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Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer

Genes & Diseases 2024年第1期11卷 218-233页

作者： Zanwen zuo Zerong Zhou Yuzhou Chang Yan Liu Yuping Shen Qizhang Li Lei Zhang Innovative Drug R&D Center College of Life SciencesHuaibei Normal UniversityHuaibeiAnhui 235000China National"111"Center for Cellular Regulation and Molecular Pharmaceutics Key Laboratory of Fermentation Engineering(Ministry of Education)Hubei Key Laboratory of Industrial MicrobiologyCooperative Innovation Center of Industrial Fermentation(Ministry of Education&Hubei Province)and School of Food and Biological EngineeringHubei University of TechnologyWuhanHubei 430068China Department of Biomedical Informatics The Ohio State UniversityColumbusOH 43210USA School of Agriculture and Biology and Engineering Research Center of Cell&Therapeutic AntibodyMinistry of EducationShanghai Jiao Tong UniversityShanghai 200240China College of Chemistry and Bioengineering Hunan University of Science and EngineeringYongzhouHunan425199China Department of Pharmaceutical Botany School of PharmacyNaval Medical UniversityShanghai 200433China

Ribonucleotide reductase M2(RRM2)is a small subunit in ribonucleotide reduc-tases,which participate in nucleotide metabolism and catalyze the conversion of nucleotides to deoxynucleotides,maintaining the dNTP pools for DNA biosynthesis,repair,and ***2 performs a critical role in the malignant biological behaviors of *** structure,regulation,and function of RRM2 and its inhibitors were ***2 gene can produce two transcripts encoding the same ***2 expression is regulated at multiple levels during the processes from transcription to ***,this gene is associated with resistance,regulated cell death,and tumor *** order to develop and design inhibitors of RRM2,appropriate strategies can be adopted based on different ***,a greater appreciation of the characteristics of RRM2 is a benefit for understanding tumorigenesis,resistance in cancer,and tumor ***,RRM2-targeted therapy will be more attention in future therapeutic approaches for enhancement of treatment effects and amelioration of the dismal prognosis.

关键词： Function Inhibition Regulation Resistance RRM2

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Air pressure law of a reservoir constructed in karst sinkholes

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Journal of Mountain Science 2024年第3期21卷 1048-1057页

作者： YU Bo TAI Shengping ZHENG Kexun CHEN Shiwan HAN Xiao WANG Senlin zuo Shuangying Power China Guiyang Engineering Corporation Limited Guiyang 550081China College of Resources and Environmental Engineering Key Laboratory of Karst Georesources and EnvironmentMinistry of EducationGuizhou UniversityGuiyang 550025China

Karst sinkholes with natural negative landform provide favorable conditions for the pumped storage reservoir construction for less excavation ***,the construction of the reservoir would plug the natural karst channels for water and air,which would cause remarkable air pressure in karst channels when the groundwater level fluctuates.A large laboratory simulation test was carried out to study the air pressure variation of a reservoir built on the karst *** air pressure in the karst channel and inside the model was monitored during the groundwater rising and falling *** showed that the variation of air pressure in the karst channel and the surrounding rock exhibited a high degree of *** air pressure increased rapidly at the initial stage of water level rising,followed by a slight decrease,then the air pressure increased sharply when the water level approached the top of the karst *** initial peak of air pressure and the final peak of air pressure were defined,and both air pressure peaks were linearly increasing with the water level rising *** negative air pressure was also analyzed during the drainage process,which was linearly correlated with the water level falling *** causes of air pressure variation in karst channels of a pumped storage reservoir built on the karst sinkhole were *** initial rapid increase,then slight decrease and final sudden increase of air pressure were controlled by the combined effects of air compression in karst channel and air seepage into the surrounding *** the drainage process,the instant negative air pressure and gradual recovering of air pressure were controlled by the combined effects of negative air pressure induced by water level falling and air supply from surrounding *** work could provide valuable reference for the reservoir construction in karst area.

关键词： Simulation test Karst sinkhole Pumped storage reservoir Air pressure Flow rate

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Palladium-catalyzed stereoselective decarboxylative[4+2]cyclization of 2-methylidenetrimethylene carbonates with pyrrolidone-derived enones:Straightforward access to chiral tetrahydropyran-fused spiro-pyrrolidine-2,3-diones

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Chinese Chemical Letters 2024年第6期35卷 279-282页

作者： Ke Zhang Sheng zuo Pengyuan You Tong Ru Fen-Er Chen Key Laboratory of Natural Medicines of the Changbai Mountain Ministry of EducationCollege of PharmacyYanbian UniversityYanji 133002China College of Chemistry and Chemical Engineering Jiangxi Normal UniversityNanchang 330022China Engineering Center of Catalysis and Synthesis for Chiral Molecules Fudan UniversityShanghai 200433China Shanghai Engineering Center of Industrial Catalysis for Chiral Drugs Shanghai 200433China

A novel asymmetric[4+2]cycloaddition of 2-methylidenetrimethylene carbonate with pyrrolidonederived enones has been achieved to produce the functionalized tetrahydropyran-fused spirocyclic scaffolds via *** array of enantioenriched spiro-pyrrolidine-2,3-diones bearing adjacent quaternary and tertiary stereocenters are obtained in high yields with excellent enantioselectivities(up to 96% yield and 99% ee).The further transformation of the product has been accomplished for the construction of medical interesting β^(2,2)-amino acids and β-*** mechanistic research was well conducted.

关键词： Pyrrolidine-2,3-diones 2-Methylidenetrimethylene carbonate Asymmetric annulation Spiroheterocycles Allylic 1,3-strain

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Study on the optimal incident proton energy of ^(7)Li(p,n)^(7)Be neutron source for boron neutron capture therapy

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Nuclear Science and Techniques 2024年第3期35卷 170-180页

作者： Yi-Nan Zhu zuo-Kang Lin Hai-Yan Yu Ye Dai Zhi-Min Dai Xiao-Han Yu Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Science Beijing 100049China

Boron neutron capture therapy(BNCT)is recognized as a precise binary targeted radiotherapy technique that effectively eliminates tumors through the^(10)B(n,α)^(7)Li nuclear *** various neutron sources,accelerator-based sources have emerged as particularly promising for BNCT ***^(7)Li(p,n)^(7)Be reaction is highly regarded as a potential neutron source for BNCT,owing to its low threshold energy for the reaction,significant neutron yield,appropriate average neutron energy,and additional *** study utilized Monte Carlo simulations to model the physical interactions within a lithium target subjected to proton bombardment,including neutron moderation by an MgF_(2)moderator and subsequent BNCT dose analysis using a Snyder head *** study focused on calculating the yields of epithermal neutrons for various incident proton energies,finding an optimal energy at 2.7 ***,the Snyder head phantom was employed in dose simulations to validate the effectiveness of this specific incident energy when utilizing a^(7)Li(p,n)^(7)Be neutron source for BNCT purposes.

关键词： Boron neutron capture therapy ^(7)Li(p,n)7Be neutron source Incident proton energy Monte Carlo simulation

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Explainable artificial intelligence models for mineral prospectivity mapping

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Science China Earth Sciences 2024年第9期67卷 2864-2875页

作者： Renguang zuo Qiuming CHENG Ying XU Fanfan YANG Yihui XIONG Ziye WANG Oliver P.KREUZER State Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesWuhan 430074China School of Earth Sciences and Engineering Sun Yat-sen UniversityZhuhai 519000China Corporate Geoscience Group(CGSG) PO Box 5128 Rockingham BeachWA 6969Australia Economic Geology Research Centre(EGRU) College of Science and EngineeringJames Cook UniversityTownsvilleQLD 4811Australia

Mineral prospectivity mapping(MPM)is designed to reduce the exploration search space by combining and analyzing geological prospecting big *** geological big data are too large and complex for humans to effectively handle and *** intelligence(AI)algorithms,which are powerful tools for mining nonlinear mineralization patterns in big data obtained from mineral exploration,have demonstrated excellent performance in ***,AI-driven MPM faces several challenges,including difficult interpretability,poor generalizability,and physical *** this study,based on previous studies,we devised a novel workflow that aims to constructing more transparent and explainable artificial intelligence(XAI)models for MPM by embedding domain knowledge throughout the AI-driven MPM,from input data to model design and model *** newly proposed approach provides strong geological and conceptual leads that guide the entire AI-driven MPM model training process,thereby improving model interpretability and ***,the development of XAI models for MPM is capable of embedding prior and expert knowledge throughout the modeling process,presenting a valuable and promising area for future research designed to improve MPM.

关键词： Artificial intelligence Mineral prospectivity mapping Geological prospecting big data Domain knowledge Interpretability

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Bayesian inference-based wear prediction method for plain bearings under stationary mixed-friction conditions

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Friction 2024年第6期12卷 1272-1282页

作者： Florian KÖNIG Florian WIRSING Georg JACOBS Rui HE Zhigang TIAN Ming J.zuo Institute for Machine Elements and Systems Engineering RWTH Aachen UniversityAachen 52062Germany Department of Mechanical Engineering University of AlbertaEdmonton T6G1H9Canada Qingdao International Academician Park Research Institute Qingdao 266000China

This study introduces a method to predict the remaining useful life(RUL)of plain bearings operating under stationary,wear-critical *** this method,the transient wear data of a coupled elastohydrodynamic lubrication(mixed-EHL)and wear simulation approach is used to parametrize a statistical,linear degradation *** method incorporates Bayesian inference to update the linear degradation model throughout the runtime and thereby consider the transient,system-dependent wear progression within the RUL prediction.A case study is used to show the suitability of the proposed *** results show that the method can be applied to three distinct types of post-wearing-in behavior:wearing-in with subsequent hydrodynamic,stationary wear,and progressive wear *** hydrodynamic operation leads to an infinite lifetime,the method is successfully applied to predict RUL in cases with stationary and progressive wear.

关键词： plain bearings wear modeling remaining useful life prediction Bayesian inference

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A layered multifunctional framework based on polyacrylonitrile and MOF derivatives for stable lithium metal anode

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Journal of Energy Chemistry 2024年第6期93卷 282-288,I0007页

作者： Fanfan Liu Peng zuo Jing Li Pengcheng Shi Yu Shao Linwei Chen Yihong Tan Tao Ma Engineering Research Center of High-frequency Soft Magnetic Materials and Ceramic Powder Materials of Anhui Province School of Chemistry and Material EngineeringChaohu UniversityHefei 238024AnhuiChina Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China School of Pharmacy Anhui University of Chinese MedicineHefei 230012AnhuiChina School of Materials and Energy Guangdong University of TechnologyGuangzhou 510006GuangdongChina Jiujiang DeFu Technology Co. Ltd.Jiujiang 332000JiangxiChina

Composite Li metal anodes based on three-dimensional(3D) porous frameworks have been considered as an effective material for achieving stable Li metal batteries with high energy ***,uneven Li deposition behavior still occurs at the top of 3D frameworks owing to the local accumulation of Li *** promote uniform Li deposition without top dendrite growth,herein,a layered multifunctional framework based on oxidation-treated polyacrylonitrile(OPAN) and metal-organic framework(MOF) derivatives was proposed for rationally regulating the distribution of Li ions flux,nucleation sites,and electrical *** from these merits,the OPAN/carbon nano fiber-MOF(CMOF) composite framework demonstrated a reversible Li plating/stripping behavior for 500 cycles with a stable Coulombic efficiency of around 99.0% at the current density of 2 mA/cm~***,such a Li composite anode exhibited a superior cycle lifespan of over 1300 h under a low polarized voltage of 18 mV in symmetrical *** the Li composite anode was paired with LiFePO_(4)(LFP) cathode,the obtained full cell exhibited a stable cycling over 500 ***,the COMSOL Multiphysics simulation was conducted to reveal the effects on homogeneous Li ions distribution derived from the above-mentioned OPAN/CMOF framework and electrical insulation/conduction *** electrochemical and simulated results shed light on the difficulties of designing stable and safe Li metal anode via optimizing the 3D frameworks.

关键词： Lithium metal anode Layered multifunctional framework Ions flux redistribution Electrical insulation/conduction structure Uniform Li deposition

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Revealing the intrinsic mechanisms for accelerating nitrogen removal efficiency in the Anammox reactor by adding Fe(Ⅱ)at low temperature

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Chinese Chemical Letters 2024年第8期35卷 341-348页

作者： Linjing Li Wenlai Xu Jianyong Ning Yaping Zhong Chuyue Zhang Jiane zuo Zhicheng Pan State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu 610059China State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China National Postdoctoral Research Station Haitian Water GroupChengdu 610213China National Enterprise Technology Center Haitian Water GroupChengdu 610213China Water Safety and Water Pollution Control Engineering Technology Research Center in Sichuan Province Chengdu 610213China Laboratory of Municipal Wastewater Treatment Technology in Sichuan Province Chengdu 610213China Institute of Environment and Ecology Tsinghua Shenzhen International Graduate SchoolShenzhen 518055China

Fe(Ⅱ)is an essential trace element for anaerobic ammonium oxidation bacteria(AAOB)metabolism,and can improve the nitrogen removal efficiency of anaerobic ammonia oxidation(Anammox).Here we oper-ated two identical expanded granular sludge bed(EGSB)reactors at low temperature(15±3℃)for 154 *** 1(R_(1))received additional Fe(Ⅱ)(0.12 mmol/L)during the late startup phase,while reactor 0(R_(0))served as the control and did not receive extra Fe(Ⅱ).Nitrogen removal in R_(1)became stable at 55 d of operation,ten days earlier than R_(0).The nitrogen removal rate(NRR)of R_(1) was 1.64 kg N m^(−3)d^(−1)and its TN removal rate was as high as 89%,while R_(0)only reached 75%.The addition of Fe(Ⅱ)was fur-ther beneficial to aggregation and stability of the granular sludge,and the used sludge of both reactors showed enrichment for AAOB populations compared to the inoculum,for instance,increased abundance of Candidatus-Kuenenia and in particular of Candidatus-Brocadia(from 0.17%to 10.10%in R_(0)and 7.79%in R_(1)).Diverse microbial species and complex microbial network structure in R_(1)compared to R_(0)promoted the coupled denitrogenation by Anammox,dissimilatory nitrate reduction to ammonium(DNRA),nitrate-dependent Fe oxidation(NDFO),and ferric ammonium oxidation(Feammox).In addition,the microbial community in R_(1)was more resistant to short-term low temperature(2-7℃)starvation,illustrating a further positive effect of adding Fe(Ⅱ)during the startup phase of an Anammox reactor.

关键词： Ambient low temperature Anammox Fe(Ⅱ) Extracellular polymeric substances Microbial community Microbial network analysis

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Mitochondria-specific near-infrared photoactivation of peroxynitrite upconversion luminescent nanogenerator for precision cancer gas therapy

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Acta Pharmaceutica Sinica B 2024年第1期14卷 378-391页

作者： Hui Yu Aliya Tiemuer Xufeng Yao Mingyuan zuo Hai-Yan Wang Yi Liu Xiaoyuan Chen Department of Biomedical Engineering School of EngineeringChina Pharmaceutical UniversityNanjing 211198China School of Mechanical Engineering Southeast UniversityNanjing 211189China Departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingapore 119074Singapore Clinical Imaging Research Centre Centre for Translational MedicineYong Loo Lin School of MedicineNational University of SingaporeSingapore 117599Singapore Nanomedicine Translational Research Program Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore Institute of Molecular and Cell Biology Agency for ScienceTechnologyand Research(A*STAR)ProteosSingapore 138673Singapore

Gas therapy is emerging as a highly promising therapeutic strategy for cancer ***,there are limitations,including the lack of targeted subcellular organelle accuracy and spatiotemporal release precision,associated with gas *** this study,we developed a series of photoactivatable nitric oxide(NO)donors NRh-R-NO(R=Me,Et,Bn,iPr,and Ph)based on an N-nitrosated upconversion luminescent rhodamine *** the irradiation of 808 nm light,only NRh-Ph-NO could effectively release NO and NRh-Ph with a significant turn-on frequency upconversion luminescence(FUCL)signal at 740 nm,ascribed to lower N-N bond dissociation *** also investigated the involved multistage near-infrared-controlled cascade release of gas therapy,including the NO released from NRh-Ph-NO along with one NRh-Ph molecule generation,the superoxide anion O_(2)^(⋅−)produced by the photodynamic therapy(PDT)effect of NRh-Ph,and highly toxic peroxynitrite anion(ONOO‒)generated from the co-existence of NO and O_(2)^(⋅−).After mild nano-modification,the nanogenerator(NRh-Ph-NO NPs)empowered with superior biocompatibility could target *** an 808 nm laser irradiation,NRh-Ph-NO NPs could induce NO/ROS to generate RNS,causing a decrease in the mitochondrial membrane potential and initiating apoptosis by caspase-3 activation,which further induced tumor immunogenic cell death(ICD).In vivo therapeutic results of NRh-Ph-NO NPs showed augmented RNS-potentiated gas therapy,demonstrating excellent biocompatibility and effective tumor inhibition guided by real-time FUCL ***,this versatile strategy defines the targeted RNS-mediated cancer therapy.

关键词： Near infrared Photo-triggered Mitochondrion Upconversion luminescent bioimaging Peroxynitrite Nanogenerator Gas therapy In vivo

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Black phosphorus quantum dots induce myocardial inflammatory responses and metabolic disorders in mice

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Journal of Environmental Sciences 2024年第3期137卷 53-64页

作者： Chao Shen Xiaoyan Ding Jinpeng Ruan Fengkai Ruan Weiping Hu Jiyi Huang Chengyong He Yi Yu Zhenghong zuo Department of Nephrology State Key Laboratory of Cellular Stress BiologySchool of Life SciencesFaculty of Medicine and Life SciencesFujian Clinical Research Center for Chronic Glomerular DiseaseThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361102China

As an ultrasmall derivative of black phosphorus(BP)sheets,BP quantum dots(BP-QDs)have been effectively used in many ***,information on the cardiotoxicity induced by BP-QDs remains *** aimed to evaluate BP-QD-induced cardiac toxicity in *** examination of heart tissue sections was *** sequencing,real-time quantitative PCR(RT–qPCR),western blotting,and enzyme-linked immunosorbent assay(ELISA)assays were used to detect the m RNA and/or protein expression of proinfammatory cytokines,nuclear factor kappa B(NF-κB),phosphatidylinositol3 kinase-protein kinase B(PI3K-AKT),peroxisome proliferator-activated receptor gamma(PPARγ),and glucose/lipid metabolism pathway-related *** found that heart weight and heart/body weight index(HBI)were significantly reduced in mice after intragastric administration of 0.1 or 1 mg/kg BP-QDs for 28 *** addition,obvious infammatory cell infiltration and increased cardiomyocyte diameter were observed in the BP-QD-treated *** expression of proinfammatory cytokines and genes related to the NF-κB signaling pathway further confirmed that BP-QD exposure induced infammatory *** addition,BP-QD treatment also affected the PI3K-AKT,PPARγ,thermogenesis,oxidative phosphorylation,and cardiac muscle contraction signaling *** expression of genes related to glucose/lipid metabolism signaling pathways was dramatically affected by BP-QD exposure,and the effect was primarily mediated by the PPAR signaling *** study provides new insights into the toxicity of BP-QDs to human health.

关键词： BP-QDs Cardiac toxicity Infammatory responses NF-κB signaling pathway PPARγsignaling pathway Glucose/lipid metabolism

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