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Rare solitary splenic metastasis from a thymic carcinoma detected on fluorodeoxyglucose-positron emission tomography:A case report

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World Journal of Clinical Cases 2022年第15期10卷 5072-5076页

作者： yueh-Hsun Tsai Kuan-Hsun lin Tsai-Wang Huang Department of Surgery Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan

BACKGROUND Thymic carcinoma is a rare,aggressive tumor arising from the *** less than 7%of patients with thymic carcinoma,extrathoracic metastases occur in the extrathoracic lymph nodes,liver,and *** splenic metastasis can occur but is very *** date,only 2 cases of splenic metastases from thymic carcinoma have been *** SUMMARY A 45-year-old man presented with chronic cough,dyspnea,persistent hoarseness and unintentional weight loss 17 kgs in 6 *** magnetic resonance imaging revealed a large,lobulated,soft-tissue mass measuring 5.4 cm×6.6 cm×3.8 cm which involved the left superior mediastinum and supraclavicular *** computed tomography(CT)revealed a confluent and lobulated soft tissue mass encased the right brachiocephalic artery,right and left carotid arteries,and left subclavian artery in the mediastinum.A fluorodeoxyglucose-positron emission tomography was arranged for malignancy *** image revealed intense fluorodeoxyglucose avidity in a soft tissue lobulated mass occupying the superior mediastinum,over the cystic lesion in the spleen and in few enlarged nodules over the left supraclavicular ***-guided biopsy of the thymic mass and the ultrasound-guided biopsy of the splenic lesion were consistent with a thymic carcinoma with splenic *** patient was diagnosed of thymic carcinoma,cT2N2M1b,stage *** A fluorodeoxyglucose(FDG)-positron emission tomography(PET)scan can provide a useful diagnostic value in conjunction with pathological result in evaluating tumor *** case emphasizes the utility of FDG-PET for metastasis detection in thymic carcinoma.

关键词： Thymic carcinoma Splenic metastasis Positron emission tomography Extrathoracic metastases Mediastinal tumor Case report

Helicobacter pylori infection concomitant with metabolic syndrome further increase risk of colorectal adenomas

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World Journal of Gastroenterology 2010年第30期16卷 3841-3846页

作者： Ying-Lung lin Jui-Kun Chiang shih-Min lin Chih-En Tseng Department of Family Medicine Buddhist Tzu-Chi Dalin General Hospital Department of Biological Sciences University of Waikato Department of Anatomic Pathology Buddhist Dalin Tzu Chi General Hospital School of Medicine Buddhist Tzu Chi University

AIM: To investigate the association of colorectal adenomas with both Helicobacter pylori (H. pylori) infection and metabolic syndrome. METHODS: Using a cross-sectional hospital-based study, we analyzed physical examination data from 9311 healthy subjects with overnight physical examinations performed between January 2004 and December 2006. Examined data included gender, age, life style, anthropometric measurements, blood pressure, biochemical and hematological studies, H. pylori infection detected by esophagogastroduodenoscopy and biopsy urease tests, and colorectal adenomas detected with a complete total colonoscopy. RESULTS: The prevalence values for H. pylori infection, metabolic syndrome, and colorectal adenoma were39.2%, 18.7%, and 20.7%, respectively. Colorectal adenoma risk factors included male gender [odd ratio (OR): 2.005, 95% conf idence interval (CI): 1.740-2.310, P < 0.001], advanced age (OR: 1.046, 95% CI: 1.040-1.052, P < 0.001), smoking (OR: 1.377, 95% CI: 1.146-1.654, P = 0.001), increased body fat (OR: 1.016, 95% CI: 1.007-1.026, P = 0.001), higher white blood cell count (OR: 1.038, 95% CI: 1.005-1.073, P = 0.025), H. pylori infection (OR: 1.366, 95% CI: 1.230-1.517, P < 0.001), and metabolic syndrome (OR: 1.408, 95% CI: 1.231-1.610, P < 0.001). In addition, concomitant H. pylori infection with metabolic syndrome further increased the probability of colorectal adenomas. CONCLUSION: Our study revealed H. pylori infection with concomitant metabolic syndrome might further increase the risk of colorectal adenomas.

关键词： Biopsy urease test Colorectal adenoma Colorectal cancer Helicobacter pylori Metabolic syndrome

Sediment control function of river notches

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Journal of Mountain Science 2018年第3期15卷 485-494页

作者： Chia-Hsing lin Cheng-Ju LIU shih-Hsun lin Chjeng-Lun SHIEH Department of Hydraulic and Ocean Engineering National Cheng Kung University

The purpose of this study is to investigate the control function and mechanisms of natural river notches. Physical and numerical experiments are analyzed in this study for two representative types of sediment events： high intensity and short duration Type A sediment disaster events, and low intensity and long duration Type B moderate non-disaster events. Two dimensionless parameters, sediment trapping rate and reduction rate of peak sediment transport, are defined to evaluate the sediment control function of river notches. Study results indicate that the contraction ratio of the notch has a significant influence on sediment control function, with high contraction ratios resulting in both high sediment-trapping and high reduction rates. River notches provide better sediment control during Type A events than Type B events. The sediment control mechanism of river notches is the result of multiple interactions among river flow, sediment transport, and riverbed variation. Analysis of these interactions supports the significant protection role of river notches on sediment control for disaster events.

关键词： River notch Sediment control function Sediment control mechanism Sediment trapping rate Reduction rate of peak sediment transport

Diffusion characteristics of HTO and 99TcO_4^- in compacted Gaomiaozi(GMZ) bentonite

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Nuclear Science and Techniques 2017年第5期28卷 60-67页

作者： Tsuey-lin Tsai shih-Chin Tsai Yu-Hung shih Liang-Cheng Chen Chuan-Pin Lee Te-Yen Su Chemistry Division Institute of Nuclear Energy ResearchNo. 1000 Wenhua Rd. Jiaan Village Longtan DistrictTaoyuan China Nuclear Science and Technology Development Center National Tsing Hua University Hsinchu China Department of Earth Sciences National Cheng Kung University No. 1 University Road Tainan China

The characteristics of diffusion are essential to the transport of radionuclides through buffer/backfill materials, such as bentonite, which are commonly found in waste repositories. This study used through-diffusion techniques to investigate the diffusion behavior of HTO and ^(99)TcO_4^- on GMZ bentonite of various densities. Diffusion rates were calculated by measuring the diffusion coefficients(De, Da), plotting breakthrough curves and interpreting experiment data. The apparent and effective diffusion coefficients of HTO ranged from(1.68 ± 0.40) 9 × 10^(-11) to(2.80 ± 0.62) 9 × 10^(-11) m^2/s and from(4.61 ±1.28) 9 × 10^(-12) to (16.2 ± 2.50) 9 × 10^(-12) m^2/s, *** apparent and effective diffusion coefficients of^(99)TcO_4^-ranged from(5.26 ± 0.16) 9 × 10^-12to(7.78 ± 0.43) 9× 10^-12m^2/s and from(1.49 ± 0.002) 9 × 10^(-12) to(4.16 ±0.07) 9 × 10^(-12) m^2/s, respectively. The distribution coefficients of HTO and^(99)TcO_4^-ranged from(0.70 ± 0.12) 9× 10^(-2) to(1.36 ± 0.53) 9 × 10^(-2) mL/g and from(1.12 ±0.06) 9 × 10^(-2) to(5.79 ± 2.22) 9 × 10^(-2) mL/g, *** Deand Kdvalues were shown to decrease with an increase in the bulk dry density of compacted bentonite. Our results show that HTO and ^(99)Tc could be considered nonsorbent radionuclides. The data obtained in this studyprovide a valuable reference for the safety assessment of waste repositories.

关键词： Distribution coefficient Apparent diffusion coefficient Effective diffusion coefficient Compacted bentonite Through-diffusion

Disseminated peritoneal leiomyomatosis with malignant transformation involving right ureter:A case report

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World Journal of Clinical Cases 2022年第5期10卷 1639-1644页

作者： Chen-yueh Wen Herng-Sheng Lee Jen-Tai lin Chia-Cheng Yu Division of Urology Department of SurgeryKaohsiung Veterans General HospitalKaohsiung 81346Taiwan Lee Department of Pathology and Laboratory MedicineKaohsiung Veterans General HospitalKaohsiung 81346Taiwan School of Medicine National Yang-Ming UniversityTaipei 814Taiwan Department of Pharmacy Tajen UniversityPingtung 900Taiwan

BACKGROUND Disseminated peritoneal leiomyomatosis(DPL)with myxoid leiomyosarcoma is a rare variant of leiomysosarcoma,and hematuria as a presenting symptom has never been *** this case report,we emphasize the investigation of the etiology,clinical presentation,diagnosis,treatment,and prognosis of DPL with malignant changes mimicking metastatic urinary tract cancer and to help develop further clinical *** SUMMARY We describe a case of DPL with malignant transformation involving the right ureter after laparoscopic *** exploratory laparotomy was performed and all visible nodules were surgically *** with focal malignant transformation to myxoid leiomyosarcoma was confirmed based on pathology *** Professionals who preoperatively diagnose DPL with malignant change to myxoid leiomyosarcoma involving the genitourinary tract should consider symptoms of abdominal pain,hematuria,and imaging of disseminated pelvic tumors in women,especially those with prior history of laparoscopic *** complete removal of all tumors is the cornerstone to prevent DPL from malignant changes.

关键词： Disseminated peritoneal leiomyomatosis Leiomyosarcoma Laparoscopic hysterectomy Hematuria Ureteroneocystostomy Case report

Characterization of solid particles sampled from condensates in boiling water reactor

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Nuclear Science and Techniques 2016年第2期27卷 141-148页

作者： Yu-Hung shih Tung-Jen Wen Liang-Cheng Chen Tsuey-lin Tsai Chemistry Division Institute of Nuclear Energy Research

The growth, activation and deposition of corrosion products are the primary sources of radiation buildup on the surface of out-of-core piping in nuclear power plants. The buildup of radiation can have negative effects on the performance of the facility and cause harm to staff during maintenance outages for refueling. This paper reports on the crystalline and amorphous structures of corrosion products sampled in the boiling water reactors in nuclear power plants of Kuo-Sheng and identified using an acid dissolving technique. X-ray diffraction, scanning electron microprobe and inductively coupled plasmaatomic emission spectroscopy were used to analyze the samples. The results indicate that the quantity of amorphous iron oxide at inlet of the condensate demineralizer in Unit 2 is higher than that in Unit 1. The proportion of crystalline to amorphous corrosion products can affect the efficiency of removal. Thus, these results can be used to explain the difference in removal efficiency of condensate demineralizers in different units. Moreover, the iron oxide structures with various properties were observed in different operational periods. It is probable that the higher proportion of amorphous structures with a smaller particle size would reduce efficiency in the removal of condensate demineralization in Unit 2.

关键词：沸水反应堆电感耦合等离子体原子发射光谱法固体颗粒采样无定形结构表征凝聚腐蚀产物

AN EXPERIMENTAL OBSERVATION OF A SOLITARY WAVE IMPINGE-MENT,RUN-UP AND OVERTOPPING ON A SEAWALL

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Journal of Hydrodynamics 2012年第1期24卷 76-85页

作者： lin Ting-Chieh HWANG Kao-Shu HSIAO shih-Chun YANG Ray-Yeng Tainan Hydraulics Laboratory National Cheng Kung UniversityTainan 701 Department of Hydraulic and Ocean Engineering National Cheng Kung UniversityTainan 701 Tainan Hydraulics Laboratory and Department of Hydraulic and Ocean Engineering National Cheng Kung UniversityTainan 701

A sequence of laboratory experiments using solitary waves was performed to model the effect of leading form of three types of tsunamis（a bore,an impinging wave and an overtopping wave）on a seawall on a sloping *** wave evolution process,impinging pressure along the seawall surface,total overtopping discharge behind the seawall and the maximum run-up height on the rear slope were measured and *** data were employed to re-examine relevant empirical formulae in the *** effect of the presence of the seawall in reducing maximum run-up height using the present setup was briefly *** present data can be used for calibrating numerical and mathematical models.

关键词： solitary wave tsunami wave force run-up overtopping

Notch ligand-expressing adenovirus infection enhances the efficacy of dendritic cell-based immunotherapy for allergic asthma in mice

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Cellular & Molecular Immunology 2019年第8期16卷 730-732页

作者： Chu-Lun lin Chen-Chen Lee Chia-Kwung Fan yueh-Lun Lee Department of Microbiology and Immunology School of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11031 TaiwanChina Department of Microbiology and Immunology School of MedicineChina Medical UniversityTaichung 40402 TaiwanChina Department of Molecular Parasitology and Tropical Medicine School of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11031 TaiwanChina

According to the World Health Organization,the prevalence of asthma is rising worldwide,and asthma causes 250,000 deaths annually.1 Allergic asthma is a type of chronic airway inflammation caused by dysregulated T helper type 2(Th2)-type immune *** with allergic asthma are characterized by elevated serum immunoglobulin E(IgE)antibody levels,mucus production,and pulmonary inflammation as well as airway hyperresponsiveness(AHR).2 Current therapeutic methods for asthma include inhaled corticosteroids andβ2 agonists to relieve asthma syndromes,but these treatments do not change the chronic disease course in *** patients need high doses of inhaled corticosteroids or require long-term daily treatment with oral steroids.3 Therefore,efforts should be targeted towards developing innovative therapeutic strategies to improve patient quality of life and reduce unwanted *** of the advances in the development of future therapies is the use of genetically modified dendritic cells(DCs)to decrease pathological Th2-mediated responses and maintain a disease-modifying effect long *** activation is crucial for inducing T cell immunity as well as determining T cell differentiation.4 Importantly,DCs can be cultured in vitro,and large amounts of generated clinical-grade DCs have become ***,DCs has been shown to be permissive of adenoviral(Ad)vector infection in vitro,and Ad vectors are a promising gene delivery platform for a variety of therapeutic and vaccine applications.5 In this regard,overexpressing immunoregulatory proteins in Ad-modified DCs would be an effective way to suppress Th2 cell immunity and establish an antiallergic response.

关键词： asthma allergic immunity

Application of artificial intelligence-driven endoscopic screening and diagnosis of gastric cancer

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World Journal of Gastroenterology 2021年第22期27卷 2979-2993页

作者： Yu-Jer Hsiao Yuan-Chih Wen Wei-Yi Lai Yi-Ying lin Yi-Ping Yang yueh Chien Aliaksandr A Yarmishyn De-Kuang Hwang Tai-Chi lin Yun-Chia Chang Ting-Yi lin Kao-Jung Chang shih-Hwa Chiou Ying-Chun Jheng Department of Medical Research Taipei Veterans General HospitalTaipei 112201Taiwan School of Medicine National Yang-Ming Chiao Tung UniversityTaipei 112304Taiwan Department of Medical Education Taipei Veterans General HospitalTaipei 112201Taiwan Institute of Pharmacology National Yang-Ming Chiao Tung UniversityTaipei 112304Taiwan Department of Internal Medicine Taipei Veterans General HospitalTaipei 112201Taiwan Critical Center Taipei Veterans General HospitalTaipei 112201Taiwan Department of Ophthalmology Taipei Veterans General HospitalTaipei 112201Taiwan Institute of Clinical Medicine National Yang-Ming Chiao Tung UniversityTaipei 112201Taiwan Department of Medicine Kaohsiung Medical UniversityKaohsiung 80708Taiwan Institute of Clinical Medicine National Yang-Ming Chiao Tung UniversityTaipei 112304Taiwan Big Data Center Taipei Veterans General HospitalTaipei 112201Taiwan

The landscape of gastrointestinal endoscopy continues to evolve as new technologies and techniques become *** advent of image-enhanced and magnifying endoscopies has highlighted the step toward perfecting endoscopic screening and diagnosis of gastric ***,with the development of convolutional neural network,artificial intelligence(AI)has made unprecedented breakthroughs in medical imaging,including the ongoing trials of computer-aided detection of colorectal polyps and gastrointestinal *** the past demi-decade,applications of AI systems in gastric cancer have also *** AI’s efficient computational power and learning capacities,endoscopists can improve their diagnostic accuracies and avoid the missing or mischaracterization of gastric neoplastic *** far,several AI systems that incorporated both traditional and novel endoscopy technologies have been developed for various purposes,with most systems achieving an accuracy of more than 80%.However,their feasibility,effectiveness,and safety in clinical practice remain to be seen as there have been no clinical trials ***,AI-assisted endoscopies shed light on more accurate and sensitive ways for early detection,treatment guidance and prognosis prediction of gastric *** review summarizes the current status of various AI applications in gastric cancer and pinpoints directions for future research and clinical practice implementation from a clinical perspective.

关键词： Artificial intelligence Diagnostic Therapeutic Endoscopy Gastric cancer Gastritis