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基于中医证素辨证的糖尿病心脏自主神经病变研究

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山东中医杂志 2022年第3期41卷 264-269,297页

作者：徐梦珠张珊樊月月沈晓喻郝娟吴坚上海中医药大学上海200082 上海中医药大学附属上海市中西医结合医院上海200082

目的:基于中医证素辨证体系探讨糖尿病心脏自主神经病变的中医证型分布,为糖尿病心脏自主神经病变的辨证论治提供参考依据。方法:纳入101例糖尿病心脏自主神经病变患者,制定四诊信息采集表,建立数据库,采用因子分析、聚类分析等统计学... 详细信息

目的:基于中医证素辨证体系探讨糖尿病心脏自主神经病变的中医证型分布,为糖尿病心脏自主神经病变的辨证论治提供参考依据。方法:纳入101例糖尿病心脏自主神经病变患者,制定四诊信息采集表,建立数据库,采用因子分析、聚类分析等统计学方法及中医证素辨证方法,进行中医证候研究。结果:通过因子分析共获得16个公因子,进一步结合中医理论及临床知识进行聚类,依据证素辨证的方法共获得6个病性及3个病位证素,分别为气虚、血虚、阴虚、阳虚、热、血热与心、脾、肝。结论:对分析得出的病性及病位证素进行组合,获得4种有效中医证型,分别为阴虚热盛证、脾阳不振证、心气亏虚证及肝肾阴虚证。

关键词：糖尿病心脏自主神经病变证素辨证阴虚热盛证脾阳不振证心气亏虚证肝肾阴虚证因子分析聚类分析

针刺对支气管哮喘大鼠肺组织P-AKT蛋白表达的调控

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辽宁中医杂志 2017年第10期44卷 2190-2193,I0003页

作者：杨金华赵叶李双韩君萍虞跃跃樊志忠崔建美华北理工大学中医学院河北唐山063000

目的:探讨针刺对哮喘大鼠肺组织中P-AKT蛋白表达的影响。方法:将40只SPF级雄性SD大鼠随机分为空白组、哮喘模型组、哮喘模型针刺组和哮喘模型雾化阻断剂组,每组10只。各组分别给予相应干预后,用HE染色观察大鼠肺组织形态学改变,Western ... 详细信息

目的:探讨针刺对哮喘大鼠肺组织中P-AKT蛋白表达的影响。方法:将40只SPF级雄性SD大鼠随机分为空白组、哮喘模型组、哮喘模型针刺组和哮喘模型雾化阻断剂组,每组10只。各组分别给予相应干预后,用HE染色观察大鼠肺组织形态学改变,Western Blot法和免疫组织化学法检测大鼠肺组织P-AKT蛋白的表达。结果:HE染色显示哮喘模型组大鼠气道周围有多种炎症细胞的浸润和聚集,支气管平滑肌痉挛,官腔狭窄;针刺组和雾化阻断剂组有少量炎症细胞,官腔狭窄管壁增厚程度较模型组减轻。Western Blot和免疫组化法检测示哮喘模型组P-AKT蛋白表达较空白组、针刺组、雾化阻断剂组升高(P0.05)。结论:针刺可降低大鼠肺组织中P-AKT蛋白表达以减轻炎症反应和气道重塑。

关键词：针刺哮喘 P-AKT HE染色 Western Blot

基于SWAT模型的马莲河流域水沙变化及对人类活动的响应

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水利规划与设计 2025年第1期 5-12页

作者：樊尚斌汪月月周颖马金珠平凉市水资源中心甘肃平凉744000 兰州大学资源环境学院/西部环境教育部重点实验室甘肃兰州730000

为定量分析马莲河流域水沙时空变化特征及其对人类活动的响应,文章构建SWAT分布式水文模型,对流域出口水文站雨落萍站2006—2019年的逐月径流量与输沙量进行模拟,模型验证期R^(2)和NS均满足模型精度要求。在此基础上,对马莲河流域模拟... 详细信息

为定量分析马莲河流域水沙时空变化特征及其对人类活动的响应,文章构建SWAT分布式水文模型,对流域出口水文站雨落萍站2006—2019年的逐月径流量与输沙量进行模拟,模型验证期R^(2)和NS均满足模型精度要求。在此基础上,对马莲河流域模拟期的降水量、蒸散发、径流深与泥沙负荷的分布格局进行分析,发现流域下游干流处是主要的产流产沙区,且流域月累计降水、月径流量与月输沙量之间响应较好。分析人类活动对水沙变化的影响,土地利用类型中耕地的减少与草地面积的增加以及淤地坝建设对流域减水减沙等水保效益具有显著效果。

关键词：马莲河流域 SWAT模型径流泥沙人类活动

In Situ Directional Polymerization of Poly(1,3-dioxolane)Solid Electrolyte Induced by Cellulose Paper-Based Composite Separator for Lithium Metal Batteries

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Energy & Environmental Materials 2023年第3期6卷 134-143页

作者： Jian Ma yueyue Wu Hao Jiang Xin Yao fan Zhang Xianglong Hou Xuyong Feng Hongfa Xiang School of Materials Science and Engineering Anhui Provincial Key Laboratory of Advanced Functional Materials and DevicesHefei University of TechnologyHefei 230009China

In traditional in situ polymerization preparation for solid-state electrolytes,initiators are directly added to the liquid *** this article,a novel cellulose paper-based composite separator is fabricated,which employs alumina as the inorganic reinforcing material and is loaded with polymerization initiator aluminum *** upon this,a separator-induced in situ directional polymerization technique is demonstrated,and the extra addition of initiators into liquid precursors is no longer *** polymerization starts from the surface and interior of the separator and extends outward with the gradually dissolving of initiators into the *** with its traditional counterpart,the separator-induced poly(1,3-dioxolane)electrolyte shows improved interfacial contact as well as appropriately mitigated polymerization rate,which are conducive to practical *** measurement results show that the prepared poly(1,3-dioxolane)solid electrolyte possesses an oxidation potential up to 4.4 V and a high Li+transference number of *** 1000 cycles at 2 C rate(340 mA g^(−1)),the assembled Li||LiFePO_(4)solid battery possesses a 106.8 mAh g^(−1)discharge capacity retention and 83.5%capacity retention ratio,with high average Coulombic efficiency of 99.5%*** work may provide new ideas for the design and application of in situ polymerization technique for solid electrolytes and solid batteries.

关键词： cellulose paper-based composite separator in situ directional polymerization lithium metal battery poly-DOL electrolyte solid-state electrolyte

Robust Control Strategy of Gradient Magnetic Drive for Microrobots Based on Extended State Observer

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Cyborg and Bionic Systems 2022年第1期2022卷 210-220页

作者： Jiawei Lu yueyue Liu Wentao Huang Kaitao Bi Yixin Zhu Qigao fan College of Internet of Things Engineering Jiangnan UniversityWuxi 214000China

Microrobots have great application pot ential in the biomedical field,to realize the precision and eficiency of microrobots in vivo is research focus in this *** are accompanied by various disturbances in complex *** disturbances will affect the motion control of microrobots,resulting in the inability of the micromanipulation tasks to be completed *** this end,a robust motion control method is proposed for precise path tracking of microrobots in this *** extended state observer(ESO)is used to estimate the total disturbances and uncertainties of the system.A path tracking controller is designed by combining sliding mode control(SMC)and disturbances compensation,which is used to eliminate the total disturbances of the system and realize the fast and accurate path tracking of ***,the path tracking experiments are implemented in the gradient magnetic field drive *** experimental results show that the mean absolute error of the path tracking for microrobots in a simulated vascular structure is less than 14μm,and the root mean square error is less than 17 um by using the robust control method proposed in this *** with the traditional PID control method,it can better suppress external disturbances and uncertainties of the system and improve the path tracking accuracy of microrobots *** shows stronger anti interference ability and robustness.

关键词： Observer system Strategy

Spatiotemporal variations of carbon flux and nitrogen deposition flux linked with climate change at the centennial scale in China

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Science China Earth Sciences 2020年第5期63卷 731-748页

作者： Dongdong GAO Li DAN Guangzhou fan Hanqin TIAN Jing PENG Xiujing YANG Fuqiang YANG yueyue LI Key Laboratory of Regional Climate-Environment for Temperate East Asia Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China College of Atmospheric Science Chengdu University of Information EngineeringChengdu 610225China International Center for Climate and Global Change Research Auburn UniversityAL 36849USA Key Laboratory of Water Cycle and Related Land Surface Processes Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

The spatial and temporal variations of the vegetation carbon flux in China from 1901 to 2005 were studied using the vegetation net primary production(NPP)values from seven Earth-system *** addition,the temporal and spatial changes in the nitrogen deposition flux in China were studied using the NHx and NOy fluxes from 1901 to *** relationship between changes in the carbon flux,nitrogen flux and climate was *** results show that(1)over the past 100 years,NPP in China has shown an upward *** average trend coefficient is 0.88 and the NPP distribution trend is generally low in the north and high in the south,with a gradual increase from the northwest to the ***,precipitation and radiation are all conducive to plant growth in the direction of the *** correlation coefficients between the ensemble model mean NPP and temperature,precipitation,longwave radiation and shortwave radiation are 0.88,0.73,0.91 and 0.67,respectively.(2)In the past 100 years,the NHx and NOy fluxes in China have shown an upward trend,with trend coefficients of 0.98 and 0.98,respectively,which pass the 99.9%confidence level of the *** and NOy fluxes are also generally low in the north and high in the south,with a gradual increase from the northwest to the southeast in a step-like pattern.(3)The spatial distribution of the correlation coefficients between the NHx and NOy fluxes and air temperature is similar,with only slight differences in *** spatial distribution of the correlation coefficients between the NHx and NOy fluxes and precipitation is similar in overall pattern,but the pattern is relatively complicated,with a positive-negative-positive-negative-positive pattern occurring across the monsoon region from north to south,and a negative-positive-negative-positive pattern occurring beyond the monsoon region from east to west.(4)The spatial distribution of the correlation coefficients between the NHx and NOy fluxes and NPP shows a ge

关键词： Net primary production(NPP) Temperature Precipitation NHx NOy

Recognizing single phospholipid vesicle collisions on carbon fiber nanoelectrode

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Science China Chemistry 2017年第11期60卷 1474-1480页

作者： yueyue Zhang Min Li Zhenhua Li Qian Li Ali Aldalbahi Jiye Shi Lihua Wang Chunhai fan Xiaolei Zuo Division of Physical Biology Shanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China Chemistry Department King Saud UniversityRiyadh 11451Saudi Arabia

We recognize the stochastic collisions of dopamine contained phospholipid vesicle on carbon fiber nanoelectrode, extending the observation of discrete collision events on nanoelectrode to biologically relevant analytes. To decrease noise interference to the technique, the dimensions of nanoelectrode was systematically investigated and optimized. Scanning electron microscopy(SEM) further supported the comparable sizes of nanoelectrode and vesicles(~100 nm in diameter). Vesicles collision and rupture on the surface of nanoelectrode led to the dopamine release from vesicles, which could be electrochemically oxidized to dopamine-o-quinone and detected via voltammetry. The comparable size of the nanoelectrode with vesicles and fast voltammetry allowed differentiation of single collision events from the current magnitudes and peak widths in the electrochemical collision experiments, which shows the efficacy of the method to characterize vesicle samples. This work provides a foundation upon which quantitative sensor technology might be built for the detection of dopamine contained vesicles with high spatial and temporal resolution.

关键词： single vesicle carbon fiber nanoelectrode high resolution electrochemical detection

Structural Isomers:Small Change with Big Difference in Anion Storage

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Nano-Micro Letters 2024年第1期16卷 222-234页

作者： Huichao Dai Yuan Chen yueyue Cao Manli Fu Linnan Guan Guoqun Zhang Lei Gong Mi Tang Kun fan Chengliang Wang School of Integrated Circuits Wuhan National Laboratory for Optoelectronics(WNLO)Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China Wenzhou Advanced Manufacturing Institute Huazhong University of Science and TechnologyWenzhou 325035People’s Republic of China Hubei Key Laboratory of Polymer Materials School of Materials Science and EngineeringHubei UniversityWuhan 430062People’s Republic of China School of Chemistry and Environmental Engineering Wuhan Institute of TechnologyWuhan 430073People’s Republic of China

Organic electrode materials are promising for ***,the reported organic electrodes are often facing the challenges of low specific capacity,low voltage,poor rate capability and vague charge storage mechanisms,*** are good platform to investigate the charge storage mechanisms and enhance the performance of batteries,which,however,have not been focused in ***,two isomers are reported for *** a result,the isomer tetrathiafulvalene(TTF)could store two monovalent anions reversibly,deriving an average discharge voltage of 1.05 V and a specific capacity of 220 mAh g−1 at a current density of 2 *** the other hand,the other isomer tetrathianaphthalene could only reversibly store one monovalent anion and upon further oxidation,it would undergo an irreversible solid-state molecular rearrangement to *** molecular rearrangement was confirmed by electrochemical performances,X-ray diffraction patterns,nuclear magnetic resonance spectra,and 1H detected heteronuclear multiple bond correlation *** results suggested the small structural change could lead to a big difference in anion storage,and we hope this work will stimulate more attention to the structural design for boosting the performance of organic batteries.

关键词： Zinc-organic batteries Isomers Solid-state molecular rearrangement Anion storage P-type organic electrode materials

Papillary fibroblast-recruiting injectable self-healing multifunctional hydrogels for wound regeneration

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Nano Research 2023年第7期16卷 9792-9803页

作者： yueyue Li Weifeng Zhong Junjie Wu Yuan Jia Zhonghua Chen Kaiwen Zhang Danyang Guo Yifei Fu Mengnan Chen Weiwei Chen fan Tian Xia Li Hongji Zhang Xiaojin Zhou Feng-Lai Yuan Institute of Integrated Chinese and Western Medicine Affiliated Hospital of Jiangnan UniversityWuxi 214000China The Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214000China

The recruitment of key cells to regeneration sites is a promising strategy to promote functional wound *** fibroblasts exhibit a heterogeneous population of cells during homeostasis and in response to *** fibroblasts play central regulatory roles in the regeneration of skin appendages during wound *** by the phenomenon where bait for grass carp can attract grouped grass carps to a fishing spot soon,“Grass Carp Fishing”multifunctional hydrogels,that is,codelivery of an antibody of leucine-rich repeats and immunoglobulin-like domains 1(Lrig1)on the surface of papillary fibroblasts and insulinlike growth factor 1(IGF1)with recruitment function,can recruit papillary *** the experiments,carboxymethyl chitosan showed positive effects in promoting cell proliferation and neovascularization,while dopamine-grafted gelatin was effective in stabilizing the structure and prolonging the degradation *** sustained release of Lrig1 antibodies and IGF1 from injectable self-healing multifunctional hydrogels persistently accelerated the migration and proliferation of Lrig1+*** in vivo results from a full-thickness cutaneous wound model showed that injectable self-healing multifunctional hydrogel accelerated wound healing and skin regeneration through the recruitment of Lrig1+papillary fibroblasts in wound *** findings reveal an injectable self-healing multifunctional hydrogel for regeneration,a promising approach to promoting skin wound healing.

关键词： wound healing regeneration papillary fibroblasts recruitment