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抗MCV抗体、抗CCP抗体对类风湿关节炎的诊断价值及其与疾病活动度的相关性

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广西医学 2024年第1期46卷 53-58页

作者：张宪波刘月皎江苏省中医院检验科江苏省南京市210029

目的探讨抗突变型瓜氨酸波形蛋白(MCV)抗体、抗环瓜氨酸肽(CCP)抗体对类风湿关节炎(RA)的诊断价值,并分析其与RA疾病活动度的相关性。方法选取74例RA患者(RA组)、95例结缔组织病患者(非RA组)和60例健康体检者(健康对照组)作为研究对象... 详细信息

目的探讨抗突变型瓜氨酸波形蛋白(MCV)抗体、抗环瓜氨酸肽(CCP)抗体对类风湿关节炎(RA)的诊断价值,并分析其与RA疾病活动度的相关性。方法选取74例RA患者(RA组)、95例结缔组织病患者(非RA组)和60例健康体检者(健康对照组)作为研究对象。基于红细胞沉降率的28个关节疾病活动度评分(DAS28-ESR)将RA组患者分为高活动期组(n=22)、中活动期组(n=18)、低活动期组(n=14)和缓解期组(n=20)。比较RA组、非RA组、健康对照组之间的血清抗MCV抗体、血清抗CCP抗体、血清类风湿因子(RF)和ESR阳性率,以及RA不同活动期组之间的血清抗MCV抗体水平、血清抗CCP抗体水平、血清RF水平和ESR。通过绘制受试者工作特征曲线分析血清抗MCV抗体水平、血清抗CCP抗体水平、血清RF水平和ESR单独及联合诊断RA的价值。分析RA组患者血清抗MCV抗体水平、血清抗CCP抗体水平、血清RF水平和ESR与DAS28-ESR的相关性。结果(1)RA组的血清抗MCV抗体、血清抗CCP抗体、血清RF和ESR阳性率高于非RA组和健康对照组(P0.05)。(2)缓解期组、低活动期组、中活动期组、高活动期组的血清抗MCV抗体水平、血清抗CCP抗体水平和ESR依次升高(P0.05)。(3)血清抗MCV抗体水平、血清抗CCP抗体水平单独诊断RA的曲线下面积(AUC)均>0.85,且均大于血清RF水平和ESR的AUC(P0.05);血清抗MCV抗体水平、血清抗CCP抗体水平、血清RF水平和ESR联合诊断RA的AUC达0.935,大于任意单一指标诊断RA的AUC(P<0.05)。(4)RA患者的血清抗MCV抗体水平、血清抗CCP抗体水平和ESR与DAS28-ESR均呈正相关(P<0.05)。结论相比于传统指标血清RF和ESR,血清抗MCV抗体和血清抗CCP抗体对RA均有较高的诊断价值;将二者联合血清RF和ESR用于诊断RA,可明显提高诊断效能。血清抗MCV抗体水平、血清抗CCP抗体水平均与RA疾病活动度呈正相关,可作为评估患者疾病活动度的辅助指标。

关键词：类风湿关节炎抗突变型瓜氨酸波形蛋白抗体抗环瓜氨酸肽抗体诊断价值疾病活动度

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横窦狭窄的影像学研究进展

中国医学影像技术 2024年第1期40卷 121-124页

作者：刘月皎丁贺宇仇晓妤代驰航赵鹏飞王振常成都市第五人民医院放射科四川成都611130 首都医科大学附属北京友谊医院放射科北京100050

横窦是颅内静脉回流重要通路,对维持脑循环及稳定颅内压至关重要。横窦狭窄(TSS)为横窦最常见变异,可致窦腔血流动力学及压力变化,与特发性颅高压、搏动性耳鸣及慢性头痛等密切相关。本文对影像学研究TSS进展进行综述。

关键词：横窦狭窄体层摄影术,X线计算机磁共振成像

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Distribution and dynamics of niche and interspecific association of dominant phytoplankton species in the Feiyun River basin,Zhejiang,China

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Journal of Oceanology and Limnology 2024年第4期42卷 1157-1172页

作者： Shengnan ZHU Zengchuan DONG Guobin FU Shujun WU Jinyu MENG Weilin liu Yupeng liu Xun CUI yuejiao ZHOU College of Hydrology and Water Resources Hohai UniversityNanjing 210098China CSIRO Environment Private Bag 5Wembley WA 6913Australia Department of Agricultural and Biological Engineering Indian River Research and Education CenterUniversity of FloridaFort Pierce 34945USA Jiangxi Provincial Key Laboratory of Hydrology-Water Resources and Water Environment Nanchang Institute of TechnologyNanchang 330099China

To investigate the dominant species and interspecific association in the phytoplankton community of the Feiyun River basin in Zhejiang Province,East China,the main stream and the Shanxi Zhaoshandu Reservoir in the downstream were chosen as the study area,for which 22 sampling sites were *** was conducted in September 2021,January,May,and July *** species were identified from both quantitative samples and in-vivo *** was quantified by direct *** show that there were 98 species belonging to 6 phyla and 78 *** addition,to clarify the niches of the dominant phytoplankton species and their interspecific association,the dominance index was calculated,and a comprehensive analysis was conducted including niche width,niche overlap value,ecological response rate,overall association,chi-square test,and the *** phytoplankton community exhibited characteristics of a Cyanobacteria-Chlorophyta-Diatom type community,showing higher diversity in spring and lower diversity in *** 11 dominants phytoplankton species from 3 phyla,both frequency and dominance degree varied seasonally,of which Microcystis *** the dominant species in Spring,Autumn,and *** niche widths of the dominant species ranged from 0.234 to 0.933,and were categorized into three *** niche overlap values of the 11 dominant species ranged from 0.359 to 0.959,exhibiting significant seasonal differences-highest in winter followed by autumn,spring,and summer in *** overall correlation among dominant species in all four seasons revealed a non-significant negative association,resulting in an unstable community structure.A significant portion(84.2%)of species pairs displayed positive associations,suggesting a successional pattern where Diatoms dominated while other dominant species shared resources and *** this pattern,stability measurements indicated that the dominant species community remained unstable.T

关键词： phytoplankton dominant species niche interspecific association Feiyun River basin

High loading carbon nanotubes deposited onto porous nickel yarns by solution imbibition as flexible wire-shaped supercapacitor electrodes

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Journal of Energy Chemistry 2018年第3期27卷 836-842页

作者： Chaoqun Kang Dashun Cao yuejiao liu Zhiwei liu Ruiqing liu Xiaomiao Feng Dan Wang Yanwen Ma Key Laboratory for Organic Electronics & Information Displays and Institute of Advanced Materials(IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) Nanjing University of Posts & Telecommunications National Key Laboratory of Biochemical Engineering CAS Center for Excellence in Nanoscience Institute of Process Engineering Chinese Academy of Sciences

The deposition of active materials directly onto metal wires is a general strategy to prepare wire-shaped electrodes for flexible and wearable energy storage devices. However, it is still a critical challenge to coat active materials onto the aimed metal wires because of their smooth surface and small specific surface area. In this work, high porous nickel yarns（PNYs） was fabricated using commercial nylon yarns as templates through step-wise electroless plating, electroplating and calcination processes. The PNYs are composed of multiplied fibers with hollow tubular structure of 5–10 μm in diameter, allowing the imbibition of carbon nanotubes（CNTs） solution by a facile capillary action process. The prepared CNTs/PNY electrodes showed a typical electrochemical double layer capacitive performance and the constructed allsolid flexible wire-shaped symmetric supercapacitors provided a specific capacitance of 4.67 F/cm3 with good cycling stability at a current density of 0.6 A/cm3.

关键词： Porous-yarn Flexible supercapacitor Adsorption phenomenon Capillary action Wire-shaped electrode

Exploration of 5-cyano-6-phenylpyrimidin derivatives containing an 1,2,3-triazole moiety as potent FAD-based LSD1 inhibitors

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Acta Pharmaceutica Sinica B 2020年第9期10卷 1658-1668页

作者： Liying May Haojie Wangy Yinghua You Chaoya Ma yuejiao liu Feifei Yang Yichao Zheng Hongmin liu Collaborative Innovation Center of New Drug Research and Safety Evaluation Henan ProvinceKey Laboratory of Technology of Drug Preparation(Zhengzhou University)Ministry of Education of ChinaKey Laboratory of Henan Province for Drug Quality and EvaluationSchool of Pharmaceutical SciencesZhengzhou UniversityZhengzhou 450001China

Histone lysine specific demethylase 1(LSD1)has become a potential therapeutic target for the treatment of *** and develop novel and potent LSD1 inhibitors is a challenge,although several of them have already entered into clinical ***,for the first time,we reported the discovery of a series of 5-cyano-6-phenylpyrimidine derivatives as LSD1 inhibitors using flavin adenine dinucleotide(FAD)similarity-based designing strategy,of which compound 14 q was finally identified to repress LSD1 with IC50=183 nmol/*** analysis suggested that compound 14 q fitted well into the FAD-binding *** mechanism studies showed that compound 14 q may inhibit LSD1 activity competitively by occupying the FAD binding sites of LSD1 and inhibit cell migration and invasion by reversing epithelial to mesenchymal transition(EMT).Overall,these findings showed that compound14 q is a suitable candidate for further development of novel FAD similarity-based LSD1 inhibitors.

关键词： LSD1 inhibitors Pyrimidine Anticancer Flavin adenine dinucleotide(FAD) Gastric cancer

The calcium-binding activity of fish scale protein hydrolysates

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Journal of Agricultural Chemistry and Environment 2014年第1期3卷 11-15页

作者： Ruiyan Nie yuejiao liu Zunying liu College of Food Science and Engineering Ocean University of China Qingdao China

The calcium-binding activity of tilapia scale protein hydrolysates sequentially hydrolyzed by trypsin, flavor enzyme and pepsin were investigated. The hydrolysates were divided into four fractions using G-15 gel chromatography, and the F3 fraction has the higher calcium-binding activity of 196.3 mg/g. The UV-vis and the Fourier transform infrared spectroscopy (FTIR) demonstrate that the amino nitrogen atoms and the oxygen atoms belonging to the carboxylate groups are the primary binding sites for Ca2+. The X-ray diffraction and scanning electron microscopy (SEM) confirmed the reaction between the peptde and calcium. The results obtained indicated that this fish scale protein hydroly-sates have potential as functional foods for calcium-supplementation.

关键词： Tilapia Fish Scale Calcium-Binding Activity Peptide

陆相页岩及其夹层储集特征对比与差异演化模式

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石油与天然气地质 2023年第6期44卷 1393-1404页

作者：胡宗全王濡岳路菁冯动军刘粤蛟申宝剑刘忠宝王冠平何建华页岩油气富集机理与高效开发全国重点实验室北京102206 中国石化页岩油气勘探开发重点实验室北京102206 中国石化石油勘探开发研究院北京102206 重庆科技学院复杂油田勘探开发重庆市重点实验室重庆401331 成都理工大学能源学院四川成都610059

不同于海相页岩,中国陆相页岩层系源-储配置与耦合关系复杂,页岩与夹层储集特征差异显著,明确其演化规律对陆相页岩油气的勘探具有重要指导意义。利用矿物组分、有机地球化学和物性资料,结合岩心、薄片、扫描电镜观察分析,对处于不同热... 详细信息

不同于海相页岩,中国陆相页岩层系源-储配置与耦合关系复杂,页岩与夹层储集特征差异显著,明确其演化规律对陆相页岩油气的勘探具有重要指导意义。利用矿物组分、有机地球化学和物性资料,结合岩心、薄片、扫描电镜观察分析,对处于不同热演化程度的鄂尔多斯盆地三叠系延长组、四川盆地侏罗系自流井组和松辽盆地白垩系营城组陆相页岩开展系统研究。通过分析页岩层系内页岩与夹层的储集空间类型与物性特征,探讨成岩-生烃协同作用下页岩与夹层孔隙形成演化过程,建立了陆相页岩和夹层孔隙的差异演化模式。结果表明:①中国陆相页岩岩相类型多样,以混合质、黏土质和粉砂质页岩为主,并常与碳酸盐岩、砂岩及凝灰岩等夹层频繁互层,岩相组合类型复杂。页岩储集空间以无机孔为主,有机孔次之,局部发育微裂缝。夹层储集空间以残余粒间(溶)孔、粒内(溶)孔和微裂缝等无机孔缝为主。②陆相页岩及夹层孔隙演化受成岩-生烃作用共同控制,页岩黏土矿物含量高、抗压实能力弱、生烃之前无机孔隙快速减少。进入生油窗后,页岩有机孔、黏土粒间/晶间孔、溶蚀孔和微裂缝发育程度逐渐增加。晚成岩阶段之前,以生油高峰为界,页岩孔隙度具有先降后升的变化规律。夹层则在压实和胶结等作用下逐渐致密,储集性逐渐变差。③延长组处于生油期,有机孔发育程度低,页岩储集条件差,砂岩夹层页岩油富集条件更优;自流井组处于成熟-高熟阶段,油、气共存,页岩有机、无机孔隙均较为发育,页岩储集条件更优,夹层主要为次要储层或隔层;营城组已进入高熟-过熟阶段,最利于页岩气和有机孔的形成,页岩储集条件最优。

关键词：孔隙演化陆相页岩延长组自流井组营城组鄂尔多斯盆地四川盆地松辽盆地

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Frequency Regulation of VSC-MTDC System with Offshore Wind Farms

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 275-286页

作者： Haoyu liu Chongru liu North China Electric Power University Beijing 102206China

Frequency regulation of voltage source converter-based multi-terminal high-voltage direct current(VSC-MTDC)system with offshore wind farms enhances the frequency stability by compensating the power for a disturbed AC ***,it is difficult to reasonably allocate frequency-regulation resources due to a lack of coordination mechanisms between wind farms and the MTDC ***,it is difficult for the frequency control of the wind farms to manage changes in wind speed;and the risk of wind-turbine stalls is ***,based on the kinetic energy of wind turbines and the power margin of the converters,the frequency-regulation capability of wind turbines is evaluated,and a dynamic frequency-support scheme considering the real-time frequency-support capability of the wind turbines and system frequency evolution is proposed to improve the frequency-support performance.A power adaptation technique at variable wind speeds is developed;the active power in the frequency-support stage and restoration stage is switched according to the wind speed.A hierarchical zoning frequency-regulation scheme is designed to use the frequency-regulation resources of different links in the MTDC system with wind *** simulation results show that the novel frequency-regulation strategy maintains frequency stability with wind-speed changes and avoids multiple frequency dips.

关键词： Wind generation voltage source converter-based multi-terminal high-voltage direct current(VSC-MTDC) frequency regulation cooperative control adaptive control variable wind speed

基于数字岩心模拟的深层页岩气储层可压性评价模型

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中国石油大学学报（自然科学版） 2022年第5期46卷 1-11页

作者：赖富强刘粤蛟张海杰王海涛毛海艳张国统重庆科技学院复杂油田勘探开发重庆市重点实验室重庆401331 重庆页岩气勘探开发有限责任公司重庆401147

首先构建深层页岩气储层典型的三维数字岩心模型,再采用有限元分析模拟岩石弹性参数,然后利用摩尔斯分类法确定弹性参数控制因素敏感性相对大小,最终建立基于层次分析法的深层页岩气储层可压性评价模型。结果表明:经过与理论值与实验测... 详细信息

首先构建深层页岩气储层典型的三维数字岩心模型,再采用有限元分析模拟岩石弹性参数,然后利用摩尔斯分类法确定弹性参数控制因素敏感性相对大小,最终建立基于层次分析法的深层页岩气储层可压性评价模型。结果表明:经过与理论值与实验测试值误差分析,数字岩心模拟值可靠;经微地震监测和压裂施工曲线验证,基于数字岩心模拟建立的可压性评价指数与储层改造体积和压裂曲线取得较好的一致性,可为深层页岩气储层靶点层位选取和压裂工艺优化提供指导。

关键词：深层页岩气储层三维数字岩心摩尔斯分类筛选法层次分析法可压性评价

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