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Current insights into the oncogenic roles of lncRNA LINC00355

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Cancer Innovation 2023年第6期2卷 448-462页

作者： Jinze Shen Xinming Su Ming Pan Zehua Wang yufei ke Qurui Wang Jingyin Dong Shiwei Duan key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province School of MedicineHangzhou City UniversityHangzhouZhejiangChina

Long noncoding RNAs(lncRNAs)are a class of nonprotein-coding transcripts that are longer than 200 nucleotides.LINC00355 is a lncRNA located on chromosome 13q21.31 and is consistently upregulated in various cancers.It regulates the expression of downstream genes at both transcriptional and posttranscriptional levels,including eight microRNAs(miR-15a-5p,miR-34b-5p,miR-424-5p,miR-1225,miR-217-5p,miR-6777-3p,miR-195,and miR-466)and three protein-coding genes(ITGA2,RAD18,and UBE3C).LINC00355 plays a role in regulating various biological processes such as cell cycle progression,proliferation,apoptosis,epithelial-mesenchymal transition,invasion,and metastasis of cancer cells.It is involved in the regulation of the Wnt/β-catenin signaling pathway and p53 signaling pathway.Upregulation of LINC00355 has been identified as a high-risk factor in cancer patients and its increased expression is associated with poorer overall survival,recurrence-free survival,and disease-free survival.LINC00355 upregulation has been linked to several unfavorable clinical characteristics,including advanced tumor node metastasis and World Health Organization stages,reduced Karnofsky Performance Scale scores,increased tumor size,greater depth of invasion,and more extensive lymph node metastasis.LINC00355 induces chemotherapy resistance in cancer cells by regulating five downstream genes,namely HMGA2,ABCB1,ITGA2,WNT10B,and CCNE1 genes.In summary,LINC00355 is a potential oncogene with great potential as a diagnostic marker and therapeutic target for cancer.

关键词： ceRNA chemotherapy resistance lncRNA LINC00355 miRNA prognosis

高铁连通对企业跨区域合作创新的影响及作用机制

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中国人口·资源与环境 2024年第5期34卷 149-161页

作者：王雨飞王云辉许可曹清峰北京邮电大学经济管理学院北京100876 北京邮电大学区域经济与产业发展研究中心北京100876 山东大学国际创新转化学院山东青岛266237 中国社会科学院财经战略研究院北京100006

创新主体之间的跨区域合作是应对并解决现有企业创新需求的有效手段,是发挥创新合力打造科技创新共同体的重要形式。该研究从企业跨区域合作创新的视角,基于2005—2019年高铁连通与“企业-城市关系对”的合作专利申请的面板数据,采用多... 详细信息

创新主体之间的跨区域合作是应对并解决现有企业创新需求的有效手段,是发挥创新合力打造科技创新共同体的重要形式。该研究从企业跨区域合作创新的视角,基于2005—2019年高铁连通与“企业-城市关系对”的合作专利申请的面板数据,采用多期双重差分法,实证检验高铁连通促进企业跨区域合作创新的影响及作用机制。研究发现:①企业所在城市与合作对象所在城市高铁连通显著提升了企业合作专利申请的数量,该结论在经过内生性检验、平行趋势检验、安慰剂检验和稳健性检验后依然稳健;②在高铁连通影响下,企业跨区域合作创新对象的数量明显增加,但主要分布在近距离及近距离的中心城市范围内,整体呈现“散中有聚”的空间收缩效应和空间分级效应;③高铁连通还使得企业合作创新质量得到提升,将近距离范围内的低质量合作创新转化为高质量的合作创新,呈现空间上的分层效应。进一步研究发现:①高铁连通主要促进了非制造业企业的合作创新,而对制造业企业的促进效果不显著;②高铁连通使国有资本背景的企业跨区域合作专利申请的数量得到提高,而对民营、外资和其他企业的影响不显著;③高铁连通更能提高规模较大企业的合作创新水平,但对规模相对较小的企业作用不显著。该研究结论可为国家推动企业牵头组建创新联合体,完善创新体系建设提供新思路;建议持续优化完善高铁主干及支线网络布局,将更多潜力城市接入高铁网络。

关键词：高铁连通企业合作创新空间优化

石英纱线/石英纤维毡三维织物的设计及其隔热性能

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纺织学报 2024年第6期45卷 53-58页

作者：李久刚石玉菲刘可帅李文斌柯贵珍武汉纺织大学纺织科学与工程学院湖北武汉430200 武汉纺织大学纺织新材料与先进加工技术省部共建国家重点实验室湖北武汉430200

为充分利用石英纱线及其纤维毡良好的隔热效果制备隔热性能优异的石英纱线/石英纤维毡三维织物,采用石英纱线和纤维毡在小样织机上进行三维立体编织,针对石英纱线/石英纤维毡三维织物不易编织等诸多问题,对织机综丝综框进行降低摩擦处理... 详细信息

为充分利用石英纱线及其纤维毡良好的隔热效果制备隔热性能优异的石英纱线/石英纤维毡三维织物,采用石英纱线和纤维毡在小样织机上进行三维立体编织,针对石英纱线/石英纤维毡三维织物不易编织等诸多问题,对织机综丝综框进行降低摩擦处理;然后采用控制变量法和实验对比法,对所得石英纱线/石英纤维毡三维织物在热环境下的隔热性能进行测试表征,对其加热状态下的温度和外观形状的变化趋势和规律进行探讨。实验结果表明:石英纱线/石英纤维毡三维织物在300~700℃时,平均隔热保留率是相等厚度普通石英纤维织物的4倍,验证了石英纱线/石英纤维毡三维织物的优越隔热性能。确定了石英纱线/石英纤维毡三维织物具有良好的整体性能和隔热性,能够作为航天飞行器的外部隔热材料抵挡高温冲刷,因此对石英纱线/石英纤维毡三维织物性能的研究具有深远意义。

关键词：石英纱线纤维毡三维织物间隔织物隔热性能

引入自抗扰控制的MMC均压环流简化控制策略

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重庆理工大学学报（自然科学） 2024年第4期38卷 258-265页

作者：刘述喜曲雨霏罗钦刘科王乾蕴重庆理工大学电气与电子工程学院重庆400054 重庆市能源互联网工程技术研究中心重庆400054

针对模块化多电平换流器(MMC)正常工作时,子模块电容电压不平衡和三相桥臂间存在环流分量的问题,通过引入自抗扰控制,提出一种新的均压环流控制策略。分析子模块电容电压波动以及环流机理,提出基于自抗扰控制的单环子模块均压控制;结合... 详细信息

针对模块化多电平换流器(MMC)正常工作时,子模块电容电压不平衡和三相桥臂间存在环流分量的问题,通过引入自抗扰控制,提出一种新的均压环流控制策略。分析子模块电容电压波动以及环流机理,提出基于自抗扰控制的单环子模块均压控制;结合二阶广义积分器滤波环节提取交流分量,使用准PR控制对环流二倍频分量进行抑制。在稳态、动态条件下进行实验,结果表明:在稳态条件下,基于ADRC的单环控制波动系数降低0.5%,环流抑制降低19%,输出电流畸变率降低0.46%;在动态条件下,可以快速达到新的稳定状态,对电容电压脉动有良好的抑制作用。

关键词：模块化多电平换流器电容电压均衡自抗扰控制环流抑制二阶广义积分器

新型吡啶甲酸类铱磷光材料的合成、晶体结构及性能

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材料导报 2024年第S1期38卷 516-521页

作者：陈祝安张柯黄光英晏彩先钱昱霏常桥稳昆明贵金属研究所云南贵金属实验室有限公司稀贵金属综合利用新技术国家重点实验室昆明650106 昆明市第一人民医院昆明650000

铱磷光材料由于发光效率高、热稳定性好、发光颜色易调控等优点,成为目前综合性能最优异的有机电致发光材料。Ir(C^N)2(L^X)型铱磷光配合物是最为重要的一类铱磷光发光材料,通过调控配体的化学结构,如引入供/吸电子基团、增大共轭程度... 详细信息

铱磷光材料由于发光效率高、热稳定性好、发光颜色易调控等优点,成为目前综合性能最优异的有机电致发光材料。Ir(C^N)2(L^X)型铱磷光配合物是最为重要的一类铱磷光发光材料,通过调控配体的化学结构,如引入供/吸电子基团、增大共轭程度等来达到改变发光颜色、发射波长和性能等目的。本工作从辅助配体着手,选用N^O型的吡啶甲酸衍生物为辅助配体,通过不同性质的基团对其结构进行调控;分别以3-三氟甲基-2-吡啶甲酸(Tricid)和异喹啉-1-甲酸(Qicid)为辅助配体,以2-(2,4-二氟苯基)-5-甲基吡啶(Medfppy)为主配体,设计合成出两种吡啶甲酸类铱磷光材料Ir1和Ir2。通过核磁共振谱、质谱和单晶X射线衍射等测试手段表征了它们的组成和化学结构,并确定了Ir1和Ir2的晶体结构,Ir1为单斜晶系,P2_(1)/c空间群;Ir2为三斜晶系,P-1空间群,均呈现出稍微扭曲的八面体构型;通过热重分析测试了材料的热稳定性,Ir1和Ir2的热分解温度分别为319℃和364℃;通过紫外-可见光谱和光致发光光谱研究了材料的光物理性能,Ir1和Ir2在二氯甲烷溶液中的最大发射波长分别为582 nm和607 nm;通过循环伏安法测试了材料的电化学性质,并计算得到材料的HOMO-LUMO能级。研究结果表明:与吡啶甲酸(Pic)上引入吸电子基团(-CF_(3))相比,增大共轭程度对铱磷光材料的发射波长作用程度较大;增大共轭程度不仅使配合物的最大发射波长产生了红移,还提高了材料的热稳定性,对设计新型的铱磷光材料具有一定的借鉴意义。

关键词：铱磷光材料辅助配体吡啶甲酸衍生物结构修饰光物理性能

A developed dual-site Langmuir model to represent the high-pressure methane adsorption and thermodynamic parameters in shale

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International Journal of Coal Science & Technology 2023年第5期10卷 21-37页

作者： ke Hu Qian Zhang yufei Liu Muhammad Abdurrahman Thaika School of Mining and Petroleum Engineering University of AlbertaEdmontonT6G1H9Canada Institute of Energy School of Earth and Space SciencePeking UniversityBeijing100871China

Comprehending the mechanism of methane adsorption in shales is a crucial step towards optimizing the development of deep-buried shale gas. This is because the methane adsorbed in shale represents a significant proportion of the subsurface shale gas resource. To properly characterize the methane adsorption on shale, which exhibits diverse mineral compositions and multi-scale pore sizes, it is crucial to capture the energy heterogeneity of the adsorption sites. In this paper, a dual-site Langmuir model is proposed, which accounts for the temperature and pressure dependence of the density of the adsorbed phase. The model is applied to the isothermals of methane adsorption on shale, at pressures of up to 30 MPa and temperatures ranging from 40 to 100 ℃. The results show that the proposed model can describe the adsorption behavior of methane on shale more accurately than conventional models, which assume a constant value for the density of adsorbed phase. Furthermore, the proposed model can be extrapolated to higher temperatures and pressures. Thermodynamic parameters were analyzed using correctly derived equations. The results indicate that the widely used, but incorrect, equation would underestimate the isosteric heat of adsorption. Neglecting the real gas behavior, volume of the adsorbed phase, and energy heterogeneity of the adsorption sites can lead to overestimation of the isosteric heat of adsorption. Furthermore, the isosteric heat evaluated from excess adsorption data can only be used to make a rough estimate of the real isosteric heat at very low pressure.

关键词： Shale gas Adsorption-Dual-site Langmuir model Energy heterogeneity Isosteric heat

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电力系统继电保护二次安全措施的规范化管理

电力系统装备 2024年第1期 46-48页

作者：温新鹏苏宇飞冉科新疆送变电有限公司新疆乌鲁木齐830011

为进一步提高电力系统继电保护二次安全管理规范化,文章以电力系统继电保护二次安全措施的规范化管理为研究方向。提出了当前电力系统继电保护二次回路存在的问题,进而提出电力系统继电保护二次安全措施的规范化管理的建议,从停电检查... 详细信息

为进一步提高电力系统继电保护二次安全管理规范化,文章以电力系统继电保护二次安全措施的规范化管理为研究方向。提出了当前电力系统继电保护二次回路存在的问题,进而提出电力系统继电保护二次安全措施的规范化管理的建议,从停电检查、带电检修规程、电缆电路、设备元件、“投检修态”压板、软压板投退及光纤拔除的规范化管理进行讨论,旨在为电力系统继电保护二次安全措施的规范化管理提供理论指导与帮助。

关键词：电力系统继电保护安全措施规范化管理

Coronene and Bipyridine Derivatives Inducing Diversified Structural Transitions of Carboxylic Acids at the Liquid/Solid Interface

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Chinese Journal of Chemistry 2022年第23期40卷 2727-2733页

作者： Ting Meng Peng Lei yufei Zhang ke Deng Xunwen Xiao Qingdao Zeng CAS key Laboratory of Standardization and Measurement for Nanotechnology CAS Centerfor Excellence in NanoscienceNational Center forNanoscienceandTechnology(NCNST)Beijing 100190China Center of Materials Scienceand Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China School of Materials and Chemical Engineering Ningbo University of TechnologyNingboZhejiang 315211China

In recent years, the construction of stable multicomponent assembled structures on surfaces and the exploration of the assembled mechanism have become research hotspots. In this paper, the azobenzene-carboxylic acid called (E)-4’,4”’-(diazene-1,2-diyl) bis(([1,1’-biphenyl]-3,5-dicarboxylic acid)) (H4DBBD) could self-assemble into regular network structure at heptanoic acid/graphite via hydrogen bonding, and could be regulated into analogous kagomé network by coronene (COR) molecules. In addition, a series of bipyridine derivatives were further introduced to construct bi-component systems with H4DBBD molecules, and successfully induced diversified structural transitions of H4DBBD on the graphite surface. Combined with scanning tunneling microscope (STM) and density functional theory (DFT) calculations, we have investigated the diversified structural transitions and analyzed the formation mechanism of the assembled systems.

关键词： Self-assembly Supramolecular chemistry Scanning tunneling microscope DFT calculations Hydrogen bonds

Effects of DOM characteristics from real wastewater on the degradation of pharmaceutically active compounds by the UV/H_(2)O_(2) process

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Journal of Environmental Sciences 2022年第6期34卷 220-228页

作者： yufei Shi Jinju Geng Xiang Li Yuli Qian Hongzhou Li Liye Wang Gang Wu Qingmiao Yu ke Xu Hongqiang Ren State key Laboratory of Pollution Control and Resource Reuse School of the EnvironmentNanjing UniversityNanjing 210008China

The characteristics of dissolved organic matter(DOM) can significantly affect the degradation of target compounds by the advanced oxidation processes. In this study, the effects of the different hydrophobicity/hydrophilicity fractions, molecular weight(MW) fractions,fluorescence components and molecular components of DOM extracted from municipal wastewater on the degradation of 4 pharmaceutically active compounds(Ph ACs), including carbamazepine, clofibric acid, atenolol and erythromycin by the UV/H_(2)O_(2) process were investigated. The results showed that the degradation rate constants of 4 Ph ACs decreased dramatically in the presence of DOM. The linear regressions of 4 Ph ACs degradation as a function of specific fluorescence intensity(SFI) are exhibited during the degradation of 4Ph ACs and the SFI may be used to evaluate effect of DOM on target compounds in wastewater. The hydrophobic acid(HPO-A) exhibited the strongest inhibitory effect on degradation of 4 Ph ACs during oxidation process. The small MW fractions of DOM significantly inhibited the degradation of 4 Ph ACs during oxidation process. Among three fluorescence components,hydrophobic humic-like substances may significantly inhibit the degradation of 4 Ph ACs during oxidation process. At the molecular level, the formulas may be derived from terrestrial sources. CHO compound may significantly inhibit the degradation of 4 Ph ACs during oxidation process on formula classes. The unsaturated hydrocarbons, carbohydrates and tannins compounds may significantly inhibit the effectiveness of the UV/H_(2)O_(2) process on compound classes.

关键词： DOM UV/H_(2)O_(2) PhACs Effect Real wastewater