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Chinese Herbal Medicines 2022年第3期14卷 464-469页

作者： Dan Li yuetao liu Xuemei Qin Modern Research Center for Traditional Chinese Medicine Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of EducationShanxi UniversityTaiyuan 030006China Shanxi Key Laboratory of Effective Substances Research and Utilization in Traditional Chinese Medicine Taiyuan 030006China

Objective:Astragali Radix(AR)is one of the most widely used traditional Chinese medicines(TCMs)for tonic,which can be divided into wild-simulated and cultivated AR according to its cultivation method.However,whether cultivated AR can replace wild-simulated AR has always been a concern.Methods:In this study,a rapid,highly sensitive and specific analytical method using ultra-high performance liquid chromatography tandem mass spectrometry(UHPLC-MS)was developed to quantitatively measure 12 chemical constituents of AR in the different cultivation methods.Results:AR samples were analyzed with a good linear regression relationship(R2,0.9983–0.9995),precisions(relative standard deviation(RSD),1.31%-2.36%),repeatability(RSD,2.65%-4.92%),stability(RSD,1.50%-4.05%),and recovery(95.13%-106.52%).Through the determination of AR samples,we found the components of favonoids in wild-simulated AR were higher than cultivated AR,the saponins in cultivated AR were higher,the ratio of saponins/favonoids in cultivated AR was higher than wildsimulated AR.Conclusion:Based on this research,it could provide guidance for the quality control of AR.

关键词： Astragali Radix chemical constituent cultivation method quantification UHPLC-MS

Cephalopods-inspired Repairable MWCNTs/PDMS Conductive Elastomers for Sensitive Strain Sensor

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Chinese Journal of Polymer Science 2022年第4期40卷 384-393页

作者： Kaiming Zhang Zhe Wang yuetao liu Haoyu Zhao Chuanhui Gao Yumin Wu State Key Laboratory Base for Eco-Chemical Engineering College of Chemical EngineeringQingdao University of Science and TechnologyQingdao 266042China Key Laboratory of Colloid and Interface Chemistry and Key Laboratory of Special Aggregated Materials(Ministry of Education) Shandong UniversityJinan 250100China

Flexible electronic devices based on reversible bonds for self-curing capabilities arouses extensive interest.However,most of the composite conductive elastomers have the problems of poor mechanical properties and slow recovery of mechanical properties during multiple stretching,which hinder their stability in continuous operation.In this study,hyperbranched-MWCNTs/hyperbranched-PDMS self-healable conductive elastomers inspired by cephalopods were successfully developed.The prepared conductive elastomer exhibited good self-healing ability(91%)at room temperature excited by multiple reversible interactions.The prepared elastomer showed outstanding mechanical properties and anti-fatigue ability,so that it can cope with more arduous tasks.Moreover,the elastomer was sensitive to the change of stress states and can be used as a stable strain sensor.Therefore,the self-repairing conductive elastomer has potential practicability in the fields of human-computer interaction,motion monitoring,soft robot and so on.

关键词： Self-healable Reversible interactions Hyperbranched Anti-fatigue Strain sensor

基于ZYNQ的Stewart并联机器人运动学算法实现

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传感器与微系统 2024年第7期43卷 141-144页

作者：边宗政刘曰涛于长松姜佩岑山东理工大学机械工程学院山东淄博255000

针对实时的控制和监控,而导致Stewart机器人实时性不高的问题,提出了基于ZYNQ芯片的软硬件协同计算Stewart并联机器人运动学解的方案。ZYNQ芯片集成了PL(FPGA)和PS(ARM)两种不同的嵌入式芯片,PL(FPGA)作为PS(ARM)的协处理器进行运动学... 详细信息

针对实时的控制和监控,而导致Stewart机器人实时性不高的问题,提出了基于ZYNQ芯片的软硬件协同计算Stewart并联机器人运动学解的方案。ZYNQ芯片集成了PL(FPGA)和PS(ARM)两种不同的嵌入式芯片,PL(FPGA)作为PS(ARM)的协处理器进行运动学算法解算,PS(ARM)则运行实时系统,对Stewart机器人进行实时的控制。实验证明:硬件计算Stewart并联机器人运动学解与理论计算结果误差在合理范围内,且解算时间满足实时系统控制周期小于2ms的要求。

关键词： Stewart并联机器人运动学 ZYNQ芯片高层次综合 Linux系统

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用于纳米压电定位平台的电容传感器设计

传感器与微系统 2024年第4期43卷 100-103页

作者：付连壮刘曰涛韩振蔡如岩李自帅山东理工大学机械工程学院山东淄博255049

针对纳米压电定位平台中电阻应变片式传感器无法满足定位精度的问题,设计了一种非接触式测量的双极板电容式位移传感器。首先,详细分析了电容传感器的基本测量原理和闭环控制原理。对电容传感器固有的边缘效应问题进行理论分析,并通过... 详细信息

针对纳米压电定位平台中电阻应变片式传感器无法满足定位精度的问题,设计了一种非接触式测量的双极板电容式位移传感器。首先,详细分析了电容传感器的基本测量原理和闭环控制原理。对电容传感器固有的边缘效应问题进行理论分析,并通过保护环措施消除其影响。在建立电磁仿真参数模型的基础上,带保护环结构的电容仿真值与理想值误差小于1.8%。改进了一种基于有源电桥的高灵敏度运算放大器式电容检测电路,使电路具有更高的分辨率和线性度。通过对该传感器进行标定,其测量范围在0~30μm内,线性度为0.05%,分辨力优于0.01μm。

关键词：电容传感器压电平台闭环控制保护环电磁仿真电容检测电路

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基于FPGA的永磁同步电机速度控制

组合机床与自动化加工技术 2024年第4期 131-134,140页

作者：于长松刘曰涛姜佩岑邹大林祝保财山东理工大学机械工程学院淄博255049

针对永磁同步电机(PMSM)速度控制器中采用传统PI控制存在响应速度慢、超调量大以及容易出现积分饱和等问题,设计了采取Anti-Windup策略的速度控制器,并在现场可编辑逻辑门阵列(FPGA)中实现对PMSM的控制。首先采用高层次综合技术(HLS)对P... 详细信息

针对永磁同步电机(PMSM)速度控制器中采用传统PI控制存在响应速度慢、超调量大以及容易出现积分饱和等问题,设计了采取Anti-Windup策略的速度控制器,并在现场可编辑逻辑门阵列(FPGA)中实现对PMSM的控制。首先采用高层次综合技术(HLS)对PMSM伺服控制关键模块完成建模,其次封装成IP核导入到工程中,最后下载到FPGA芯片上完成对PMSM的控制。经过与传统PI控制器实验比较,使用该速度控制方法超调量减小到4.3%,在负载处转速下降了14r/min,调节时间为0.01s,具有良好的动态性能和抗干扰性能,满足永磁同步电机伺服控制系统的应用需求。

关键词：现场可编辑逻辑门阵列高层次综合技术永磁同步电机 Anti-Windup策略

An Economical Method for Preparative Purification of Five Alkaloids from Coptis Chinensis Franch by High-Speed Counter-Current Chromatography Using Singled Prepared Solvent System by GC

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American Journal of Analytical Chemistry 2011年第4期2卷 411-421页

作者： Lianhong Yin Lina Xu Xiaona Wang Binan Lu Yingnan Li Mingming Hu yuetao liu Jinyong Peng College of Pharmacy Dalian Medical University 9 Western Lvshun South Road Dalian 116044 China

Coptis chinensis Franch, a widely used Traditional Chinese Medicine, shows various kinds of bioactivity. The major active components of the herb are considered to be alkaloids. Thus, preparative separation of these alkaloids is critical important for further pharmacology and mechanism studies. In the paper, five alkaloids from C. chinensis were purified by HSCCC using the solvent system composed of chloro-form-metha- nol-water (2:1:1, v/v/v) single prepared. The content of each solvent in solvent system were determined by gas chromatography (GC), then according the ratios of solvents in each phase to prepare the mobile and stationary phase respectively. And a comparative study was carried out between together preparation and single preparation of the solvent system. The purities and recoveries of all the products were over 98.5% and 92%. However, 134 mL chloroform, 336 mL methanol and 452 mL water were saved when the two phase were singled by GC. Our research showed an economical method for separating alkaloids from C. chinensis by HSCCC using the solvent system single prepared by GC.

关键词： Alkaloid Coptis Chinensis Franch High Speed Counter-Current Chromaotgraphy Gas Chromatography Solvent System

Research on the Orientated Effective Components of Huangqi in Huangqi Jianzhong Tang Against Chronic Atrophic Gastritis Based on Multi-Spectrum–Effect Correlation

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 244-253页

作者： Guo-Hong Wang Long-Fei Yang Shi-Wei Wang Yue-Tao liu Department of Pharmacy Shanxi Traditional Chinese Medicine Hospital Department of Pharmacy Shijiazhuang Hospital of Traditional Chinese Medicine Modern Research Center for Traditional Chinese Medicine Key Laboratory of Chemical Biology and Molecular Engineering of the Ministry of Education Key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province Shanxi University

Objective: This study aimed to investigate the orientated effective components of Astragali Radix Huangqi(HQ) in HQ Jianzhong Tang(HQJZ), a classical formula of traditional Chinese medicine(TCM) used for treating chronic atrophic gastritis(CAG), using HQ as a monarch medicine. Materials and Methods: The spectra of HQJZ containing different polar parts of HQ were obtained using ultra-high-performance liquid chromatography-Q-Exactive mass spectrometry. Furthermore, the efficacy of HQJZ, which contains different polar parts of HQ, in treating rats with CAG was evaluated using traditional pharmacodynamic and nuclear magnetic resonance-based metabonomics. Grey relation analysis and partial least squares analysis were applied to analyze the spectrum–effect relationship and to screen out the orientated effective components related to HQ in the treatment of CAG. Results: Spectrum–effect relationship analysis showed that 24 compounds identified from the fingerprint spectrum were strongly correlated with efficacy. Compounds 8(calycosin-7-O-glc-6”-O-acetate), 9(3-hydroxy-9, 10-dimethoxyptercarpan), and 22(astragaloside II) were ranked among the top three. Conclusions: This study showed that integrating metabolomics and spectrum–effect relationship analysis is a powerful tool for obtaining orientated effective components of Chinese medicine in a given TCM formula.

关键词： Astragali radix chronic atrophic gastritis Huangqi Jianzhong Tang metabonomics spectrum-effect relationship

互利共生在有机化学中的应用:锡氢烷的杂脱氢偶联与喹啉还原的相互促进

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Chinese Journal of Catalysis 2024年第3期58卷 129-137页

作者：刘天伟何江华张越涛吉林大学化学学院超分子结构与材料国家重点实验室吉林长春130012

S,O,N,P与Sn原子组成的杂原子锡化合物(SSn,OSn,NSn和PSn)在有机合成和医药领域中具有广泛的应用.目前,构建杂原子锡化合物主要采用传统的复分解方法,但这种方法反应条件苛刻且效率低.其他构建杂原子锡化合物的方法,如加成反应和自由基... 详细信息

S,O,N,P与Sn原子组成的杂原子锡化合物(SSn,OSn,NSn和PSn)在有机合成和医药领域中具有广泛的应用.目前,构建杂原子锡化合物主要采用传统的复分解方法,但这种方法反应条件苛刻且效率低.其他构建杂原子锡化合物的方法,如加成反应和自由基反应等,也存在底物范围较窄的问题.在锡烷杂脱氢偶联反应中,锡烷上的负氢和杂原子上的正氢以氢气的方式逸出,该过程需要较高的反应能量,可能导致部分底物反应困难或效率低.为了解决上述问题,本课题组在前期工作中(Adv.Synth.Catal.,2021,363,5319–5329)将互利共生的概念应用于有机合成,采用B(C_(6)F_(5))_(3)作为催化剂,通过一锅法实现吲哚的C3位硅烷化或硼烷化以及喹啉的还原.在这一过程中,喹啉能够将副产物吲哚啉上的正氢和负氢通过氢转移的方式移除,既促进了吲哚的官能化反应,又实现了自身的还原.在前期工作的基础上,本文以B(C_(6)F_(5))_(3)为催化剂,在锡烷杂脱氢偶联反应中引入喹啉,协助锡烷和杂原子上的负氢和正氢以氢转移的方式移除,该反应同时会促进喹啉还原得到四氢喹啉.在反应过程中,B(C_(6)F_(5))_(3)催化喹啉的1,4-氢锡化反应生成少量1,4-N-锡化-二氢喹啉,反应很快达到平衡.同时游离的B(C_(6)F_(5))_(3)与杂原子氢化合物(EH)底物组成中间体[ESnH]+[HB(C_(6)F_(5))_(3)]‒,该中间体通过氢转移将1,4-N-锡化-二氢喹啉中间体转化为N-锡化-四氢喹啉进而加速喹啉的还原,而1,4-N-锡化-二氢喹啉可以作为氢受体促进[ESnH]+[HB(C_(6)F_(5))_(3)]‒中间体转化生成ESn(E=S,O,N和P).N-锡化-四氢喹啉与EH发生复分解反应迅速生成另一分子ESn和四氢喹啉,实现相互促进的过程.该策略能够在温和条件下快速获得57种ESn产物和17种四氢喹啉产物.在喹啉的辅助下,含有较大位阻或强吸电子基团的酚类、部分烷基醇、苯胺、吲哚、烷基或芳基磷底物的产率明显提升.利用该反应体系,以较高的产率合成了两种药物结构的类似物.根据一系列控制实验、反应监测、关键中间体捕获及合成实验和氘代控制实验结果,提出了反应机理.该互促反应由三部分组成,分别为喹啉的1,4-氢锡化、正负氢转移以及复分解反应,氢锡化和氢转移反应相互促进,复分解反应同时促进氢锡化和氢转移,进而实现整个反应的相互促进.综上,本工作高效合成了杂原子锡化合物以及四氢喹啉化合物,并对反应机理进行了详尽的研究和阐述,为有机锡化合物的构建和应用提供借鉴和参考.

关键词：互利共生三(五氟)苯基硼杂脱氢偶联还原反应喹啉

Effectiveness and safety of acupuncture in treatment of pregnancyrelated symptoms:a systematic review and Meta-analysis

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Journal of Traditional Chinese Medicine 2024年第1期44卷 16-26页

作者： liu Tingting liu Tongou liu Mingfu School of Traditional Chinese Medicine Clinical Medicine Hubei University of Traditional Chinese MedicineWuhan 430000China First Clinical College of Hubei University of Traditional Chinese Medicine Wuhan 430000China Department of Acupuncture and Tuina Affiliated Hospital of Hubei University of Traditional Chinese MedicineHubei Provincial Hospital of Traditional Chinese MedicineWuhan 430000China

OBJECTIVE:To systematically evaluate the efficacy and safety of acupuncture(AM)in the treatment of pregnancyrelated symptoms such as acute vomiting during pregnancy.METHODS:We comprehensively searched the available literature up to November 2021,including Pub Med,Embase,Cochrane Library,Chinese Biomedical Literature Database,and China National Knowledge Infrastructure Database,for randomized controlled trials(RCTs)on AM for the treatment of severe vomiting,insomnia,pharyngeal and pelvic pain,mood abnormalities,and dyspepsia during pregnancy.RESULTS:Sixteen RCTs with a cumulative sample size of 1178 cases were included.Of these,964 patients were included in the Meta-analysis.The Meta-analysis results showed that AM was more efficient than Western medicine in treating discomfort during pregnancy[odds ratio(OR)=1.19,95%confidence interval(CI)(1.11,1.28),P<0.01].AM was better than the control group in improving the visual analog scale scores[standard mean difference(SMD)=0.62,95%CI(0.53,0.71),P<0.01].AM was superior to the control group in improving Numerical Rating Scale(NRS)symptom scores[OR=7.31,95%CI(3.36,15.94),P<0.01].There was no significant difference in adverse effects between the AM and sham-AM groups and the analgesic drug group[OR=0.70,95%CI(0.39,1.28),P=0.25],but the treatment and control groups had mild adverse effects with a low incidence.CONCLUSIONS:AM is more effective than other treatments or pharmacotherapy alone in the treatment of pregnancy-related symptoms,and is relatively safe.However,the quality of the included trials was rather poor,and high-quality studies are required to confirm our findings.

关键词： acupuncture pregnancy nausea vomiting sleep initiation and maintenance disorders low back pain pelvic pain mood abnormalities Meta-analysis systematic review

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女子柔道运动员尿液代谢组学代谢物特点研究

中国体育科技 2023年第5期59卷 20-26页

作者：赵丽霞刘月涛朱彦蓉邵彤太原师范学院山西晋中030619 山西大学山西太原030006 山西工商学院山西太原030006 山西省体育科学研究所山西太原030000

目的:通过对女子柔道运动员运动训练后的尿液代谢组学代谢物特征的研究,分析运动员运动训练后的代谢物变化与运动训练状态监测心理量表评定值的关系,探究运动训练负荷对运动员的影响。方法:以山西女子柔道队18名参加日常训练的运动员为... 详细信息

目的:通过对女子柔道运动员运动训练后的尿液代谢组学代谢物特征的研究,分析运动员运动训练后的代谢物变化与运动训练状态监测心理量表评定值的关系,探究运动训练负荷对运动员的影响。方法:以山西女子柔道队18名参加日常训练的运动员为研究对象,采用1H核磁共振波谱(1H nuclear magnetic resonance,1H NMR)法指认运动员尿液代谢组学代谢物,并对积分数据进行多元统计分析,了解其尿液代谢物分布特点;向运动员发放运动训练状态监测量表;采用SPSS 21.0软件对数据进行统计分析,采用单因素方差分析法分析运动员尿液代谢组学代谢物峰面积值的差异性,分析运动训练状态监测心理量表评定值间的差异性。结果:1)在1H NMR的主要化合物归属中共指认出24种化合物。采用PCA散点图观察样本的聚类特征,将除2号样本外的其余17个样本分为3个组别(A、B、C组);2)A、B、C组在所指认的代谢物缬氨酸、谷氨酰胺、琥珀酸、胆碱上有显著差异(P<0.05),A组的峰面积均值较大;3)A、B、C组在心理疲劳上有显著差异(P<0.05),A组运动训练状态监测心理量表评定均值较B、C组均值更大,即A组在心理疲劳上较B、C组更明显。结论:1)基于1H NMR法研究运动员尿液代谢组学代谢物特点,可以客观反映女子柔道运动员在运动训练后机体的代谢状况;2)运动训练状态监测评定为心理疲劳的A组运动员,其代谢物缬氨酸、谷氨酰胺、琥珀酸、胆碱相对含量升高,可能是由运动员对运动训练的应激-适应所导致的。从机体代谢物的角度对运动员进行运动训练监测,可反映运动员机体机能代谢特点与运动员较早出现心理疲劳之间的联系。

关键词：女子柔道运动员尿液代谢组学代谢物