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含铜硅酸钙纳米棒复合水凝胶用于肿瘤治疗和皮肤伤口愈合性能研究

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无机材料学报 2022年第11期37卷 1203-1216页

作者：吴爱军朱敏朱钰方上海理工大学材料与化学学院上海200093 中国科学院上海硅酸盐研究所高性能陶瓷与超微结构国家重点实验室上海200050

为了清除皮肤肿瘤手术切除后的残余肿瘤细胞并促进皮肤伤口愈合,开发一种具有肿瘤治疗和促进皮肤伤口愈合功能的水凝胶具有重要意义。本研究以水合硅酸钙纳米线为基体材料,以NaCl和KCl为熔盐介质,CuSO_(4)·5H_(2)O为铜源,采用熔盐法制... 详细信息

为了清除皮肤肿瘤手术切除后的残余肿瘤细胞并促进皮肤伤口愈合,开发一种具有肿瘤治疗和促进皮肤伤口愈合功能的水凝胶具有重要意义。本研究以水合硅酸钙纳米线为基体材料,以NaCl和KCl为熔盐介质,CuSO_(4)·5H_(2)O为铜源,采用熔盐法制备了含铜硅酸钙(Cu-CS)纳米棒,并将其复合到海藻酸钠水凝胶得到Cu-CS纳米棒复合水凝胶(Cu-CS/SA)。实验结果表明,随着铜盐添加量增大和熔盐处理温度升高,Cu-CS纳米棒的Cu含量逐渐上升,但其催化过氧化氢(H_(2)O_(2))生成羟基自由基(·OH)的性能呈现先升高后下降的趋势;在3%铜盐添加量和熔盐处理温度700℃条件下所制备的3Cu-CS纳米棒具有最佳的催化性能,Cu元素均匀地分布在纳米棒表面,其价态为+2价,且Cu元素的含量极低,仅为0.61%。细胞实验发现Cu-CS纳米棒含量不超过20%的复合水凝胶具有良好的生物相容性,并且Cu-CS/SA水凝胶在模拟肿瘤微环境条件下能催化H_(2)O_(2)生成高细胞毒性的·OH,进而实现化学动力学治疗肿瘤的效果,同时还能促进血管内皮细胞和成纤维细胞的增殖和迁移。因此,Cu-CS纳米棒复合水凝胶有望用于皮肤肿瘤术后治疗。

关键词：熔盐法含铜硅酸钙纳米棒水凝胶化学动力学治疗皮肤伤口愈合

Multistep continuous flow synthesis of Erlotinib

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Chinese Chemical Letters 2024年第4期35卷 371-375页

作者： Hui Jin Qin Cai Peiwen Liu Yan Chen Derong Wang Weiping zhu yufang Xu Xuhong Qian State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of Chemical BiologySchool of PharmacyEast China University of Science and TechnologyShanghai 200237China

Erlotinib is an orally administered, highly effective, specific epidermal growth factor receptor tyrosine kinase inhibitor, used to treat non-small cell lung cancer and pancreatic cancer. The traditional synthetic methods for Erlotinib exhibit long reaction time and safety concern. Herein, we describe a novel five-step route for the synthesis of Erlotinib in flow. These five steps comprise etherification, nitration, reduction,addition and cyclization reactions. All steps were optimized and converted to continuous flow process,which drastically reduces the reaction time and considerably improves the process safety as well as the total yield. Enabled by five continuous flow units, Erlotinib is efficiently afforded with an E-factor of 38,an overall yield of 83%, and a total residence time of 25.1 min. Majority steps in this process have been optimized for quantitative conversion, which offers the possibility of telescoping the entire process.

关键词： Erlotinib Continuous flow synthesis Microchannel flow reactor Process optimization Continuous nitration Continuous hydrogenation

熔盐法制备含钴氯磷灰石及其抗氧化性能和细胞相容性研究

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无机材料学报 2022年第11期37卷 1225-1235页

作者：舒朝琴朱敏朱钰方上海理工大学材料与化学学院上海200093 中国科学院上海硅酸盐研究所高性能陶瓷与超微结构国家重点实验室上海200050

生物活性陶瓷骨修复材料虽然具有优异的成骨性能,但缺乏抗氧化应激的能力,妨碍骨修复进程。本研究以β相磷酸三钙(β-TCP)粉体为原料,采用LiCl-KCl熔盐体系,以六水合氯化钴(CoCl_(2)·6H_(2)O)为钴源,利用熔盐法制备出含钴氯磷灰石(Co-M... 详细信息

生物活性陶瓷骨修复材料虽然具有优异的成骨性能,但缺乏抗氧化应激的能力,妨碍骨修复进程。本研究以β相磷酸三钙(β-TCP)粉体为原料,采用LiCl-KCl熔盐体系,以六水合氯化钴(CoCl_(2)·6H_(2)O)为钴源,利用熔盐法制备出含钴氯磷灰石(Co-MS-TCP)。通过Co-MS-TCP粉体清除过氧化氢(H_(2)O_(2))分析了含钴氯磷灰石的抗氧化能力;通过细胞活性、胞内活性氧(ROS)含量变化评价了材料的细胞相容性和细胞水平抗氧化性能。结果表明,熔盐处理β-TCP粉体能够制备含钴氯磷灰石,钴含量随CoCl_(2)·6H_(2)O加入量增加而增大;H_(2)O_(2)清除能力随氯磷灰石中钴含量的增加而增强, 6 h内对H_(2)O_(2)的清除率可达90%以上。细胞实验证实,含钴氯磷灰石具有良好的细胞相容性和抗氧化性能,1.5mg·mL^(-1)加3%Co盐的MS-TCP(3%Co-MS-TCP)即可保证软骨细胞和骨髓间充质干细胞存活率大于85%,并且3%Co-MS-TCP可有效清除H_(2)O_(2),使得细胞内ROS含量显著降低。因此,通过熔盐法制备含钴生物活性陶瓷是实现抗氧化应激的一种有效途径,这也为开发催化活性高、生物相容好的功能化生物活性陶瓷提供了新的策略。

关键词：生物活性陶瓷熔盐法钴抗氧化

Manganese silicate nanospheres-incorporated hydrogels:starvation therapy and tissue regeneration

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Bioactive Materials 2021年第12期6卷 4558-4567页

作者： Hongshi Ma Qingqing Yu Yu Qu yufang zhu Chengtie Wu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of Sciences1295 Dingxi RoadShanghai200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesNo19(A)Yuquan RoadBeijing100049China

To prevent postoperative skin tumor recurrence and repair skin wound,a glucose oxidase(GOx)-loaded manganese silicate hollow nanospheres(MS HNSs)-incorporated alginate hydrogel(G/MS-SA)was constructed for starvation-photothermal therapy and skin tissue *** MS HNSs showed a photothermal conversion efficiency of 38.5%,and endowed composite hydrogels with satisfactory photothermal *** advantage of the catalytic activity of Mn ions,the composite hydrogels could decompose hydrogen peroxide(H2O2)into oxygen(O2),which can alleviate the problem of tumor hypoxia microenvironment and endow GOx with an ability to consume glucose in the presence of O2 for tumor ***,hyperthermia triggered by near infrared(NIR)irradiation could not only accelerate the reaction rate of H2O2 decomposition by MS HNSs and glucose consumption by GOx,but also ablate tumor *** anti-tumor results showed that synergistic effect of starvation-photothermal therapy led to the highest death rate of tumor cells among all groups,and its anti-tumor effect was obviously improved as compared with that of single photothermal treatment or starvation ***,the introduction of MS HNSs into hydrogels could distinctly promote the epithelialization of the wound beds by releasing Mn ions as compared with the hydrogels without MS *** is expected that such a multifunctional platform with starvation-photothermal therapy will be promising for treating tumor-caused skin defects in combination of its regeneration bioactivity in the future.

关键词： Manganese silicate hollow nanospheres Composite hydrogel Starvation therapy Photothermal therapy Tissue regeneration

Temperature-sensitive splicing is an important molecular regulation mechanism of thermosensitive genic male sterility in rice

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Chinese Science Bulletin 2009年第14期54卷 2354-2362页

作者： CHEN RongZhi PAN yufang WANG Yang zhu LiLi HE GuangCun Key Laboratory of Ministry of Education for Plant Developmental Biology College of Life Sciences Wuhan University Wuhan 430072 China

Photoperiod and temperature-sensitive genetic male sterility (PGMS and TGMS) plants have a number of desirable characteristics for hybrid production. Two-line hybrids developed using the PGMS/TGMS system now account for a large proportion of rice production in China. In this paper, we summarize recent advances on molecular regulation mechanisms and genetics of PGMS/TGMS in rice. We suggest that temperature-sensitive splicing, an important posttranscriptional regulatory mechanism in modulating gene expression and eventually development and differentiation, is also an important molecular regulation mechanism of TGMS in rice. We review those factors involved in temperature-sensitive splicing like cis splice site, snRNA, trans premRNA splicing protein and SR proteins, and delineate that splicing could be regulated by a complex cell signaling pathway. These might shed light on other unknown molecular PGMS/TGMS mechanisms.

关键词：温敏核不育水稻分子调节机制雄性不育基因剪接位点温度敏感分子调控机制信号转导通路 SR蛋白

生物活性玻璃–二氧化锰复合支架的制备与表征

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无机材料学报 2022年第4期37卷 427-435页

作者：施吉翔翟东朱敏朱钰方上海理工大学材料科学与工程学院上海200093 中国科学院上海硅酸盐研究所上海200050

骨修复支架在植入缺损处后出现的炎症与氧化应激有关,其中过氧化氢(H_(2)O_(2))浓度过高是引起氧化应激的主要原因之一。二氧化锰(MnO_(2))能够通过催化分解H_(2)O_(2)来消除植入物周围环境过量的H_(2)O_(2),同时催化H_(2)O_(2)分解产... 详细信息

骨修复支架在植入缺损处后出现的炎症与氧化应激有关,其中过氧化氢(H_(2)O_(2))浓度过高是引起氧化应激的主要原因之一。二氧化锰(MnO_(2))能够通过催化分解H_(2)O_(2)来消除植入物周围环境过量的H_(2)O_(2),同时催化H_(2)O_(2)分解产生的氧气(O_(2))能够缓解骨缺损处因血供不足而导致的缺氧环境,从而有利于骨组织再生与骨缺损修复。本研究采用简单的氧化还原法在3D打印制备的生物活性玻璃(BG)支架表面原位沉积MnO_(2)颗粒,得到BG-MnO_(2)复合支架(BGM),赋予BG支架清除H_(2)O_(2)的同时提供O_(2)的能力。研究结果表明, BGM支架表面沉积MnO_(2)含量随反应溶液中高锰酸钾浓度升高而增加,其抗压强度随MnO_(2)含量增加而增强,但这些支架的孔隙率和降解速度基本保持不变。更为重要的是, BGM支架能够在H_(2)O_(2)环境中持续催化分解H_(2)O_(2)产生O_(2),当不同Mn含量的BGM(BGM5和BMG9)支架在浓度为2 mmol/L的H_(2)O_(2)溶液中催化分解H_(2)O_(2)产生的O_(2)能使溶液中饱和氧浓度分别达到8.4和11 mg/L。细胞实验结果表明, BGM支架对骨髓间充质干细胞的增殖和碱性磷酸酶活性有一定促进作用。因此, BGM支架在骨组织修复领域具有较大的应用潜力。

关键词：生物活性玻璃支架二氧化锰氧化应激三维打印骨组织工程

喷雾干燥法制备含铈生物玻璃微球及其体外生物活性

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硅酸盐学报 2023年第10期51卷 2527-2535页

作者：陈宝龙胡亚萍朱敏朱钰方上海理工大学材料与化学学院上海200093 中国科学院上海硅酸盐研究所上海200050

CaO-SiO_(2)-P_(2)O_(5)体系生物玻璃微球在骨修复材料领域具有应用前景。适量铈离子可赋予生物玻璃抗氧化、抗炎、促血管生成等功能特性。通过喷雾干燥法制备了不同铈离子含量的生物玻璃(Ce-BG)微球粉体材料,研究了Ce含量对Ce-BG微球... 详细信息

CaO-SiO_(2)-P_(2)O_(5)体系生物玻璃微球在骨修复材料领域具有应用前景。适量铈离子可赋予生物玻璃抗氧化、抗炎、促血管生成等功能特性。通过喷雾干燥法制备了不同铈离子含量的生物玻璃(Ce-BG)微球粉体材料,研究了Ce含量对Ce-BG微球的物相组成、降解性能以及体外生物活性的影响。结果表明:Ce-BG微球表面光滑,球形度高,元素分布均匀;BG微球中添加Ce会生成CePO_(4)及CeO_(2)相,且随Ce含量提高,Ce-BG微球降解速率变慢,降解产物引起环境pH值升高逐渐减缓。Ce与Ce+Ca的摩尔比为0.03:1.00的Ce-BG微球浸泡在Tris-HCl缓冲液中7 d后pH值最低。不同Ce含量的Ce-BG微球都具有良好的体外诱导磷灰石沉积的能力。

关键词：生物玻璃铈喷雾干燥微球

Advancements in life-on-a-chip: The impact of “Beyond Limits Manufacturing” technology

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Chinese Chemical Letters 2024年第5期35卷 13-16页

作者： Weiwei He Hongbo Zhang Xudong Lin Lili zhu Tingting Zheng Hao Pei Yang Tian Min Zhang Guoyue Shi Lei Wu Jianlong Zhao Gulinuer Wumaier Shengqing Li yufang Xu Honglin Li Xuhong Qian Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science and TechnologyShanghai 200237China School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai 200237China Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical EngineeringShenzhen Campus of Sun Yat-sen UniversityShenzhen 518000China Shanghai Key Laboratory of Green Chemistry and Chemical Processes Department of ChemistrySchool of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200241China Shanghai Institute of Microsystem and Information Technology Chinese Academy of SciencesShanghai 200050China Department of Pulmonary and Critical Care Medicine Huashan HospitalFudan UniversityShanghai 200040China Innovation Center for AI and Drug Discovery East China Normal UniversityShanghai 200062China Lingang Laboratory Shanghai 200031China

This review explores the concept of life-on-a-chip,which involves the creation of miniaturized biological systems,such as organs,tissues,and model organisms,on microscale platforms called microfluidic *** chips consist of intricately etched channels,wells,and chambers that enable precise control and observation of fluids,cells,and biochemical reactions,facilitating the simulation of various aspects of human or animal physiology and the study of responses to different stimuli,drugs,or disease *** review highlights the application of a novel technology,“Beyond Limit Manufacturing”(BLM),in the development of sophisticated three-dimensional cell models and model organism ***-on-a-chip and organ-on-a-chip(OoC)are among the thriving developments in the field of microfluidics,allowing for the reconstruction of living microenvironments and implementation of multiple *** review discusses the latest advancements in life-on-a-chip technology using BLM and outlines potential future research directions,emphasizing the significant role of these chips in studying complex biological processes in a controlled and scalable manner.

关键词： Beyond Limit Manufacturing Model-organism-on-a-chip Organ-on-a-chip

3D打印制备镁黄长石生物陶瓷骨组织工程支架及其性能

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无机材料学报 2023年第7期38卷 763-770页

作者：施哲刘伟业翟东谢建军朱钰方上海大学材料科学与工程学院上海200444 中国科学院上海硅酸盐研究所上海200050 上海理工大学材料与化学学院上海200093

具备良好成骨性能和降解速率的生物陶瓷骨组织工程支架在骨修复领域极具应用潜力。镁黄长石(Ca_(2)MgSi_(2)O_(7))因其具有良好的力学性能、生物降解能力以及促成骨性能而备受关注。本研究以硅树脂为聚合物前驱体、碳酸钙与氧化镁为活... 详细信息

具备良好成骨性能和降解速率的生物陶瓷骨组织工程支架在骨修复领域极具应用潜力。镁黄长石(Ca_(2)MgSi_(2)O_(7))因其具有良好的力学性能、生物降解能力以及促成骨性能而备受关注。本研究以硅树脂为聚合物前驱体、碳酸钙与氧化镁为活性填料制备打印浆料,采用挤出式3D打印技术在室温条件下制备支架素坯,并在惰性气氛下高温烧结制备了镁黄长石生物陶瓷支架,并对比研究了镁黄长石支架与斜硅钙石(Ca_(2)SiO_(4))、镁橄榄石(Mg_(2)SiO_(4))支架在结构、抗压强度、体外降解能力以及体外生物学性能等方面的差异。结果表明:镁黄长石支架与斜硅钙石、镁橄榄石支架具有相似的三维多孔结构,抗压强度、降解速率介于镁橄榄石和斜硅钙石之间,但促进骨髓间充质干细胞的成骨基因表达能力显著强于镁橄榄石和斜硅钙石支架。本研究证实采用3D打印制备的镁黄长石支架有望作为骨组织工程较理想的支架。

关键词：聚合物前驱体 3D打印生物陶瓷镁黄长石

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