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Journal of Integrative Plant Biology 2024年第1期66卷 86-102页

作者： Yufei Zhang Lingyan Wang yuexin wu Donghui Wang Xin‐Qiang He State Key Laboratory of Protein and Plant Gene Research School of Life SciencesPeking UniversityBeijing 100871China

Secondary vascular tissue(SVT)development and regeneration are regulated by phytohormones.In this study,we used an in vitro SVT regeneration system to demonstrate that gibberellin(GA)treatment significantly promotes auxin-induced cambium reestablishment.Altering GA content by overexpressing or knocking down ent-kaurene synthase(KS)affected secondary growth and SVT regeneration in poplar.The poplar DELLA gene GIBBERELLIC ACID INSENSITIVE(PtoGAI)is expressed in a specific pattern during secondary growth and cambium regeneration after girdling.Overexpression of PtoGAI disrupted poplar growth and inhibited cambium regeneration,and the inhibition of cambium regeneration could be partially restored by GA application.Further analysis of the PtaDR5:GUS transgenic plants,the localization of PIN-FORMED 1(PIN1)and the expression of auxin-related genes found that an additional GA treatment could enhance the auxin response as well as the expression of PIN1,which mediates auxin transport during SVT regeneration.Taken together,these findings suggest that GA promotes cambium regeneration by stimulating auxin signal transduction.

关键词： auxin cambium gibberellin Populus secondary vascular tissue regeneration

Type IV collagen α5 chain promotes luminal breast cancer progression through c-Myc-driven glycolysis

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Journal of Molecular Cell Biology 2022年第10期14卷 37-49页

作者： yuexin wu Xiangming Liu Yue Zhu Yuemei Qiao Yuan Gao Jianfeng Chen Gaoxiang Ge State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beĳing 100049China Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer Hospital Zhengzhou 450008China Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China

Cancer cell metabolism reprogramming is one of the hallmarks of cancer.Cancer cells preferentially utilize aerobic glycolysis,which is regulated by activated oncogenes and the tumor microenvironment.Extracellular matrix(ECM)in the tumor microenvironment,including the basement membranes(BMs),is dynamically remodeled.However,whether and how ECM regulates tumor glycolysis is largely unknown.We show that type IV collagens,components of BMs essential for the tissue integrity and proper function,are differentially expressed in breast cancer subtypes thatα5 chain(α5(IV))is preferentially expressed in the luminal-type breast cancer and is regulated by estrogen receptor-α.α5(IV)is indispensable for luminal breast cancer development.Ablation ofα5(IV)significantly reduces the growth of luminal-type breast cancer cells and impedes the development of luminal-type breast cancer.Impaired cell growth and tumor development capability ofα5(IV)-ablated luminal breast cancer cells is attributed to the reduced expression of glucose transporter and glycolytic enzymes and impaired glycolysis in luminal breast cancer cells.Non-integrin collagen receptor discoidin domain receptor-1(DDR1)expression and p38 mitogen-activated protein kinase activation are attenuated inα5(IV)-ablated luminal breast cancer cells,resulting in reduced c-Myc oncogene expression and phosphorylation.Ectopic expression of constitutively active DDR1 or c-Myc restores the expression of glucose transporter and glycolytic enzymes,and thereafter restores aerobic glycolysis,cell proliferation,and tumor growth of luminal breast cancer.Thus,type IV collagenα5 chain is a luminal-type breast cancer-specific microenvironmental regulator modulating cancer cell metabolism.

关键词： luminal breast cancer basement membrane type IV collagen COL4A5 glycolysis Myc

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双一流高校学生数据素养能力评价及提升策略

新世纪图书馆 2024年第1期 27-34页

作者：高伟郭书宏吴悦昕徐绪堪河海大学图书馆资源建设部江苏南京213022 河海大学商学院江苏南京213022 河海大学江苏南京213022

数字经济时代,科学数据素养成为双一流高校学生综合素质能力评价的重要组成部分。为了提升双一流高校学生数据素养能力,论文在分析国内外数据素养研究现状基础上,基于科学数据生命周期理论及KSAO模型构建了双一流高校学生科学数据素养... 详细信息

数字经济时代,科学数据素养成为双一流高校学生综合素质能力评价的重要组成部分。为了提升双一流高校学生数据素养能力,论文在分析国内外数据素养研究现状基础上,基于科学数据生命周期理论及KSAO模型构建了双一流高校学生科学数据素养评价体系,并依此选取河海大学作为调研对象进行实证调查和分析,根据分析结果提出针对性提升策略。

关键词：数据素养评价指标 KSAO模型层次分析法

Service-Oriented Middleware for Heterogeneous Environment in Internet of Things

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China Communications 2012年第9期9卷 41-51页

作者： wu yuexin Zhang Yinghai Fan Chunxiao Zou Junwei School of Electronic Engineer Beijing University of Posts and TelecommunicationsBeijing 100876P.R.China

A great number of sensor technologies are applied in the Internet of Things (IoT) currently and more are emerging,which makes the IoT a heterogeneous network.This paper discusses the convergence and integration problem in IoT.A Service-Oriented Middleware for Heterogeneous Environment (SOMHE) in IoT is proposed.The purpose of the middleware is to shield the difference between protocols in the sensor layers such as Radio Frequency Identification (RFID) and ZigBee by defining the data conversion and mapping model.A Web service interface is supplied by this middleware,thus the complexity of high level application development can be reduced greatly.The feasibility and reliability of this middleware is verified by a demonstration system.

关键词：异构环境面向服务中间件物联网因特网传感器技术可靠性验证异构网络

X-box binding protein 1 caused an imbalance in pyroptosis and mitophagy in immature rats with di-(2-ethylhexyl)phthalate-induced testis toxicity

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Genes & Diseases 2024年第2期11卷 935-951页

作者： Yifan Hong Xiazhu Zhou Qi Li Jing Chen yuexin Wei Chunlan Long Lianju Shen Xiangqin Zheng Dinggang Li Xia Wang Chenjun Yu Shengde wu Guanghui Wei Department of Urology Children's Hospital of Chongqing Medical UniversityChongqing 400014China Pediatric Research Institute Children's Hospital of Chongqing Medical UniversityChongqing 400014China Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering Children's Hospital of Chongqing Medical UniversityChongqing 400014China Chongqing Key Laboratory of Pediatrics Children's Hospital of Chongqing Medical UniversityChongqing 400014China Ministry of Education Key Laboratory of Child Development and Disorders Children's Hospital of Chongqing Medical UniversityChongqing 400014China National Clinical Research Center for Child Health and Disorders Children's Hospital of Chongqing Medical UniversityChongqing 400014China China International Science and Technology Cooperation Base of Child Development and Critical Disorders Children's Hospital of Chongqing Medical UniversityChongqing 400014China

As a widely used plasticizer,di-(2-ethylhexyl)phthalate(DEHP)is known to induce significant testicular injury.However,the potential mechanism and effects of pubertal exposure to DEHP on testis development remain unclear.In vivo,postnatal day(PND)21 male rats were gavaged with 0,250,and 500 mg/kg DEHP for ten days.Damage to the seminiferous epithelium and disturbed spermatogenesis were observed after DEHP exposure.Meanwhile,oxidative stress-induced injury and pyroptosis were activated.Both endoplasmic reticulum(ER)stress and mitophagy were involved in this process.Monoethylhexyl phthalate(MEHP)was used as the biometabolite of DEHP in vitro.The GC-1 and GC-2 cell lines were exposed to 0,100μM,200μM,and 400μM MEHP for 24 h.Reactive oxygen species(ROS)generation,oxidative stress damage,ER stress,mitophagy,and pyroptosis were significantly increased after MEHP exposure.The ultrastructure of the ER and mitochondria was destroyed.X-box binding protein 1(XBP1)was observed to be activated and translocated into the nucleus.ROS generation was inhibited by acetylcysteine.The levels of antioxidative stress,ER stress,mitophagy,and pyroptosis were decreased as well.After the administration of the ER stress inhibitor 4-phenyl-butyric acid,both mitophagy and pyroptosis were inhibited.Toyocamycin-induced XBP1 down-regulation decreased the levels of mitophagy and pyroptosis.The equilibrium between pyroptosis and mitophagy was disturbed by XBP1 accumulation.In summary,our findings confirmed that DEHP induced a ROS-mediated imbalance in pyroptosis and mitophagy in immature rat testes via XBP1.Moreover,XBP1 might be the key target in DEHP-related testis dysfunction.

关键词： DEHP Mitophagy Pyroptosis Testicular development XBP1

广义SBM模型及其在医疗机构效率分析中的应用

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内蒙古大学学报（自然科学版） 2023年第5期54卷 537-547页

作者：曹莉马智瑞马占新吴悦欣内蒙古医科大学计算机信息学院呼和浩特010110 山西医科大学公共卫生学院太原030001 内蒙古大学经济管理学院呼和浩特010021

SBM模型是一种重要的DEA模型,由于其考虑到了各指标的松弛量,因此,在实践中得到广泛应用。然而,该方法也存在不足之处:(1)原有的DEA生产可能集由所有决策单元构成,但实际上决策单元的参考集可能包含更多的形式。(2)对决策单元的数据按... 详细信息

SBM模型是一种重要的DEA模型,由于其考虑到了各指标的松弛量,因此,在实践中得到广泛应用。然而,该方法也存在不足之处:(1)原有的DEA生产可能集由所有决策单元构成,但实际上决策单元的参考集可能包含更多的形式。(2)对决策单元的数据按年度分组计算DEA效率的方法可能缺乏传递性。(3)SBM模型无法测算残缺的面板数据。为了解决这些问题,本文提出了可以依据多种生产前沿面,对带有非期望产出的非平衡面板数据进行评价的基于广义参考集的SBM模型,并应用该模型分析了内蒙古地区三甲医院的效率状况。

关键词：多目标决策综合评价数据包络分析 SBM模型医疗机构

接纳与排斥:融合教育背景下残疾人的职业教育体验

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中国特殊教育 2024年第1期 17-28页

作者：张悦歆王琪武之琳北京师范大学教育学部北京100875

残疾人在融合教育环境中的经历和感受是职业教育中不容忽视的重要部分,但目前对融合环境教育中的残疾人职业教育的质性研究仅有少数。经过筛选和质量评估,共有20篇文献被纳入,均为英文文献。该研究对纳入文献进行质性元分析,经概念转译... 详细信息

残疾人在融合教育环境中的经历和感受是职业教育中不容忽视的重要部分,但目前对融合环境教育中的残疾人职业教育的质性研究仅有少数。经过筛选和质量评估,共有20篇文献被纳入,均为英文文献。该研究对纳入文献进行质性元分析,经概念转译与提炼,研究主题可归纳为外界接纳体验、外界排斥体验、自我接纳体验、自我排斥体验4个主题。该研究的发现一定程度上解释了残疾人职业教育质量和就业结果的影响因素,为融合教育环境下残疾人如何进行职业准备提供了参考。

关键词：残疾人职业教育质性元分析

Chaos－Shift－Keying　Secure　Digital　Communications　Using　Feedback　to　Synchronize　Chua＇s　Circuit

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The Journal of China Universities of Posts and Telecommunications 1996年第1期3卷 43-47页

作者： Liu Jie Cai Tao Xiao Jinghua Zhang Yinghai and wu yuexin(Department of Applied Science and Technology, Beliing University of Posts and Telecommunications,Beijing 100088,P.R.China)

in this paper a chaotic secure communication System using a feedback controlling subsystem is presented.The transmitter and the receiver are built with Chua's circuits.We find that,using feedback controlling,the time for the receiver to obtain the Synchronization with the transmitter can be obviously decreased.Thecorrelation between the time and the feedback coefficient is presented at the end of this paper.

关键词： s:digital communications,chaos,synchronization,feedback

基于非局部U-Net模型的汽车零部件缺陷分割算法

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电子设计工程 2022年第16期30卷 70-74页

作者：孙繁荣肖楠吴月新工业互联网创新中心(上海)有限公司上海201303

为了保证汽车零部件的生产质量,采用了一种基于非局部U-Net卷积神经网络的轴套缺陷自动分割算法,在汽车零部件出厂之前便可准确检测出存在的缺陷。通过在原始的U-Net网络中引入了规范化非局部模块的方法,可以提升模型的准确性和鲁棒性... 详细信息

为了保证汽车零部件的生产质量,采用了一种基于非局部U-Net卷积神经网络的轴套缺陷自动分割算法,在汽车零部件出厂之前便可准确检测出存在的缺陷。通过在原始的U-Net网络中引入了规范化非局部模块的方法,可以提升模型的准确性和鲁棒性。在轴套数据库上的实验结果表明,非局部U-Net网络在汽车零部件的缺陷分割中取得了不错的效果,Dice系数达到了0.812 9,该模型可以很好地实现汽车零部件图像缺陷的自动化分割,满足自动化无损检测的要求。

关键词：缺陷分割语义分割深度学习卷积神经网络数据增强

2006—2020年国际组织人才培养与输送研究述评

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世界教育信息 2022年第9期35卷 49-57页

作者：覃云云李蓥妍吴岳欣北京外国语大学国际教育学院

文章系统梳理了我国2006—2020年关于“国际组织人才培养与输送”的主要研究成果,并总结了国际组织人才培养与输送在国别研究中的主要特点。研究显示,国际组织人才培养与输送相关学术成果在总体数量上呈增长趋势,并基本形成了以师范类... 详细信息

文章系统梳理了我国2006—2020年关于“国际组织人才培养与输送”的主要研究成果,并总结了国际组织人才培养与输送在国别研究中的主要特点。研究显示,国际组织人才培养与输送相关学术成果在总体数量上呈增长趋势,并基本形成了以师范类高校和外国语类高校为主、综合类大学有所涉及的研究集群。国际组织人才培养和输送的研究领域呈现出多学科的研究特点,研究方法以文献研究为主,缺乏实地研究。国际组织人才培养与输送的国别研究对象主要集中在发达国家,并主要呈现出三大模式:自下而上,注重人才培养的美英模式;自上而下,注重人才输送的日韩模式;上下联动,人才培养与输送并重的瑞法模式。

关键词：国际组织人才培养人才输送