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Safety and Current Status of the COVID-19 Vaccine among Patients with Breast cancer: A Cross-Sectional Study from China

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Infectious Diseases & Immunity 2023年第3期3卷 127-131页

作者： Shaohua Zhang Jianbin Li Ruonan Xu Qianjun Chen Gang Sun Ying Lin Feng Jin Xinlan Liu Zhimin Fan Yiding Chen Yali Cao Xinzheng Li Jianyun Nie Guiying Xu Xiaojia Wang yuee teng Tao Sun Hong Liu Jing Luo Cuizhi Geng Man Li Ting Luo Yinhua Liu Fu-Sheng Wang Zefei Jiang Department of Oncology the Fifth Medical Center of PLA General HospitalBeijing 100071China Department of Infectious Diseases the Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Department of Breast Cancer Guangdong Provincial Hospital of Traditional Chinese MedicineGuangzhou 510000China Department of Breast Head and Neck Surgery Cancer Hospital Affiliated to Xinjiang Medical UniversityUrumqi 830011China Department of Breast Surgery the First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510062China Department of Breast Surgery the First Affiliated Hospital of China Medical UniversityShenyang 110001China Department of Oncology General Hospital of Ningxia Medical UniversityNingxia 750003China Department of Breast Surgery the First Hospital of Jilin UniversityChangchun 130031China Department of Oncology Surgery the Second Affiliated Hospital of Medical College of Zhejiang UniversityHangzhou 310009China Department of Oncology Nanchang Third HospitalNanchang 330009China Department of Breast Surgery Shanxi Cancer HospitalTaiyuan 030013China Department of Breast Surgery Yunnan Cancer HospitalKunming 650118China Department of Breast Surgery Jilin Cancer HospitalChangchun 130012China Department of Oncology Cancer Hospital Affiliated to the University of Chinese Academy of SciencesHangzhou 310005China Department of Oncology the First Affiliated Hospital of China Medical UniversityShenyang 110001China Department of Oncology Liaoning Cancer HospitalShenyang 110801China Department of Oncology Tumor Hospital of Tianjin Medical UniversityTianjin 300060China Department of Breast Surgery Sichuan Provincial People's HospitalChengdu 610042China Department of Breast Cancer the Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011China Department of Oncology the Second Affiliated Hospital of Dalian Medical UniversityDalian 116050China Department of Head and Neck Tumor West China Hospital of Sichuan UniversityChengdu 610042China Department of Breast Su

In this study,we aimed to explore the safety and vaccination coverage data of Chinese patients with breast cancer receiving coronavirus disease 2019(COVID-19)*** patients were recruited from 41 hospitals across 20 Chinese *** vaccination coverage was approximately 22.4%,and the frequency of total adverse events was 13.3%after the first dose and 9.9%after the second *** most frequent adverse reaction within 14 days of the first dose was local pain(5.7%).Unvaccinated patients were very likely to reject the vaccine rather than be hesitant in patients with old age(odds ratio[OR],1.238;95%confidence interval[CI],1.101-1.391),chronic disease history(OR,1.189;95%CI,1.057-1.337),and cancer relapse(OR,1.398;95%CI,1.233-1.585).Of the unvaccinated patients with breast cancer,54.1%opted to receive COVID-19 vaccines if more data were *** the safety but low vaccination coverage for breast cancer,increased positive attitudes and acceptance toward COVID-19 vaccines are important.

关键词： Breast cancer COVID-19 vaccine Safety

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Prevalence and risk factors of intestinal parasitism among two indigenous subethnic groups in Peninsular Malaysia

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Infectious Diseases of Poverty 2016年第1期5卷 700-714页

作者： yuee teng Chin Yvonne Ai Lian Lim Chun Wie Chong Cindy Shuan Ju Teh Ivan Kok Seng Yap Soo Ching Lee Mian Zi Tee Vinnie Wei Yin Siow Kek Heng Chua Department of Biomedical Science Faculty of MedicineUniversity of Malaya50603 Kuala LumpurMalaysia Department of Parasitology Faculty of MedicineUniversity of Malaya50603 Kuala LumpurMalaysia Department of Life Sciences School of PharmacyInternational Medical University57000 Kuala LumpurMalaysia Department of Medical Microbiology Faculty of MedicineUniversity of Malaya50603 Kuala LumpurMalaysia

Background:Intestinal parasitic infections(IPIs)among indigenous people have been widely documented in Malaysia,however,the prevalence of these infections remains *** the past,most studies have focused on specific species of parasites but polyparasitism has received limited *** addition,epidemiology studies on indigenous people tend to consider them as a homogenous group,whereas in reality different sub-ethnic groups have different cultural and living *** in living habits such as personal hygiene practices may predispose different groups to different parasitic *** better understand prevalence and risk factors of intestinal parasitism among different sub-ethnic groups,the present study was conducted among two sub-ethnic groups of indigenous people(Temuan and Mah Meri)residing in Selangor state,***:A cross-sectional study that focused on two distinct sub-ethnic groups was carried out from February to September *** samples were collected from 186 participants and examined using the formalin-ether sedimentation technique.A molecular approach was adopted to conduct a genetic characterisation of the ***,questionnaires were administered to obtain information on the demographics,socioeconomic backgrounds and behavioural risks relating to the participants,as well as information about their *** analyses(*** and multivariate logistic regression analyses)were performed to measure risk ***:For Temuan communities,trichuriasis(64.2%)was the most common infection found,preceding hookworm infection(34%),ascariasis(7.5%),giardiasis(14.2%)and amoebiasis(7.5%).As for the Mah Meri communities,trichuriasis(77.5%)prevailed over ascariasis(21.3%),hookworm(15%),giardiasis(7.5%)and amoebiasis(3.8%).Significant differences in proportions of trichuriasis,ascariasis and hookworm infections were observed between the Temuan and Mah Meri sub-ethnic *** was more

关键词： Intestinal parasites Intestinal parasitism Indigenous people Risk factors Prevalence Sub-ethnic group Temuan sub-ethnic group Mah Meri sub-ethnic group Peninsular Malaysia

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Nomogram-based prediction of survival in unresectable or metastatic gastric cancer patients with good performance status who received first-line chemotherapy

Nomogram-based prediction of survival in unresectable or met...

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2018年中国肿瘤标志物学术大会暨第十二届肿瘤标志物青年科学家论坛

作者： Jin Wang Zhi Li Bowen Yang Jinglei Qu Xiaofang Che Jing Liu yuee teng Bo Jin Mingfang Zhao Yunpeng Liu Xiujuan Qu Department of Medical Oncology the First Hospital of China Medical University Key Laboratory of Anticancer Drugs and Biotherapy of LiaoNing Province the First Hospital of China Medical University

Background: Good performance status is widely known as a superior prognostic *** purpose of this study was to explore baseline host-or tumor-related factors and to establish a nomogram-based prediction of survival in unresectable or metastatic gastric cancer(GC) patients with good performance status who received first-line ***: 309 patients from April 2007 and December 2013 at the First Hospital of China Medical University were involved in this study. We used a credible random split-sample method to divide patients into the training cohort(259 patients,80%) and the internal validation cohort(50 patients, 20%). Prognostic significance was determined in the training cohort using multivariate Cox regression analysis, and then was represented as a prognostic nomogram. We validated the nomogram in the internal validation cohort and the external cohort including 147 patients from January 2014 to October 2016. Results: The nomogram includes three covariates(the number of metastatic sites, fibrinogen and CA19-9) correlated significantly with survival. The median survival of the training cohort was 10.1 months(95% CI, 9.295–10.944). The nomogram showed good discrimination, with a c-index of 0.623(95% CI, 0.579-0.667). When applied to the internal validation and the external validation cohort, the nomogram achieved c-indices of 0.614(95% CI, 0.511-0.717) and 0.638(95% CI, 0.577-0.699), respectively. Calibration plots suggested that the nomogram was well calibrated for all ***: We developed and validated a reliable nomogram to predict the overall survival of unresectable or metastatic GC patients with good performance status who received first-line chemotherapy.

关键词： nomogram gastric adenocarcinoma prognosis

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Raman signal enhancement for gas detection using a dual near-concentric cavities group

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Chinese Optics Letters 2024年第5期22卷 47-52页

作者：任一凡杨德旺孙颖欣许家旋刘硕芳陈月娥 Key Laboratory for Microstructural Material Physics of Hebei Province School of ScienceYanshan UniversityQinhuangdao 066004China College of Ocean Science and Engineering Shandong University of Science and TechnologyQingdao 266590China

Effective methods are urgently required to optimize Raman spectroscopy technology to ameliorate its low detection ***,we superposed two near-concentric cavities to develop a dual near-concentric cavities group(DNCCG)to assess its effect on gas Raman signal intensity,signal-to-noise ratio(SNR),and limit of detection(LOD).The results showed that DNCCG generally had higher CO_(2) Raman signal intensity than the sum of two near-concentric ***,the noise intensity of DNCCG was not enhanced by the superposition of near-concentric ***,DNCCG increased the *** LOD for CO_(2) was 24.6 parts per *** could be an effective method to improve the detection capability of trace gases and broaden the dynamic detection range,which might aid the future development of innovative technology for multicomponent gas detection.

关键词： Raman spectroscopy gas detection sensitivity dual near-concentric cavities group

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Molecular characterization of an outbreak-involved Bacillus anthracis strain confirms the spillover of anthrax from West Africa

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Infectious Diseases of Poverty 2024年第1期13卷 93-94页

作者： Shuchao Wang Roland Suluku Mohamed B.Jalloh Ahmed F.Samba Baogui Jiang Yubiao Xie Doris Harding Mengyao Zhang Foday Sahr Mahmud E.Sesay James S.Squire Mohamed A.Vandi Moinina N.Kallon Shoufeng Zhang Rongliang Hu yuee Zhao Zhiqiang Mi Changchun Veterinary Research Institute Chinese Academy of Agricultural Sciences Changchun China Department of Animal Sciences School of Agriculture and Food Sciences Njala University Njala Sierra Leone Department of Microbiology College of Medicine and Allied Health Sciences University of Sierra Leone Freetown Sierra Leone Ministry of Agriculture and Food Sciences Freetown Sierra Leone Beijing Institute of Microbiology and Epidemiology Beijing China Ministry of Health and Sanitation Freetown Sierra Leone Beijing Institute of Biotechnology Beijing China

Background Anthrax,a zoonotic disease caused by the spore-forming bacterium Bacillus anthracis,remains a major global public health concern,especially in countries with limited *** Leone,a West African country historically plagued by anthrax,has almost been out of report on this disease in recent *** this study,we described a large-scale anthrax outbreak affecting both animals and humans and attempted to characterize the *** The causative agent of the animal outbreak in Port Loko District,Sierra Leone,between March and May 2022 was identified using the nanopore sequencing technique.A nationwide active surveillance was implemented from May 2022 to June 2023 to monitor the occurrence of anthrax-specific symptoms in *** cases were subsequently verified using quantitative polymerase chain ***-genome sequencing was accomplished by combining long-read and short-read sequencing *** phylogenetic analysis was performed based on the full-chromosome single nucleotide *** The outbreak in Port Loko District,Sierra Leone,led to the death of 233 animals between March 26th and May 16th,*** ruled out the initial suspicion of Anaplasma species and successfully identified *** as the causative agent of the *** a result of the government's prompt response,out of the 49 suspected human cases identifed during the one-year active surveillance,only 6 human cases tested positive,all within the frst month after the official declaration of the *** phylogenetic analysis indicated that the BaSL2022 isolate responsible for the outbreak was positioned in the ***.153 clade within the TransEuroAsian group of *** We successfully identifed a large-scale anthrax outbreak in Sierra *** causative isolate of ***,BaSL2022,phylogenetically bridged other lineages in ***.153 clade and neighboring genetic groups,***.144 and ***.148,

关键词： Molecular identification Anthrax Bacillus anthracis Sierra Leone Phylogeny Single nucleotide polymorphism

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c-Src表达在转移性乳腺癌中的预后价值

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中国肿瘤临床 2012年第5期29卷 245-248页

作者：张凌云滕月娥曲秀娟刘云鹏侯科佐中国医科大学附属第一医院肿瘤内科沈阳市110001

目的:实验研究表明非受体酪氨酸激酶(c-Src)与乳腺癌的转移密切相关,本研究探讨c-Src表达在转移性乳腺癌中的预后价值。方法:收集2007年1月至2010年10月102例转移性乳腺癌患者的原发癌组织蜡块,免疫组化法检测c-Src的表达。回顾性分析c-... 详细信息

目的:实验研究表明非受体酪氨酸激酶(c-Src)与乳腺癌的转移密切相关,本研究探讨c-Src表达在转移性乳腺癌中的预后价值。方法:收集2007年1月至2010年10月102例转移性乳腺癌患者的原发癌组织蜡块,免疫组化法检测c-Src的表达。回顾性分析c-Src表达与乳腺癌临床病理特征的关系、生存分析及Cox风险模型,探讨c-Src表达对患者预后的影响。结果:102例乳腺癌组织中c-Src表达率为54.9%,c-Src高表达于无进展生存期(PFS)≤3年(P=0.048)的患者。生存分析显示c-Src阳性较阴性的患者疾病特异性生存(DSS)显著缩短(P=0.017)。分层分析显示激素受体(HR)阳性/c-Src阳性患者DSS最短,而HR阳性/c-Src阴性的患者DSS最长(P=0.016)。多因素分析显示,HR阳性/c-Src阳性、PFS≤3年、肿瘤组织学分级Ⅲ级和年龄≤35岁均是较差的DSS独立预测因子。结论:转移性乳腺癌患者中,HR阳性且c-Src阳性预测患者的不良预后。

关键词： c—Src 转移性乳腺癌 ER/PR预后

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COX-2、VEGF、CD105在乳腺癌中的表达及其对预后的意义

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中国组织化学与细胞化学杂志 2008年第2期17卷 150-155页

作者：宋敏滕月娥刘云鹏侯科佐中国医科大学附属一院肿瘤内科沈阳110001

目的探讨环氧化酶-2(COX-2)、血管内皮生长因子(VEGF)、CD105抗体标记的微血管密度(MVD)与乳腺癌的病理生物学特征及预后的关系。方法收集了我院1999-2006年有完整存档蜡块资料的117例乳腺癌蜡块以随机分配的原则组成组织微阵列,用S-P... 详细信息

目的探讨环氧化酶-2(COX-2)、血管内皮生长因子(VEGF)、CD105抗体标记的微血管密度(MVD)与乳腺癌的病理生物学特征及预后的关系。方法收集了我院1999-2006年有完整存档蜡块资料的117例乳腺癌蜡块以随机分配的原则组成组织微阵列,用S-P法对上述三个指标的表达情况进行了检测,并且对其表达情况与疾病的生物学特点、患者的生存时间进行了分析,以判断其对预后的意义。结果117例乳腺癌蜡块中COX-2阳性表达65例(55.6%),COX-2在肿瘤中的表达与肿瘤临床分期(P=0.01,r=0.238)、淋巴结转移(P=0.0006,r=0.326)、HER-2(P=0.025,r=0.218)及雌激素受体(ER)(P=0.026,r=-0.205)状态具有密切关系;VEGF同样在乳腺癌组织中有高表达(66.7%),并且其与COX-2的阳性表达水平与患者生存时间有密切关系;CD105抗体标记的MVD值在复发组和未复发组无明显差别(P=0.148),但与COX-2、VEGF均呈正相关(P=0.023,r=0.201;P=0.006,r=0.210)。结论***-2、VEGF在乳腺癌中均有高表达,皆是预后不良指标。2.乳腺癌组织中COX-2的过表达可能是通过促进VEGF来参与肿瘤血管生成从而导致乳腺癌侵袭、转移的。

关键词：乳腺癌环氧化酶-2 血管内皮生长因子

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信息化背景下高校专门用途英语混合式教学模式构建

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锦州医科大学学报（社会科学版） 2024年第3期22卷 102-105页

作者：陈月娥安徽建筑大学外国语学院安徽合肥230601

专门用途英语是英语专业的细分方向,区别于日常通用性英语。其固定化特点展现出目标明确、针对性强等优势,为提升学生专项英语能力提供了坚实的基础。本文在厘清专门用途英语混合式教学特点与优势的基础上,从构建线上和线下混合教学载... 详细信息

专门用途英语是英语专业的细分方向,区别于日常通用性英语。其固定化特点展现出目标明确、针对性强等优势,为提升学生专项英语能力提供了坚实的基础。本文在厘清专门用途英语混合式教学特点与优势的基础上,从构建线上和线下混合教学载体、开展课内和课外混合教学评价、规划混合教学路径三个方面提出专门用途英语混合式教学模式的构建策略。

关键词：信息化专门用途英语混合式教学应变能力

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缺血缺氧再灌注对胎鼠肾组织环氧化酶表达的影响

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中国组织化学与细胞化学杂志 2005年第3期14卷 285-289页

作者：滕月娥胡潇滨魏克伦中国医科大学附属第一医院肿瘤内科沈阳110001 中国医科大学附属第一医院儿科沈阳110001 中国医科大学附属第二医院儿科沈阳110001

目的观察宫内缺血缺氧再灌注后,胎鼠肾组织COX蛋白表达及其AA代谢产物PGI2、PGE2和TXA2含量的变化,探讨COX在宫内窘迫胎鼠肾损伤发病机制中的作用。方法制备胎鼠子宫内缺血缺氧再灌注模型(缺血缺氧组:缺血缺氧30min;再灌注组:缺血缺氧30... 详细信息

目的观察宫内缺血缺氧再灌注后,胎鼠肾组织COX蛋白表达及其AA代谢产物PGI2、PGE2和TXA2含量的变化,探讨COX在宫内窘迫胎鼠肾损伤发病机制中的作用。方法制备胎鼠子宫内缺血缺氧再灌注模型(缺血缺氧组:缺血缺氧30min;再灌注组:缺血缺氧30min后,分别再灌注30min,2h,6h,12h,24h,30h)缺血氧组:取胎鼠18只;再灌注组各时间点分别取胎鼠18只;对照组取胎鼠20只。将肾组织匀浆后采用Western免疫印迹和放免法检测COX蛋白表达及其PGI2、PGE2和TXA2含量的变化。同时HE染色观察肾组织病理学改变。结果子宫内缺血缺氧再灌注后胎肾组织COX2蛋白表达上调,PGI2的稳定代谢产物6KetaPGF1α及PGE2均于再灌注2h开始增高(P<0.05)。其中6ketaPGF1α增加迅速,于再灌注12h达假手术组的6倍(P<0.01),PGE2于再灌注24h达假手术组的2倍(P<0.01),而TXB2增加幅度不大,无统计学意义。结论宫内缺血缺氧再灌注选择性地诱导胎肾COX2蛋白表达增强,COX2可能通过PGI2和PGE2对缺血性胎肾损伤具有保护作用,因此,在围产期肾损伤不宜应用COX2抑制剂。

关键词：缺血再灌注环氧化酶前列腺素肾脏胎鼠

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初始Ⅳ期乳腺癌预后因素分析

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中国医科大学学报 2020年第12期49卷 1118-1124,1129页

作者：孙源迪杨博文李智赵雷滕月娥中国医科大学附属第一医院肿瘤内科沈阳110001

目的通过建立列线图模型对影响初始Ⅳ期乳腺癌患者的预后因素进行分析。方法回顾性分析204例初始Ⅳ期乳腺癌患者临床资料,应用Kaplan-Meier法确定临床病理参数、治疗因素与总生存期(OS)的关系,基于Cox风险比例回归模型的单因素及多因素... 详细信息

目的通过建立列线图模型对影响初始Ⅳ期乳腺癌患者的预后因素进行分析。方法回顾性分析204例初始Ⅳ期乳腺癌患者临床资料,应用Kaplan-Meier法确定临床病理参数、治疗因素与总生存期(OS)的关系,基于Cox风险比例回归模型的单因素及多因素分析,构建列线图并进行内部验证。一致性指数和校准曲线用于评估列线图的有效性。结果患者是否接受乳腺局部手术治疗(P=0.001)、分子分型(P=0.009)及内脏转移(P=0.019)是影响患者生存的独立预后因素。由此三因素建立列线图模型,内部验证的一致性指数为0.671(95%CI:0.647~0.695)。校准曲线表明本预测模型在1年、3年和5年时生存概率与实际情况的符合度较高,具有良好的一致性。结论初始Ⅳ期乳腺癌患者是否接受乳腺局部病灶手术,分子分型和内脏转移是影响预后的独立因素,由此建立的列线图可以较好地预测患者预后,并指导个体化治疗。

关键词：初始Ⅳ期乳腺癌临床病理特征列线图预后

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