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Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-Zheng Lan Zheng Wu Wen-Jia Chen Xin-ning Yu Hua-Tao Wu Jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

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芍药苷对血管紧张素Ⅱ诱导心肌成纤维细胞纤维化的保护作用

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中国组织工程研究 2025年第25期29卷 5382-5389页

作者：纪雅琼宁忠平上海中医药大学上海市201203 上海健康医学院附属周浦医院心血管内科上海市201318

背景:研究表明芍药苷对肝、肾等器官纤维化具有改善作用,尤其是在肝纤维化中表现出突出优势,但芍药苷对于血管紧张素Ⅱ诱导的心肌纤维化的保护作用尚不明确。目的:探讨芍药苷对血管紧张素Ⅱ诱导的心肌成纤维细胞的保护作用及分子机制。... 详细信息

背景:研究表明芍药苷对肝、肾等器官纤维化具有改善作用,尤其是在肝纤维化中表现出突出优势,但芍药苷对于血管紧张素Ⅱ诱导的心肌纤维化的保护作用尚不明确。目的:探讨芍药苷对血管紧张素Ⅱ诱导的心肌成纤维细胞的保护作用及分子机制。方法:在分离培养的SD大鼠乳鼠心肌成纤维细胞中加入血管紧张素Ⅱ(1μmol/L)干预48 h作为模型组;芍药苷低、高剂量组给予不同剂量的芍药苷(50,100μmol/L)预处理2 h,再用血管紧张素Ⅱ处理48 h;SIRT1抑制剂组先用10μmol/L SIRT1抑制剂EX527处理2 h,再用100μmol/L芍药苷处理2 h,最后用血管紧张素Ⅱ处理48 h。采用CCK-8法检测细胞活力,Transwell检测细胞迁移能力,用DHA荧光探针检测细胞内活性氧水平,用试剂盒检测氧化应激标志物水平,Western blot检测纤维化相关基因的蛋白表达,qRT-PCR检测细胞外基质和纤维化相关基因的mRNA表达。结果与结论:①与对照组相比,血管紧张素Ⅱ干预后心肌成纤维细胞的增殖、迁移能力明显提高,细胞内活性氧和丙二醛水平升高,超氧化物歧化酶和过氧化氢酶活性降低,α-平滑肌肌动蛋白、Ⅰ型胶原蛋白、Ⅲ型胶原蛋白、纤维连接蛋白、结缔组织生长因子、基质金属蛋白酶9的mRNA表达增加;与模型组相比,芍药苷剂量依赖性抑制上述效应改变(P<0.01);②与模型组相比,芍药苷剂量依赖性上调SIRT1的蛋白表达(P<0.001);③与芍药苷高剂量组相比,SIRT1抑制剂组细胞迁移数量、α-平滑肌肌动蛋白、Ⅰ型胶原蛋白、Ⅲ型胶原蛋白表达水平显著增加(P<0.01)。结果表明,芍药苷可能通过上调SIRT1的表达,有效减轻了血管紧张素Ⅱ诱导的心肌成纤维细胞纤维化改变,剂量依赖性地抑制了心肌成纤维细胞氧化应激和细胞外基质沉积,对于心肌成纤维细胞纤维化具有保护作用。

关键词：芍药苷心肌成纤维细胞血管紧张素Ⅱ 细胞外基质纤维化氧化应激

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Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report

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World Journal of Clinical Cases 2025年第1期13卷 48-55页

作者： Xiao-Yu Zhao Juan-Han Yu Yi-Hua Wang Yi-Xin Liu Lu Xu Lin Fu ning Yi China Medical University The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Anshan Cancer Hospital Anshan 114000Liaoning ProvinceChina

BACKGROUND Ependymoma with lipomatous differentiation is a rare type of *** ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system *** fusion-positive lipomatous ependymoma has not been reported to *** SUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six *** resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination showed characteristic perivascular pseudorosettes and adipose differentiation in the ***-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,Syn and p53,but positive for GFAP,vimentin and S-100 ***-ficant punctate intracytoplasmic EMA immunoreactivity was *** level of Ki-67 was about 5%.Genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was *** follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance *** Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous *** case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关键词： Ependymoma Lipomatous Molecular classification Supratentorial ZFTA:RELA fusion Case report

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Alloying Behaviour and Atomic Size Effect in Palladium-rich Pd-RE Systems

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Journal of Materials Science & Technology 1997年第1期13卷 21-26页

作者： ning, YN ning, YT KUNMING INST PRECIOUS MET KUNMING 650221PEOPLES R CHINA

The alloying behaviour, including solid solubilities of rare-earths as well as the formation and stability of various intermediate phases in palladium-rich Pd-RE systems were studied by means of the atomic size factor and the reduced transition temperatures. A strong analogy is observed in the plots of the reduced transition temperatures of Various intermediate phases against the atomic numbers of rare-earths, and the law proposed by Hume-Rothery and Raynor for dependence of liquidus temperature on atomic radius in simple alloy systems has been extended to more complicated alloy systems.

关键词： Palladium alloys

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弹目交会条件下爆炸驱动结构体的展开过程研究

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高压物理学报 2025年第1期39卷 1-16页

作者：宁建国汪齐栗建桥北京理工大学爆炸科学与安全防护全国重点实验室北京100081

复杂结构在爆炸驱动作用下的展开是展开型定向战斗部定向过程中的关键问题,对展开过程进行有效控制,有利于战斗部的起爆延时控制和破片利用率提高。针对复杂结构体的展开问题,基于JWL状态方程和第二类拉格朗日方程,从能量守恒出发推导... 详细信息

复杂结构在爆炸驱动作用下的展开是展开型定向战斗部定向过程中的关键问题,对展开过程进行有效控制,有利于战斗部的起爆延时控制和破片利用率提高。针对复杂结构体的展开问题,基于JWL状态方程和第二类拉格朗日方程,从能量守恒出发推导了考虑爆轰产物膨胀过程和对目标命中状态的爆炸驱动展开模型。将驱动展开模型计算结果与文献实验结果进行对比,验证了爆炸驱动展开模型计算结果的准确性。结果表明,基于该模型的理论计算结果与实验结果的一致性较好,能较为精确地预测不同装药量下结构的展开时间;将辅助装药1与辅助装药2的质量比控制在1.5~1.7,结构体展开可达最佳命中姿态,更有利于命中目标。研究成果可充实定向战斗部设计理论,为展开型定向战斗部的设计提供参考。

关键词：爆炸驱动展开姿态展开时间辅助装药定向战斗部

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Phase Behaviors of Soft-core Particle Systems

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Chinese Journal of Polymer Science 2019年第11期37卷 1065-1082页

作者： ning Xu Hefei National Laboratory for Physical Sciences at the Microscale CAS Key Laboratory of Soft Matter Chemistry and Department of Physics University of Science and Technology of China

This paper reviews some of our recent works on phase behaviors of particulate systems with a soft-core interaction potential. The potential is purely repulsive and bounded, i.e., it is finite even when two particles completely overlap. The one-sided linear spring (harmonic) potential is one of the representatives. This model system has been successively employed to study the jamming transition, i.e., the formation of rigid and disordered packings of hard particles, and establish the jamming physics. This is actually based on the "hard" aspect of the potential, because at low densities and when particle overlap is tiny the potential resembles the hard sphere limit. At high densities, the potential exhibits its "soft" aspect: with the increase of density, there are successive reentrant crystallizations with many types of solid phases. Taking advantage of the dual nature of the potential, we investigate the criticality of the jamming transition from different perspectives, extend the jamming scenario to high densities, reveal the novel density evolution of two-dimensional melting, and find unexpected formation of quasicrystals. It is surprising that such a simple potential can exhibit so rich and unexpected phenomena in phase transitions. The phase behaviors discussed in this paper are also highly regarded in polymer science, which may thus shed light on our understanding of polymeric systems or inspire new ideas in studies of polymers.

关键词： Phase transitions Soft-core particles Jamming Two-dimensional melting Quasicrystals

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SUPERCONVERGENCE AND A POSTERIORI ERROR ESTIMATES FOR BOUNDARY CONTROL GOVERNED BY STOKES EQUATIONS

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Journal of Computational Mathematics 2006年第3期24卷 343-356页

作者： Hui-po Liu ning-ning Yan Institute of Systems Science Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100080 China

In this paper, the superconvergence results are derived for a class of boundary control problems governed by Stokes equations. We derive superconvergence results for both the control and the state approximation. Base ... 详细信息

关键词： Boundary control Finite element method Superconvergence A posteriori error estimates.

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Delaunay graph-based moving mesh method with damping functions

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Chinese Journal of Aeronautics 2018年第11期31卷 2093-2103页

作者： Yibin WANG ning QIN ning ZHAO College of Aerospace Engineering Nanjing University of Aeronautics and Astronautics Department of Mechanical Engineering The University of Sheffield

The fluid–structure interaction and aerodynamic shape optimization usually involve the moving or deforming boundaries, thus the dynamic mesh techniques are the key techniques to cope with such deformation. A novel dynamic mesh method was developed based on the Delaunay graph in this paper. According to the Delaunay graph, the mesh points were divided into groups. In each group, a factor ranging from 0 to 1 was calculated based on the area/volume ratio. By introducing a proper function for this factor, this method can control the mesh quality with high efficiency. Several test cases were compared with other dynamic mesh methods regarding mesh quality and CPU time, such as radial basis function method and Delaunay graph mapping method.

关键词： Delaunay graph mapping Dynamic mesh Grid deformation Mesh Moving mesh

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北师大版初中数学新教材的特色及变化分析

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教学与管理 2025年第1期 44-48页

作者：常海斌宁依敏首都师范大学教育学院北京100048 华东师范大学数学科学学院上海200241

深刻理解和准确解读教材是有效使用教材的前提。北师大版初中数学新教材遵循“教育本位”的教材编写理念,在章首语、栏目设置、问题解决、习题设计和素材选取上各具特色;教材整体采用跨领域混编、螺旋式上升和小结整合式的编写模式,着... 详细信息

深刻理解和准确解读教材是有效使用教材的前提。北师大版初中数学新教材遵循“教育本位”的教材编写理念,在章首语、栏目设置、问题解决、习题设计和素材选取上各具特色;教材整体采用跨领域混编、螺旋式上升和小结整合式的编写模式,着重凸显课程内容的结构化和认知过程的进阶性;四个学习领域以“研究对象”的形式进行内容整合,具有重视代数推理、重构统计量的组合形式以及对综合与实践领域进行主题迭代和核心创变等变化。

关键词：初中数学新教材教材编写特色北师大版教材新教材变化分析

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Changing structures of summertime heatwaves over China during 1961–2017

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Science China Earth Sciences 2021年第8期64卷 1242-1253页

作者： ning AN Zhiyan ZUO State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China Department of Atmospheric and Oceanic Sciences/Institute of Atmospheric Sciences Fudan UniversityShanghai 200438China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 210044China

Despite the prevalence of artificial separation of daytime and nighttime hot extremes, they may actually co-occur or occur sequentially. Considering their potential lead-lag configuration, this study identified an entire heatwave period as consecutive days with either daytime or nighttime hot extremes and investigated the changes of the prevalence and sequence of daytime and nighttime hot extremes during heatwaves over China from 1961 to 2017. It was found that the majority(82%) of heatwaves were compound heatwaves that had both daytime and nighttime hot extremes exceeding the 90 th percentile-based thresholds, while only 7%(11%) were purely daytime(nighttime) heatwaves that contained only daytime(nighttime) hot extremes. During the entire periods of compound heatwaves, daytime hot extremes usually occurred one day or a few days before nighttime hot extremes, which was in accordance with the daily variations in radiation and meteorological conditions, such as the increasing surface humidity and cloud cover, and decreasing solar radiation during the entire heatwave periods. From 1961 to2017, compound heatwave numbers exhibited the sharpest increase with a statistically significant trend of 0.44 times decade-1, in contrast to an insignificant trend of 0.00 times decade-1 for purely daytime heatwaves and a significant trend of 0.09 times decade-1 for purely nighttime heatwaves. Within the compound heatwave periods, hot nights were starting earlier and ending later, and numbers of concurrent daytime-nighttime hot extremes increased significantly at 0.20 days decade-1. In particular,urban area were not only subject to increasingly more frequent and longer compound heatwaves, but also to more occurrences of concurrent daytime-nighttime hot extremes with more serious impact. This study provides instructions for researchers to customize and select appropriate heatwave indices.

关键词： Heatwaves Daytime-nighttime coupling Urbanization Meteorological conditions

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