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Reinforcement Learning Based Quantization Strategy Optimal Assignment Algorithm for Mixed Precision

Computers, Materials & Continua 2024年第4期79卷 819-836页

作者： yuejiao wang Zhong Ma Chaojie Yang Yu Yang Lu Wei Xi’an Microelectronics Technology Institute Xi’an710065China

The quantization algorithm compresses the original network by reducing the numerical bit width of the model,which improves the computation speed. Because different layers have different redundancy and sensitivity to databit width. Reducing the data bit width will result in a loss of accuracy. Therefore, it is difficult to determinethe optimal bit width for different parts of the network with guaranteed accuracy. Mixed precision quantizationcan effectively reduce the amount of computation while keeping the model accuracy basically unchanged. In thispaper, a hardware-aware mixed precision quantization strategy optimal assignment algorithm adapted to low bitwidth is proposed, and reinforcement learning is used to automatically predict the mixed precision that meets theconstraints of hardware resources. In the state-space design, the standard deviation of weights is used to measurethe distribution difference of data, the execution speed feedback of simulated neural network accelerator inferenceis used as the environment to limit the action space of the agent, and the accuracy of the quantization model afterretraining is used as the reward function to guide the agent to carry out deep reinforcement learning training. Theexperimental results show that the proposed method obtains a suitable model layer-by-layer quantization strategyunder the condition that the computational resources are satisfied, and themodel accuracy is effectively *** proposed method has strong intelligence and certain universality and has strong application potential in thefield of mixed precision quantization and embedded neural network model deployment.

关键词： Mixed precision quantization quantization strategy optimal assignment reinforcement learning neural network model deployment

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circVRK1靶向miR-4428调控急性淋巴细胞白血病KOCL44细胞增殖及凋亡的分子机制研究

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四川大学学报（医学版） 2024年第4期55卷 872-877页

作者：张欢吴斌王月娇中国医科大学附属盛京医院血液内科沈阳110004 中国医科大学附属盛京医院风湿免疫科沈阳110004

目的分析circVRK1和miR-4428在急性淋巴细胞白血病(acute lymphoblastic leukemia, ALL)细胞增殖和凋亡中的关系。方法体外培养ALL细胞KOCL44,实验分组为:pcDNA、pcDNA-circVRK1、anti-miR-NC、anti-miR-4428、si-NC、si-circVRK1、pcDNA-circVRK1+miR-NC和pcDNA-circVRK1+miR-4428组。qRT-PCR检测细胞circVRK1和miR-4428的表达水平;CCK-8法、流式细胞术分别检测细胞增殖及凋亡;双荧光素酶报告实验检测circVRK1与miR-4428的靶向关系[实验分为circVRK1野生型报告质粒(WT-circVRK1)+miR-NC、WT-circVRK1+miR-4428、circVRK1突变报告质粒(MUT-circVRK1)+miR-NC和MUT-circVRK1+miR-4428组];Western blot检测Ki-67、cleaved caspase-3、cleaved caspase-9蛋白表达量。结果相较于pcDNA组,pcDNA-circVRK1组的circVRK1表达上调(P<0.05);与转染pcDNA或者转染anti-miRNC相比,转染pcDNA-circVRK1或anti-miR-4428后,KOCL44细胞活力和Ki-67蛋白表达降低(P<0.05),凋亡率和cleaved caspase-3、cleaved caspase-9蛋白水平增加(P<0.05);circVRK1可负向调控miR-4428的表达,但该作用仅在转染WTcircVRK1的组别中体现;与pcDNA组相比,pcDNA-circVRK1组miR-4428表达降低(P<0.05);与si-NC组相比,si-circVRK1组miR-4428表达增加(P<0.05);与共转染pcDNA-circVRK1+miR-NC相比,共转染pcDNA-circVRK1+miR-4428后细胞活力升高(P<0.05),Ki-67蛋白表达增加(P<0.05),凋亡率和cleaved caspase-3、cleaved caspase-9蛋白水平降低(P<0.05)。结论 circVRK1过表达可通过下调miR-4428表达而减弱ALL细胞增殖能力及诱导细胞凋亡。

关键词：急性淋巴细胞白血病 circVRK1 miR-4428 细胞增殖细胞凋亡

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女性雄性激素质谱多指标检测在多囊卵巢综合征诊断中的应用

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首都医科大学学报 2024年第4期45卷 602-608页

作者：赵越阮祥燕王月姣马郡金婧首都医科大学附属北京妇产医院/北京妇幼保健院内分泌科北京100026

目的探讨液相色谱串联质谱(liquid chromatography-tandem mass spectrometry,LC-MS/MS)法在多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者中高雄激素血症(hyperandrogenemia,HA)检出率,探讨不同种类雄激素在PCOS中的诊断价值。方法纳入2023年1月至2023年12月于首都医科大学附属北京妇产医院妇科内分泌门诊就诊合并雄激素过多临床表现的PCOS患者100例为试验组,同期就诊的健康备孕人群100例为对照组。LC-MS/MS法检测总睾酮(total testosterone,TT)、游离睾酮(free testosterone,FT)、生物活性睾酮(bioavailable testosterone,BIO-T)、雄烯二酮(androstenedione,A2)、17羟孕酮、双氢睾酮、脱氢表雄酮、硫酸脱氢表雄酮、性激素结合球蛋白指标,绘制受试者工作特征曲线,计算曲线下面积(area under curve,AUC),评价各雄激素水平对PCOS的诊断效能,化学发光免疫法(chemiluminescence immunoassay,CLIA)和LC-MS/MS 2种方法比较TT检测水平的诊断价值以及对HA的检出率。结果与对照组相比,试验组TT、黄体生成素(luteinizing hormone,LH)、LH/卵泡刺激素(follicle stimulating hormone,FSH)、抗苗勒管激素、空腹胰岛素、稳态模型的胰岛素抵抗指数均明显升高(P<0.05),FT的AUC诊断灵敏度最高为86.4%(P<0.05,95%CI:0.815~0.912),其次为TT的AUC为84.4%(P<0.05,95%CI:0.812~0.909)、BIO-T的AUC为82.2%(P<0.05,95%CI:0.792~0.896)、A2的AUC为84.2%(P<0.05,95%CI:0.790~0.895)。与CILA法相比,利用LC-MS/MS法检测TT诊断PCOS的灵敏度更高(AUC 0.891 vs 0.841),且对于合并雄激素过多临床征象的PCOS患者HA检出率明显高于CLIA法(P<0.05)。结论LC-MS/MS法对多种雄激素指标检测灵敏度高、准确性好,FT对于高雄激素临床表现的PCOS诊断价值最高,且该法可提高PCOS的检出率,实现HA的早期筛查,更适合临床推广应用。

关键词：多囊卵巢综合征高雄激素血症液相色谱串联质谱游离睾酮化学发光免疫

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Machine Learning‑Enhanced Flexible Mechanical Sensing

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Nano-Micro Letters 2023年第4期15卷 190-222页

作者： yuejiao wang Mukhtar Lawan Adam Yunlong Zhao Weihao Zheng Libo Gao Zongyou Yin Haitao Zhao Applied Mechanics Laboratory Department of Engineering MechanicsTsinghua UniversityBeijing 100084People’s Republic of China Materials Interfaces Center Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055People’s Republic of China Department of Mechanical and Electrical Engineering Xiamen UniversityXiamen 361102People’s Republic of China School of Mechano‑Electronic Engineering Xidian UniversityXi’an 710071People’s Republic of China Research School of Chemistry Australian National UniversityCanberraACT 2601Australia

To realize a hyperconnected smart society with high productivity,advances in flexible sensing technology are highly ***,flexible sensing technology has witnessed improvements in both the hardware performances of sensor devices and the data processing capabilities of the device’s *** research efforts have been devoted to improving materials,sensing mechanism,and configurations of flexible sensing systems in a quest to fulfill the requirements of future ***,advanced data analysis methods are being developed to extract useful information from increasingly complicated data collected by a single sensor or network of *** learning(ML)as an important branch of artificial intelligence can efficiently handle such complex data,which can be multi-dimensional and multi-faceted,thus providing a powerful tool for easy interpretation of sensing *** this review,the fundamental working mechanisms and common types of flexible mechanical sensors are firstly *** how ML-assisted data interpretation improves the applications of flexible mechanical sensors and other closely-related sensors in various areas is elaborated,which includes health monitoring,human-machine interfaces,object/surface recognition,pressure prediction,and human posture/motion ***,the advantages,challenges,and future perspectives associated with the fusion of flexible mechanical sensing technology and ML algorithms are *** will give significant insights to enable the advancement of next-generation artificial flexible mechanical sensing.

关键词： Flexible mechanical sensors Machine learning Artificial intelligence Data processing

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人工智能在生殖内分泌领域中的应用

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首都医科大学学报 2024年第4期45卷 566-572页

作者：裴友娟阮祥燕鞠蕊王月姣蒋玲玲马郡首都医科大学附属北京妇产医院内分泌科北京100026 首都医科大学附属北京怀柔医院妇产科北京100041

随着人工智能(artificial intelligence,AI)在医学领域的广泛应用与迅猛发展,生殖内分泌亚专科作为妇产科重要的一部分,也越来越多地应用AI技术解决生殖内分泌疾病的诊断、治疗、健康管理、监督及预防等问题。本文将从AI发展简史及AI在... 详细信息

随着人工智能(artificial intelligence,AI)在医学领域的广泛应用与迅猛发展,生殖内分泌亚专科作为妇产科重要的一部分,也越来越多地应用AI技术解决生殖内分泌疾病的诊断、治疗、健康管理、监督及预防等问题。本文将从AI发展简史及AI在生殖内分泌领域中的应用进行阐述,总结AI在生殖内分泌领域应用中的现状、可行性及局限性,为AI在生殖内分泌领域的研究提供更广阔的思路。

关键词：人工智能生殖内分泌机器学习深度学习 ChatGPT

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Adaptively temporal graph convolution model for epidemic prediction of multiple age groups

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Fundamental Research 2022年第2期2卷 311-320页

作者： yuejiao wang Dajun Daniel Zeng Qingpeng Zhang Pengfei Zhao Xiaoli wang Quanyi wang Yin Luo Zhidong Cao The State Key Laboratory of Management and Control for Complex Systems Institute of AutomationChinese Academy of SciencesBeijingChina School of Artificial Intelligence University of Chinese Academy of SciencesBeijingChina Shenzhen Artificial Intelligence and Data Science Institute(Longhua) ShenzhenChina School of Data Science City University of Hong Kong-Hong Kong SARChina Institute for Infectious Disease and Endemic Disease Control Beijing Center for Disease Prevention and Control BeijingChina

Introduction:Multivariate time series prediction of infectious diseases is significant to public health,and the deep learning method has attracted increasing attention in this research *** and methods:An adaptively temporal graph convolution(ATGCN)model,which leams the contact patterns of multiple age groups in a graph-based approach,was proposed for COVID-19 and influenza *** compared ATGCN with autoregressive models,deep sequence learning models,and experience-based ATGCN models in short-term and long-term prediction ***:Results showed that the ATGCN model performed better than the autoregressive models and the deep sequence learning models on two datasets in both short-term(12.5%and 10%improvements on RMSE)and longterm(12.4%and 5%improvements on RMSE)prediction *** the RMSE of ATGCN predictions fluctuated least in different age groups of COVID-19(0.029±0.003)and influenza(0.059±0.008).Compared with the Ones-ATGCN model or the Pre-ATGCN model,the ATGCN model was more robust in performance,with RMSE of 0.0293 and 0.06 on two datasets when horizon is ***:Our research indicates a broad application prospect of deep learning in the field of infectious disease *** characteristics and domain knowledge of infectious diseases should be further applied to the design of deep learning models and feature ***:The ATGCN model addressed the multivariate time series forecasting in a graph-based deep learning approach and achieved robust prediction on the confirmed cases of multiple age groups,indicating its great potentials for exploring the implicit interactions of multivariate variables.

关键词： Graph convolution model Infectious disease prediction Multiple age group Multivariate time series Public health

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乳双歧杆菌Probio-M8发酵乳缓解便秘的作用

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食品研究与开发 2024年第2期45卷 22-27,43页

作者：李培培李树森孙二娜王月娇刘巨龙内蒙古农业大学乳品生物技术与工程教育部重点实验室内蒙古呼和浩特010018 蒙牛高科乳制品(北京)有限责任公司北京101107

便秘是一种常见的消化道疾病,益生菌可通过维持肠道菌群平衡、产生有益代谢产物、促进肠道蠕动和缓解炎症等方式改善便秘。该文对乳双歧杆菌Probio-M8发酵乳进行动态体外仿生消化系统测试,并利用人群实验探究发酵乳对便秘的有益影响。... 详细信息

便秘是一种常见的消化道疾病,益生菌可通过维持肠道菌群平衡、产生有益代谢产物、促进肠道蠕动和缓解炎症等方式改善便秘。该文对乳双歧杆菌Probio-M8发酵乳进行动态体外仿生消化系统测试,并利用人群实验探究发酵乳对便秘的有益影响。结果发现:乳双歧杆菌Probio-M8具有良好的耐胃肠液能力,能够以活菌的状态进入宿主体内发挥益生功效。受试者在饮用乳双歧杆菌Probio-M8发酵乳后,排便频次、排便类型和排便用力程度均得到改善,其中排便类型和排便用力程度的改善效果在40~50岁的人群中尤为明显。

关键词：便秘益生菌乳双歧杆菌Probio-M8 发酵乳动态体外仿生消化系统

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Nickel-Catalyzed Regiodivergent Asymmetric Cycloadditions of α,β-Unsaturated Carbonyl Compounds

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CCS Chemistry 2022年第9期4卷 3122-3133页

作者： Shi Cao Ziqi Ye Yuehua Chen Yu-Mei Lin Jiahua Fang yuejiao wang Boxuan Yang Lei Gong Key Laboratory of Chemical Biology of Fujian Province iChEMCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamenFujian 361005

Regiodivergent asymmetric cycloadditions from the same set of starting materials offer interesting opportunities for rapid construction of optically active cyclic molecules with structural ***,this remains a challenging task due to the difficulty of simultaneously controlling the regio-,diastereo-,and enantioselectivity in the ring formation *** address this long-standing problem.

关键词： cycloaddition regiodivergent asymmetric photocatalysis visible light nickel

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Highly Sensitive Pseudocapacitive Iontronic Pressure Sensor with Broad Sensing Range

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Nano-Micro Letters 2021年第9期13卷 209-222页

作者： Libo Gao Meng wang Weidong wang Hongcheng Xu yuejiao wang Haitao Zhao Ke Cao Dandan Xu Lei Li School of Mechano-Electronic Engineering Xidian UniversityXian 710071ShaanxiP.R.China CityU-Xidian Joint Laboratory of Micro/Nano-Manufacturing Shenzhen 518057P.R.China Department of Mechanical Engineering City University of Hong KongKowloon 999077Hong Kong SARP.R.China Materials Interfaces Center Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055GuangdongP.R.China State Key Laboratory for Mechanical Behavior of Materials Xian Jiaotong UniversityNo.28Xianning West RoadXian 710049ShaanxiP.R.China

Flexible pressure sensors are unprecedentedly studied on monitoring human physical activities and ***,improving the response sensitivity and sensing range of flexible pressure sensors is a great challenge,which hinders the devices’practical *** this obstacle,we developed a Ti_(3)C_(2)T_(x)-derived iontronic pressure sensor(TIPS)by taking the advantages of the high intercalation pseudocapacitance under high pressure and rationally designed structural *** achieved an ultrahigh sen-sitivity(S_(min)>200 kPa^(−1),S_(max)>45,000 kPa^(−1))in a broad sensing range of over 1.4 MPa and low limit of detection of 20 Pa as well as stable long-term working durability for 10,000 *** practical application of TIPS in physical activity monitoring and flexible robot manifested its versatile *** study provides a demonstration for exploring pseudocapacitive materials for building flexible iontronic sensors with ultrahigh sensitivity and sensing range to advance the development of high-performance wearable electronics.

关键词： Iontronic sensor Flexible electronics Pressure sensor Pseudocapacitance Ti_(3)C_(2)T_(x)MXene

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Flexible Waterproof Piezoresistive Pressure Sensors with Wide Linear Working Range Based on Conductive Fabrics

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Nano-Micro Letters 2020年第11期12卷 229-241页

作者： Hongcheng Xu Libo Gao yuejiao wang Ke Cao Xinkang Hu Liang wang Meng Mu Min Liu Haiyan Zhang Weidong wang Yang Lu School of Mechano‑Electronic Engineering Xidian UniversityXi’an 710071People’s Republic of China CityU-Xidian Joint Laboratory of Micro/Nano-Manufacturing Xi’an 710071People’s Republic of China Department of Mechanical Engineering City University of Hong KongKowloon 999077Hong Kong SARPeople’s Republic of China Nano‑Manufacturing Laboratory(NML) Shenzhen Research Institute of City University of Hong KongShenzhen 518057People’s Republic of China Micro‑/Nano‑technology Research Center State Key Laboratory for Manufacturing Systems EngineeringXi’an Jiaotong UniversityXi’an 710049People’s Republic of China

Developing flexible sensors with high working performance holds intense interest for diverse applications in leveraging the Internet-of-things(IoT)*** flexible piezoresistive sensors,traditionally most efforts are focused on tailoring the sensing materials to enhance the contact resistance variation for improving the sensitivity and working range,and it,however,remains challenging to simultaneously achieve flexible sensor with a linear working range over a high-pressure region(>100 kPa)and keep a reliable ***,we devised a laserengraved silver-coated fabric as"soft"sensor electrode material to markedly advance the flexible sensor's linear working range to a level of 800 kPa with a high sensitivity of 6.4 kPa^-1 yet a fast response time of only 4 ms as well as long-time durability,which was rarely reported *** integrated sensor successfully routed the wireless signal of pulse rate to the portable smartphone,further demonstrating its potential as a reliable *** with the rationally building the electrode instead of merely focusing on sensing materials capable of significantly improving the sensor's performance,we expect that this design concept and sensor system could potentially pave the way for developing more advanced wearable electronics in the future.

关键词： Flexible sensor Piezoresistive Graphite flakes Laser engraving Silver fabrics

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