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Left ventricular thrombosis caused cerebral embolism during venoarterial extracorporeal membrane oxygenation support: A case report

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World Journal of Clinical Cases 2024年第5期12卷 973-979页

作者： Yao-Bang Bai Feng Zhao Zhen-Hua Wu Guo-ning Shi Nan Jiang Intensive Care Unit Department of Cardiac SurgeryTianjin Chest HospitalTianjin 300222China Department of Cardiac Surgery Tianjin Chest HospitalTianjin 300222China

BACKGROUND Venoarterial(VA)extracorporeal membrane oxygenation(ECMO),an effective short-term circulatory support method for refractory cardiogenic shock,is widely ***,retrospective analyses have shown that VA-ECMO-assisted cases were associated with a relatively high mortality rate of approximately 60%.Embolization in important organs caused by complications of left ventricular thrombosis(LVT)during VA-ECMO is also an important *** the incidence of LVT during VA-ECMO is not high,the consequences of embolization are *** SUMMARY A 37-year-old female patient was admitted to hospital because of fever for 4 d and palpitations for 3 *** excluding the diagnosis of coronary heart disease,we established a diagnosis of“clinically explosive myocarditis”.The patient still had unstable hemodynamics after drug treatment supported by VA-ECMO,with heparin for *** day 4 of ECMO support,a left ventricular thro-mbus attached to the papillary muscle root of the mitral valve was found by transthoracic *** ventricular decompression was performed and ECMO was successfully removed,but the patient eventually died of multiple cerebral *** LVT with high mobility during VA-ECMO may cause embolism in important ***,a"wait and see"strategy should be avoided.

关键词： Venoarterial extracorporeal membrane oxygenation Left ventricular thrombosis Cerebral embolism Magnetic Resonance Imaging Therapy Case report

Perfusion and plaque evaluation to predict recurrent stroke in symptomatic middle cerebral artery stenosis

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Stroke & Vascular Neurology 2019年第3期4卷 129-134页

作者： Jinhao Lyu ning Ma Chenglin Tian Feng Xu Hang Shao Xin Zhou Lin Ma Xin Lou Department of Radiology Chinese PLA General HospitalBeijingChina Department of Interventional Neurology Beijing Tiantan HospitalCapital Medical UniversityChina National Clinical Research Center for Neurological DiseasesCenter of StrokeBeijing Institute for Brain DisordersBeijingChina Department of Neurology Chinese PLA General HospitalBeijingChina Automation Department Tsinghua UniversityBeijingChina State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics National Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsChinese Academy of SciencesWuhanHubeiChina University of ChineseAcademy of Sciences BeijingChina

Background and purpose We investigated the baseline demographics of patients with severe unilateral atherosclerotic stenosis of the middle cerebral artery(MCA)using multimodal MRI and evaluated the haemodynamic impairments and plaque characteristics of patients who had a recurrent *** and methods We retrospectively recruited consecutive patients with severe unilateral atherosclerotic MCA stenosis who underwent arterial spin labelling(ASL)with postlabelling delay(PLD)of 1.5 and 2.5 s,and vessel wall *** each PLD,cerebral blood flow(CBF)maps were *** volume ratio(HVR)from 2 PLD CBF was *** HVR value≥50%was considered as severe *** areas,plaque burden,plaque length and remodelling index were *** enhancement at maximal lumen narrowing site were *** clinical and imaging characteristics were compared between patients with(event+)and without(event?)1 year ischaemic *** Forty-three patients(47.23±12.15 years;28 men)were enrolled in this *** patients had an HVR≥50%.During the 1-year follow-up,7 patients had experienced a recurrent *** were significantly higher in the event+than event?(53.17%±29.82%vs 16.9%±15.57%,p=0.0002),whereas no significant difference was detected in plaque areas,plaque burden,remodelling index,plaque length and plaque enhancement *** multivariable analysis revealed that a severe HVR was significantly associated with a recurrent stroke(Odds ratio=12.93,95%confidence interval 1.57 to 106.24,p=0.017)after adjusted by hypertension and *** HVR obtained from two PLD ASL may be a useful imaging predictor of recurrent stroke.

关键词： stenosis cerebral plaque

Human bronchial epithelial cell injuries induced by fine particulate matter from sandstorm and non-sandstorm periods：Association with particle constituents

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Journal of Environmental Sciences 2016年第9期28卷 201-210页

作者： Bin Wang ning Li Furong Deng Nicholas Buglak George Park Shu Su Aiguo Ren Guofeng Shen Shu Tao Xinbiao Guo Institute of Reproductive & Child Health/Ministry of Health Key Laboratory of Reproductive Health School of Public Health Peking University Beijing 100192 China Department of Pathobiology & Diagnostic Investigation College of Veterinary Medicine Michigan State University East Lansing 48824 USA Department of Occupational & Environmental Health Sciences School of Public Health Peking University Beijing 100191 China Laboratory for Earth Surface Processes College of Urban & Environmental Sciences Peking University Beijing 100871 China Jiangsu Provincial Academy of Environmental Science Nanjing 210036 China

Epidemiological studies have demonstrated the exacerbation of respiratory diseases following sandstorm-derived particulate matter（PM） *** presence of anthropogenic and biological agents on the sandstorm PM and the escalation of PM 〈 2.5 μm（PM2.5）pollution in China have led to serious concerns regarding the health effects of PM2.5during Asian *** investigated how changes in PM2.5composition,as the weather transitioned towards a sandstorm,affected human airway epithelial *** PM2.5samples covering two sandstorm events and their respective background and transition periods were collected in Baotou,an industrial city near the Gobi Desert in *** samples from all three periods had mild cytotoxicity in human bronchial epithelial cell line BEAS-2B,which was positively correlated with the contents of polycyclic aromatic hydrocarbons and several *** PM samples potently increased the release of interleukin-6（IL-6） and interleukin-8（IL-8）.Endotoxin in all samples contributed significantly to the IL-6 response,with only a minor effect on *** was positively correlated with both IL-6 and IL-8 release,while Si was only associated with the increase of *** study suggests that local agricultural and industrial surroundings in addition to the sandstorm play important roles in the respiratory effects of sandstorm-derived PM.

关键词： Sandstorm particles Human bronchial epithelial cells Particle constituents Inflammation Local environmental surroundings

Defect physics of the quasi-two-dimensional photovoltaic semiconductor GeSe

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Chinese Physics B 2022年第11期31卷 60-66页

作者： Saichao Yan Jinchen Wei Shanshan Wang Menglin Huang Yu-ning Wu Shiyou Chen Key Laboratory of Polar Materials and Devices(MOE)and Department of Electronics East China Normal UniversityShanghai 200241China State Key Laboratory of ASIC and System School of MicroelectronicsFudan UniversityShanghai 200433China

GeSe has recently emerged as a photovoltaic absorber material due to its attractive optical and electrical properties as well as earth abundancy and low ***,the efficiency of GeSe thin-film solar cells(TFSCs)is still low compared to the Shockley–Queisser *** defects are believed to play important roles in the electrical and optical properties of GeSe thin ***,we perform first-principles calculations to study the defect characteristics of *** results demonstrate that no matter under the Ge-rich or Se-rich condition,the Fermi level is always located near the valence band edge,leading to the p-type conductivity of undoped *** Se-rich condition,the Ge vacancy(V_(Ge))has the lowest formation energy,with a(0/2–)charge-state transition level at 0.22 eV above the valence band *** high density(above 10^(17)cm^(-3))and shallow level of VGeimply that it is the p-type origin of *** Se-rich growth condition,Seihas a low formation energy in the neutral state,but it does not introduce any defect level in the band gap,suggesting that it neither contributes to electrical conductivity nor induces non-radiative *** addition,Gei introduces a deep charge-state transition level,making it a possible recombination ***,we propose that the Se-rich condition should be adopted to fabricate high-efficiency GeSe solar cells.

关键词： GeSe bulk point defect concentration photovoltaic

The Formation of SO_(2) and Emission Reduction Solutions in the Preparation of a Hydrogenation Catalyst Support

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China Petroleum Processing & Petrochemical Technology 2024年第1期26卷 98-106页

作者： Hu Anpeng Wang Zhen Yang Qinghe Hu Dawei Gong Yu Jia Yanzi Dai Qiaoling Pu ning SINOPEC Research Institute of Petroleum Processing Beijing 100083China Zibo Qimao Catalyst Co. Ltd.Zibo 255400China

The key reason for SO_(2) formation during the production of a residue hydrogenation catalyst support was identified and subsequent emission reduction solutions were then investigated and verified *** results demonstrated that carbon-containing organic materials,including sesbania powder and cellulose,did not completely decompose over the temperature range of 350−600℃during the heating stage of the calcination process,but rather underwent a condensation reaction within the same temperature range to form carbon-containing species with a lower ratio of hydrogen to carbon and a higher condensation degree,which promoted the decomposition of sulfate to form SO_(2).Systematic experimental work revealed that three different measures,i.e.,applying the staged calcination method,reducing the heating rate,and increasing the air flow rate,during the calcination process could all achieve the effect of reducing SO_(2) emissions.

关键词： alumina sesbania powder cellulose sulfur dioxide

Evaluation of atherosclerotic lesions in cholesterol-fed mice during treatment with paclitaxel in lipid nanoparticles： a magnetic resonance imaging study

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The Journal of Biomedical Research 2017年第2期31卷 116-121页

作者： Aline D. Lima ning Hua Raul C. Maranhao James A. Hamilton Laboratory of Metabolism and Lipids Heart Institute of the Medical School HospitalSao PauloBrazil Department of Physiology and Biophysics Boston University School of MedicineBostonMA 02118USA

Cholesterol-core nanoparticles （LDE） have been shown to be recognized by low-density lipoprotein receptors （LDLR） after administration; therefore, LDE is an ideal vehicle to deliver drug with targeting property. Paclitaxel, when incorporated into LDE, promotes atherosclerosis regression with reduced drug toxicity in rabbits through LDLR. Here, we tested whether LDE-paclitaxel could still be effective in reducing diet-induced atherosclerosis in a mouse model without LDLR. Nineteen LDLR knockout male mice were fed 1% cholesterol for 12 weeks. Then, 12 animals received 4-weekly intraperitoneal LDE-paclitaxel （4 mg/kg） while 7 controls received saline solution. On week 12 and 16, in vivo MR/of the aortic roots was performed. Aorta macroscopy was made after euthanasia. Reduction ofatherosclerotic lesions was observed. LDE-paclitaxel treatment resulted in reduction of wall area （14%） and stenosis （22%） by MR/and 33% by macroscopy. Thus, LDE-paclitaxel may produce pharmacological effects through LDE uptake by mechanisms other than LDLR.

关键词： atherosclerosis treatment lipid solid nanoparticles emulsions paclitaxel MRI drug targeting

Machine learning models for outcome prediction of Chinese uveal melanoma patients: A 15-year follow-up study

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Cancer Communications 2022年第3期42卷 273-276页

作者： Yu-ning Chen Yi-ning Wang Meng-Xi Chen Kai Zhang Rong-Tian Chen Rui Fang Heng Wang Hai-Han Zhang Yi-ning Huang Yu Feng Jing-Ting Luo Yin-Jun Lan Yue-Ming Liu Yang Li Wen-Bin Wei Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Ophthalmology&Visual Sciences Key LabMedical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information TechnologyBeijing Tongren HospitalCapital Medical UniversityBeijing 100730P.R.China InferVision Healthcare Science and Technology Limited Company Shanghai 200030P.R.China

Dear Editor Uveal melanoma(UM)is the most frequent primary malig-nant intraocular tumor in adults with an estimated inci-dence of 4-5 per million per year in western countries[1].About 50%of UM patients eventually develop *** a previous study,the prognosis of Chinese UM was mainly correlated with visual clinical features and gene sequencing *** designed to predict UM prognosis have been previously described[2],but these studies were based on Caucasians,not Chinese.

关键词： melanoma patients prognosis

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基于局域波分解的大系统派生模态降维研究

西北工业大学学报 2010年第1期28卷 33-36页

作者：宁宁张骏杨秉政西北工业大学自动化学院陕西西安710072

文章分析了当前以平衡与截裁为代表的大系统降维理论,鉴于其内容不尽完善,因此基于系统运动模态的特征,在科技与哲理的辩证分析基础上,建立了大系统派生模态理论和组合降维模型。对于工程实际中的系统响应曲线,提出了基于局域波分解的... 详细信息

文章分析了当前以平衡与截裁为代表的大系统降维理论,鉴于其内容不尽完善,因此基于系统运动模态的特征,在科技与哲理的辩证分析基础上,建立了大系统派生模态理论和组合降维模型。对于工程实际中的系统响应曲线,提出了基于局域波分解的大系统派生模态提取策略实现系统降维。仿真结果表明,基于模态和图形的协同算法应用简便,并可获得较高精度的降维模型。

关键词：算法模型派生模态组合降维模型局域波分解

Long-Cycle Lithium Batteries with LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2) Cathodes above 4.5 V Enabled by Uniform Coating of Nanosized Garnet Electrolytes

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Chinese Physics Letters 2024年第7期41卷 161-175页

作者：王建群赵宁郭向欣 College of Physics Qingdao UniversityQingdao 266071China

The pursuit of high-energy cathode materials has been focused on raising the charging cutoff voltage of nickel (Ni)-rich layered oxide cathode such as LiNi_(0.8)Co_(0.1)Mn_(0.1)O2 (NCM811). However, the NCM811 suffers from rapid capacity fading upon cycling at cutoff voltage higher than 4.5 V, owing to their structural degradation and labile surface reactivity. Surface-coating with solid electrolytes has been recognized as an effective method to mitigate the performance failure of NCM811 at high voltage. Herein, the nano-sized Li_(6.4)La_(3)Ta_(0.6)Zr_(1.4)O_(12) (LLZTO) is uniformly coated on the surface of single-crystal NCM811 particles, accompanied with the long-range Ta^(5+) diffusion into the transition metal layer of NCM811 lattice. It is revealed that the LLZTO coating can not only inhibit the surface reactions of NCM811 with liquid electrolytes but also play an important role in suppressing the bulk microcracking within the NCM811 particles. The incorporation of Ta^(5+) ion expands the lattice spacing and thereby improves the homogeneity of the Li^(+) diffusion in the single-crystal NCM811, which alleviates the mechanical strain and intragranular cracks caused by nonuniform phases-transformation at high charging voltage. The synergy of surface protection and structural stabilization realized by LLZTO coating enables the NCM811-based lithium batteries to achieve a remarkable electrochemical performance. Typically, LLZTO coated NCM811 delivers a high reversible specific capacity of 202.1 mAh⋅g^(−1) with an excellent capacity retention as high as 70% over 1000 cycles upon charging to 4.5 V at 1 C.

关键词： coating cycling sized