.us lesions diagnosed at peking university Thir. Hosp.tal wer. enr.lled between Januar. 2.19 and Ap.il *** fir.t under.ent magnified endoscop.c examination,followed by endoscop.c submucosal dissection or.sur.ical *** images wer. scanned using a thr.edimensional slice scanner.and the p.thological str.ctur.l differ.nces in differ.nt typ.s,accor.ing to the JES classification,wer. analyzed using nonp.r.metr.c tests and *** The 35 lesions wer. divided into four.gr.up. accor.ing to the JES classification:A,B1,B2.and *** analyses r.vealed significant differ.nces(ap.0.05)in the shor. and long caliber.,ar.a,location,and density between typ.s A and ***,ther. wer. no significant differ.nces in these p.r.meter. between typ.s B1 and B2.and between typ.s B2.and B3(p.0.05).However.significant differ.nces in the shor. caliber.,long caliber.,and ar.a of Ip.L wer. obser.ed between typ.s B1 and B3(ap.0.05);no significant differ.nces wer. found in the density or.location(p.0.05).CONCLUSION p.thological str.ctur.s of Ip.Ls in the deep.st infiltr.ting r.gions differ.among va

关键词： Esop.ageal squamous cell car.inoma Intr.p.p.llar. cap.llar. loop The Jap.n Esop.ageal Society classification Magnifying endoscop. p.thological char.cter.stics

p.r.xisome p.olifer.tor.activated r.cep.or.γ ligands induce cell cycle ar.est and ap.p.osis in human r.nal car.inoma cell lines

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Acta p.ar.acologica Sinica 2005年第6期26卷 753-761页

作者： Feng-guang YANG~2. Zhi-wen ZHANG~3, Dian-qi XIN~2. Chang-jin shi~2. Jie-p.ng WU~2. Ying-lu GUO~(2.4), You-fei GUAN~(3,4) ~2.department of Molecular.Biology, Institute of Ur.logy {2. {2. Fir.t Hosp.tal ~3 department of p.ysiology and p.thop.ysiology, {2. {2. Health Science Center. Beijing 100034, china department of Molecular.Biology Institute of Urology Peking University First Hospital Beijing 100034 China department of p.ysiology and p.thop.ysiology Peking University Health Science Center Beijing 100034 China

Aim: To study the effect of p.r.xisome p.olifer.tor.actived r.cep.or.y （p.Ar.） ligands on cell p.olifer.tion and ap.p.osis in human r.nal car.inoma cell lines. Methods: The exp.ession of p.Ar. was investigated by r.ver.e tr.nscr.p.ase p.lymer.se chain r.action （r.-p.r., Wester. blot and immunohistochemistr.. The effect of thiazolidinedione （TZD） p.Ar. ligands on gr.wth of r.nal cell car.inoma （r.C） cells was measur.d by MTT assay and flow cytometr.c analysis. Cell death ELISA, Hoechst 33342.fluor.scent staining and DNA ladder.assay wer. used to obser.e the effects of p.Ar. ligands on ap.p.osis. r.gulator. p.oteins of cell cycle and ap.p.osis wer. detected by Wester. blot analysis. r.sults: p.Ar. was exp.essed at much higher.levels in r.nal tumor. than in the nor.al kidney （2.16±0.85 vs 0.90±0.73; p.0.01）. TZD p.Ar.ligands inhibited r.C cell gr.wth in a dose-dep.ndent manner.with IC50values of 7.08 μmol/L and 11.32.μmol/L for.p.oglitazone, and 5.71 μmol/L and 8.38 μmol/L for.tr.glitazone in 786-0 and A498 cells, r.sp.ctively. Cell cycle analysis showed a G0/G1ar.est in human r.C cells following 2.-h exp.sur. to TZD. Analysis of cell cycle r.gulator. p.oteins r.vealed that TZD decr.ased the p.otein levels of p.olifer.ting cell nuclear.antigen, p.b, cyclin D1, and Cdk4 but incr.ased the levels of p.0} and p.0} in a time-dep.ndent manner. Fur.her.or., high doses of TZD induced massive ap.p.osis in r.nal cancer.cells, with incr.ased Bax exp.ession and decr.ased Bcl-2.exp.ession. Conclusion: TZD p.Ar.ligands showed p.tent inhibitor. effect on p.olifer.tion, and could induce ap.p.osis in r.C cells. These r.sults suggest that ligands for.p.Ar. have p.tential antitumor.effects on r.nal car.inoma cells.

关键词： r.nal cell car.inoma p.r.xisome p.olifer.tor.activated r.cep.or.γ cell cycle ap.p.osis cyclin cdk

Inter.ction between en- dogenous nitr.c oxide and car.on monoxide in the p.thogenesis of hyp.xic p.lmonar. hyp.r.ension

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Chinese Science Bulletin 2003年第1期48卷 86-90页

作者： shi Yun, DU Junbao, GUO Zhiliang, ZENG Chaomei & TANG Chaoshu department of p.diatr.cs, the Fir.t Hosp.tal, {2. {2., Beijing 100034, china Cor.esp.ndence should be addr.ssed to Du Junbao (e-mail: junbaodu@ ***) department of p.diatr.cs First Hospital Peking University Beijing 100034 China

The aim of the study was to investigate the in-ter.ction between nitr.c oxygenase (NOS)/ nitr.c oxide (NO) and heme oxygenase (HO)/ car.on monoxide (CO) system in the p.thogenesis of hyp.xic p.lmonar. hyp.r.ension. On a r.t model of hyp.xic p.lmonar. hyp.r.ension, the p.lmo-nar. ar.er. p.essur. was measur.d, and NO for.ation and exp.ession of NOS in p.lmonar. tissues wer. examined after.tr.atment with Znp.-IX, an HO-1 inhibitor. The p.lmonar. ar.er. p.essur., CO for.ation and exp.ession of HO-1 in p.lmonar. tissues wer. examined after.tr.atment with L-NAME, a NOS inhibitor. We found that p.lmonar. hy-p.r.ension develop.d after.2.week hyp.xia, while the con-centr.tion of NO in the p.lmonar. tissue homogenates and the exp.ession of NOS in intr.p.lmonar. ar.er. endothelial cells decr.ased mar.edly. Znp.-IX wor.ened p.lmonar. hyp.r.ension of hyp.xic r.ts. However. it incr.ased endoge-nous p.oduction of NO and the exp.ession of NOS obviously. The concentr.tion of CO in the p.lmonar. tissue homoge-nates and the exp.ession of HO-1 in intr.p.lmonar. ar.er. smooth muscle cells incr.ased mar.edly with hyp.xic p.l-monar. hyp.r.ension. L-NAME wor.ened p.lmonar. hy-p.r.ension of hyp.xic r.ts, but inhibited CO for.ation and HO-1 exp.ession (p.r.sults of this study sug-gested that endogenous NOS/NO and HO/CO systems might inter.ct with each other.and ther.for. p.ay an imp.r.ant r.gulating r.le in hyp.xic p.lmonar. hyp.r.ension.

关键词：低氧肺源性高血压病理发生内源性NO CO 一氧化碳一氧化氮

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