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The regulatory mechanisms and inhibitors of isocitrate dehydrogenase 1 in cancer

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Acta Pharmaceutica Sinica B 2023年第4期13卷 1438-1466页

作者： yang Liu Wei Xu Mingxue Li yueying yang Dejuan Sun Lidian Chen Hua Li Lixia Chen Wuya College of Innovation Key Laboratory of Structure-Based Drug Design&DiscoveryMinistry of EducationShenyang Pharmaceutical UniversityShenyang 110016China The Institute of Rehabilitation Industry Fujian University of Traditional Chinese MedicineFuzhou 350122China Institute of Structural Pharmacology&TCM Chemical Biology College of PharmacyFujian University of Traditional Chinese MedicineFuzhou 350122China

Reprogramming of energy metabolism is one of the basic characteristics of cancer and has been proved to be an important cancer treatment *** dehydrogenases(IDHs)are a class of key proteins in energy metabolism,including IDH1,IDH2,and IDH3,which are involved in the oxidative decarboxylation of isocitrate to yield a-ketoglutarate(a-KG).Mutants of IDH1 or IDH2 can produce D-2-hydroxyglutarate(D-2HG)with a-KG as the substrate,and then mediate the occurrence and development of *** present,no IDH3 mutation has been *** results of pan-cancer research showed that IDH1 has a higher mutation frequency and involves more cancer types than IDH2,implying IDH1 as a promising anti-cancer ***,in this review,we summarized the regulatory mechanisms of IDH1 on cancer from four aspects:metabolic reprogramming,epigenetics,immune microenvironment,and phenotypic changes,which will provide guidance for the understanding of IDH1 and exploring leading-edge targeted treatment *** addition,we also reviewed available IDH1 inhibitors so *** detailed clinical trial results and diverse structures of preclinical candidates illustrated here will provide a deep insight into the research for the treatment of IDH1-related cancers.

关键词： IDH1 Cancer Regulatory mechanisms IDH1 inhibitors D-2HG Metabolic reprogramming Epigenetics Immune microenvironment

SHARP BOUNDS FOR TOADER-TYPE MEANS IN TERMS OF TWO-PARAMETER MEANS

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Acta Mathematica Scientia 2021年第3期41卷 719-728页

作者： yueying yang Weimao QIAN Hongwei ZHANG Yuming CHU School of Mechanical and Electrical Engineering Huzhou Vocational&Technical CollegeHuzhou 313000China School of Continuing Education Huzhou Vocational&Technical CollegeHuzhou 313000China School of Mathematics and Statistics Changsha University of Science&TechnologyChangsha 410014China Department of Mathematics Huzhou UniversityHuzhou 313000China

In the article,we prove that the double inequalities Gp[λ1a+(1-λ1)b,λ1 b+(1-λ1)a]A1-p(a,b)0 with a≠b if and only ifλ1≤1/2-(1-(2/π)2/p)1/2/2,μ1≥1/2-(2p)1/2/(4 p),λ2≤1/2+(2(3/(2 s)(E(21/2/2)/π)1/s)-1)1/2/2 andμ2≥1/2+s1/2/(4 s)ifλ1,μ1∈(0,1/2),λ2,μ2∈(1/2,1),p≥1 and s≥1/2,where G(a,b)=(ab)1/2,A(a,b)=(a+b)/2,T(a,b)=∫0π/2(a2 cos2 t+b2 sin2)1/2 tdt/π,Q(a,b)=((a2+b2)/2)1/2,C(a,b)=(a2+b2)/(a+b)and E(r)=∫0π/2(1-r^(2) sin^(2))1/2 tdt.

关键词： Geometric mean arithmetic mean Toader mean ontraharmonic mean complete elliptic integral

A practical strategy to subcutaneous administered in-situ gelling co-delivery system of arsenic and retinoic acid for the treatment of acute promyelocytic leukemia

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Asian Journal of Pharmaceutical Sciences 2021年第5期16卷 633-642页

作者： Xiao Liu Weiwei Yin Andy Samuel Widjaya yueying yang Yunhu Liu Yanyan Jiang Department of Pharmaceutics School of PharmacyFudan UniversityShanghai 201023China

Arsenic trioxide(ATO) combined with all trans retinoic acid(ATRA) is the first choice for the treatment of low and medium risk acute promyelocytic leukemia(APL). Clinical studies reported that the combination of ATO and ATRA could achieve a significant curative effect. However, the retinoic acid syndrome, serious drug resistance and the short half-life in vivo which lead to frequent and large dose administration limit the application of ATRA. In addition, the preparations of arsenic are conventional injections and tablets in clinic, which has poor patients’ compliance caused by frequent long-term administration and serious side effects. In order to overcome the above limitations, a phospholipid phase separation gel(PPSG) loaded with ATO and ATRA was developed. ATO + ATRA-PPSG(AAP), as a biodegradable sustained-release delivery system, was the first achievement of co-delivery of hydrophilic ATO and lipophilic ATRA with high drug loading which is the main problem in the application of nano preparation. The prepared PPSG displayed high safety and biocompatibility. The drug in PPSG was released slowly and continuously in vivo and in vitro for up to 10 d, which could reduce the side effects caused by the fluctuation of blood drug concentration and solve the problem of the long treatment cycle and frequent administration. In vivo pharmacokinetics depicted that PPSG could improve the bioavailability, decrease the peak concentration, and prolong the t 1/2 of ATO and ATRA. Particularly, AAP significantly inhibited the tumor volume, extended the survival period of tumor-bearing mice, and promoted the differentiation of APL cells into normal cells. Therefore, ATO + ATRA-PPSG not only could co-load hydrophilic ATO and lipophilic ATRA according to the clinical dosage, but also possessed the sustained-release and long-acting treatment effect which was expected to reduce administration time and ameliorate compliance of patients. Thus, it had great potential for clinical transforma

关键词： Arsenic trioxide All trans retinoic acid Phospholipid phase separation gel Sustained-release Bioavailability Compliance

Atomic-level coupled RuO_(2)/BaRuO_(3) heterostructure for efficient alkaline hydrogen evolution reaction

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Journal of Energy Chemistry 2024年第1期88卷 356-362,I0009页

作者： yueying Yan Tian Meng Yuting Chen yang yang Dewen Wang Zhicai Xing Xiurong yang State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022JilinChina School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026AnhuiChina

The slow water dissociation is the rate-determining step that slows down the reaction rate in alkaline hydrogen evolution reaction(HER).Optimizing the surface electronic structure of the catalyst to lower the energy barrier of water dissociation and regulating the binding strength of adsorption intermediates are crucial strategy for boosting the catalytic performance of *** this study,RuO_(2)/BaRuO_(3)(RBRO)heterostructures with abundant oxygen vacancies and lattice distortion were in-situ constructed under a low temperature via the thermal decomposition of *** RBRO heterostructures obtained at 550℃ exhibited the highest HER activity in 1 M KOH,showing an ultra-low overpotential of 16 mV at 10 mA cm^(-2)and a Tafel slope of 33.37 m V dec^(-1).Additionally,the material demonstrated remarkable durability,with only 25 mV of degradation in overpotential after 200 h of stability testing at 10 mA cm^(-2).Density functional theory calculations revealed that the redistribution of charges at the heterojunction interface can optimize the binding energies of H*and OH*and effectively lower the energy barrier of water *** research offers novel perspectives on surpassing the water dissociation threshold of alkaline HER catalysts by means of a systematic design of heterogeneous interfaces.

关键词： Heterostructure Hydrogen evolution reaction Interfacial electron transfer Oxygen vacancies

Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods

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Acta Pharmaceutica Sinica B 2020年第5期10卷 766-788页

作者： Canrong Wu yang Liu yueying yang Peng Zhang Wu Zhong Yali Wang Qiqi Wang yang Xu Mingxue Li Xingzhou Li Mengzhu Zheng Lixia Chen Hua Li Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation School of PharmacyTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Wuya College of Innovation Key Laboratory of Structure-Based Drug Design&DiscoveryMinistry of EducationShenyang Pharmaceutical UniversityShenyang 110016China National Engineering Research Center for the Emergency Drug Beijing Institute of Pharmacology and ToxicologyBeijing 100850China

SARS-CoV-2 has caused tens of thousands of infections and more than one thousand *** are currently no registered therapies for treating coronavirus *** of time consuming process of new drug development,drug repositioning may be the only solution to the epidemic of sudden infectious *** systematically analyzed all the proteins encoded by SARS-CoV-2 genes,compared them with proteins from other coronavirnses,predicted their structures,and built 19 structures that could be done by homology *** performing target-based virtual ligand screening,a total of21 targets(including two human targets)were screened against compound libraries including ZINC drug database and our own database of natural *** and screening results of important targets such as 3-chymotrypsin-like protease(3 CLpro),Spike,RNA-dependent RNA polymerase(RdRp),and papain like protease(PLpro)were discussed in *** addition,a database of 78 commonly used antiviral drugs including those currently on the market and undergoing clinical trials for SARS-CoV-2 was *** targets of these compounds and potential drugs acting on a certain target were *** study will provide new lead compounds and targets for further in vitro and in vivo studies of SARS-CoV-2,new insights for those drugs currently ongoing clinical studies,and also possible new strategies for drug repositioning to treat SARS-CoV-2 infections.

关键词： SARS-CoV-2 Drug repurposing Molecular docking Remdesivir Homology modeling

Vacancy engineering induced reaction kinetics enhancement of cobalt metaphosphate for pH-universal hydrogen evolution

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Nano Research 2024年第5期17卷 3879-3887页

作者： Yuting Chen Tian Meng Zhicai Xing yueying Yan yang yang Bohan Yao Dewen Wang Xiurong yang State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China

Developing efficient pH-universal hydrogen evolution reaction(HER)catalysts is critical in the field of water electrolysis,however,which is severely hampered by the sluggish kinetics in alkaline ***,a ruthenium(Ru)incorporation induced vacancy engineering strategy is firstly proposed to precisely construct oxygen vacancy(V_(O))-riched cobalt-ruthenium metaphosphate(CRPO)for high-efficiency pH-universal *** V_(O) modifies the electronic structure,improves the superficial hydrophilic and gas spillover capacity,it also reduces the coordination number of Ru atoms and regulates the coordination *** calculations indicate that Ru tends to adsorb H_(2)O and H^(*),whereas V_(O) tends to adsorb OH^(-),which greatly promotes the H_(2)O adsorption and the dissociation of HO-H ***,CRPO-2 exhibits remarkable HER performance,the mass activity is about 18.34,21.73,and 38.07 times higher than that of Pt/C in acidic,neutral,and alkaline media,respectively,at the same time maintain excellent *** findings may pave a new avenue for the rational design of electrocatalysts toward pH-universal water electrolysis.

关键词： cobalt metaphosphate pH-universal hydrogen evolution reaction(HER) vacancy engineering low-coordination atoms oxygen vacancy

交流滤波器电抗器故障时谐波电流异常增大分析

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广西电力 2024年第2期47卷 87-93页

作者：杨洁民彭福琨潘建雷朝煜岑韬李清杨月莹超高压输电公司天生桥局贵州兴义562400 超高压输电公司电力科研院广东广州510663 天生桥一级水电厂贵州兴义562400

本文分析了天生桥换流站交流滤波器电抗器故障原因,通过仿真实验分析得出在电抗器故障时,其35次、37次、47次、49次谐波电流异常过大的根本原因是电抗器故障导致交流滤波器阻抗发生变化,与系统其它支路发生并联谐振造成的,同时提出了防... 详细信息

本文分析了天生桥换流站交流滤波器电抗器故障原因,通过仿真实验分析得出在电抗器故障时,其35次、37次、47次、49次谐波电流异常过大的根本原因是电抗器故障导致交流滤波器阻抗发生变化,与系统其它支路发生并联谐振造成的,同时提出了防止天生桥换流站交流滤波器电抗器故障的解决措施。

关键词：交流滤波器电抗器谐波并联谐振

Minimally invasive bioprinting for in situ liver regeneration

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Bioactive Materials 2023年第8期26卷 465-477页

作者： yueying yang Zhengyang Yu Xiaohuan Lu Jiahao Dai Cheng Zhou Jing Yan Lin Wang Zheng Wang Jianfeng Zang School of Integrated Circuits and Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan430074PR China Research Center for Tissue Engineering and Regenerative Medicine Department of Gastrointestinal SurgeryWuhan Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022PR China Research Center for Tissue Engineering and Regenerative Medicine Department of Clinical LaboratoryWuhan Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022PR China State Key Laboratory of Digital Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan430074PR China

In situ bioprinting is promising for developing scaffolds directly on defect models in operating rooms,which provides a new strategy for in situ tissue ***,due to the limitation of existing in situ biofabrication technologies including printing depth and suitable bioinks,bioprinting scaffolds in deep dermal or extremity injuries remains a grand ***,we present an in vivo scaffold fabrication approach by minimally invasive bioprinting electroactive hydrogel scaffolds to promote in situ tissue *** minimally invasive bioprinting system consists of a ferromagnetic soft catheter robot for extrusion,a digital laparoscope for in situ monitoring,and a Veress needle for establishing a *** 3D reconstruction of the defects with computed tomography,electroactive hydrogel scaffolds are printed within partial liver resection of live rats,and in situ tissue regeneration is achieved by promoting the proliferation,migration,and differentiation of cells and maintaining liver function in vivo.

关键词： In vivo tissue regeneration In situ bioprinting Minimally invasive surgery Conductive hydrogel

基于正交试验法的KDF-5MF滤棒成型机设备参数优化

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自动化应用 2024年第15期65卷 300-303页

作者：李金奥张芸萍张文文杨玥莹廖小波红云红河烟草(集团)有限责任公司云南昆明650000

为解决因KDF-5MF设备运行速度提升后而造成的设备运行效率下降以及机器稳定性降低的问题,采用单因素方差分析筛选出影响设备运行效率的关键设备参数,并采用正交试验法对参数进行优化。通过改进设备参数配比,可以有效提高设备的运行稳定... 详细信息

为解决因KDF-5MF设备运行速度提升后而造成的设备运行效率下降以及机器稳定性降低的问题,采用单因素方差分析筛选出影响设备运行效率的关键设备参数,并采用正交试验法对参数进行优化。通过改进设备参数配比,可以有效提高设备的运行稳定性及生产效率。当SEF制动空气节流阀位置为45%、SEF滤嘴加速器超速为9%、SEF鼓负压为12 kPa时,设备的运行效率最高,由原有的82.46%提升至88.66%。经验证,该方法解决了因设备运行速度提升而带来的运行效率下降问题,提高了设备的运行稳定性,同时降低了因设备停机而出现产能不足、物料损耗、设备零部件损坏等的概率。

关键词： KDF-5MF设备设备参数正交试验法