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Number and distribution of eosinophils and lymphocytes in the Japanese pediatric gastrointestinal tract:in search of a definition for"abnormally increased eosinophils"

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World Journal of Pediatrics 2023年第3期19卷 251-260页

作者： Mai iwaya Shota Kobayashi Yoshiko Nakayama Sawako Kato Shingo Kurasawa Tomomitsu Sado yugo lwaya Takeshi Uehara Hiroyoshi Ota Department of Laboratory Medicine Shinshu University Hospital3-1-1 AsahiMatsumotoNaganoJapan Department of Pediatrics Shinshu University School of MedicineMatsumotoJapan Division of Gastroenterology and Hepatology Department of MedicineShinshu University School of MedicineMatsumotoJapan Department of Laboratory Medicine Shinshu University School of MedicineMatsumotoJapan Department of Clinical Laboratory Sciences School of Health SciencesShinshu UniversityMatsumotoJapan

Background Primary eosinophilic gastrointestinal disorders(EGIDs)constitute chronic allergic *** number of eosinophils is one of the diagnostic criteria;more than 20 eosinophils per high-power field(HPF)in the gastrointestinal(GI)tract are considered abnormal in ***,the quantity of eosinophils considered normal varies according to anatomical location and geographical region;such values have not been reported in Japanese pediatric patients,nor have the numbers of lymphocytes in the normal pediatric *** establish a reference for defining diagnostic criteria for EGIDs,we evaluated the number of eosinophils in the normal Japanese pediatric GI *** We examined 131 biopsy cases without significant clinical history,endoscopic abnormality,or histological *** analysis of CD3 and CD20 was *** The mean eosinophil density was highest in the cecum(49.5±22.4 per HPF).Counts of more than 20 eosinophils per HPF were observed in the duodenum[bulb(20.0±9.6)and second portion(30.0±15.8)],terminal ileum(38.3±22.7),cecum(49.5±22.4),ascending colon(42.3±25.3),transverse colon(29.4±17.0),and descending colon(32.2±17.9).Counts of fewer than 10 eosinophils per HPF were observed in the stomach and rectum;a count of fewer than one eosinophil per HPF was observed in the *** than 100 CD3-positive T cells per HPF were observed in the *** The mean numbers of eosinophils in the bowel were greater than 20 per *** Japanese pediatrics,the cur-rent threshold eosinophil count should be revised.

关键词： Eosinophil Gastrointestinal tract Japanese Lymphocyte Normal Pediatrics

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Factors hindering the degradation of pharmaceuticals from human urine in an iron-activated persulfate system

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Journal of Environmental Sciences 2024年第1期135卷 130-148页

作者： Yiruiwen Xie Dao Guan Yangfan Deng yugo Sato Yu Luo Guanghao Chen Department of Civil and Environmental Engineering Water Technology LabHong Kong Branch of Chinese National Engineering Research Center for Control&Treatment of Heavy Metal PollutionThe Hong Kong University of Science&TechnologyHong Kong 999077China

This study investigated the degradation of clofibric acid(CFA),bezafibrate(BZF),and sulfamethoxazole(SMX)in synthetic human urine using a novel mesoporous iron powderactivated persulfate system(mFe-PS system),and identified the factors limiting their degradation in synthetic human urine.A kinetic model was established to expose the radical production in various reaction conditions,and experiments were conducted to verify the modeling *** the phosphate-containing mFe-PS system,the 120 min removal efficiency of CFA decreased from 95.1%to 76.6%as the phosphate concentration increased from 0.32 to 6.45 mmol/L,but recovered to 90.5%when phosphate concentration increased to 16.10 mmol/***,the increased concentration of phosphate from 0.32 to 16.10mmol/L reduced the BZF degradation efficacy from 91.5%to 79.0%,whereas SMX removal improved from 37.3%to 62.9%.The m Fe-PS system containing(bi)carbonate,from 4.20 to166.70 mmol/L,reduced CFA and BZF removal efficiencies from 100%to 76.8%and 80.4%,respectively,and SMX from 83.5%to 56.7%within a 120-min reaction *** addition,alkaline conditions(pH≥8.0)inhibited CFA and BZF degradations,while nonacidic pH(pH≥7.0)remarkably inhibited SMX *** of the kinetic model indicated the formation of phosphate(H_(2)PO_(4)^(·)/HPO_(4)^(·-))and/or carbonate radicals(CO_(3)^(·-))could limit pharmaceutical *** transformation products(TPs)of the pharmaceuticals revealed more incompletely oxidized TPs occurred in the phosphate-and(bi)carbonate-containing m Fe-PS systems,and indicated that H_(2)PO_(4)^(·)/HPO_(4)^(·-)mainly degraded pharmaceuticals via a benzene ring-opening reaction while CO_(3)^(·-)preferentially oxidized pharmaceuticals via a hydroxylation reaction.

关键词： Pharmaceutical degradation Human urine Iron-activated persulfate system Phosphate radicals Carbonate radicals Transformation products

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Clinical characteristics of young patients with early Barrett’s neoplasia

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World Journal of Gastroenterology 2019年第24期25卷 3069-3078页

作者： yugo iwaya Yuto Shimamura Kenichi Goda Enrique Rodríguez de Santiago John Gerard Coneys Jeffrey D Mosko Gabor Kandel Paul Kortan Gary May Norman Marcon Christopher Teshima Advanced Therapeutic Endoscopy Centre St Michael’s HospitalUniversity of TorontoToronto M5B 1W8OntarioCanada Department of Gastroenterology Dokkyo Medical UniversityTochigi 321-0293Japan Department of Gastroenterology Ramón y Cajal university hospitalMadrid 28034Spain

BACKGROUND Esophageal adenocarcinoma(EAC)and high-grade dysplasia(HGD)may appear in young patients with Barrett's esophagus(BE).However,characteristics of Barrett's-related neoplasia in this younger population remain *** To identify clinical characteristics that differ between young and old patients with early-stage Barrett's-related *** We conducted a retrospective analysis of a prospectively maintained database comprised of consecutive patients with early-stage EAC(pT1)and HGD at a tertiary-referral center between 2001 and *** characteristics,drug and risk factor exposures,clinicopathological staging of EAC/HGD and treatment outcomes[complete eradication of neoplasia(CE-N),complete eradication of intestinal metaplasia(CE-IM),recurrence of neoplasia and recurrence of intestinal metaplasia]were *** analyses were performed to identify factors that differed significantly between older and younger(≤50 years)*** We identified 450 patients with T1 EAC and HGD(74%and 26%,respectively);45(10%)were≤50 *** to the older group,young patients were more likely to present with ongoing gastroesophageal reflux disease(GERD)symptoms(55%vs 38%,P=0.04)and to be obese(body mass index>30,48%vs 32%,P=0.04).Multivariate logistic regression analysis showed that young patients were significantly more likely to have ongoing GERD symptoms[odds ratio(OR)2.00,95%confidence interval(CI)1.04-3.85,P=0.04]and to be obese(OR 2.06,95%CI 1.07-3.98,P=0.03)whereas the young group was less likely to have a smoking history(OR 0.39,95%CI 0.20-0.75,P50 years of age,younger patients should be considered for screening endoscopy if they suffer from obesity and GERD symptoms.

关键词： Barrett's Esophagus Gastroesophageal reflux disease Obesity Esophageal adenocarcinoma High-grade dysplasia Guideline Young patient

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Laparoscopic duodenojejunostomy for malignant stenosis as a part of multimodal therapy:A case report

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World Journal of Clinical Cases 2022年第16期10卷 5324-5330页

作者： Teppei Murakami yugo Matsui Department of Surgery Kobe City Hospital Organization Kobe City Center West HospitalKobe 653-0013HyogoJapan

BACKGROUND Laparoscopic duodenojejunostomy(LDJ) has become the standard surgical procedure for superior mesenteric artery syndrome due to its sufficient outcome in terms of safety and symptom relief. However, there are only a few reports about LDJ for malignant stenosis and its indication remains *** SUMMARY A 77-year-old woman with a history of pancreatic cancer(PC) treated with distal pancreatectomy with en bloc resection of the transverse colon 7 mo ago was admitted for recurrent vomiting. Imaging upon admission revealed marked distention of the duodenum and a tumor around the duodenojejunal flexure. She was diagnosed with malignant stenosis caused by local recurrence of PC. LDJ was performed with an uneventful postoperative course, followed by chemotherapy which gave her 10 mo overall *** We think that LDJ is a valuable method for unresectable malignant stenosis around the duodenojejunal flexure as a part of multimodal therapy.

关键词： Duodenojejunostomy Laparoscopic surgery Malignant stenosis Pancreatic cancer Multimodal therapy

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可见光驱动改性氮化碳无牺牲剂光催化析氢

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Chinese Journal of Catalysis 2022年第9期43卷 2316-2320页

作者： Shunta Nishioka Kengo Shibata yugo Miseki Kazuhiro Sayama Kazuhiko Maeda 东京工业大学理学院化学系日本国家先进工业科学技术研究所全球零排放研究中心日本

载铂石墨氮化碳(g-C_(3)N_(4))是一种较好的可见光下催化析氢光催化剂.但催化水裂解需要牺牲电子供体,如三乙醇胺等.目前,无牺牲剂条件下g-C_(3)N_(4)的催化析氢仍是一个挑战.本文通过尿素热处理制备了氮化碳纳米片(NS-C_(3)N_(4)),并... 详细信息

载铂石墨氮化碳(g-C_(3)N_(4))是一种较好的可见光下催化析氢光催化剂.但催化水裂解需要牺牲电子供体,如三乙醇胺等.目前,无牺牲剂条件下g-C_(3)N_(4)的催化析氢仍是一个挑战.本文通过尿素热处理制备了氮化碳纳米片(NS-C_(3)N_(4)),并研究了其在可见光(λ>400 nm)下利用可逆电子给体无牺牲剂条件下析氢的光催化活性.在含有I−,Fe^(2+)或[Fe(CN)_(6)]^(4−)的水溶液中,负载铂的NS-C_(3)N_(4)上无H_(2)产生,用CrO_(x)改性Pt/NS-C_(3)N_(4)的光催化剂上可观察到H_(2)的析出.透射电镜和能量色散X射线光谱结果表明,在NS-C_(3)N_(4)上形成了Pt/CrO_(x)核壳结构.在[Fe(CN)_(6)]^(3−/4−)氧化还原介质存在下,CrO_(x)/Pt/NS-C_(3)N_(4)与改性WO_(3)光催化剂在可见光下共同催化水分解析氢.

关键词：人工光合成太阳燃料水分解

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URANS simulations for a free-running container ship:Part 2. Added power

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Journal of Hydrodynamics 2021年第3期33卷 448-467页

作者： Dong-Hwan Kim yugo Sanada Hamid Sadat-Hosseini Frederick Stern IIHR-Hydroscience and Engineering The University of IowaIowa CityUSA Costal Development and Ocean Energy Research Center Korea Institute of Ocean Science and TechnologyBusanKorea Mechanical Engineering University of North TexasDentonUSA

Part 2 reports the validation,local force and local flow study results for the free-running added power simulations whose conditions are the same as the self-propulsion test except for the increased propeller rotational speed and the presence of *** targeting the same mean Froude number in the wave condition,the propeller requires the increased propeller rotational speed for the operation at the low advance ratio due to the added *** test is performed at five different wavelengths in head waves and four different headings in the oblique *** the validation study,the time series of the validation variables is decomposed with discrete Fourier transform to extract the harmonic *** variables are global parameters,including motions,propeller thrust,and torque coefficients,added power variables,and self-propulsion factors which show reasonable agreement against the experiment results and produces a similar error from the self-propulsion *** local force study shows that the added resistance mostly appears at the bow due to the bow plunging during the short head wave and resonance *** contributions of the gravitational force and the buoyant force are found to increase as the stern motion exceeds the bow motion during the long head wave *** oscillation of the propeller performances shows correlation with the first harmonic amplitude of the propeller ***,pitch,and roll decay tests are performed prior to the main test to assess the natural frequencies of the *** as Part 1,a discretized propeller is used.

关键词： Added power unsteady Reynolds-averaged Navier-Stokes(URANS) KRISO Container Ship(KCS) CFDShip-IOWA

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Analysis of blasting damage in adjacent mining excavations

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Journal of Rock Mechanics and Geotechnical Engineering 2015年第3期7卷 282-290页

作者： Nick yugo Woo Shin Yukon Zinc Corporation

Following a small-scale wedge failure at Yukon Zinc＇s Wolverine Mine in Yukon, Canada, a vibration monitoring program was added to the existing rockbolt pull testing regime. The failure in the 1150 drift occurred after numerous successive blasts in an adjacent tunnel had loosened friction bolts passing through an unmapped fault. Analysis of blasting vibration revealed that support integrity is not compromised unless there is a geological structure to act as a failure plane. The peak particle velocity（PPV） rarely exceeded 250 mm/s with a frequency larger than 50 Hz. As expected, blasting more competent rock resulted in higher PPVs. In such cases, reducing the round length from 3.5 m to 2.0 m was an effective means of limiting potential rock mass and support damage.

关键词： Blasting damage Vibration monitoring Adjacent tunnel development Dynamic loading of friction bolts Jinduicheng Molybdenum Wolver

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A 60 000-year loess-paleosol record of millennial-scale summer monsoon instability from Lanzhou, China

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Chinese Science Bulletin 1999年第24期44卷 2264-2267页

作者： yugo Ono Hitoshi Fukusawa Keiichi Oi Department of Geography Tokyo Metropolitan University Hachioji 192-03 JapanDepartment of Geography Tokyo Metropolitan University Hachioji 192-03 JapanGraduate School of Environmental Earth Science Hokkaido University Sapporo 060 Japan

The 28-m high-resolution Shajinping loess section in Lanzhou on the Chinese western Loess Plateau records a detailed history of millennial Asian summer monsoon change since the earlier last glaciation. Summer monsoon proxies of soil magnetic susceptibility, carbonate content and soil color show that Asian summer monsoon experienced a series of rapid

关键词： last glaciation summer monsoon instability.

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URANS simulations for a free-running container ship:Part 1. Turning-circle

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Journal of Hydrodynamics 2021年第3期33卷 421-447页

作者： Dong-Hwan Kim yugo Sanada Sungtek Park Hamid Sadat-Hosseini Frederick Stern IIHR-Hydroscience and Engineering The University of IowaIowa CityUSA Costal Development and Ocean Energy Research Center Korea Institute of Ocean Science and TechnologyBusanKorea Mechanical Engineering University of North TexasDentonUSA

The incompressible unsteady Reynolds-averaged Navier-Stokes(URANS)simulations are performed for a free-running container ship in maneuvering conditions:the starboard and portside turning circle simulations with 35°rudder *** validation variables include trajectory,motions,and propeller performances,and the prediction shows acceptable agreements against the experimental *** the steady-state part of the turning,the inertial forces balancing the local forces are reported to quantitatively assess the centrifugal force which appears from the force equilibrium between the rudder,propeller,and the *** study on the local flow focuses on finding the correlations between the propeller inflow and the propeller performance to investigate the differences in propeller performances during the portside and starboard *** preliminary simulations,performed with the grid triplet,comprise propeller open-water,resistance,and self-propulsion simulations,from which the validation studies and the studies for the local force and the local flow are fulfilled and applied for the main *** propeller and rudder are fully discretized and controlled,mimicking the ***-set,overset approach and Mentor’s SST model are employed for the free-surface capturing,large motion prediction,and turbulence closure.

关键词： Turning-circle unsteady Reynolds-averaged Navier-Stokes(URANS) KRISO Container Ship(KCS) CFDShip-IOWA

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Effect of Doped Alkali Metal Ions on the SO_(2) Capture Performance of MnO_(2) Desulfurization Materials at Low Temperature

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Journal of Renewable Materials 2021年第9期9卷 1541-1553页

作者： Xing Li yugo Osaka Hongyu Huang Takuya Tsujiguchi Akio Kodama Guangzhou Institute of Energy Conversion Chinese Academy of ScienceGuangzhou510640China School of Mechanical Engineering College of Science and EngineeringKanazawa UniversityKanazawa9201192Japan School of Mechanical and Power Engineering Nanjing Tech UniversityNanjing211800China

Sulfur dioxide(SO_(2))emissions from diesel exhaust pose a serious threat to the environment and human ***,desulfurization technology and the performance of desulfurization materials must be *** this study,MnO_(2) was modified with various alkali metal ions using the impregnation method to enhance its SO_(2) capture *** composites were characterized intensively by scanning electron microscopy,energydispersive X-ray spectroscopy,X-ray diffraction spectroscopy,and Brunauer-Emmett-Teller *** SO_(2) capture performance of these composites were measured via thermogravimetry,and the effect of doping with alkali metal ions on the SO_(2) capture performance of MnO_(2) was *** showed that the SO_(2) capture performance of MnO_(2) could be enhanced by doping with alkali metal ions,and the MnO_(2) composite doped with LiOH(2.0 mol/L)had the best SO_(2) capture capacity(124 mgSO_(2)/gMaterial),which was 18%higher than that of pure MnO_(2).Moreover,the type and concentration of alkali metal ions had varying effects on the SO_(2) capture performance of MnO_(2).In our experiment,the SO_(2) capture performance of the MnO_(2) doped with NaOH,LiCl,Na2CO3,K2CO3,and Li2CO3 composites were worse than that of pure MnO_(2).Therefore,the influences of the type and concentration of alkali metal ions to be doped into desulfurization materials must be considered comprehensively.

关键词： Sulfur dioxide capture desulfurization materials manganese dioxide alkali metal ions doped

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