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Aldo-keto reductase family member C3(AKR1C3)promotes hepatocellular carcinoma cell growth by producing prostaglandin F2α

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Oncology Research 2024年第1期32卷 163-174页

作者： KUO-SHYANG JENG PO-YU CHENG yueh-HSIEN lin PO-CHUN LIU PING-HUI TSENG YU-CHAO WANG CHIUNG-FANG CHANG CHUEN-MIIN LEU Division of General Surgery Far Eastern Memorial HospitalNew Taipei City22060Taiwan Institute of Microbiology and Immunology National Yang Ming Chiao Tung UniversityTaipei City11221Taiwan Institute of Biochemistry and Molecular Biology National Yang Ming Chiao Tung UniversityTaipei City11221Taiwan Institute of Biomedical Informatics National Yang Ming Chiao Tung UniversityTaipei City11221Taiwan Department of Medical Research Far Eastern Memorial HospitalNew Taipei City22060Taiwan

Hepatocellular carcinoma(HCC)is a leading cause of death *** therapies are effective for HCC patients with early disease,but many patients suffer recurrence after surgery and have a poor response to ***,new therapeutic targets are *** analyzed gene expression profiles between HCC tissues and normal adjacent tissues from public databases and found that the expression of genes involved in lipid metabolism was significantly *** analysis showed that AKR1C3 was upregulated in tumors,and high AKR1C3 expression was associated with a poorer prognosis in HCC *** vitro,assays demonstrated that the knockdown of AKR1C3 or the addition of the AKR1C3 inhibitor indomethacin suppressed the growth and colony formation of HCC cell *** of AKR1C3 in Huh7 cells reduced tumor growth in *** explore the mechanism,we performed pathway enrichment analysis,and the results linked the expression of AKR1C3 with prostaglandin F2 alpha(PGF2a)downstream target *** of AKR1C3 activity reduced the production of PGF2a,and supplementation with PGF2a restored the growth of indomethacin-treated Huh7 *** of the PGF receptor(PTGFR)and treatment with a PTGFR inhibitor significantly reduced HCC *** showed that indomethacin potentiated the sensitivity of Huh7 cells to *** summary,our results indicate that AKR1C3 upregulation may promote HCC growth by promoting the production of PGF2α,and suppression of PTGFR limited HCC ***,targeting the AKR1C3-PGF2a-PTGFR axis may be a new strategy for the treatment of HCC.

关键词： Hepatocellular carcinoma Aldo-keto reductase family member C3 Prostaglandin F2 alpha Prostaglandin F receptor

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Benign esophageal lesions: Endoscopic and pathologic features

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World Journal of Gastroenterology 2015年第4期21卷 1091-1098页

作者： Shu-Jung Tsai Ching-Chung lin Chen-Wang Chang Chien-Yuan Hung Tze-Yu Shieh Horng-Yuan Wang Shou-Chuan shih Ming-Jen Chen Division of Gastroenterology Department of Internal MedicineMackay Memorial Hospital Department of Nursing Nursing and Management Mackay Junior College of Medicine Mackay Medical College

Benign esophageal lesions have a wide spectrum of clinical and pathologic features. Understanding the endoscopic and pathologic features of esophageal lesions is essential for their detection, differential diagnosis, and management. The purpose of this review is to provide updated features that may help physicians to appropriately manage these esophageal lesions. The endoscopic features of 2997 patients are reviewed. In epithelial lesions, the frequency of occurrence was in the following order: glycogenic acanthosis, heterotopic gastric mucosa, squamous papilloma, hyperplastic polyp, ectopic sebaceous gland and xanthoma. In subepithelial lesions, the order was as follows: hemangioma, leiomyoma, dysphagia aortica and granular cell tumor. Most benign esophageal lesions can be diagnosed according to their endoscopic appearance and findings on routine biopsy, and submucosal lesions, by endoscopic resection. Management is generally based upon the confidence of diagnosis and whether the lesion causes symptoms. We suggest endoscopic resection of all granular cell tumors and squamous papillomas because, while rare, these lesions have malignant potential. Dysphagia aortica should be considered in the differential diagnosis of dysphagia in the elderly.

关键词： Benign tumor Esophagus Epithelial lesions Subepith

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Financial Support Mechanisms and Financing Instruments for Climate Change Adaptation

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Journal of Environmental Protection 2016年第2期7卷 242-252页

作者： shih-Fang Lo Chou-Yen Wu Chun-Hsu lin Center for Green Economy Chung-Hua Institution for Economic Research Taiwan Research Division V Taiwan Institute of Economic Research Taiwan

Extreme weather has been having an increase in frequency and severity because of global warming. Heavy financial burden on governments has been increasing as reconstruction of natural disaster and prevention of public construction spending. Unlike the climate mitigation activities, the main purpose of climate adaptation is to establish climate risk management system. We discuss several types of financing instruments and collect several cases in both developed and developing countries internationally. We find that budget reallocation or government bonds are regularly used for losses from natural disaster in developing countries while both government bonds and insurance penetration are used to against catastrophe risks in the developed countries. Finally, we also find that insurance-related instruments are feasible and have been applied in some middle-income countries with assistance from the World Bank.

关键词： Climate Change Adaptation Insurance Tools Capital Market Review Case Study

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Effect of autologous blood donation on the central venous pressure, blood loss and blood transfusion during living donor left hepatectomy

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World Journal of Gastroenterology 2005年第27期11卷 4233-4236页

作者： Bruno Jawan Yu-Fan Cheng Chia-Chi Tseng Yaw-Sen Chen Chih-Chi Wang Tung-Liang Huang Hock-Liew Eng Po-Ping Liu King-Wah Chiu shih-Hor Wang Chih-Che lin Tsan-Shiun lin yueh-Wei Liu Chao-Long Chen Department of Anesthesiology Chang Gung Memorial Hospital Kaohsiung Medical Center TaiwanChina Liver Transplantation Program Chang Gung Memorial Hospital Kaohsiung Medical Center Taiwan China

AIM： Autologous blood donation （ABD） is mainly used to reduce the use of banked blood. In fact, ABD can be regarded as acute blood loss. Would ABD 2-3 d before operation affect the CVP level and subsequently result in less blood loss during liver resection was to be ***： Eighty-four patients undergoing living donor left hepatectomy were retrospectively divided as group Ⅰ （GⅠ） and group Ⅱ （GⅡ） according to have donated 250-300 mL blood 2-3 d before living donor hepatectomy or not. The changes of the intraoperative CVP, surgical blood loss,blood products used and the changes of perioperative hemoglobin （Hb） between groups were analyzed and compared by using Mann-Whitney ***： The results show that the intraoperative CVP changes between GⅠ （n = 35） and GⅡ （n = 49） up to graft procurement were the same, subsequently the blood loss,but ABD resulted in significantly lower perioperative Hb levels in ***： Since none of the patients required any blood products perioperatively, all the predonated bloods were discarded after the patients were discharged from the hospital. It indicates that ABD in current series had no any beneficial effects, in term of cost, lowering the CVP, blood loss and reduce the use of banked blood products, but resulted in significant lower Hb in perioperative period.

关键词： Blood Transfusion, Autologous Central Venous Pressure Hepatectomy Liver Transplantation Living Donors Adult Blood Loss, Surgical control Female Humans Intraoperative Care Male Retrospective Studies

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Carbon Dots as Artificial Peroxidases for Analytical Applications

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Journal of Analysis and Testing 2019年第3期3卷 191-205页

作者： shih-Chun Wei Yang-Wei lin Huan-Tsung Chang Department of Chemistry National Taiwan UniversityTaipei 10617Taiwan Department of Chemistry National Changhua University of EducationChanghua 50017Taiwan Department of Chemistry Chung Yuan Christian UniversityTaoyuan City 32023Taiwan

Nanozymes have become attractive in analytical and biomedical fields,mainly because of their low cost,long shelf life,and less environmental ***,nanozymes formed from nanomaterials having high surface area and rich active sites are interesting since their activities can be tuned through carefully controlling their size,morphology,and surface *** review article focuses on preparation of carbon dots(C dots)possessing peroxidase-like activity and their analytical *** highlight the important roles of the oxidation states and surface residues of C dots and their nanocomposites with metal,metal oxides,or metal sulfides playing on determining their specificity and sensitivity toward *** of C dot nanozymes(CDzymes)for developing sensitive and selective absorption,fluorescence,and elec-trochemical sensing systems in the presence of substrates are presented to show their potential in analytical *** example,CDzymes couple with glucose oxidase and cholesterol oxidase are specific and sensitive for quantitation of glucose and cholesterol,separately,when using 3,3′,5,5′-tetramethylbenzidine(TMB)as the signal *** review article concludes with possible strategies for enhancing and tuning the catalytic activity of CDzymes.

关键词： Nanozymes Peroxidase Carbon dots CDzymes Sensing

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Laparoscopic Sleeve Gastrectomy following Pylorus-Preserving Pancreaticoduodenectomy

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Surgical Science 2023年第5期14卷 355-359页

作者： Chien-Hua lin Jing-Jim Ou yueh-Tsung Lee Hurng-Sheng Wu Department of Surgery Chang Bing Show Chwan Memorial Hospital Taiwan IRCAD Taiwan

Background: A 35-year-old married female (68 kg, 150 cm, BMI: 30.2) with pancreatic divisum complicated chronic pancreatitis and underwent pylorus-preserving pancreaticoduodenectomy in 2010. After that, her condition was well. However, body weight gained progressively to 76 kg (BMI: 33.7) and hypertension developed. During these two years, tried exercise and medication control for hypertension, but in vain. She received a laparoscopic sleeve gastrectomy in October 2013. The post-operative course was uneventful. Methods: We applied three ports for laparoscopic operation, including two 12 mm and one 5 mm trocars. The liver was not needed to be elevated due to adhesion. The operative time was 75 minutes. Results: The patient’s body weight was 10 kg reduced in the first two months and reduced to 59 kg 6 months later. Conclusions: We report a case that received laparoscopic sleeve gastrectomy following pylorus-preserving pancreaticoduodenectomy due to pancreatic divisum. This case encourages us to extend the indication of laparoscopic sleeve gastrectomy.

关键词： Sleeve Gastrectomy Morbid Obesity Obesity Pancreatectomy

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Postoperative retroperitoneal desmoid tumor mimics recurrent gastrointestinal stromal tumor:A case report

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World Journal of Gastroenterology 2012年第42期18卷 6172-6176页

作者： Liang-Yu shih Chang-Kuo Wei Chih-Wen lin Chih-En Tseng Department of Anatomic Pathology BuddhistDalin Tzu Chi General Hospital Chiayi 62247 Taiwan Department of General Surgery BuddhistDalin Tzu Chi General Hospital Chiayi 62247 Taiwan Department of Medical Imaging Buddhist Da-lin Tzu Chi General Hospital Chiayi 62247 Taiwan School of Medicine Buddhist Tzu Chi Uni-versity Hualien 97004 Taiwan

Desmoid tumor is a locally invasive,myofibroblastic,nonmetastatic *** pathogenesis remains unclear and it may involve genetic abnormalities,sex hormones and traumatic injury,including *** intra-abdominal desmoid tumor is rare,especially in the *** report a case of postoperative retroperitoneal desmoid tumor that developed 29 mo after the first excision of a gastrointestinal stromal *** trauma-related intraabdominal desmoid tumors reported in the English literature are also *** an extremely low incidence,postoperative desmoid tumor should be considered in the differential diagnosis when a recurrent neoplasm is found at least one year after ***,it is a clinical challenge to distinguish recurrent malignant neoplasms from desmoid tumors,and surgical resection is the treatment option depending on the anatomic location.

关键词： Desmoid tumor Gastrointestinal stromal tumor Recurrence Retroperitoneum Surgery

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The utilization of traditional Chinese medicine and associated factors in Taiwan in 2002

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Chinese Medical Journal 2009年第13期122卷 1544-1548页

作者： Chun-chuan shih Jaung-geng lin Chien-chang Liao Yi-chang Su Graduate Institute of Chinese Medical Science College of Chinese Medicine China Medical University Taichung Taiwan China Graduate Institute of Acupuncture Science College of Chinese Medicine China Medical University Taichung Taiwan China Dry Lab China Medical University Hospital Taichung Taiwan China

Background Previous studies have noted that there is a high utilization rate of traditional Chinese medicine （TCM） services in Taiwan, China and in western countries, but few studies investigated factors associated with the utilization of TCM in Taiwan. This study analyzes the utilization rate and the factors associated with the utilization of TCM in Taiwan. Methods Data for this study were from the 2002 HPKAP Survey that conducted the face-to-face questionnaire interviews of people aged 15 years and over from October 2002 to March 2003 in Taiwan. This study analyzed the utilization of TCM outpatient services, including admission to the hospital and clinic visits. Results A total of 26 755 participants completed the survey in the six-month period. The data revealed that 10.4% of participants had utilized TCM services in the past one month while 4.2% of participants utilized TCM only （without using Western medicine outpatient services （WM） or Folk therapy （FT））. The average visits of TCM services per patient was higher among people who had utilized TCM and FT services （2.68 visits） than among those who had utilized WM and FT services （2.15 visits） or TCM services alone （2.15 visits） during the previous one month. Younger people （odds ratio OR = 1.78, 95%CI= 1.47-2.16）, women （compared with men）, and people with higher education levels （OR = 1.58, 95%CI= 1.25-1.98） were more likely to visit TCM than compared groups. People with self-reported poor health status （OR = 2.07, 95%CI= 1.76-2.44） and people who exercise regularly （OR = 1.17, 95%CI= 1.07-1.27） had higher ORs to visit TCM service than comparison group. Conclusions There is a high utilization of TCM in Taiwan. Further studies are needed to investigate the related factors and determinants between the utilization of TCM and the utilization of FT in Taiwan.

关键词： traditional Chinese medicine utilization survey complementary and alternative medicine

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Gallbladder polyp as a manifestation of hemobilia caused by arterial-portal fistula after percutaneous liver biopsy: A case report

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World Journal of Gastroenterology 2005年第2期11卷 305-307页

作者： Chih-Lang lin Tsung-shih Lee Kar-Wai Lui Cho-Li Yen Division of Gastroenterology Department of Internal MedicineChang-Gung Memorial Hospital and UniversityKeelungTaiwanChina

Outpatient percutaneous liver biopsy is a common practice in the differential diagnosis and treatment of chronic liver disease. The major complication and mortality rate were about 2-4% and 0.01-0.33% respectively. Arterio-portal fistula as a complication of percutaneous liver biopsy was infrequently seen and normally asymptomatic. Hemobilia, which accounted for about 3% of overall major percutaneous liver biopsy complications, resulted rarely from arterio-portal fistula We report a hemobilia case of 68 years old woman who was admitted for abdominal pain after liver biopsy. The initial ultrasonography revealed a gallbladder polypoid tumor and common bile duct (CBD) dilatation. Blood clot was extracted as endoscopic retrograde cholangiopancreatography (ERCP) showed hemobilia. The patient was shortly readmitted because of recurrence of symptoms. A celiac angiography showed an intrahepatic arterio-portal fistula. After superselective embolization of the feeding artery, the patient was discharged uneventfully. Most cases of hemobilia caused by percutaneous liver biopsy resolved spontaneously. Selective angiography embolization or surgical intervention is reserved for patients who failed to respond to conservative treatment.

关键词： Gallbladder polyp Hemobilia Arterial-portal fistula Percutaneous liver biopsy

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Plasmacytosis mimicking multiple myeloma in angioimmunoblastic T-cell lymphoma:A case report and review of literature

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World Journal of Clinical Cases 2024年第17期12卷 3226-3234页

作者： Chia-Ching lin Hsu-lin Lee Hsin-Yi Chuo Tuo-An Chen Ming-yueh Liu Li-Mien Chen Division of Cardiovascular Surgery Department of SurgeryKaohsiung Armed Forces General HospitalKaohsiung 802Taiwan Division of Cardiovascular Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Hematology and Oncology Department of Internal MedicineTaichung Armed Forces General HospitalTaichung 411Taiwan Division of Hematology and Oncology Department of Internal MedicineTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Department of Internal Medicine Taichung Armed-Forces General HospitalTaichung 411Taiwan Department of Pathology Taichung Armed-Forces General HospitalTaichung 411Taiwan Department of Radiation Oncology Taichung Armed-Forces General HospitalTaichung 411Taiwan Department of Radiation Oncology Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan

BACKGROUND Angioimmunoblastic T-cell lymphoma(AITL)is a common subtype of peripheral T-cell *** half of patients with AITL may concurrently present with *** numbers of plasma cells in the bone marrow are commonly observed at *** tumors mimic plasma cell myelomas,hindering a conundrum of clinical diagnoses and potentially delaying appropriate *** SUMMARY A 78-year-old woman experienced poor appetite,weight loss of 5 kg,fatigue 2 months before presentation,and shortness of breath 2 d before presentation,but no fever or night *** examination revealed splenomegaly and many palpable masses over the bilateral axillary regions,approximately>2 cm in size,with rubbery consistency and no *** tests revealed anemia and thrombocytopenia,lactate dehydrogenase level of 153 U/L,total protein level of 10.9 g/dL,albumin to globulin ratio of 0.2,and immunoglobulin G level more than the upper limit of 3000 mg/*** free kappa and lambda light chain concentrations were 451 and 614 mg/L,respectively.A pathological examination confirmed the diagnosis of *** initial treatment was the cyclophosphamide,epirubicin,vincristine,and prednisolone *** this treatment,pleural effusion was controlled,and the patient was discharged in a stable condition and followed up in our outpatient *** This report highlights the importance of differentiating reactive plasmacytosis from plasma cell myeloma in patients with hypergammaglobulinemia.A precise diagnosis of AITL requires a comprehensive evaluation,involving clinical,immunophenotypic,and histological findings conducted by a multidisciplinary team to ensure appropriate treatment.

关键词： Angioimmunoblastic T-cell lymphoma Plasmacytosis Multiple myeloma Lymphoma,Hypergammaglobulinemia Case report

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