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Flexible wearable sensors:An emerging platform for monitoring of bacterial infection in skin wounds

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Engineered Regeneration 2024年第2期5卷 186-198页

作者： hao Meng Weicheng Zhong Kui Ma Jianlong Su Liqian Ma Yaying hao yufeng Jiang Xi Liu Xiaobing Fu Cuiping Zhang Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department PLA General Hospital and PLA Medical CollegeBeijing 100048PR China PLA Key Laboratory of Tissue Repair and Regenerative Medicine Beijing 100048PR China Beijing Key Research Laboratory of Skin Injury Repair and RegenerationBeijing 100048PR China Research Unit of Trauma Care Tissue Repair and RegenerationChinese Academy of Medical Sciences2019RU051Beijing 100048PR China College of Graduate Tianjin Medical UniversityTianjin300070PR China Department of Tissue Regeneration and Wound Repair PLA General HospitalBeijingPR China

Persistent inflammatory responses often occur when bacteria and other microorganisms frequently invade and colonize open wounds and eventually result in the formation of chronic ***,achieving real-time detection of invasive bacteria accurately and promptly is essential for efficient wound management and accelerat-ing the healing ***,flexible wearable sensors have garnered significant attention,especially those designed for monitoring real-time biophysical or biochemical signals in wound sites in a minimally invasive *** provide more precise and continuous monitoring data,making them as emerging tools for clinical *** this review,we first discuss the species and community distribution of different types of bacteria in chronic ***,we introduce currently developed techniques for detecting bacteria at wound ***-lowing that,we discuss the recent progress and unresolved issues of various flexible wearable sensors in detecting bacteria at wound *** believe that this review can provide meaningful guidance for the development of flexible wearable sensors for bacteria detection.

关键词： Flexible wearable sensors Chronic wounds Bacterial infections Real-time detection

Step-edge controlled fast growth of wafer-scale MoSe_(2)films by MOCVD

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Nano Research 2023年第7期16卷 9577-9583页

作者： Rui Ji Jing Liao Lintao Li Rongji Wen Mengjie Liu Yifeng Ren Jianghua Wu Yunrui Song Minru Qi Zhixing Qiao Liwei Liu Chengbing Qin Yu Deng Yongtao Tian Suotang Jia yufeng hao Key Laboratory of Material Physics of Ministry of Education School of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052China National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesJiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210023China State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Laser SpectroscopyShanxi UniversityTaiyuan 030006China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China College of Medical Imaging Shanxi Medical UniversityTaiyuan 030001China MIIT Key Laboratory for Low-Dimensional Quantum Structure and Devices School of Integrated Circuits and ElectronicsBeijing Institute of TechnologyBeijing 100081China

Two-dimensional(2D)transition metal dichalcogenides(TMDCs),due to their unique physical properties,have a wide range of applications in the next generation of electronics,optoelectronics,and ***-scale preparation of high-quality TMDCs films is critical to realize these potential *** we report a study on metal-organic chemical vapor deposition(MOCVD)growth of wafer-scale MoSe_(2)films guided by the crystalline step edges of miscut sapphire *** established that the nucleation density and growth rate of MoSe_(2)films were positively correlated with the step-edge density and negatively with the growth *** a certain temperature,the MoSe_(2)domains on the substrate with high step-edge density grow faster than that with low *** a result,wafer-scale and continuous MoSe_(2)films can be formed in a short duration(30 min).The MoSe_(2)films are of high crystalline quality,as confirmed by systematic Raman and photoluminescence(PL)*** results provide an important methodology for the rapid growth of wafer-scale TMDCs,which may promote the application of 2D semiconductors.

关键词： MoSe_(2) nucleation density transition metal dichalcogenides metal-organic chemical vapor deposition(MOCVD) waferscale two-dimensional(2D)semiconductor

HelloNPU:A Corpus for Small-footprint Wake-Up Word Detection Research

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HelloNPU:A Corpus for Small-footprint Wake-Up Word Detection...

步履式顶推施工过程中大跨度钢箱梁的受力性状

第十四届全国人机语音通讯学术会议

作者： Senmao WANG Jingyong HOU Lei XIE yufeng hao School of Computer Science Northwestern Polytechnical University

As the first very step to activate speech interfaces,wake-up word detection aims to achieve a fully hand-free experience by detecting a specific word or phrase to activate the speech recognition and understanding *** task usually requires low-latency,highly accurate,small-footprint and easily migratory to power limited *** this paper,we describe the creation of HelloNPU,a publicly-available corpus that provides a common testbed to facilitate wake-up word detection *** also introduce some baseline experimental results on this proposed corpus using the deep KWS *** hope the release of this corpus can trigger more studies on small-footprint wake-up word detection.

关键词： Keyword Spotting Wake-Up Word Detection Deep Neural Network

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工业建筑 2020年第10期50卷 133-137页

作者：郝玉峰中铁建大桥工程局集团第五工程有限公司成都610500

顶推施工技术因其具有对桥下基础和空间要求较低、施工效率高等特点,被广泛应用于桥梁建设之中。目前国内对于钢箱梁步履式顶推施工技术一般采用有限元模拟研究,或根据监测数据进行实际工程研究,较少有将两者结合的研究。基于下部龙大... 详细信息

顶推施工技术因其具有对桥下基础和空间要求较低、施工效率高等特点,被广泛应用于桥梁建设之中。目前国内对于钢箱梁步履式顶推施工技术一般采用有限元模拟研究,或根据监测数据进行实际工程研究,较少有将两者结合的研究。基于下部龙大桥钢箱梁步履式顶推施工,采用MIDAS/Civil软件建立桥梁各典型工况下顶推施工有限元模型,对各工况钢箱梁顶推至最不利位置时钢箱梁关键截面应力状态及导梁前端位移进行计算,通过与现场监测数据进行对比,发现通过该模型计算所得的钢箱梁关键截面应力状态及导梁前端位移与实际施工中所得数据吻合良好,误差均不超过15%。

关键词：步履式顶推施工施工应力监测有限元分析

Tim4 deficiency reduces CD301b+macrophage and aggravates periodontitis bone loss

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International Journal of Oral Science 2024年第2期16卷 280-292页

作者： Ziming Wang hao Zeng Can Wang Jiaolong Wang Jing Zhang Shuyuan Qu Yue Han Liu Yang Yueqi Ni Wenan Peng Huan Liu Hua Tang Qin Zhao yufeng Zhang State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool&Hospital of StomatologyTaikang Center for Life and Medical SciencesWuhan UniversityWuhanChina School of Stomatology Nanchang UniversityNanchangChina Institute of Infection and Immunity Science and Technology Innovation CenterShandong First Medical University&Shandong Academy of Medical SciencesJinanChina Medical Research Institute School of MedicineWuhan UniversityWuhanChina

Periodontitis is a common chronic inflammatory disease that causes the periodontal bone destruction and may ultimately result in tooth *** the progression of periodontitis,the osteoimmunology microenvironment in periodontitis is damaged and leads to the formation of pathological alveolar bone ***301b^(+)macrophages are specific to the osteoimmunology microenvironment,and are emerging as vital booster for conducting bone ***,the key upstream targets of CD301b^(+)macrophages and their potential mechanism in periodontitis remain *** this study,we concentrated on the role of Tim4,a latent upstream regulator of CD301b^(+)*** first demonstrated that the transcription level of Timd4(gene name of Tim4)in CD301b^(+)macrophages was significantly upregulated compared to CD301b^(-) macrophages via high-throughput RNA ***,several Tim4-related functions such as apoptotic cell clearance,phagocytosis and engulfment were positively regulated by CD301b^(+)*** single-cell RNA sequencing analysis subsequently discovered that Cd301b and Timd4 were specifically co-expressed in *** following flow cytometric analysis indicated that Tim4 positive expression rates in total macrophages shared highly synchronized dynamic changes with the proportions of CD301b^(+)macrophages as periodontitis ***,the deficiency of Tim4 in mice decreased CD301b^(+)macrophages and eventually magnified alveolar bone resorption in ***,Tim4 controlled the p38 MAPK signaling pathway to ultimately mediate CD301b^(+)macrophages *** a word,Tim4 might regulate CD301b^(+)macrophages through p38 MAPK signaling pathway in periodontitis,which provided new insights into periodontitis immunoregulation as well as help to develop innovative therapeutic targets and treatment strategies for periodontitis.

关键词： period upstream eventually

Optical conductivity-based ultrasensitive mid-infrared biosensing on a hybrid metasurface

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Light(Science & Applications) 2018年第1期7卷 405-415页

作者： Yibo Zhu Zhaoyi Li Zhuang hao Christopher DiMarco Panita Maturavongsadit yufeng hao Ming Lu Aaron Stein Qian Wang James Hone Nanfang Yu Qiao Lin Department of Mechanical Engineering Columbia UniversityNew YorkNY 10027USA Department of Applied Physics and Applied Math Columbia UniversityNew YorkNY 10027USA Department of Chemistry and Biochemistry University of South CarolinaColumbiaSC 29208USA National Laboratory of Solid State Microstructures College of Engineering and Applied Sciencesand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China Center for Functional Nanomaterials Brookhaven National LaboratoryUptonNY 11973USA

Optical devices are highly attractive for biosensing as they can not only enable quantitative measurements of analytes but also provide information on molecular ***,typical refractive index-based optical sensors do not have sufficient sensitivity to probe the binding of low-molecular-weight ***-optical devices such as field-effect transistors can be more sensitive but do not offer some of the significant features of optical devices,particularly molecular *** present optical conductivity-based mid-infrared(mid-IR)biosensors that allow for sensitive and quantitative measurements of low-molecular-weight analytes as well as the enhancement of spectral *** sensors employ a hybrid metasurface consisting of monolayer graphene and metallic nano-antennas and combine individual advantages of plasmonic,electronic and spectroscopic ***,the hybrid metasurface sensors can optically detect target molecule-induced carrier doping to graphene,allowing highly sensitive detection of low-molecular-weight analytes despite their small ***,the resonance shifts caused by changes in graphene optical conductivity is a well-defined function of graphene carrier density,thereby allowing for quantification of the binding of ***,the sensor performance is highly stable and consistent thanks to its insensitivity to graphene carrier mobility ***,the sensors can also act as substrates for surfaceenhanced infrared *** demonstrated the measurement of monolayers of sub-nanometer-sized molecules or particles and affinity binding-based quantitative detection of glucose down to 200 pM(36 pg/mL).We also demonstrated enhanced fingerprinting of minute quantities of glucose and polymer molecules.

关键词： conductivity surface Optical

Oxygen influencing the photocarriers lifetime of CH3NH3PbI3-xClx film grown by two-step interdiffusion method and its photovoltaic performance

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Oxygen influencing the photocarriers lifetime of CH3NH3PbI3-...

第三届新型太阳能电池学术研讨会

作者： Shuai Yuan Zhiwen Qiu Hailiang Zhang Haibo Gong yufeng hao Bingqiang Cao Laboratory of Inorganic Energy and Environment Materials School of Material Science and EngineeringUniversity of Jinan

During the growth of CH

关键词： Perovskite solar cell

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计算机唇读研究进展

数据采集与处理 2007年第3期22卷 353-359页

作者：王晓平郝玉峰付德刚袁春伟东南大学生物电子学国家重点实验室南京210096 北京捷通华声语音技术有限公司北京100094

计算机唇读是利用计算机对说话者的唇动等视觉语音信息进行分析以识别出其所说内容的过程,并可与听觉语音信息相融合以进一步提高计算机的识别率,从而使人机交互更加自然。本文从计算机唇读系统的各环节入手综述了该领域的研究进展,并... 详细信息

计算机唇读是利用计算机对说话者的唇动等视觉语音信息进行分析以识别出其所说内容的过程,并可与听觉语音信息相融合以进一步提高计算机的识别率,从而使人机交互更加自然。本文从计算机唇读系统的各环节入手综述了该领域的研究进展,并讨论了现有诸方法的优缺点,最后提出了有待进一步研究的问题。

关键词：唇读定位特征抽取信息融合

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HTPB复合底排药压缩屈服应力模型研究

力学学报 2019年第6期51卷 1810-1819页

作者：武智慧牛公杰郝玉风钱建平刘荣忠南京理工大学机械工程学院南京210094 中国工程物理研究院总体工程研究所四川绵阳621999 辽沈工业集团有限公司产品研发中心沈阳110045

目前广泛应用于底排增程技术的HTPB复合底排药(composite base bleed grain,CBBG)是一种颗粒填充含能材料,战场环境中将承受冲击、温度等载荷作用.为研究HTPB CBBG冲击压缩力学性能,进行了不同温度(233~323K)和应变率(1100~7900s-1)下... 详细信息

目前广泛应用于底排增程技术的HTPB复合底排药(composite base bleed grain,CBBG)是一种颗粒填充含能材料,战场环境中将承受冲击、温度等载荷作用.为研究HTPB CBBG冲击压缩力学性能,进行了不同温度(233~323K)和应变率(1100~7900s-1)下的分离式霍普金森压杆实验.实验结果表明,各工况下,应力应变曲线均呈现屈服-应变硬化特征,HTPB CBBG保持高韧性.提高应变率和降低温度均导致相同应变下的应力幅值上升,但温度较应变率对HTPB CBBG冲击压缩力学性能的影响更为显著.基于所研究温度范围高于HTPB CBBG玻璃化转变温度,通过将水平、垂直移位因子与温度的关系表示为WLF方程的形式,将时温等效原理引入协同模型,并计及内应力的应变率增强效应,提出了一种新的屈服应力模型.选取参考温度,利用水平、垂直移位因子-温度曲线和屈服应力主曲线拟合模型参数.模型预测值与实验数据对比结果表明:该模型可准确表征233~323K时HTPB CBBG屈服应力的双线性应变率相关性,明确了较低和较高应变率时,应变率效应分别主要由内应力和驱动力贡献.

关键词： HTPB复合底排药冲击压缩力学性能时温等效原理屈服应力