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Journal of Wuhan University of Technology(Materials Science) 2013年第1期28卷 163-171页

作者：林孙忠屈树新 CHANG Lina guo yuehua DUAN Ke WENG Jie Key Lab of Advanced Technologies of Materials Ministry of Education School of Materials Science and Engineering Southwest Jiaotong University

The present work shows drug-carrier interactions, release behaviors and cell responses of hydroxyapatite （HA） containing salvianolic acid B （Sal B）, astragalus polysaecharide （APS）, and naringin. X-ray diffraction （XRD） showed that the crystallinity and crystal size of HA decreased significantly when Sal B was added （p〈0.05）. Transmission electron microscope （TEM） confirmed that the nano-acicular crystals of HA containing Sal B were the most fine among all specimens. It was conjectured that Sal B preferentially adsorbed on the positively charged surface of HA crystals to inhibit their growth. In vitro release of HA containing Chinese medicines followed the first-order equation. The drug-carrier affinity between HA and Sal B might have prolonged the release of Sal B. The proliferation and differentiation of osteoblasts were promoted by Chinese medicines containing HA in the time and dosage dependent manner. The osteoblasts displayed a polygonal morphology with cell-cell junctions in all cases. It is suggested that the contained Chinese medicines would promote the activities of the osteoblasts.

关键词： hydroxyapatite chinese medicines crystallinity crystal size drug release cell response

Hyaluronic acid-based dual-responsive nanomicelles mediated mutually synergistic photothermal and molecular targeting therapies

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Nano Research 2022年第7期15卷 6361-6371页

作者： Liangliang Cai Ronghua Ni Xiaofei Ma Rongrong Huang Zhiyuan Tang Jinqiu Xu Yong Han yuehua guo Zhifeng Gu Department of Pharmacy Affiliated Hospital of Nantong UniversityNantong 226001China Department of Radiation Oncology Affiliated Hospital of Nantong UniversityNantong 226001China Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityNantong 226001China Department of Rheumatology Affiliated Hospital of Nantong UniversityNantong 226001China

Precise clinical treatment of triple-negative breast cancer(TNBC)is an obstacle in ***-assisted photothermal therapy(PTT)is a superior treatment modality for TNBC in terms of ***,thermoresistance arising from PTT and insufficient drug release from nanocarriers decrease the efficacy of ***13387 is a novel HSP90 inhibitor that can weaken thermoresistance and undergoing clinic II phase study,showing satisfactory antitumour activity through molecularly targeted therapy(MTT).Whereas,it has poor *** hyaluronic acid and stearic acid were connected by hydrazone bonds and disulfide bonds,forming an amphipathic copolymer that could self-assembled into nanomicelles,followed by encapsulating Cypate and *** nanomicelles exhibited great features,including achieving mutually synergistic PTT/MTT for overcoming thermoresistance and promoting translocation of drugs,increasing the solubility of Cypate and AT13387,showing a pH/redox dual response that contributes to drug release,and having the ability of active ***,the nanomicelles developed in this study may be a promising strategy for the precise treatment of TNBC.

关键词： hyaluronic acid nanomicelles dual responsive photothermal therapy molecular targeting therapy

Polydopamine functionalized mesoporous silica as ROS-sensitive drug delivery vehicles for periodontitis treatment by modulating macrophage polarization

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Nano Research 2021年第12期14卷 4577-4583页

作者： Bingbing Bai Chaoyu Gu Xiaohui Lu Xingyu Ge Junling Yang Chenfei Wang Yongchun Gu Aidong Deng yuehua guo Xingmei Feng Zhifeng Gu Department of Stomatology Affiliated Hospital of Nantong UniversityNantong226001China Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityNantong226001China Department of Rheumatology Affiliated Hospital of Nantong UniversityNantong226001China Department of Stomatology Suzhou Ninth People’s HospitalSuzhou215200China

Periodontitis is recognized as the major cause of tooth loss in adults, posing an adverse impact on systemic health. In periodontitis, excessive production of reactive oxygen species (ROS) at the inflamed site culminates in periodontal destruction. In this study, a novel ROS-responsive drug delivery system based on polydopamine (PDA) functionalized mesoporous silica nanoparticles was developed for delivering minocycline hydrochloride (MH) to treat periodontitis. The outer PDA layer and the inner MH of the nanoparticles acted as ROS scavengers and anti-inflammatory agents, respectively. Under the synergistic action of PDA and MH, macrophages were polarized from the pro-inflammatory M1 to the anti-inflammatory M2 phenotype. The in vitro experiments provided convincing evidence that PDA could scavenge ROS effectively, and the expression of pro-inflammatory cytokines was attenuated and the secretion of anti-inflammatory cytokines was enhanced through M1 to M2 polarization of macrophages with the cooperation of MH. In addition, the results obtained from the periodontitis rat models demonstrated that the synergetic effect of PDA and MH prevented alveolar bone loss without causing any adverse effect. Taken together, the results from the present investigation provide a new strategy to remodel the inflammatory microenvironment by inducing the polarization of macrophages from M1 toward M2 state for the treatment of periodontitis.

关键词： periodontitis drug delivery reactive oxygen species macrophage polarization inflammatory microenvironment

Map-based cloning of q LP_(A01.1),a favorable allele from the Gossypium tomentosum chromosome segment line

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Journal of Integrative Agriculture 2024年第10期23卷 3283-3293页

作者： Wenwen Wang Lei Chen Yan Wu Xin guo Jinming Yang Dexin Liu Xueying Liu Kai guo Dajun Liu Zhonghua Teng yuehua Xiao Zhengsheng Zhang Engineering Research Center of South Upland Agriculture Ministry of EducationSouthwest UniversityChongqing 400716China

Cotton is an important natural fiber crop worldwide which plays a vital role in our daily *** yield is a constant goal of cotton breeding,and lint percentage(LP)is one of the important components of cotton fiber yield.A stable QTL controlling LP,qLP_(A01.1),was identified on chromosome A01 from Gossypium hirsutum introgressed lines with *** chromosome segments in a previous *** fine-map qLP_(A01.1),an F2 population with 986individuals was established by crossing *** cultivar CCRI35 with the chromosome segment substitution line HT_390.A high-resolution genetic map including 47 loci and spanning 56.98 cM was constructed in the QTL region,and qLP_(A01.1)was ultimately mapped into an interval corresponding to an~80 kb genome region of chromosome A01in the reference genome,which contained six annotated *** data and sequence analysis revealed that S-acyltransferase protein 24(GoPAT24)might be the target gene of qLP_(A01.1).This result provides the basis for cotton fiber yield improvement via marker-assisted selection(MAS)and further studies on the mechanism of cotton fiber development.

关键词： cotton lint percentage fine-mapping qLPA01.1 GoPAT24

Innovations in metallurgical and materials processes:advancing liquid theory and honoring ***-jie guo's contributions to physical chemistry in metallurgy

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Journal of Iron and Steel Research International 2024年第1期31卷 1-2页

作者： Shuai Liu Jing guo Han-jie guo School of Artificial Intelligence Beijing Technology and Business UniversityBeijing100048China School of Metallurgical and Ecological Engineering University of Science and Technology Beijing(USTB)Beijing100083China

Spanning three decades,***-jie guo's research group has dedicated itself to exploring the fundamental theories and practical applications of physical chemistry within the realm of *** under the assumption that molecul... 详细信息

关键词： chemistry liquid complexes

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国际化多重R&D联盟及其治理模式选择研究

科技管理研究 2005年第10期25卷 75-78页

作者：郭跃华华南理工大学工商管理学院广东广州510640

阐述了国际化多重R&D联盟的概念,并构建了用于分析R&D联盟的过程模型,在此基础上对国际化多重R&D联盟的特点及其所遇到的挑战进行了探讨。最后,提出了一个分析不同类型的国际化多重R&D联盟如何选择合适治理模式的理论框架。

关键词：国际化多重R&D联盟治理模式

飞秒激光参数对四态阶跃型分子光电子能谱的影响

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计算物理 2016年第4期33卷 453-459页

作者：李月华郭玮南华大学电气工程学院湖南衡阳421001

利用含时波包法研究三激光场中四态阶跃型K_2分子光电子能谱的Autler-Townes(AT)分裂.研究第二束激光场强和波长对AT分裂的影响.共振时,光电子谱为对称三分裂,非共振时,不对称三分裂逐渐变为双分裂.波长增加,谱峰以不等位移向低能方向移... 详细信息

利用含时波包法研究三激光场中四态阶跃型K_2分子光电子能谱的Autler-Townes(AT)分裂.研究第二束激光场强和波长对AT分裂的影响.共振时,光电子谱为对称三分裂,非共振时,不对称三分裂逐渐变为双分裂.波长增加,谱峰以不等位移向低能方向移动.边峰间距不随波长的改变而改变,随场强增强而增大.研究结果为进一步从第一性原理的理论研究提供有用的信息,为实现分子的光控制及量子调控提供重要参考.

关键词：含时波包法四态阶跃型K2分子光电子能谱 Autler-Townes分裂

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西部民族地区市场化程度探讨

经济问题探索 2007年第9期 20-25页

作者：郭跃华云南行政学院昆明650111

市场化程度是衡量一个地区市场经济发育发展的基本手段,目前西部民族地区市场化水平同全国水平相比有较大差距,本文阐述西部民族地区市场化进程的状况,探讨完善西部民族地区市场化进程对策措施。

关键词：市场化进程经济发展水平西部民族地区指标体系

Rational Design of High-Activity G-quadruplex/hemin DNAzymes

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Rational Design of High-Activity G-quadruplex/hemin DNAzymes

钒氮微合金化HRB500E热轧带肋钢筋开发

第十届全国化学生物学学术会议

作者： Jielin Chen yuehua guo Yingying Zhang Jun Zhou Huangxian Ju State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing University

G-quadruplex/hemin DNAzymes have been the focus of an intense interest recently owing to their quite unique enzyme-mimicking properties, but limited by its much lower catalytic activity than that of proteinous enzymes. To this end, several strategies have been proposed.[1,2] Herein,[3] we incorporated adenine repeats into several designed G-quadruplex structures either in the loops, bulges, or linkers, and the constructed G-quadruplex/hemin DNAzymes exhibit about fivefold improvement in peroxidase-mimicking activity in our research. Interestingly, the loops exhibit a position-independent but length-dependent effect. The novel enhancement method described here may help in the development of high-activity DNAzymes, illustrated by a dimer G-quadruplex with flanking adenine at one end, a relatively long adenine run in one loop, and another adenine run in the linker. Furthermore, the results inspired us to investigate the role played by the distance between ―prosthetic group‖ and active site of DNAzymes in G-quadruplex/hemin system, which broaden our cognition on the mechanism of DNAzymes.

关键词： G-quadruplex/hemin DNAzyme peroxides

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钢铁钒钛 2019年第6期40卷 113-117页

作者：郭跃华攀钢集团攀枝花钢铁研究院有限公司钒钛资源综合利用国家重点实验室

HRB500E热轧带肋钢筋开发难点在于既要满足高强度,又要满足强屈比Ml.25抗震要求。国内部分钢厂采用VN16合金化工艺生产HRB500E,钢筋强屈比难以达到1.25,针对上述问题采用“VN16+FeV80”锐氮合金化工艺,将饥控制在0.07%-0.11%,氮控制在0.... 详细信息

HRB500E热轧带肋钢筋开发难点在于既要满足高强度,又要满足强屈比Ml.25抗震要求。国内部分钢厂采用VN16合金化工艺生产HRB500E,钢筋强屈比难以达到1.25,针对上述问题采用“VN16+FeV80”锐氮合金化工艺,将饥控制在0.07%-0.11%,氮控制在0.011%-0.015%,通过既发挥锐的析出强化作用又不至于飢过量析出导致强屈比显著下降技术手段,开发并批量稳定生产出强屈比富余量充足的012-032 mm规格HRB500E热轧带肋钢筋,解决了单独采用VN16合金化生产HRB500E钢筋强屈比不合格难题。

关键词：钢筋 HRB500E 帆微合金化飢氮合金饥铁合金强屈比强度