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Chinese Chemical Letters 2024年第3期35卷 415-418页

作者： Chunyang zhang Yuelan Li Zhaojun Chu Shuangzhi Yuan Yanan Qiao Jiaozhen zhang Lin Li yueqing zhang Ruifeng Tian Yajie Tang Hongxiang Lou Department of Natural Products Chemistry Key Lab of Chemical Biology(MOE)School of Pharmaceutical SciencesShandong UniversityJi'nan 250012China State Key Laboratory of Microbial Technology Shandong UniversityQingdao 266237China

Two distinctive rearranged 19-nor-7,8-seco-labdane diterpenoids(1 and 2)with a novel tetracyclo[5.***.1.0^(2,5.)0^(4,10)]decane skeleton,a derivative of the open tetrahydrofuran ring(7),three dimeric compounds(8-10),and four revised homologs(3-6)were obtained from Chinese liverwort Pallavicinia ambigua.Their structures were identified via combined analysis of their spectroscopic data,single-crystal X-ray diffraction patterns,and ECD calculations.The light-driven conversion of compound 5 to compounds 1-4 demonstrated that photochemically induced postmodification involved in biosynthesis is an important way to diversify natural structures.A preliminary cytotoxicity assay revealed that compound 5 showed significant inhibition in the human prostate cancer(PC-3)cell line via an apoptotic pathway.

关键词： Liverwort Pallavicinia ambigua 19-nor-7 8-seco-Labdan diterpenoid Photoinduced rearrangement Cytotoxic activity

Urban and rural transport of semivolatile organic compounds at regional scale: A multimedia model approach

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Journal of Environmental Sciences 2016年第1期28卷 228-241页

作者： Shuai Song Chao Su Yonglong Lu Tieyu Wang yueqing zhang Shijie Liu State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences

Urban areas are generally regarded as major sources of some semivolatile organic compounds and other persistent organic pollutants（POPs） to the surrounding regions. Huge differences in contaminant emissions between urban and rural areas directly affect their fate in environmental media. Little is known about POPs behavior between urban and rural areas at a regional scale. A spatially resolved Berkeley-Trent-Urban-Rural Fate Model（BETR-UR） was designed by coupling land cover information to simulate the transport of POPs between urban and rural areas, and the Bohai Rim was used as a case study to estimate Polycyclic Aromatic Hydrocarbon（PAH） fate. The processes of contaminant fate including emission, inter-compartmental transfer, advection and degradation in urban and rural areas were simulated in the model. Simulated PAH concentrations in environmental media of urban and rural areas were very close to measured values. The model accuracy was highly improved, with the average absolute relative error for PAH concentrations reduced from 37% to 3% compared with unimproved model results. PAH concentrations in urban soil and air were considerably higher than those in rural areas. Sensitivity analysis showed temperature was the most influential parameter for Phen rather than for Bap, whose fate was more influenced by emission rate, compartment dimension, transport velocity and chemical persistence. Uncertainty analysis indicated modeled results in urban media had higher uncertainty than those in rural areas due to larger variations of emissions in urban areas. The differences in urban and rural areas provided us with valuable guidance on policy setting for urban–rural POP control.

关键词： Land use PAH fate Regional scale Multimedia model

Which metal represents the greatest risk to freshwater ecosystem in bohai region of china?

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Ecosystem Health and Sustainability 2017年第2期3卷 30-39页

作者： Chao Su Yonglong Lu Andrew C.Johnson Yajuan Shi Meng zhang yueqing zhang Monika D.Juergens Xiaowei Jin State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100085 China University of Chinese Academy of Sciences Beijing100049 China Centre for Ecology&Hydrology Maclean BuildingCrowmarsh GiffordWallingfordOxon OX108BB UK China National Environmental Monitoring Center Beijing100012 China

Metals discharged from industrial effluents,agricultural wastewater,and sewage runoff by rapid urbanization are of concern as contaminants of freshwater ecosystem because of their persistence and high toxicity to aquatic organisms.This study attempted to identify which metal posed the greatest risk to freshwater ecosystem in the Bohai Region,China.The metals arsenic(As),cadmium(Cd),chromium(Cr),copper(Cu),zinc(Zn),lead(Pb),nickel(Ni),mercury(Hg),iron(Fe),and manganese(Mn)were compared against norfloxacin and gamma-hexachlorocyclohexane(lindane).By comparing the median reported environmental and ecotoxicity concentrations,it showed that Cu,Fe,Zn,Mn,and Cr were the top five metals of concern.Of these,Cu was deemed to represent the highest risk and Hg the lowest risk.The risks for all metals were higher than those for norfloxacin and lindane.Almost all the metals except Hg had water concentrations that exceeded levels where ecotoxicity effects had been recorded in the literature.A comparison with the measurements across the UK rivers suggested that all metals examined had water concentrations about 5-to 10-fold higher than the UK median values except for Cu,Fe,Cd,and Pb.The Fuyang River,a tributary of the Haihe River Basin,seemed to be the location with the highest metal concentrations.However,comparing the post-2010 period to 2000-2009,concentrations of all the metals had fallen except for Fe and Mn,so risks have decreased over the last 7 yr with the greatest improvements for Cd and Pb.While metals still pose high risks to freshwater ecosystem in this region,there is encouragement that some control measures are taken into effect.

关键词： chemical pollution freshwater ecosystem metals risk ranking

Ecosystem health towards sustainability

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Ecosystem Health and Sustainability 2015年第1期1卷 7-22页

作者： Yonglong Lu Ruoshi Wang yueqing zhang Hongqiao Su Pei Wang Alan Jenkins Rober C.Ferrier Mark Bailey Geoff Squire State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085 China University of Chinese Academy of Sciences Beijing 100049 China Centre for Ecology and Hydrology Wallingford OX108BB United Kingdom James Hutton Institute Aberdeen AB158QH ScotlandUnited Kingdom

Ecosystems are becoming damaged or degraded as a result of stresses especially associated with human activities.A healthy ecosystem is essential to provide the services that humans and the natural environment require and has tremendous social and economic value.Exploration of the definition of ecosystem health includes what constitutes health and what it means to be healthy.To evaluate ecosystem health,it is necessary to quantify ecosystem conditions using a variety of indicators.In this paper,the main principles and criteria for indicator selection,classification of indicators for different kinds of ecosystems,the most appropriate indicators for measuring ecosystem sustainability,and various methods and models for the assessment of ecosystem health are presented.Drivers,sustainability,and resilience are considered to be critical factors for ecosystem health and its assessment.Effective integration of ecological understanding with socioeconomic,biophysical,biogeochemical,and public-policy dimensions is still the primary challenge in this field,and devising workable strategies to achieve and maintain ecosystem health is a key future challenge.

关键词： assessment methodology ecological indicator ecosystem functioning ecosystem health ecosystem sustainability resilience

考虑新产品观测与体验特征的播种营销策略研究

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系统工程理论与实践 2022年第10期42卷 2740-2756页

作者：毛照昉张悦晴天津大学管理与经济学部天津300072

本文研究垄断厂商线上线下分期销售背景下,向消费者发放试用品以消除新产品不确定性,进而通过试用者评价影响其他消费者的播种策略,建立了考虑产品观测特征与体验特征的播种模型,分析了商家在不同定价策略和市场环境下的最优播种量和收... 详细信息

本文研究垄断厂商线上线下分期销售背景下,向消费者发放试用品以消除新产品不确定性,进而通过试用者评价影响其他消费者的播种策略,建立了考虑产品观测特征与体验特征的播种模型,分析了商家在不同定价策略和市场环境下的最优播种量和收益,并进一步对商家决策播种影响力模型展开研究.结果表明:1)商家是否播种与线下目标消费者定位、消费者分布、产品的体验品特性程度有关;2)线下渠道服务全部潜在消费者时播种的益处更明显,且高估值消费者比例越大或产品越倾向于体验品,播种范围应该越大;3)当商家在线下渠道只服务高估值消费者为更优策略时不应播种;4)当商家决策播种影响力且线下服务全部消费者时,商品越倾向体验品,越有动机提高影响力并减少播种量来增加受播种影响的消费者.

关键词：体验品播种策略在线评论社交影响

Improvement of cloud microphysical parameterization and its advantages in simulating precipitation along the Sichuan-Xizang Railway

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Science China Earth Sciences 2024年第3期67卷 856-873页

作者： Xiaoqi XU Zhiwei HENG yueqing LI Shunjiu WANG Jian LI Yuan WANG Jinghua CHEN Peiwen zhang Chunsong LU China Meteorological Administration Transportation Meteorology Key Laboratory Nanjing Joint Institute for Atmospheric SciencesNanjing 210041China Heavy Rain and Drought-Flood Disasters in Plateau and Basin Key Laboratory of Sichuan Province Institute of Plateau MeteorologyCMAChengdu 610072China State Key Laboratory of Disaster Weather Chinese Academy of Meteorological SciencesBeijing 100081China Collaborative Innovation Center for Western Ecological Safety Lanzhou UniversityLanzhou 730000China China Meteorological Administration Aerosol-Cloud and Precipitation Key Laboratory and Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD) Nanjing University of Information Science and TechnologyNanjing 210044China

The Sichuan-Xizang Railway is an important part of the railway network in China, and geological disasters, such as mountain floods and landslides, frequently occur in this region. Precipitation is an important cause of these disasters;therefore,accurate simulation of the precipitation in this region is highly important. In this study, the descriptions for uncertain processes in the cloud microphysics scheme are improved;these processes include cloud droplet activation, cloud-rain autoconversion, rain accretion by cloud droplets, and the entrainment-mixing process. In the default scheme, the cloud water content of different sizes corresponds to the same cloud droplet concentration, which is inconsistent with the actual content;this results in excessive cloud droplet size, unreasonable related conversion rates of microphysical process(such as cloud-rain autoconversion), and an overestimation of precipitation. Our new scheme overcomes the problem of excessive cloud droplet size. The processes of cloudrain autoconversion and rain accretion by cloud droplets are similar to the stochastic collection equation, and the mixing mechanism of cloud droplets is more consistent with that occurred during the actual physical process in the cloud. Based on the new and old schemes, multiple precipitation processes in the flood season of 2021 along the Sichuan-Xizang Railway are simulated, and the results are evaluated using ground observations and satellite data. Compared to the default scheme, the new scheme is more suitable for the simulation of cloud physics, reducing the simulation deviation of the liquid water path and droplet radius from 2 times to less than 1 time and significantly alleviating the overestimation of precipitation intensity and range of precipitation center. The average root-mean-square error is reduced by 22%. Our results can provide a scientific reference for improving precipitation forecasting and disaster prevention in this region.

关键词： The Sichuan-Xizang Railway Cloud microphysics Precipitation Model improvement

Design and optimization of fluid lubricated bearings operated with extreme working performances——a comprehensive review

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International Journal of Extreme Manufacturing 2024年第2期6卷 325-376页

作者： Guohua zhang Ming Huang Gangli Chen Jiasheng Li Yang Liu Jianguo He yueqing Zheng Siwei Tang Hailong Cui Institute of Machinery Manufacturing Technology China Academy of Engineering PhysicsMianyangSichuan 621999People’s Republic of China

Fluid lubricated bearings have been widely adopted as support components for high-end equipment in metrology,semiconductor devices,aviation,strategic defense,ultraprecision manufacturing,medical treatment,and power generation.In all these applications,the equipment must deliver extreme working performances such as ultraprecise movement,ultrahigh rotation speed,ultraheavy bearing loads,ultrahigh environmental temperatures,strong radiation resistance,and high vacuum operation,which have challenged the design and optimization of reliable fluid lubricated bearings.Breakthrough of any related bottlenecks will promote the development course of high-end equipment.To promote the advancement of high-end equipment,this paper reviews the design and optimization of fluid lubricated bearings operated at typical extreme working performances,targeting the realization of extreme working performances,current challenges and solutions,underlying deficiencies,and promising developmental directions.This paper can guide the selection of suitable fluid lubricated bearings and optimize their structures to meet their required working performances.

关键词： fluid lubricated bearings structural design performance optimization extreme working performances

Unraveling the regulatory network of flower coloration in soybean:Insights into roles of GmMYBA3 and GmMYBR1

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The Crop Journal 2024年第2期12卷 443-455页

作者： Ruifang Gao yueqing Li Yanan Wang Xiaotong Shan Siqi Yang Ye zhang Saiyu Ma Chunbao zhang Jianchun Qin Li Wang Xiang Gao College of Plant Science Jilin UniversityChangchun 130062JilinChina Key Laboratory of Molecular Epigenetics of MOE and Institute of Genetics&Cytology Northeast Normal UniversityChangchun 130024JilinChina Soybean Research Institute National Engineering Research Center for SoybeanJilin Academy of Agricultural SciencesChangchun 130033JilinChina

Anthocyanins play crucial roles in pollen protection and pollinator attraction in flowering plants.However,the mechanisms underlying flower color determination and whether floral anthocyanin regulators participate in other processes remain largely unresolved in soybeans(Glycine max).In this study,we investigated the genetic components and mechanisms governing anthocyanin biosynthesis in soybean flowers.Molecular and genetic studies have characterized two antagonistic regulators,the positive activator GmMYBA3 and the negative repressor GmMYBR1,that modulate the gene expression of anthocyanin biosynthesis in soybean flowers.Further findings revealed a regulatory interplay between GmMYBA3 and GmMYBR1 bridged by GmTT8a,highlighting the complexity of anthocyanin regulation in different soybean organs.Exploration of additional soybean cultivars demonstrated the universality of GmMYBA3 and GmMYBR1 in regulating floral anthocyanin biosynthesis-related genes,with GmF3’5’H identified as a crucial determinant of white flower color.This study provides a molecular mechanism underlying soybean flower color determination,paving the way for the molecular modification of soybean flowers to probably enhance their resistance to abiotic stresses and attractiveness to pollinators.

关键词： Anthocyanin Flower color determination MBW complex MYB repressor Pleiotropic regulator

Neutralization of SARS-CoV-2 infection by antibodies targeting diverse epitopes

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Genes & Diseases 2024年第4期11卷 134-137页

作者： Shusheng Wang Yunji Liao Kaiyong Yang Hang Ma zhangyi Song Haiqiu Huang Li zhang Ailing Wang Lei Han Jiawei zhang Hui Chen Haiyang Yin Yantin Bian Hua Jiang Xiaodong Xiao yueqing Xie Yunsheng Yuan Jianwei Zhu Engineering Research Center of Cell and Therapeutic Antibody Ministry of EducationSchool of PharmacyShanghai Jiao Tong UniversityShanghai 200240China Jecho Laboratories Inc.FrederickMD 21704USA Jecho Institute Co. Ltd.Shanghai 200240China

The CoVID-19 pandemic that started in late 2019 is sweeping through the world,posing historic challenges to global health,and disrupting social and economic lives.Previous and recent studies indicate that monoclonal antibodies can be efficacious in preventing and treating SARSCoV-1 and SARS-CoV-2 infections.Using a phage display platform,we have identified dozens of monoclonal antibodies that bind to diverse epitope groups on the SARS-CoV-2 spike protein.Many of them bound to the receptor binding domain(RBD)and inhibited ACE2-RBD interaction.

关键词： antibodies inhibited monoclonal

以人民为中心:思想渊源、意涵演化与践行原则

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安徽工业大学学报（社会科学版） 2023年第5期40卷 78-81页

作者：张月情上海师范大学马克思主义学院上海200234

中华优秀传统文化蕴含的朴素的民本思想以及马克思主义经典作家对现实的人的物质利益的关注和无产阶级政党同人民群众关系的重视,是中国共产党坚持以人民为中心的源本。在革命、建设、改革不同时期,依据社会发展和主要矛盾的转变,以人... 详细信息

中华优秀传统文化蕴含的朴素的民本思想以及马克思主义经典作家对现实的人的物质利益的关注和无产阶级政党同人民群众关系的重视,是中国共产党坚持以人民为中心的源本。在革命、建设、改革不同时期,依据社会发展和主要矛盾的转变,以人民为中心的意涵不断深化,蕴含了全心全意为人民服务,保障人民当家作主,满足人民物质文化需要,实现人民美好生活等重要内容。坚持党的领导与人民主体相统一、社会发展与人的发展相统一、群众路线与自我革命相统一、民族发展与人类进步相统一,是党以人民为中心的实践旨归,对新时代坚持以人民为中心的发展思想具有重要价值指引。

关键词：中国共产党以人民为中心意涵践行原则