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硫酸羟氯喹联合糖皮质激素治疗特发性膜性肾病效果及安全性研究

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中国医药 2024年第4期19卷 567-570页

作者：李娜蓝晓红王玥坤高宏玉东部战区总医院药剂科南京210018

目的探讨硫酸羟氯喹联合糖皮质激素治疗特发性膜性肾病(IMN)的临床效果。方法选取东部战区总医院2021年10月至2023年2月收治的83例IMN患者,采用随机数字表法将患者分为对照组(41例)和观察组(42例)。所有患者均接受肾素-血管紧张素系... 详细信息

目的探讨硫酸羟氯喹联合糖皮质激素治疗特发性膜性肾病(IMN)的临床效果。方法选取东部战区总医院2021年10月至2023年2月收治的83例IMN患者,采用随机数字表法将患者分为对照组(41例)和观察组(42例)。所有患者均接受肾素-血管紧张素系统抑制剂、利尿剂、抗凝药和钙调神经磷酸酶抑制剂环孢素的常规治疗。对照组在常规治疗基础上给予醋酸泼尼松片口服治疗;在对照组基础上,观察组给予硫酸羟氯喹口服治疗;2组患者均治疗12个月。比较2组临床治疗效果。检测并比较2组治疗前后总胆固醇、血肌酐、甘油三酯、白蛋白、C反应蛋白、低密度脂蛋白胆固醇、估算肾小球滤过率和24 h尿蛋白水平。比较2组不良反应发生情况。结果治疗后,观察组临床总有效率高于对照组[92.9%(39/42)比70.7%(29/41)],差异有统计学意义(χ2=6.860,P=0.009)。治疗后,观察组总胆固醇、血肌酐、甘油三酯、C反应蛋白、24 h尿蛋白和低密度脂蛋白胆固醇水平低于对照组,差异均有统计学意义(均P<0.05);观察组白蛋白和估算肾小球滤过率水平高于对照组,差异均有统计学意义(均P<0.05)。2组不良反应发生率比较,差异无统计学意义(P=0.526)。结论硫酸羟氯喹联合糖皮质激素治疗IMN临床效果较好,能够明显控制蛋白尿,改善肾功能,调节血脂,且安全性较好。

关键词：特发性膜性肾病硫酸羟氯喹糖皮质激素治疗效果安全性

Radiotherapy in combination with systemic therapies for brain metastases:current status and progress

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Cancer Biology & Medicine 2020年第4期17卷 910-922页

作者： Lei Liu Wanqi Chen Ruopeng Zhang yuekun wang Penghao Liu Xin Lian Fuquan Zhang Yu wang Wenbin Ma Department of Neurosurgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Radiotherapy Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Brain metastases(BMs)are the most common cause of intracranial neoplasms in adults with poor *** BMs originate from lung cancer,breast cancer,or ***(RT),including whole brain radiotherapy(WBRT)and stereotactic radiation surgery(SRS),has been widely explored and is considered a mainstay anticancer treatment for *** the past decade,the advent of novel systemic therapies has revolutionized the treatment of *** this context,there is a strong rationale for using a combination of treatments based on RT,with the aim of achieving both local disease control and extracranial disease *** review focuses on describing the latest progress in RT as well as the synergistic effects of the optimal combinations of RT and systemic treatment modalities for BMs,to provide perspectives on current treatments.

关键词： supported by grants from Beijing Municipal Natural Science Foundation(Grant No.7202150) Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(Grant No.2016-I2M-2-001)

Program Construction Method for Sequential Statistics Class Algorithm Based on Bidirectional Scanning Induction

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Wuhan University Journal of Natural Sciences 2023年第6期28卷 483-492页

作者： ZUO Zhengkang wang yuekun LIANG Zanyang SU Wei HUANG Qing wang Yuan wang Changjing College of Computer Information Engineering Jiangxi Normal UniversityNanchang 330022JiangxiChina College of Software Jiangxi Normal UniversityNanchang 330022JiangxiChina Nanchang Government Service Data Administration Nanchang 330038JiangxiChina

The program construction process is based on rigorous mathematical reasoning,which leads to a fully correct algorithmic program via step-by-step refinement of the program *** existing program construction methods'refinement process is partly based on individual subjective speculation and analysis,which lacks a precise guidance ***,efficiency factors have usually been ignored in the construction process,and most of the constructed abstract programs cannot be run directly by *** order to solve these problems,a novel program construction method for the sequence statistical class algorithms based on bidirectional scan induction is proposed in this *** method takes into account the efficiency factor and thus improves the Morgan's refinement ***,this paper validates the method's feasibility using an efficiency-sensitive sequential statistics class algorithm as a program construction *** method proposed in this paper realizes the correctness construction process from program specifications to efficient executable programs.

关键词： program construction bidirectional scanning induction sequential statistics Morgan's refinement calculus

老挝色贡省达真地区水系沉积物测量地球化学特征及找矿远景

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华北地质 2024年第3期47卷 54-62页

作者：王跃堃李进龙文平李军兴李腾飞中国地质调查局西安矿产资源调查中心西安710100 中国冶金地质总局西北地质勘查院西安710119

【研究目的】老挝色贡达真地区位于老挝南部成矿元素地球化学预测区,成矿潜力优越。对该区开展地球化学测量工作,缩小找矿靶区,为下一步地质找矿提供依据。【研究方法】基于1/5万水系沉积物地球化学测量,分析了19种元素,统计了各元素分... 详细信息

【研究目的】老挝色贡达真地区位于老挝南部成矿元素地球化学预测区,成矿潜力优越。对该区开展地球化学测量工作,缩小找矿靶区,为下一步地质找矿提供依据。【研究方法】基于1/5万水系沉积物地球化学测量,分析了19种元素,统计了各元素分布情况及特征参数,总结了元素离散富集规律、元素组合特征及其与成矿地质条件的关系,初步探讨了元素在不同地层(地质体)的分布情况。【研究结果】研究认为:Au、Sn和Pb元素为研究区主成矿元素,Au元素在绢云母片岩和黑云母花岗岩中富集和离散程度高,Sn元素在绢云母片岩中富集和离散程度较高,Pb元素在黑云母花岗岩中富集和离散程度较高。【结论】结合成矿地质条件、地球化学特征,共圈定10处地球化学综合异常,在综合研究的基础上划分出了3处找矿远景区。通过开展异常查证工作,最终优选出HS8综合异常,圈定达珑(DaLong)成矿远景区具较大成矿潜力,为下一步地质找矿工作提供依据。

关键词：成矿远景区地球化学特征水系沉积物老挝达真

Progress in phase III clinical trials of molecular targeted therapy and immunotherapy for glioblastoma

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Cancer Innovation 2023年第2期2卷 114-130页

作者： yuekun wang Shenglan Li Yichen Peng Wenbin Ma Yu wang Wenbin Li Department of Neurosurgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Neuro-oncology Cancer CenterBeijing Tiantan HospitalCapital Medical UniversityBeijingChina

Glioblastoma(GBM)is the most common primary central nervous system tumor,whose prognosis remains poor under the sequential standard of care,such as neurosurgery followed by concurrent temozolomide radiochemotherapy and adjuvant temozolomide chemotherapy in the presence or absence of tumor treating ***,the advent of molecular targeted therapy and immunotherapy has opened a new era of tumor management.A diverse range of targeted drugs have been tested in patients with GBM in phase III clinical ***,these drugs are ineffective for all patients,as evidenced by the fact that only a minority of patients in these trials showed prolonged ***,there are several published phase III clinical trials that involve immune checkpoint inhibitors,peptide vaccines,dendritic cell vaccines,and ***,this review comprehensively overviews existing studies of targeted drugs and immunotherapy for glioma and discusses the challenge and perspective of targeted drugs and immunotherapy for glioma to clarify future directions.

关键词： glioblastoma immunotherapy phase III clinical trial target therapy

High-frequency Resonance Analysis and Impedance Reshaping Control of MMC-HVDC System Based on Frequency Coupling Impedance Model

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 646-657页

作者： Juanjuan wang Wei Chen yuekun Liu Chuang Fu Yunming Ye Junjie Feng School of Electric Power South China University of TechnologyGuangzhouChina Guangdong Power Grid Co. Ltd.GuangzhouChina Electric Power Research Institute China Southern Power GridGuangzhouChina

In recent years, high-frequency resonance (HFR) events occurred in several modular multilevel converter based high-voltage direct current (MMC-HVDC) projects. The time delay of an MMC-HVDC system is the critical factor that induces HFR. The frequency coupling affects the impedance characteristics of an MMC and further deteriorates system stability. Therefore, in this paper, a multi-input multi-output admittance model of an MMC-HVDC system is developed to analyze its frequency characteristics. The effects of current loop, power loop, phase-locked loop, and operating point on the MMC frequency coupling degree are analyzed in detail. Meanwhile, to further suppress HFR in the MMC-HVDC system, an enhanced impedance reshaping control strategy based on the equivalent single-input single-output impedance model is proposed. Finally, the accuracy of the enhanced impedance model and the effectiveness of the impedance reshaping control are verified by electromagnetic transient simulations in PSCAD.

关键词： Modular multilevel converter based high-voltage direct current(MMC-HVDC) high-frequency resonance frequency coupling impedance model impedance reshaping control

从ITMA ASIA+CITME 2022看织造机械的技术进步

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棉纺织技术 2024年第5期52卷 55-58页

作者：徐洋尹显波解国升王跃坤盛晓伟东华大学上海201620

总结2022中国国际纺织机械展览会暨ITMA亚洲展览会上织造机械及织造准备的最新技术进展。织造机械的结构与性能不断优化,发展更加贴近市场需求。国产剑杆、喷气、喷水织机的制造水平发展迅速,提高了国产设备的核心竞争力。随着人工智能... 详细信息

总结2022中国国际纺织机械展览会暨ITMA亚洲展览会上织造机械及织造准备的最新技术进展。织造机械的结构与性能不断优化,发展更加贴近市场需求。国产剑杆、喷气、喷水织机的制造水平发展迅速,提高了国产设备的核心竞争力。随着人工智能的爆发式增长,织造机械的数字化转型步伐加快,先进的信息技术和自动化工具的运用使织造机械呈现出个性化、智能化、绿色化发展新趋势。认为:近几年织造机械在高速化、自动化、绿色化方面进步显著。

关键词：纺织机械展览会织造机械开口机构喷气织机剑杆织机喷水织机

Effect of Modulation Error on All Optical Fiber Current Transformers

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Journal of Sensor Technology 2012年第4期2卷 172-176页

作者： Zhengping wang yuekun wang Shuai Sun Science School Harbin Engineering University Harbin China

For actively modulated In-line Sagnac interferential all optic fiber current transformers (AOFCTs), the accuracies are directly affected by the amplitude of the modulation signal. In order to deeply undertand the function of the modulator, a theoretical model of modulation effect to AOFCTs is built up in this paper. The effect of the amplitude of the modulation signal to the output intensity of AOFCTs is theoretically formulated and numerical calculated. The results show that the modulation voltage variation could affect the output accuracies significantly. This might be some references on the investigation for practical applications of AOFCTs.

关键词： Electronic Current Transformer All Optical Fiber Current Transformer Faraday Effect Active Modulation Modulation Error

基于整合药理学和转录组学的肝细胞癌和胆管癌共同差异miRNA调控网络构建及相关中药预测分析

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中国医院用药评价与分析 2024年第2期24卷 147-152,156页

作者：施金虎吴波蓝晓红王玥坤杨阳易剑峰魏玮高茗中国人民解放军东部战区总医院药剂科南京210002 江西中医药大学中医基础理论分化发展研究中心南昌330004

目的:利用整合药理学和转录组学方法,构建肝细胞癌与胆管癌共同差异微RNA(miRNA)调控网络,并对关键靶点进行中药预测分析。方法:从GEO数据库获取肝细胞癌、胆管癌芯片数据集,借助在线分析工具GEO_(2)R分析出差异表达miRNA(DEMs)并对其... 详细信息

目的:利用整合药理学和转录组学方法,构建肝细胞癌与胆管癌共同差异微RNA(miRNA)调控网络,并对关键靶点进行中药预测分析。方法:从GEO数据库获取肝细胞癌、胆管癌芯片数据集,借助在线分析工具GEO_(2)R分析出差异表达miRNA(DEMs)并对其取交集,得到共同DEMs,分别运用FunRich和miRNet软件预测上游转录因子及下游靶基因,并利用DAVID数据库对靶基因进行基因本体(GO)功能富集分析和京都基因与基因组百科全书(KEGG)通路富集分析。借助STRING数据库和Cytoscape 3.9.1软件筛选关键基因(hubGenes)并构建miRNA-hubGenes网络。运用UALCAN、Kaplan Meier-plotter和Coremin Medical数据库对关键基因进行差异表达、总体生存率及相关中药预测分析。结果:肝细胞癌筛选出14个DEMs,胆管癌筛选出104个DEMs, miR-199a-5p为两者共同DEMs,涉及28个上调转录因子,166个下游靶基因;富集分析结果显示,这些靶基因参与肿瘤细胞凋亡、增殖、间质转变和迁移等生物过程,主要通过癌症通路、FoxO信号通路、丝裂原激活的蛋白激酶信号通路以及磷脂酰肌醇3激酶-蛋白激酶B信号通路发挥作用;核心靶点关联中药性味偏微寒,主归肝经,关联最为密切的中药为丹参。结论:miR-199a-5p是肝细胞癌与胆管癌之间重要调控miRNA,丹参干预关键基因出现频次较多,与研究报道基本相符,可为后续肝胆癌机制研究和临床应用提供依据与参考。

关键词：肝细胞癌胆管癌 miRNA 中药预测转录组学