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新能源数据中心的交直流并网技术研究

电信快报 2024年第1期 45-48页

作者：洪兆金陈月琴中通服咨询设计研究院有限公司江苏省南京市210000

为提高能源效率和稳定性,文章从功率变换、控制策略和拓扑结构3个方面,研究新能源融合场景下数据中心新的交直流并网技术。文章提出一种由交流电源、交直流隔离变流器和交直流并网逆变器组成的交直流并网系统结构,以及由电压源换流器和... 详细信息

为提高能源效率和稳定性,文章从功率变换、控制策略和拓扑结构3个方面,研究新能源融合场景下数据中心新的交直流并网技术。文章提出一种由交流电源、交直流隔离变流器和交直流并网逆变器组成的交直流并网系统结构,以及由电压源换流器和储能变流器构成的电压源换流器结构,通过调节交流电源和直流负载之间的功率交换来应对电网侧功率的波动,从而保证系统的稳定运行。

关键词：新能源交直流并网技术功率变换控制策略拓扑结构

紫外标准曲线法测定对乙酰氨基酚片的不确定度评定

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化学分析计量 2024年第8期33卷 118-123页

作者：陈月琴马明唐利宇于艪无锡卫生高等职业技术学校江苏联合职业技术学院无锡卫生分院江苏无锡214000 江苏省药品监督管理局审评中心南京210000

采用紫外标准曲线法测定对乙酰氨基酚片含量,评估测定结果的不确定度。通过不确定度来源分析,建立数学模型,量化不确定度分量,计算出测定值的不确定度结果及各分量的贡献率。不确定度的主要来源为系列标准溶液的配制及样品处理过程,其... 详细信息

采用紫外标准曲线法测定对乙酰氨基酚片含量,评估测定结果的不确定度。通过不确定度来源分析,建立数学模型,量化不确定度分量,计算出测定值的不确定度结果及各分量的贡献率。不确定度的主要来源为系列标准溶液的配制及样品处理过程,其次为紫外仪器和标准工作溶液的配制。当k=2时,按置信区间为95%,对乙酰氨基酚片百分标示量含量测定值为(99.55±2.48)%。不确定度评估可以用于分析和优化紫外标准曲线法测定药品含量的过程,对药品的质量控制和方法改进有重要的指导意义。

关键词：紫外标准曲线法对乙酰氨酚片含量测定不确定度

The m6A writers regulated by the IL-6/STAT3 inflammatory pathway facilitate cancer cell stemness in cholangiocarcinoma

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Cancer Biology & Medicine 2022年第3期19卷 343-357页

作者： Hua Ye Tianqi chen Zhancheng Zeng Bo He Qianqian Yang Qi Pan yueqin chen Wentao Wang Department of Hepatobiliary Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Key Laboratory of Gene Engineering of the Ministry of Education School of Life SciencesSun Yat-sen UniversityGuangzhou 510275China Department of Anesthesiology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

Objective:Investigation of the regulatory mechanisms of cell stemness in cholangiocarcinoma(CCA)is essential for developing effective therapies to improve patient *** purpose of this study was to investigate the function and regulatory mechanism of m6A modifications in CCA cell ***:Interleukin 6(IL-6)treatment was used to induce an inflammatory response,and loss-of-function studies were conducted using mammosphere culture *** immunoprecipitation,polysome profiling,and methylated RNA immunoprecipitation analyses were used to identify signaling *** in vitro findings were verified in a mice ***:We first identified that m6A writers were highly expressed in CCAs and further showed that STAT3 directly bound to the gene loci of m6A writers,showing that IL-6/STAT3 signaling regulated expressions of m6A *** m6A writers prevented cell proliferation and migration in vitro and suppressed CCA tumorigenesis in ***,the knockdown of m6A writers inhibited CCA cell stemness that was triggered by IL-6 ***,IGF2BP2 was bound to CTNNB1 transcripts,significantly enhancing their stability and translation,and conferring stem-like ***,we confirmed that the combination of m6A writers,IGF2BP2,and CTNNB1 distinguished CCA tissues from normal ***:Overall,this study showed that the IL-6-triggered inflammatory response facilitated the expressions of m6A writers and cell stemness in an m6A-IGF2BP2-dependent ***,the study showed that m6A modification was a targetable mediator of the response to inflammation factor exposure,was a potential diagnostic biomarker for CCA,and was critical to the progression of CCA.

关键词： Cholangiocarcinoma IL-6 cell stemness N6-methyladenosine(m6A) IGF2BP2

横纹肌肉瘤的CT、MRI及PET/CT影像学表现

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医学影像学杂志 2024年第7期34卷 18-21页

作者：蒲迪刘慧君陈月芹于昊济宁医学院附属医院医学影像科山东济宁272000

目的探讨横纹肌肉瘤(RMS)的CT、MRI及^(18)F-FDG PET/CT影像学表现。方法选取经病理证实的16例RMS患者资料,分析其CT、MRI及^(18)F-FDG PET/CT影像学表现。结果 16例RMS中,10例病灶位于头颈部,1例位于肺部,4例位于四肢,1例位于腹盆腔... 详细信息

目的探讨横纹肌肉瘤(RMS)的CT、MRI及^(18)F-FDG PET/CT影像学表现。方法选取经病理证实的16例RMS患者资料,分析其CT、MRI及^(18)F-FDG PET/CT影像学表现。结果 16例RMS中,10例病灶位于头颈部,1例位于肺部,4例位于四肢,1例位于腹盆腔。按病理分型为胚胎型RMS 6例,腺泡型RMS 7例,多形性RMS 2例,硬化性RMS1例。7例接受CT检查,6例见等密度不规则软组织肿块影,1例见不均匀稍低密度肿块影;增强后病灶不均匀强化,动脉期病灶内见迂曲小血管影。10例行MRI检查,10例T_(1)WI呈低信号、T_(2)WI呈高信号,病灶中央见稍低信号;8例DWI提示扩散受限,呈不均匀高信号;8例增强MRI呈不均匀、明显强化,病灶内见条片状无强化区。5例接受^(18)F-FDG PET/CT检查,病灶呈^(18)F-FDG摄取增高。6例伴骨质破坏,1例伴肺部转移,2例伴骨髓浸润,1例侵犯右眼眶及右额部。结论 CT检查显示RMS对邻近骨质破坏,MRI检查显示RMS病变大致侵袭范围,^(18)F-FDG PET/CT检查显示病灶代谢活性及是否伴远处转移,有助于提示RMS诊断。

关键词：横纹肌肉瘤体层摄影术 X线计算机磁共振成像正电子发射断层显像术

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运动医学中尺骨撞击综合征的治疗研究

中外医疗 2024年第8期43卷 31-34页

作者：陈智琨林建春谢亮文陈跃秦刘瑞仁厦门大学附属第一医院同安院区(厦门市第三医院)骨科福建厦门361100

目的探究运动医学中尺骨撞击综合征的诊断和治疗方法。方法便利选取厦门大学附属第一医院同安院区于2021年6月—2023年1月收治的66例尺骨撞击综合征患者为研究对象,根据不同治疗方法分成观察组和对照组,每组33例。对照组患者采用尺骨缩... 详细信息

目的探究运动医学中尺骨撞击综合征的诊断和治疗方法。方法便利选取厦门大学附属第一医院同安院区于2021年6月—2023年1月收治的66例尺骨撞击综合征患者为研究对象,根据不同治疗方法分成观察组和对照组,每组33例。对照组患者采用尺骨缩短截骨术进行治疗,观察组患者采用关节镜下wafer手术进行治疗,记录两组尺骨撞击综合征患者的病情变化。结果观察组治疗总有效率(93.94%)高于对照组(84.85%),差异有统计学意义(χ^(2)=4.215,P<0.05);观察组患者出现3例不良反应(9.10%),对照组出现6例(18.19%),观察组不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。观察组腕关节改良关节功能得分高于对照组,差异有统计学意义(P<0.05)。结论关节镜下wafer手术治疗尺骨撞击综合征的疗效更加显著,可以减少不良反应的发生。

关键词：尺骨撞击综合征运动医学治疗方法手术疗法

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Protective effects of ferulic acid against ionizing radiation-induced oxidative damage in rat lens through activating Nrf2 signal pathway

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International Journal of Ophthalmology(English edition) 2023年第5期16卷 687-693页

作者： yueqin chen Jiawei Shen Xiaoran Zhang Weiping Gao Qian Cao Feng Yan Chunyan Xue Department of Ophthalmology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008Jiangsu ProvinceChina Nanjing University of Chinese Medicine Nanjing 210029Jiangsu ProvinceChina Department of Ophthalmology Nanjing Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210002Jiangsu ProvinceChina

AIM: To examine the protection of ferulic acid(FA) against ionizing radiation(IR)-induced lens injury in rats, as well as the underlying ***: FA(50 mg/kg) was administered to rats for 4 consecutive days before they were given 10 Gy γ-radiation, as well as for 3 consecutive days afterward. Two weeks after radiation, the eye tissues were collected. Histological alterations were evaluated by hematoxylineosin staining. Enzyme linked immunosorbent assay(ELISA) was utilized to assess the activities of glutathione reductase(GR) and superoxide dismutase(SOD), as well as the levels of glutathione(GSH) and malondialdehyde(MDA) in the lenses. The protein and m RNA levels of Bcl-2, caspase-3, Bax, heme oxygenase-1(HO-1), and glutamatecysteine ligase catalytic subunit(GCLC) were quantified using Western blot and quantitative reverse transcription polymerase chain reaction, respectively. With nuclear extracts, the nuclear factor erythroid-2 related factor(Nrf2) protein expressions in the nuclei were also ***: Rats exposed to IR showed lens histological alterations which could be alleviated by FA. FA treatment reversed apoptosis-related markers in IR-induced lens, as evidenced by lower levels of Bax and caspase-3 and higher level of Bcl-2. Furthermore, IR induced oxidative damage manifested by decreased GSH level, increased MDA level, and decreased SOD and GR activities. FA boosted nuclear translocation of Nrf2 and increased the expressions of HO-1 and GCLC to inhibit oxidative stress, as evidenced by an increase in GSH, a decrease in MDA, and an increase in GR and SOD ***: FA may work well in preventing and treating IR-induced cataract through promoting the Nrf2 signal pathway to attenuate oxidative damage and cell apoptosis.

关键词： ferulic acid ionizing radiation lens oxidative stress Nrf2

Role of long non-coding RNAs in normal and malignant hematopoiesis

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Science China(Life Sciences) 2013年第10期56卷 867-875页

作者： WEI PanPan HAN BoWei chen yueqin Key Laboratory of Gene Engineering of Ministry of Education State Key Laboratory for BiocontrolSchool of Life ScienceSun Yat-sen University

Long non-coding RNAs(lncRNAs)are defined as a class of nonprotein-coding transcripts greater than 200 nucleotides in length,which have diverse functions in development and diseases including *** advances have revealed that lncRNAs regulate hematopoietic development at almost every stage,including differentiation of the myelocyte,lymphocyte,and *** regulation of the lncRNAs may block aspects of blood development,which can lead to different types of hematopoietic *** findings highlight the role of lncRNAs as potential therapeutic tools in malignant *** this review,we summarize recent progress in the study of functional lncRNAs associated with blood development,as well as dysregulated lncRNAs involved in diverse blood diseases by interacting with crucial susceptibility genes in different *** addition,we discuss genome-wide studies on lncRNAs,which are helpful for genome screening and in-depth functional study of lncRNAs associated with blood development and disease.

关键词： long non-coding RNA (IncRNA) hematopoiesis blood disease susceptibility gene

Grass phasiRNAs and male fertility

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Science China(Life Sciences) 2018年第2期61卷 148-154页

作者： Yang Yu Yanfei Zhou Yuchan Zhang yueqin chen Guangdong Provincial Key Laboratory of Plant Resources State Key Laboratory for Biocontrol School of Life Sciences Sun Yat-sen University

Recent studies have indicated that a special type of small noncoding RNAs, phased small-interfering RNAs(phasiRNAs) play crucial roles in many cellular processes of plant development. PhasiRNAs are generated from long RNA precursors at intervals of 21 or 24 nt in plants, and they are produced from both protein-coding gene and long noncoding RNA genes. Different from those in eudicots, grass phasiRNAs include a special class of small RNAs that are specifically expressed in reproductive *** grass phasiRNAs are associated with gametogenesis, especially with anther development and male fertility. In this review,we summarized current knowledge on these small noncoding RNAs in male germ cells and their possible biological functions and mechanisms in grass species.

关键词： noncoding RNA phasiRNA crop fertility

宽探测器CT联合小剂量测试法在四腔心增大胸痛三联征中的应用

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中国中西医结合影像学杂志 2024年第4期22卷 390-395页

作者：王科鑫秦文恒尹思远李冲冲王培洁万小辉陈月芹济宁医学院附属医院医学影像科山东济宁272001

目的:探讨宽探测器CT联合小剂量测试法对四腔心增大胸痛三联征(TRO)患者的应用价值。方法:前瞻性收集60例四腔心增大TRO患者,随机分为观察组和对照组各30例。观察组采用宽探测器CT联合小剂量测试法,对照组采用阈值触发法,并对图像质量... 详细信息

目的:探讨宽探测器CT联合小剂量测试法对四腔心增大胸痛三联征(TRO)患者的应用价值。方法:前瞻性收集60例四腔心增大TRO患者,随机分为观察组和对照组各30例。观察组采用宽探测器CT联合小剂量测试法,对照组采用阈值触发法,并对图像质量进行主观和客观分析。主观分析由2位高年资影像医师采用4分制评分法完成,2位医师主观评分一致性采用Kappa检验,组间比较采用独立样本t检验或Wilcoxon秩检验。结果:观察组肺动脉主干、左肺动脉干、右肺动脉干、左冠状动脉(冠脉)前降支近中段、左冠脉回旋支近中段、右冠脉近中段的CT值、SNR和CNR均高于对照组,差异均有统计学意义(均P0.05)。2位医师主观评分一致性好(K>0.75)。结论:对四腔心增大TRO患者行宽探测器CT联合小剂量测试法检查,图像质量明显提高,具有一定临床应用价值。

关键词：体层摄影术 X线计算机小剂量测试四腔心增大

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