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基于儿童文学开展幼儿园语言教育活动

学前教育研究 2017年第8期 70-72页

作者：郑月琴陕西师范大学幼儿园西安710061

幼儿语言的发展对幼儿成长具有重要意义,但目前幼儿园语言教育活动存在小学化、单一化和忽视口语表达等问题。基于儿童文学的幼儿园语言活动可以提高幼儿语言表达能力,增强幼儿理解力,促进幼儿语言创造力的提升,为此教师应准确把握所选... 详细信息

幼儿语言的发展对幼儿成长具有重要意义,但目前幼儿园语言教育活动存在小学化、单一化和忽视口语表达等问题。基于儿童文学的幼儿园语言活动可以提高幼儿语言表达能力,增强幼儿理解力,促进幼儿语言创造力的提升,为此教师应准确把握所选择的儿童文学题材,通过听、读、看、参与等多种形式开展幼儿语言活动。

关键词：儿童语言发展儿童文学幼儿园语言教育

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气体信号分子硫化氢前药开发的研究进展

药学进展 2019年第11期43卷 817-830页

作者：郑月钦哈佛医学院波士顿儿童医院

硫化氢(H2S)是继一氧化氮(NO)和一氧化碳(CO)之后的第3种内源性气体信号分子,在机体中发挥着重要的生物学效应。研究表明,H2S具有舒张血管、保护心脏、抗炎、抗氧化等生理学作用。把H2S的治疗效果推向临床应用的核心是设计前药将其有效... 详细信息

硫化氢(H2S)是继一氧化氮(NO)和一氧化碳(CO)之后的第3种内源性气体信号分子,在机体中发挥着重要的生物学效应。研究表明,H2S具有舒张血管、保护心脏、抗炎、抗氧化等生理学作用。把H2S的治疗效果推向临床应用的核心是设计前药将其有效运输到需要部位。从成药性的角度,综述H2S的运输策略和前药开发的研究进展,以期对相关新药的研发与临床治疗提供参考。

关键词：气体信号分子硫化氢治疗前药成药性可控释放

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用于检测多硫化氢的荧光探针研究进展

中国药科大学学报 2023年第5期54卷 553-563页

作者：王茂林郭薇薇郑月钦中国药科大学天然药物国家重点实验室南京211198

多硫化氢(hydrogen polysulfides,H2Sn,n≥2)作为硫化氢(hydrogen sulfide,H2S)所衍生的活性硫物质,在生理调节及信号转导过程中扮演着不可或缺的角色。H2Sn与H2S互为氧化还原对,一般经氧化或酶促作用从H2S转化生成,通过调节蛋白质相互... 详细信息

多硫化氢(hydrogen polysulfides,H2Sn,n≥2)作为硫化氢(hydrogen sulfide,H2S)所衍生的活性硫物质,在生理调节及信号转导过程中扮演着不可或缺的角色。H2Sn与H2S互为氧化还原对,一般经氧化或酶促作用从H2S转化生成,通过调节蛋白质相互作用及改变酶活力等方式发挥其生理作用。随着研究的深入,发现一些原本被认为是H2S发挥的生理学功能可能是由H2Sn所发挥的,并且H2Sn具有更高的蛋白质巯基化效率。因此,实时检测生物体内的H2Sn对于研究其生理活性及与H2S之间的联系具有十分重要的意义。传统的质谱光谱等检测方法需要破碎组织细胞,不适用于生物体内的实时检测。而荧光探针因其具有高灵敏度及特异性,同时生物毒性低常被选作H2Sn原位实时检测工具。本文概述了H2Sn的生理调节活性,着重基于响应机制的反应类型的介绍H2Sn检测荧光探针的设计策略、荧光性能、检测特点及生物成像应用等方面,并对这一领域所面临的挑战与发展进行了展望。

关键词：多硫化氢荧光探针响应机制荧光成像硫化氢

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钼靶X线技术对不同分期乳腺癌的检出率分析

中国基层医药 2018年第16期25卷 2145-2147,I0003页

作者：郑月琴浙江省宁海县第一医院放射科 315600

目的探讨分析钼靶X线技术对不同分期乳腺癌的检出率.方法选择2014年5月至2016年5月宁海县第一医院收治的乳腺癌患者84例为研究对象,分别采用螺旋CT三维成像和钼靶X线技术进行诊断,并将诊断结果与病理结果作对照分析.结果螺旋CT三维... 详细信息

目的探讨分析钼靶X线技术对不同分期乳腺癌的检出率.方法选择2014年5月至2016年5月宁海县第一医院收治的乳腺癌患者84例为研究对象,分别采用螺旋CT三维成像和钼靶X线技术进行诊断,并将诊断结果与病理结果作对照分析.结果螺旋CT三维成像和钼靶X线技术对乳腺癌类型及分期均有较高的检出率,钼靶X线技术发现钙化的阳性率（73.81％）显著高于螺旋CT三维成像技术（47.62％）,差异有统计学意义（x2=12.078,P＜0.05）;螺旋CT三维成像技术发现腋窝淋巴转移59例（86.76％）,钼靶X线技术发现47例（69.12％）,钼靶X线技术发现淋巴转移的阳性率低于螺旋CT三维成像技术,差异有统计学意义（x2 =6.158,P ＜0.05）.结论螺旋CT三维成像和钼靶X线技术对乳腺癌病理结果具有较高的检出率,钼靶X线技术在发现钙化阳性方面具有较高的优势、螺旋CT三维成像在诊断乳腺癌淋巴转移方面有较高的优势,二者结合应用可大大提高乳腺癌诊断的准确率.

关键词：乳腺肿瘤体层摄影术 X线计算机体层摄影术螺旋计算机诊断

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稻瘟菌效应蛋白研究进展

分子植物育种 2013年第3期11卷 451-459页

作者：郑月琴林艳何燕华陈松彪王锋福建师范大学生命科学学院福州350007 福建省农业科学院生物技术研究所福建省农业遗传工程重点实验室福州350003

稻瘟菌是一种在世界范围内严重危害水稻生产的真菌病原。在稻瘟菌与水稻互作过程中,稻瘟菌效应蛋白起着至关重要的作用。针对效应蛋白功能及其作用机理的研究有助于阐明稻瘟菌与水稻互作分子机制,并为未来水稻抗病改良提供新的理论策略... 详细信息

稻瘟菌是一种在世界范围内严重危害水稻生产的真菌病原。在稻瘟菌与水稻互作过程中,稻瘟菌效应蛋白起着至关重要的作用。针对效应蛋白功能及其作用机理的研究有助于阐明稻瘟菌与水稻互作分子机制,并为未来水稻抗病改良提供新的理论策略。本文综述了稻瘟菌效应蛋白研究的进展,并重点针对基因克隆、蛋白转运以及功能机制等方面介绍了稻瘟菌Avr蛋白研究的最新发现,同时对未来值得重点关注的研究方向进行了探讨。

关键词：稻瘟菌分泌蛋白效应子无毒基因

Bowel preparation before colonoscopy: Consequences, mechanisms, and treatment of intestinal dysbiosis

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World Journal of Gastroenterology 2025年第2期31卷 13-26页

作者： Ze-Long zheng Qing-Fan zheng Li-Qiang Wang Yi Liu Department of Gastroenterology(Endoscopy Center) China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina

The term“gut microbiota”primarily refers to the ecological community of various microorganisms in the gut,which constitutes the largest microbial community in the human *** adequate bowel preparation can improve the results of colonoscopy,it may interfere with the gut *** preparation for colonoscopy can lead to transient changes in the gut microbiota,potentially affecting an individual’s health,especially in vulnerable populations,such as patients with inflammatory bowel ***,measures such as oral pro-biotics may ameliorate these adverse *** focused on the bowel prepa-ration-induced changes in the gut microbiota and host health status,hypothesized the factors influencing these changes,and attempted to identify measures that may reduce dysbiosis,thereby providing more information for individualized bowel preparation for colonoscopy in the future.

关键词： Bowel preparation Colonoscopy Microbiota Inflammatory bowel disease Probiotics

Red cell distribution width/platelet ratio predicts decompensation of metabolic dysfunction-associated steatotic liver disease-related compensated advanced chronic liver disease

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World Journal of Gastroenterology 2025年第3期31卷 1-10页

作者： Ming-Hua zheng Amedeo Lonardo Department of Hepatology MAFLD Research CenterThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Department of Internal Medicine Azienda Ospedaliero-Universitaria of Modena(2023)Modena 41126Italy

Prognostication of compensated advanced chronic liver disease(cACLD)is of paramount importance for the physician-and-patient communication and for rational clinical *** paper published by Dallio et al reports on red cell distribution width(RDW)/platelet ratio(RPR)as a non-invasive biomarker in predicting decompensation of metabolic dysfunction-associated steatotic liver disease(MASLD)-related *** from other biomarkers and algorithms,RPR is inexpensive and widely available,based on parameters which are included in a complete blood *** is computed on the grounds of two different items,one of which,RDW,mirrors the host’s response to a variety of disease stimuli and is *** second parameter involved in RPR,platelet count,is more specific and has been used in the hepatological clinic to discriminate cirrhotic from non-cirrhotic chronic liver disease for *** disease is the primary cause of mortality among MASLD subjects,followed by extra-hepatic cancers and liver-related ***,MASLD biomarkers should be validated not only in terms of liver-related events but also in the prediction of major adverse cardiovascular events and cardiovascular mortality and extra-hepatic *** sized multi-ethnic confirmatory investigation is required to define the role and significance of RPR in the stratification of MASLD-cACLD.

关键词： Cirrhosis Liver fibrosis Natural course Prognostication Stratification

The role of axon guidance molecules in the pathogenesis of epilepsy

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Neural Regeneration Research 2025年第5期20卷 1244-1257页

作者： zheng Liu Chunhua Pan Hao Huang Department of Neurology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target novel cellular and molecular mechanisms and mechanisms of action. Increasing evidence suggests that axon guidance molecules play a role in the structural and functional modifications of neural networks and that the dysregulation of these molecules is associated with epilepsy susceptibility. In this review, we discuss the essential role of axon guidance molecules in neuronal activity in patients with epilepsy as well as the impact of these molecules on synaptic plasticity and brain tissue remodeling. Furthermore, we examine the relationship between axon guidance molecules and neuroinflammation, as well as the structural changes in specific brain regions that contribute to the development of epilepsy. Ample evidence indicates that axon guidance molecules, including semaphorins and ephrins, play a fundamental role in guiding axon growth and the establishment of synaptic connections. Deviations in their expression or function can disrupt neuronal connections, ultimately leading to epileptic seizures. The remodeling of neural networks is a significant characteristic of epilepsy, with axon guidance molecules playing a role in the dynamic reorganization of neural circuits. This, in turn, affects synapse formation and elimination. Dysregulation of these molecules can upset the delicate balance between excitation and inhibition within a neural network, thereby increasing the risk of overexcitation and the development of epilepsy. Inflammatory signals can regulate the expression and function of axon guidance molecules, thus influencing axonal growth, axon orientation, and synaptic plasticity. The dysregulation of neuroinflammation can intensify neuronal dysfunction and contribute to the occurrence of epilepsy. This review delves into the mechanisms associated with

关键词： axon guidance drug-resistant epilepsy epilepsy nerve regeneration nervous system diseases neural pathways neuroinflammatory diseases neuronal plasticity neurons synaptic remodeling

Effect of cholesterol metabolism on hepatolithiasis

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World Journal of Gastroenterology 2025年第1期31卷 157-162页

作者： Lin zheng Zi-Yu Ye Jun-Ji Ma Department of Gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesNo.215 Heping West RoadShijiazhuang 050000Hebei ProvinceChina

Surgical intervention is currently the primary treatment for hepatolithiasis;how-ever,some patients still experience residual stones and high recurrence rates after *** metabolism seems to play an important role in hepatoli-thiasis pathogenesis.A high cholesterol diet is one of the significant reasons for the increasing incidence of ***,regular diet and appropriate medical intervention are crucial measures to prevent hepatolithiasis and reduce recurrence rate after *** dietary cholesterol and drugs that increase cholesterol stone solubility are key therapeutic approaches in treating *** article discusses the cholesterol metabolic pathways related to the pathogenesis of hepatolithiasis,as well as food intake and targeted therapeutic drugs.

关键词： Hepatolithiasis Cholesterol metabolism High-fat diet 3-hydroxy-3-methylglutaryl-coenzyme A reductase Interlobular bile duct