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Design,synthesis and biological evaluation of fluorescent derivatives of ursolic acid in living cells

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Chinese Chemical Letters 2024年第5期35卷 287-289页

作者： Wenyi Mei Lijuan xie Xiaodong Zhang Cunjian Shi Fengzhi Wang Qiqi Fu Zhenjiang Zhao Honglin Li yufang Xu Zhuo Chen Shanghai Key Laboratory of New Drug Design State Key Laboratory of Bioreactor EngineeringSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China Innovation Center for AI and Drug Discovery East China Normal UniversityShanghai 200062China Lingang Laboratory Shanghai 200031China

Ursolic acid(UA)is a naturally occurring ursane triterpenoid,which exhibits a wide range of unique biological *** clarify its mechanism of action(MOA),a series of fluorescent derivatives of UA(5a-c)were designed and synthesized by conjugation with 7-nitrobenzo-2-oxa-1,3-diazole(NBD)*** them,5c exhibited similar anti-proliferative activity with UA against HCT116 cells(half maximal inhibitory concentration(IC_(50))=9.21±0.50μmol/L).Cell imaging experiment indicated that 5c was rapidly taken up in HCT116 cells in a dose and time-dependent ***,5c was found to localize in endoplasmic reticulum(ER),lysosomes,and mitochondria,but not in nucleus of HCT116 cells by confocal microscopy *** MOA proved that UA induced autophagy with a unique intracellular distribution mechanism involving ER and *** all,our work provides new clues for revealing the molecular mechanism of UA as an antitumor agent.

关键词： Pentacyclic triterpenoid Ursolic acid Fluorescent derivatives Autophagy Apoptosis

Superior surface electron energy level endows WP_(2) nanowire arrays with N_(2) fixation functions

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Journal of Energy Chemistry 2021年第8期30卷 55-62,I0003页

作者： Dongdong Han Xiaojing Liu Jinyan Cai yufang xie Shuwen Niu Yishang Wu Yipeng Zang Yanyan Fang Fengqi Zhao Wengang Qu Minghua Chen Gongming Wang Yitai Qian Key Laboratory of Engineering Dielectric and Applications(Ministry of Education) Harbin University of Science and TechnologyHarbin 150080China Hefei National Laboratory for Physical Science at the Microscale Department of ChemistryUniversity of Science&Technology of ChinaHefei 230026China Xi’an Modern Chemistry Research Institute Xi’an 710065China

Nitrogen reduction reaction(NRR)under ambient conditions is always a long-standing challenge in science,due to the extreme difficulty in breaking the strong N≡N triple *** key to resolving this issue undoubtedly lies in searching superior catalysts to efficiently activate and hydrogenate the stable nitrogen *** herein evaluate the feasibility of WP_(2) for N2 activation and reduction,and first demonstrate WP_(2) with an impressive ammonia yield rate of 7.13 lg h^(-1)cm^(-2),representing a promising W-based catalyst for *** analysis further reveals that the NRR catalysis on WP_(2) proceeds in a distal reaction pathway,and the exceptional NRR activity is originated from superior surface electron energy level matching between WP_(2) and NRR potential which facilitates the interfacial proton-coupled electron transfer *** successfully unraveling the intrinsic catalytic mechanism of WP_(2) for NRR could offer a powerful platform to manipulate the NRR activity by tuning the electron energy levels.

关键词： WP_(2) Electrocatalysis Energy level Nitrogen reduction Nanowire arrays

Accelerating water dissociation kinetics of Ni3N by tuning interfacial orbital coupling

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Nano Research 2021年第10期14卷 3458-3465页

作者： Yishang Wu yufang xie Shuwen Niu Yipeng Zang Jinyan Cai Zenan Bian Xuanwei Yin Yanyan Fang Da Sun Di Niu Zheng Lu Amirabbas Mosallanezhad Huijuan Wang Dewei Rao Hongge Pan Gongming Wang Hefei National Laboratory for Physical Science at the Microscale Department of ChemistryUniversity of Science and Technology of ChinaHefei 230026China Experimental Center of Engineering and Material Science University of Science and Technology of ChinaHefei 230026China School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013China Institute of Science and Technology for New Energy Xi’an Technological UniversityXi’an 710021China School of Materials Science and Engineering State Key Laboratory of Silicon MaterialsZhejiang UniversityHangzhou 310027China

The high unoccupied d band energy of Ni_(3)N basically results in weak orbital coupling with water molecule,consequently leading to slow water dissociation ***,we demonstrate Cr doping can downshift the unoccupied d orbitals and strengthen the interfacial orbital coupling to boost the water dissociation *** prepared Cr-Ni_(3)N/Ni displays an impressive overpotential of 37 mV at 10 mA·cmgeo-2,close to the benchmark Pt/C in 1.0 M KOH *** structural analysis reveals the Cr dopant exists as the Cr-N_(6)states and the average d band energy of Ni_(3)N is also *** functional theory calculation further confirms the downshifted d band energy can strengthen the orbital coupling between the unpaired electrons in O 2p and the unoccupied state of Ni 3d,which thus facilitates the water adsorption and *** work provides a new concept to achieve on-demand functions for hydrogen evolution catalysis and beyond,by regulating the interfacial orbital coupling.

关键词： unoccupied d orbitals Ni_(3)N Cr-N_(6)doping interfacial orbital coupling hydrogen evolution reaction

Orbital-regulated interfacial electronic coupling endows Ni3N with superior catalytic surface for hydrogen evolution reaction

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Science China Chemistry 2020年第11期63卷 1563-1569页

作者： Yanyan Fang Da Sun Shuwen Niu Jinyan Cai Yipeng Zang Yishang Wu Linqin Zhu yufang xie Yun Liu Zixuan Zhu Amirabbas Mosallanezhad Di Niu Zheng Lu Junjie Shi Xiaojing Liu Dewei Rao Gongming Wang Yitai Qian Hefei National Laboratory for Physical Science at the Microscale Department of ChemistryUniversity of Science&Technology of ChinaHefei 230026China School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013China

The interstitial structure and weak Ni-N interaction of Ni3N lead to high unoccupied d orbital energy and unsuitable orbital orientation,which consequently results in weak orbital coupling with H2O and slow water dissociation kinetics for alkaline hydrogen evolution ***,we successfully lower the unoccupied d orbital energy of Ni3N to strengthen the interfacial electronic coupling by employing the strong electron pulling capability of oxygen *** prepared O-Ni3N catalyst delivers an overpotential of 55 mV at 10 mA cm−2,very close to the commercial Pt/*** structural characterization indicates the oxygen incorporation can decrease the electron densities around the Ni ***,density functional theory calculation further proves the oxygen incorporation can create more unoccupied orbitals with lower energy and superior orientation for water adsorption and *** concept of orbital-regulated interfacial electronic coupling could offer a unique approach for the rational design of hydrogen evolution catalysts and beyond.

关键词： hydrogen evolution reaction orbital regulation interfacial electronic coupling Ni3N electrocatalysts

A General and Programmable Synthesis of Graphene-Based Composite Aerogels by a Melamine-Sponge-Templated Hydrothermal Process

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CCS Chemistry 2020年第2期2卷 1-12页

作者： Jin Ge Hong-Wu Zhu Yuan Yang yufang xie Gang Wang Jin Huang Lu-An Shi Oliver G Schmidt Shu-Hong Yu Division of Nanomaterials&Chemistry Hefei National Laboratory for Physical Sciences at the MicroscaleDepartment of ChemistryCAS Center for Excellence in NanoscienceInstitute of Biomimetic Materials and ChemistryUniversity of Science and Technology of ChinaHefei 230026China Institute for Integrative Nanosciences IFW Dresden01609 DresdenGermany Helmholtz-Zentrum Dresden-Rossendorf e.V. Institute of Ion Beam Physics and Materials Research01328 DresdenGermany Center for Advancing Electronics Dresden(cfaed)and Faculty of Chemistry and Food Chemistry Technische Universität Dresden01062 DresdenGermany

Three-dimensional(3D)graphene networks are performance boosters for functional nanostructures in energy-related *** tremendous intriguing nanostructures-decorated 3D graphene networks have been realized,on-demand decoration of nanostructures in the specified position of interest within the whole 3D graphene skeleton is still out of reach,shedding limitations on constructing more sophisticated components with programmable structures which offer enormous potential for the enhancement of performance and exploration of new ***,we report the melamine-sponge(MS)-templated hydrothermal method capable of realizing reduced graphene oxide(RGO)-nanostructure composite aerogels with programmable structures and *** key of this method is using the MS template to preset the structures of choice through programmable solution-processed immobilization of graphene oxide(GO)and ***,the hydrothermal treatment simultaneously removed the MS template and reduced the GO networks without changing the preset *** showcased nine typical RGO-nanostructures composite aerogels to demonstrate the versatility of the MS-templated hydrothermal method.

关键词： 3D graphene graphene aerogel templated assembly macroscopic assembly nanostructures

糖尿病病人围术期高血糖对术后转归影响的研究进展

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循证护理 2023年第7期9卷 1210-1215页

作者：谢郁芳张先翠皖南医学院研究生学院(皖南医学院弋矶山医院) 安徽241000 皖南医学院第一附属医院

综述糖尿病病人围术期高血糖对其术后转归的影响,并针对发生机制、临床预测因素、血糖控制目标等进行分析,发现围术期高血糖与器官损伤、术后并发症及死亡率存在着明显的联系,以期给临床医护在血糖管理方案的制定方面提供参考依据,利于... 详细信息

综述糖尿病病人围术期高血糖对其术后转归的影响,并针对发生机制、临床预测因素、血糖控制目标等进行分析,发现围术期高血糖与器官损伤、术后并发症及死亡率存在着明显的联系,以期给临床医护在血糖管理方案的制定方面提供参考依据,利于病人围术期安全和转归。

关键词：糖尿病围术期血糖术后转归综述护理

基于反馈机制的案例导入式竞赛活动在临床护理本科生带教中的应用效果

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护理实践与研究 2023年第1期20卷 128-131页

作者：谢郁芳张先翠皖南医学院研究生学院安徽省芜湖市241001 皖南医学院第一附属医院

目的探讨基于反馈机制的案例导入式竞赛活动的教学模式在临床护理本科生带教中的应用效果。方法选取2018年12月—2019年12月来皖南医学院第一附属医院实习的117名护理本科护生作为研究对象,按照组间基本特征具有可比性的原则分为对照组5... 详细信息

目的探讨基于反馈机制的案例导入式竞赛活动的教学模式在临床护理本科生带教中的应用效果。方法选取2018年12月—2019年12月来皖南医学院第一附属医院实习的117名护理本科护生作为研究对象,按照组间基本特征具有可比性的原则分为对照组59名与观察组58名。对照组使用传统的护理实习带教模式,观察组在对照组的基础上采用基于反馈机制的案例导入式竞赛培训活动护理带教模式。比较两组护生的理论成绩、基础操作成绩、专科操作成绩及护生的实习质量自评结果。结果带教结束后,两组护生的理论成绩比较差异无统计学意义(P>0.05);观察组护生的基础操作成绩、专科操作成绩均高于对照组,差异有统计学意义(P<0.05),且护生实习质量自评(护理综合知识、临床实践技能维度、临床护理思维、沟通管理能力、教育科研能力、职业精神)评分均优于对照组,差异有统计学意义(P<0.05)。结论基于反馈机制的案例导入式竞赛培训能够提高护生的操作技能,进而提升其护理综合能力及临床实践能力,有利于改善教学效果。

关键词：反馈机制案例导入竞赛活动护理带教模式应用效果

春季珠江口万山群岛毗邻海域渔业生态环境状况评价

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南方水产科学 2022年第5期18卷 1-8页

作者：吴鹏刘永肖雅元谢雨芳唐广隆林琳王腾李纯厚中国水产科学研究院南海水产研究所/农业农村部南海渔业资源开发利用重点实验室/广东珠江口生态系统野外科学观测研究站/广东省渔业生态环境重点实验室广东广州510300 南方海洋科学与工程广东省实验室(广州) 广东广州511458

万山群岛在珠江口渔业资源养护过程中发挥着重要作用,但目前对该区域岛礁毗邻海域的渔业生态状况尚缺乏足够研究。分析了2021年4月万山群岛毗邻海域的水环境状况和浮游动物群落特征,以此评价该区域渔业生态环境状况。结果表明,万山群岛... 详细信息

万山群岛在珠江口渔业资源养护过程中发挥着重要作用,但目前对该区域岛礁毗邻海域的渔业生态状况尚缺乏足够研究。分析了2021年4月万山群岛毗邻海域的水环境状况和浮游动物群落特征,以此评价该区域渔业生态环境状况。结果表明,万山群岛海水环境状况受珠江口径流输入的影响较大,造成该区域西北侧的桂山岛和东澳岛海水中的无机氮浓度、营养状态质量指数和富营养化指数较高,部分水体为富营养状态,并且初级生产力水平相对较高,但多为中低水平。万山群岛海域浮游动物群落具有区域性分布特点,可聚为3大类,其中桂山岛临近区域内的浮游动物香农多样性指数相对较低,表明该区域水体可能受到了一定的污染;桂山岛海域的鱼卵和仔稚鱼丰度却较高,分别为133粒·m^(−3)和18尾·m^(−3),表明桂山岛可能是珠江口鱼类产卵的重要场所。海水初级生产力和浮游动物均匀度指数可很好地反映万山群岛水环境和浮游动物群落之间的关联性,并可指示水体富营养化状态。

关键词：珠江口水质评价环境因子富营养化浮游动物多样性指数

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珠江河口凤鲚的栖息地适宜性评价

南方水产科学 2023年第1期19卷 22-29页

作者：谢雨芳吴鹏刘永肖雅元唐广隆王腾林琳李纯厚中国水产科学研究院南海水产研究所/农业农村部南海渔业资源开发利用重点实验室/广东珠江口生态系统野外科学观测研究站/广东省渔业生态环境重点实验室广东广州510300 上海海洋大学水产与生命学院上海201306 南方海洋科学与工程广东省实验室(广州) 广东广州5114582

探究珠江河口洄游性鱼类凤鲚(Coilia mystus)的生境适宜度,可为其渔业资源保护和利用提供科学依据。根据2019年冬季和2020年夏季在珠江河口进行的底拖网调查数据,选取水深、底层盐度、底层水温、底层溶解氧等作为指示因子,利用层次分析... 详细信息

探究珠江河口洄游性鱼类凤鲚(Coilia mystus)的生境适宜度,可为其渔业资源保护和利用提供科学依据。根据2019年冬季和2020年夏季在珠江河口进行的底拖网调查数据,选取水深、底层盐度、底层水温、底层溶解氧等作为指示因子,利用层次分析法(Analytic hierarchy process, AHP)计算各指示因子的权重,采用算数平均法(Arithmetic Mean Model, AMM)和几何平均法(Geometric Mean Model, GMM)计算栖息地适宜度指数(Habitat Suitability Index, HSI),验证发现基于GMM且赋予权重的HSI模型精确度较高,能较好地反映珠江河口凤鲚的栖息地分布。最优模型结果显示,珠江河口冬季和夏季凤鲚适宜的底层盐度分别为21.03‰~30.55‰和20.25‰~25.82‰,溶解氧质量浓度分别为6.79~7.28和3.85~4.01 mg·L^(-1),水深分别为11.69~20.10和7.80~9.23 m,底层水温分别为19.84~19.95和28.36~29.44℃。珠江河口凤鲚HSI大于0.5的站点仅占总调查站点的17.39%,表明其栖息地适宜性较低,目前珠江河口适宜凤鲚的栖息地主要位于内伶仃海域的中华白海豚自然保护区。

关键词：凤鲚栖息地适宜性指数环境因子珠江河口