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中医治疗病理性瘢痕的研究进展

中国中医药现代远程教育 2024年第8期22卷 172-175页

作者：马臣臣徐月新宋业强山东中医药大学第一临床医学院山东济南250000 山东省中医院美容皮肤科山东济南250000

病理性瘢痕不仅影响美观,严重者还可引发功能障碍以及焦虑情绪。目前西医治疗方案众多,但因其增生力强、复发率高的特点,一直是国内外专家研究的热点和思考的难题。临床研究发现,中医治疗本病效果好,具有不良作用少、复发率低的优势。... 详细信息

病理性瘢痕不仅影响美观,严重者还可引发功能障碍以及焦虑情绪。目前西医治疗方案众多,但因其增生力强、复发率高的特点,一直是国内外专家研究的热点和思考的难题。临床研究发现,中医治疗本病效果好,具有不良作用少、复发率低的优势。作者对中医治疗病理性瘢痕的研究进行综述,以期为治疗方案的选择提供参考,为患者制定个体化、科学有效的治疗方案。

关键词：蟹足肿病理性瘢痕中医药疗法传统疗法综述

临床研究兴趣小组教学在住院医师规范化培训中的应用

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中华医学教育杂志 2024年第5期44卷 375-378页

作者：王伟周彦许悦心万小祥施国伟徐炯查英复旦大学附属上海市第五人民医院泌尿外科上海200240 复旦大学附属上海市第五人民医院中医科上海200240 复旦大学附属上海市第五人民医院全科医学科上海200240 复旦大学附属上海市第五人民医院教育科上海200240

住院医师规范化培训以临床技能与临床思维为核心,但临床研究能力培养的需求日益凸显。目前,临床研究方法的教学存在着内容枯燥、模式落后、实践不足等问题。为了提高住院医师的临床研究实践能力,复旦大学附属上海市第五人民医院于2022年... 详细信息

住院医师规范化培训以临床技能与临床思维为核心,但临床研究能力培养的需求日益凸显。目前,临床研究方法的教学存在着内容枯燥、模式落后、实践不足等问题。为了提高住院医师的临床研究实践能力,复旦大学附属上海市第五人民医院于2022年3月至2023年2月在住院医师规范化培训中开展了临床研究兴趣小组教学。本文介绍了临床研究兴趣小组教学的教学目标、教学模块、教学形式、教学组织,并通过问卷调查、临床研究设计评阅进行教学效果评价。评价结果显示,参与临床研究兴趣小组教学的22名住院医师均对该教学活动感到满意,认为该教学有助于提高住院医师的临床研究实践和自主学习能力。临床研究兴趣小组教学体现了“以学生为中心”的教学理念,有助于提升住院医师人才培养质量。

关键词：实习医师和住院医师职务规范化培训临床研究兴趣小组

From risk control to resilience: developments and trends of urban roads designed as surface flood passages to cope with extreme storms

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Frontiers of Environmental Science & Engineering 2024年第2期18卷 103-120页

作者： Zhiyu Shao yuexin Li Huafeng Gong Hongxiang Chai College of Environment and Ecology Chongqing UniversityChongqing 400030China Key Laboratory of Ecological Environment of Ministry of Education of Three Gorges Reservoir Area Chongqing UniversityChongqing 400030China T.Y.Lin International Engineering Consulting(China)Co.Ltd. Chongqing 400045China

Urban roads can be designated as surface flood passages to transport excess runoff during extreme storms, thereby preventing local flooding, which is known as the major drainage system. However, this practice poses significant risks, including human loss and property damage, due to the high flow rate and velocity carried by roads. Moreover, urban roads with low flood-resilience may significantly hamper the transportation function during severe storms, leading to dysfunction of the city. Therefore, there is an urgent need to transform risk-oriented flood passages into resilient urban road-based flood passages. This paper presents a systematic review of existing methodologies in designing a road network-based flood passage system, along with the discussion of new technologies to enhance system resilience. The study also addresses current knowledge gaps and future directions. The results indicate that flood management measures based on the urban road network should integrate accessibility assessment, lifeline and emergency planning to ensure human well-being outcomes. Furthermore, the special needs and features of vulnerable groups must be taken into serious consideration during the planning stage. In addition, a data-driven approach is recommended to facilitate real-time management and evaluate future works.

关键词： Major drainage Flood mitigation Resilient city Stormwater model Urban flooding

循环microRNA检测在骨质疏松发生中的研究进展

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中国骨质疏松杂志 2020年第2期26卷 302-307页

作者：徐月新江苏省苏北人民医院妇产科

骨质疏松是最常见的与年龄相关的骨类疾病,常常无临床症状,一般骨折发生后才被确诊。通过骨密度和常规骨标志物很难评估骨质疏松患者骨质量及预测骨折风险。microRNA (miRNA)可以调控参与骨重构的成骨细胞和破骨细胞的分化及活性。研究... 详细信息

骨质疏松是最常见的与年龄相关的骨类疾病,常常无临床症状,一般骨折发生后才被确诊。通过骨密度和常规骨标志物很难评估骨质疏松患者骨质量及预测骨折风险。microRNA (miRNA)可以调控参与骨重构的成骨细胞和破骨细胞的分化及活性。研究发现绝经后妇女血清及骨组织中miRNA存在差异表达,提示miRNA一方面在骨重构中发挥重要作用,另一方面参与绝经后妇女骨质疏松的发生。本文就miRNA在骨质疏松及其骨折患者中调控作用的最新研究进行综述,并讨论循环miRNA作为骨质疏松新型生物标志物的可能。

关键词：骨质疏松循环microRNA 生物标志物

Recent process developments in beneficiation and metallurgy of rare earths:A review

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Journal of Rare Earths 2024年第4期42卷 629-642页

作者： Shaokai Cheng Wenbo Li yuexin Han Yongsheng Sun Peng Gao Xiaolong Zhang School of Resources and Civil Engineering Northeastern UniversityShenyang110819China National-local Joint Engineering Research Center of High-efficient Exploitation Technology for Refractory Iron Ore Resources Shenyang110819China

Rare earth elements(REEs)are irreplaceable materials supporting low-carbon technology and equip-ment,and their commercial demand and strategic position are becoming increasingly *** the continuous depletion of rare earth(RE)resources,developing high-efficiency beneficiation and eco-friendly metallurgical processes has attracted widespread *** paper reviews the major minerals exploited for RE production and their deposits,as well as the beneficiation and metallurgical processes of RE ***,monazite,mixed RE ores,and ion-adsorption clays are the main raw materials in the world to ***-bearing ores(except ion-adsorption minerals)are generally beneficiated by flotation,gravity and magnetic separation *** mainstream metallurgical processes for bastnaesite,monazite and mixed RE concentrates are oxidation roasting-HCl leaching,caustic soda decomposition and high-temperature concentrated sulfuric acid roasting,***-adsorption clays are directly processed by in situ leaching-precipitation/solvent *** achieve the sustainable development of RE resources,it is essential to further explore innovative techniques to achievecomprehensive utilization and cleaner production.

关键词： Rare earths Beneficiation processes Metallurgical processes Cleaner production

MIL-100(V) derived porous vanadium oxide/carbon microspheres with oxygen defects and intercalated water molecules as high-performance cathode for aqueous zinc ion battery

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Journal of Energy Chemistry 2024年第3期90卷 578-589,I0013页

作者： yuexin Liu Jian Huang Xiaoyu Li Jiajia Li Jinhu Yang Kefeng Cai Shanghai Key Laboratory of Development and Application for Metal-Functional Materials Key Laboratory of Advanced Civil Engineering MaterialsMinistry of EducationSchool of Materials Science&EngineeringTongji UniversityShanghai 201804China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 201800China Research Center for Translational Medicine East HospitalTongji University School of MedicineShanghai 200092China

The development of aqueous zinc ion battery cathode materials with high capacity and high magnification is still a ***,porous vanadium oxide/carbon(p-VO_(x)@C,mainly VO_(2) with a small amount of V_(2)O_(3)) core/shell microspheres with oxygen vacancies are facilely fabricated by using a vanadium-based metal-organic framework(MIL-100(V)) as a sacrificial *** unique structure can improve the conductivity of the VO_(x),accelerate electrolyte diffusion,and suppress structural collapse during ***,H_(2)O molecules are introduced into the interlayer of VO_(x) through a highly efficient in-situ electrochemical activation process,facilitating the intercalation and diffusion of zinc *** the activation,an optimal sample exhibits a high specific capacity of 464.3 mA h g^(-1) at0.2 A g^(-1) and 395.2 mA h g^(-1) at 10 A g^(-1),indicating excellent rate ***,the optimal sample maintains a capacity retention of about 89.3% after 2500 cycles at 10 A g^(-1).Density functional theory calculation demonstrates that the presence of oxygen vacancies and intercalated water molecules can significantly reduce the diffusion barrier for zinc *** addition,it is proved that the storage of zinc ions in the cathode is achieved by reversible intercalation/extraction during the charge and discharge process through various ex-situ analysis *** work demonstrates that the p-VO_(x)@C has great potential for applications in aqueous ZIBs after electrochemical activation.

关键词： Metal-organic frameworks Vanadium oxide Carbon Zn-ion batteries Electrochemical activation

Identification and functional characterization of the phosphorylation sites of Osterix,a key regulator of Osteoblast differentiation

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Identification and functional characterization of the phosph...

Acetylation modification is involved in the regulation of Osterix,a key regulator of Osteoblast differentiation

江苏省遗传学会2014年学术研讨会

作者： yuexin xu Kaikai Shi Jianlei Lu Bing Yao Changyan Ma Department of Developmental Genetics School of Basic Medical SciencesNanjing Medical University

Osterix（Osx） gene encodes a zinc-finger DNA-binding domain containing transcription factor,which is essential for osteoblast differentiation and bone *** posttranslational modifications including ubiquitination and phosphorylation have been reported to be involved in the regulation of Osx expression and activity,the precise underlying molecular mechanisms of phosphorylation modification remain to be *** this study,we combined bioinformatics analysis,mass spectrometric analysis and site directed mutagenesis to identify the phosphorylation site（s） of the Osx and roles of the phosphorylation modification in the protein stability and transactivation activity of Osx were *** identified S422 as a novel phosphorylation site of ***,we demonstrated that GSK-3β interacted and colocalized with Osx by Co-immunoprecipitation（Co-IP） assay and mmunofluorescence ***,Osx target genes detection by Real-time PCR and luciferase reporter assay showed that GSK-3β increased the protein stability and transactivation activity of Osx,and GSK-3β at least partially mediated the modification of the newly identified phosphorylation *** summary,our data revealed that S422 is a novel phosphorylation site of Osx and GSK-3β is at least partially involved in the S422 phosphorylation modification,therefore increasing the protein stability and transactivation activity of Osx.

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Acetylation modification is involved in the regulation of Os...

A Simple and Effective Surface Defect Detection Method of Power Line Insulators for Difficult Small Objects

江苏省遗传学会2014年学术研讨会

作者： Jianlei Lu yuexin xu Kaikai Shi Bing Yao Changyan Ma Department of Developmental Genetics School of Basic Medical SciencesNanjing Medical University

The transcription factor Osterix（Osx） is a key regulator of osteoblast differentiation and bone ***,we have demonstrated that Osx is ***,we studied whether Osx could be controlled at a post-translational level by *** found that the levels of both the endogenous and exogenous Osx protein increased after treatment with histone deacetylase inhibitors TSA and ***（IP） assays showed that CREB binding protein（CBP）,and less efficiently p300,acetylated *** interaction and colocalization of CBP and Osx was demonstrated by Co-IP and immunofluorescence（IF）,*** addition,K307 and K312 of Osx were identified as the acetylated ***,HDAC4,a histone deacetylase,was found to interact and be colocalizated with ***,acetylation promotes Osx stability,DNA binding ability and transactivation activity proved by Cycloheximide（CHX） treatment,electrophoretic mobility shift assay（EMSA）,and luciferase reporter assay,*** together,our results provide evidence for the first time that p300/CBP-mediated acetylation and HDAC4 mediated deacetylation may be critical modifications for Osx,thus play an important role in its function.

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Computers, Materials & Continua 2024年第4期79卷 373-390页

作者： Xiao Lu Chengling Jiang Zhoujun Ma Haitao Li yuexin Liu State Grid Jiangsu Electric Power Co. Ltd.Nanjing210024China State Grid Changzhou Power Supply Company Changzhou213003China

Insulator defect detection plays a vital role in maintaining the secure operation of power *** address the issues of the difficulty of detecting small objects and missing objects due to the small scale,variable scale,and fuzzy edge morphology of insulator defects,we construct an insulator dataset with 1600 samples containing flashovers and *** a simple and effective surface defect detection method of power line insulators for difficult small objects is ***,a high-resolution featuremap is introduced and a small object prediction layer is added so that the model can detect tiny ***,a simplified adaptive spatial feature fusion(SASFF)module is introduced to perform cross-scale spatial fusion to improve adaptability to variable multi-scale ***,we propose an enhanced deformable attention mechanism(EDAM)*** integrating a gating activation function,the model is further inspired to learn a small number of critical sampling points near reference *** the module can improve the perception of object *** experimental results indicate that concerning the dataset of flashover and breakage defects,this method improves the performance of YOLOv5,YOLOv7,and *** practical application,it can simply and effectively improve the precision of power line insulator defect detection and reduce missing detection for difficult small objects.

关键词： Insulator defect detection small object power line deformable attention mechanism