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Burden of gastrointestinal cancers among working-age population over past thirty years in China

World Journal of gastrointestinal Oncology 2024年第9期16卷 3955-3979页

作者： Yu Dong Zhuan-Zhuan Fan Wen-Ting Li Jian Kang Yan Zhang yue guan Hui-Qing Xu jie Yuan Fei Xu Department of gastroenterology Nanjing First HospitalNanjing Medical UniversityNanjing 210006Jiangsu ProvinceChina Department of Primary Healthcare Management Nanjing Municipal Center for Disease Control and PreventionNanjing 210003Jiangsu ProvinceChina Department of Emergency The First Affiliated Hospital with Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Department of Epidemiology Nanjing Medical University School of Public HealthNanjing 211116Jiangsu ProvinceChina

BACKgROUND Although gastrointestinal(gI)cancers have been becoming a great public health concern in China,there is currently a lack of comprehensive literature on the overall burden and changing trends of gI cancers in the working-age *** To assess the burden of gI cancers and to examine the overall,age-and genderspecific trends among the working-age population in China from 1990 to *** Data were extracted from the global Burden of Disease Study *** burden of gI cancers was indicated by incidence,mortality,disability-adjusted life-years(DALYs),age-standardized incidence rate(ASIR),age-standardized mortality rate,and age-standardized DALYs *** in the burden of gI cancers from 1990 to 2019 were examined using annual percent change and average annual percent change with Joinpoint regression *** For overall gI cancers,a declining trend was observed in the ASIR,age-standardized mortality rate,and agestandardized DALYs rate,with reductions of 0.74%,2.23%,and 2.22%,respectively,from 1999 to 2019 in the Chinese working-age ***,an increasing trend was observed in the ASIR for overall gI cancers from *** number of either incident cases,mortality cases,and DALYs was higher for colon/rectum cancer and liver cancer in younger participants but lower for esophageal,gallbladder,biliary tract,pancreatic,and stomach cancer among older ***,sex disparity in the gI cancers burden was also examined over 30 *** The total burden of gI cancers remained heavy among the working-age population in China,although declining trends were observed from 1999 to *** in the gI cancers burden existed between sexes,age groups,and cancer ***-based precision prevention strategies are needed to tackle gI cancers among working-age individuals,considering the age,sex,and cancer type disparities in China.

关键词： gastrointestinal cancer Working-age population Disease burden Disability-adjusted life-years Chinese

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Shuxuening Injection Inhibits Apoptosis and Reduces Myocardial Ischemia-Reperfusion Injury in Rats through PI3K/AKT Pathway

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Chinese Journal of Integrative Medicine 2024年第5期30卷 421-432页

作者： yue Tong-tong CAO Ying-jie CAO Ya-xuan LI Wei-xia WANg Xiao-yan SI Chun-ying XIA Han ZHU Ming-jun TANg Jin-fa WANg He The First Clinical Medical College of Henan University of Chinese Medicine Zhengzhou 450046China Department of Pharmacy the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 451200China Department of Cardiovascular Diseases the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 451200China

Objective: To investigate the main components and potential mechanism of Shuxuening Injection(SXNI) in the treatment of myocardial ischemia-reperfusion injury(MIRI) through network pharmacology and in vivo research. Methods: The Traditional Chinese Medicine Systems Pharmacology(TCMSP) and Pharm Mapper databases were used to extract and evaluate the effective components of ginkgo biloba leaves, the main component of SXNI. The Online Mendelian Inheritance in Man(OMIM) and gene Cards databases were searched for disease targets and obtain the drug target and disease target intersections. The active ingredient-target network was built using Cytoscape 3.9.1 software. The STRINg database, Metascape online platform, and R language were used to obtain the key targets and signaling pathways of the anti-MIRI effects of SXNI. In order to verify the therapeutic effect of different concentrations of SXNI on MIRI in rats, 60 rats were first divided into 5 groups according to random number table method: the sham operation group, the model group, SXNI low-dose(3.68 mg/kg), medium-dose(7.35 mg/kg), and high-dose(14.7 mg/kg) groups, with 12 rats in each group. Then, another 60 rats were randomly divided into 5 groups: the sham operation group, the model group, SXNI group(14.7 mg/kg), SXNI+LY294002 group,and LY294002 group, with 12 rats in each group. The drug was then administered intraperitoneally at body weight for 14 days. The main biological processes were validated using in vivo testing. Evans blue/triphenyltetrazolium chloride(TTC) double staining, hematoxylin-eosin(HE) staining, terminal deoxynucleotidyl transferase d UTP nick end labeling(TUNEL) assay, enzyme-linked immunosorbent assay(ELISA), and Western blot analysis were used to investigate the efficacy and mechanism of SXNI in MIRI rats. Results: Eleven core targets and 30 Kyoto Encyclopedia of genes and genomes(KEgg) pathways were selected. Among these, the phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT) pathway was

关键词： myocardial ischemia reperfusion injury PI3K/AKT signaling pathway Shuxuening Injection apoptosis ginkgo biloba leaves

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Photobiomodulation inhibits the expression of chondroitin sulfate proteoglycans after spinal cord injury via the Sox9 pathway

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Neural Regeneration Research 2024年第1期19卷 180-189页

作者： Zhihao Zhang Zhiwen Song Liang Luo Zhijie Zhu Xiaoshuang Zuo Cheng Ju Xuankang Wang Yangguang Ma Tingyu Wu Zhou Yao jie Zhou Beiyu Chen Tan Ding zhe Wang Xueyu Hu Department of Orthopedics Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina

Both glial cells and glia scar greatly affect the development of spinal cord injury and have become hot spots in research on spinal cord injury *** cellular deposition of dense extracellular matrix proteins such as chondroitin sulfate proteoglycans inside and around the glial scar is known to affect axonal growth and be a major obstacle to autogenous *** proteins are thus candidate targets for spinal cord injury *** previous studies demonstrated that 810 nm photo biomodulation inhibited the formation of chondroitin sulfate proteoglycans after spinal cord injury and greatly improved motor function in model ***,the specific mechanism and potential targets involved remain to be *** this study,to investigate the therapeutic effect of photo biomodulation,we established a mouse model of spinal cord injury by T9 clamping and irradiated the injury site at a power density of 50 mW/cm~2 for 50 minutes once a day for 7 consecutive *** found that photobiomodulation greatly restored motor function in mice and down regulated chondroitin sulfate proteoglycan expression in the injured spinal *** analysis revealed that photobiomodulation inhibited the expression of proteoglycan-related genes induced by spinal cord injury,and versican,a type of proteoglycan,was one of the most markedly changed *** staining showed that after spinal cord injury,versican was present in astrocytes in spinal cord *** expression of versican in primary astrocytes cultured in vitro increased after inflammation induction,whereas photobiomodulation inhibited the expression of ve ***,we found that the increased levels of p-Smad3,p-P38 and p-Erk in inflammatory astrocytes were reduced after photobiomodulation treatment and after delivery of inhibitors including FR 180204,(E)-SIS3,and SB *** suggests that Sma d 3/Sox9 and MAP K/Sox9 pathways may be involved in the effects of photobiomodulatio

关键词： chondroitin sulfate proteoglycans Erk MAPK P38 photobiomodulation principal component analysis Smad3 Sox9 spinal cord injury versican

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Targeting Therapeutic Windows for Rheumatoid Arthritis Prevention

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Chinese Journal of Integrative Medicine 2024年第9期30卷 842-851页

作者： gAO Kai-xin YANg Yi-hong LIANg Qi MEI Li-yan LIANg You-bang WANg Mao-jie CHEN Xiu-min HUANg Qing-chun WEN Ze-huai HUANg Run-yue Section of Rheumatology and Immunology Research The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China The Second Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou510405China State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China guangdong-Hong Kong-Macao Joint Lab on Chinese Medicine and Immune Disease Research Guangzhou University of Chinese MedicineGuangzhou510405China guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome Guangzhou510120China guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases Guangzhou510120China The Key Unit of Methodology of Clinical Research The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China

Rheumatoid arthritis(RA)is a worldwide public health *** to delay or prevent the onset of RA have attracted much attention in recent years,and researchers are now exploring various prevention *** present,there is still no unified consensus for RA prevention,but targeting therapeutic windows and implementing interventions for at-risk individuals are extremely *** to the limited number of clinical trials on pharmacologic interventions,further studies are needed to explore and establish optimal intervention regimens and effective measures to prevent progression to *** this review,we introduce the RA disease process and risk factors,and present research on the use of both Western and Chinese medicine from clinical perspectives regarding RA ***,we describe several complete and ongoing clinical studies on the use of Chinese herbal formulae for the prevention of RA.

关键词： rheumatoid arthritis prevention Chinese medicine review

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An amorphous FeMoO_(4) nanorod array enabled high-efficiency oxygen evolution electrocatalysis in alkaline seawater

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Nano Research 2024年第4期17卷 2270-2275页

作者： jie Tang Shengjun Sun Xun He Hui Zhang Chaoxin Yang Min Zhang Meng yue Hefeng Wang Yuntong Sun Yonglan Luo Sulaiman Alfaifi Asmaa Farouk Mohamed S.Hamdy Xuping Sun Huiqing Wang Binwu Ying Department of Laboratory Medicine West China HospitalSichuan UniversityChengdu 610041China College of Chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJinan 250014China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Chemistry Department Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Chemistry College of ScienceKing Khalid UniversityAbha 61413Saudi Arabia Medical Simulation Centre West China Second University HospitalSichuan UniversityChengdu 610041China

The development of highly efficient and durable oxygen evolution reaction(OER)catalysts for seawater electrolysis is of great importance for ***,an amorphous FeMoO_(4) nanorod array on Ni foam is reported as a highly active OER electrocatalyst in alkaline seawater,requiring only overpotentials of 303 and 332 mV to achieve 100 and 300 mA·cm^(-2),***,it shows strong long-term electrochemical durability for at least 50 h.

关键词： amorphous material FeMoO_(4) nanorod array electrocatalyst seawater electrolysis oxygen evolution reaction

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Multifunctional solar-blind ultraviolet photodetectors based on p-PCDTBT/n-ga_(2)O_(3)heterojunction with high photoresponse

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InfoMat 2024年第2期6卷 118-130页

作者： Yifei Wang zhenhua Lin Jingli Ma Yongyi Wu Haidong Yuan Dongsheng Cui Mengyang Kang Xingguo jie Su Jinshui Miao Zhifeng Shi Tao Li Jincheng Zhang yue Hao Jingjing Chang State Key Discipline Laboratory of Wide Band gap Semiconductor Technology School of MicroelectronicsXidian UniversityXi'anthe People's Republic of China School of Physics and Microelectronics Key Laboratory of Material PhysicsMinistry of EducationZhengzhou UniversityZhengzhouthe People's Republic of China Center for Spintronics and Quantum Systems State Key Laboratory for Mechanical Behavior of MaterialsDepartment of Materials Science and EngineeringXi'an Jiaotong UniversityXi'anthe People's Republic of China Advanced Interdisciplinary Research Center for Flexible Electronics Xidian UniversityXi'anthe People's Republic of China State Key Laboratory of Infrared Physics Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghaithe People's Republic of China

Solar-blind ultraviolet(UV)photodetectors based on p-organic/n-ga_(2)O_(3) hybrid heterojunctions have attracted extensive attention ***,the multifunctional solar-blind photodetector based on p-type poly[N-90-heptadecanyl-2,7-carbazole-alt-5,5-(40,70-di-2-thienyl-20,10,30-benzothiadiazole)](PCDTBT)/n-type amorphous ga_(2)O_(3)(a-ga_(2)O_(3))is fabricated and investigated,which can work in the phototransistor mode coupling with self-powered *** the introduction of PCDTBT,the dark current of such the a-ga_(2)O_(3)-based photodetector is decreased to 0.48 ***,the photoresponse parameters of the a-ga_(2)O_(3)-based photodetector in the phototransistor mode to solar-blind UV light are further increased,that is,responsivity(R),photo-detectivity(D*),and external quantum efficiency(EQE)enhanced to 187 A W^(-1),1.3×10^(16) Jones and 9.1×10^(4)% under the weak light intensity of 11μW cm^(-2),*** to the formation of the built-in field in the p-PCDTBT/n-ga_(2)O_(3) type-Ⅱ heterojunction,the PCDTBT/ga_(2)O_(3) multifunctional photodetector shows self-powered *** responsivity of p-PCDTBT/n-ga_(2)O_(3) multifunctional photodetector is 57.5 mA W^(-1) at zero *** multifunctional p-n hybrid heterojunction-based photodetectors set the stage for realizing high-performance amorphous ga_(2)O_(3) heterojunction-based photodetectors.

关键词： amorphous ga_(2)O_(3) heterojunction multifunctional PCDTBT solar-blind photodetectors

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Analysis and comparison of retinal vascular parameters under different glucose metabolic status based on deep learning

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1581-1591页

作者： Yan Jiang Di gong Xiao-Hong Chen Lin Yang Jing-Jing Xu Qi-jie Wei Bin-Bin Chen Yong-Jiang Cai Wen-Qun Xi zhe Zhang Departments of Laboratory Medicine the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina Shenzhen Eye Hospital Jinan UniversityShenzhen 518040Guangdong ProvinceChina Center of Health Management Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina Visionary Intelligence Ltd. Beijing 100080China Ophthalmology Center the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina

AIM:To develop a deep learning-based model for automatic retinal vascular segmentation,analyzing and comparing parameters under diverse glucose metabolic status(normal,prediabetes,diabetes)and to assess the potential of artificial intelligence(AI)in image segmentation and retinal vascular parameters for predicting prediabetes and ***:Retinal fundus photos from 200 normal individuals,200 prediabetic patients,and 200 diabetic patients(600 eyes in total)were *** U-Net network served as the foundational architecture for retinal arteryvein *** automatic segmentation and evaluation system for retinal vascular parameters was trained,encompassing 26 ***:Significant differences were found in retinal vascular parameters across normal,prediabetes,and diabetes groups,including artery diameter(P=0.008),fractal dimension(P=0.000),vein curvature(P=0.003),C-zone artery branching vessel count(P=0.049),C-zone vein branching vessel count(P=0.041),artery branching angle(P=0.005),vein branching angle(P=0.001),artery angle asymmetry degree(P=0.003),vessel length density(P=0.000),and vessel area density(P=0.000),totaling 10 ***:The deep learning-based model facilitates retinal vascular parameter identification and quantification,revealing significant *** parameters exhibit potential as biomarkers for prediabetes and diabetes.

关键词： deep learning retinal vascular parameters segmentation model diabetes prediabetes

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Long-chain acyl-CoA synthetase regulates systemic lipid homeostasis via glycosylation-dependent lipoprotein production

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Life Metabolism 2024年第2期3卷 38-54页

作者： jie Li yue Dong Tianxing Zhou He Tian Xiahe Huang Yong Q.Zhang Yingchun Wang Sin Man Lam guanghou Shui State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100101China Lipidall Technologies Company Limited ChangzhouJiangsu 213000China

Interorgan lipid transport is crucial for organism development and the maintenance of physiological ***,we demonstrate that Drosophila long-chain acyl-CoA synthetase(dAcsl),which catalyzes the conversion of fatty acids into acyl-coenzyme As(acyl-CoAs),plays a critical role in regulating systemic lipid *** deficiency in the fat body led to the ectopic accumulation of neutral lipids in the gut,along with significantly reduced lipoprotein contents in both the fat body and *** aberrant phenotypes were rescued by fat body-specific overexpression of apolipophorin.A multi-omics investigation comprising lipidomics,metabolomics,and proteomics in conjunction with genetic screening revealed that glycosylation processes were suppressed in dAcsl knockdown *** of Cg9035,human ortholog of which is implicated in the congenital disorder of glycosylation,ame-liorated gut lipid accumulation in *** lipoprotein glycosylation led to accelerated proteasome-related degradation and induced ER stress in dAcsl knockdown flies,impairing lipoprotein release into the circulation which compromised interorgan lipid transport between the fat body and the *** of ubiquitin-proteasome-dependent degradation alleviated the phenotype of gut ectopic fat accumulation in dAcsl knockdown ***,we verified that ACSL4,the human homolog of dAcsl,also regulated lipoprotein levels in Hepg2 cells,indicating that the role of dAcsl in modulating lipoprotein secretion and systemic lipid homeostasis is possibly conserved in humans.

关键词： lipid homeostasis apolipoprotein glycosylation lipidomics metabolomics proteomics

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The prognostic value of collateral circulation in coronary chronic total occlusion underwent percutaneous coronary intervention

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Journal of geriatric Cardiology 2024年第2期21卷 232-241页

作者： Xiao-Ying HU Wei-Xian YANg Chang-Dong gUAN Li-Hua XIE Ke-Fei DOU Yong-Jian WU Jin-Qing YUAN jie QIAN yue-Jin YANg Shu-Bin QIAO Lei SONg Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina National Clinical Research Center for Cardiovascular Diseases BeijingChina Catheterization Laboratories Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

BACKgROUND The prognostic value of coronary collateral circulation(CC)in patients undergoing chronic total occlusion(CTO)percutaneous coronary intervention(PCI)is *** purpose of the study was to assess the prognostic value of current two CC grading systems and their association with long-term outcomes in patients with CTO underwent *** We consecutively enrolled patients with single-vessel CTO underwent PCI between January 2010 and *** patients were categorized into well-developed or poor-developed collaterals group according to angiographic Werner's CC(grade 2 *** 0–1)or Rentrop(grade 3 *** 0–2)grading *** primary endpoint was 5-year cardiac *** Of 2452 enrolled patients,the overall technical success rate was 74.1%.Well-developed collaterals were present in686 patients(28.0%)defined by Werner's CC grade 2,and in 1145 patients(46.7%)by Rentrop grade *** to Werner's CC grading system,patients with well-developed collaterals had a lower rate of 5-year cardiac death compared with those with poordeveloped collaterals(1.6%vs.3.3%,P=0.02),those with suboptimal recanalization was associated with higher rate of 5-year cardiac death compared with optimal recanalization(4.7%vs.0.8%,P=0.01)and failure patients(4.7%vs.1.6%,P=0.12).However,the similar effect was not shown in Rentrop grading *** In patients with the single-vessel CTO underwent PCI,well-developed collaterals by Werner's CC definition were associated with lower rate of 5-year cardiac ***'s CC grading system had a greater prognostic value than Rentrop grading system in patients with CTO underwent PCI.

关键词： coronary collateral occlusion

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新型气囊结构对高速列车横风气动性能的影响

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中南大学学报（自然科学版） 2024年第5期55卷 1745-1757页

作者：张洁许澳岳维刚王哲黄凤仪高广军中南大学重载快捷大功率电力机车全国重点实验室湖南长沙410075 中南大学交通运输工程学院轨道交通安全教育部重点实验室湖南长沙410075 中南大学轨道交通列车安全保障技术国家地方联合工程研究中心湖南长沙410075 漯阜铁路有限责任公司河南周口466000 中南大学建筑与艺术学院湖南长沙410083

为保障高速列车在大风环境下的行车安全,提出一种安装于列车背风侧、改善列车横风气动性能的新型气囊结构外形,以三车编组高速列车为基准,建立4种不同气囊−列车模型即气囊列车(模型Ⅰ)、增加气囊横向宽度(模型Ⅱ、Ⅲ)、增加气囊垂向宽度... 详细信息

为保障高速列车在大风环境下的行车安全,提出一种安装于列车背风侧、改善列车横风气动性能的新型气囊结构外形,以三车编组高速列车为基准,建立4种不同气囊−列车模型即气囊列车(模型Ⅰ)、增加气囊横向宽度(模型Ⅱ、Ⅲ)、增加气囊垂向宽度(模型Ⅳ)。基于三维稳态SST k-ω双方程湍流模型,研究不同气囊模型作用下高速列车横风气动性能。研究结果表明:列车背风侧气囊改变了背风侧车体表面压力分布,列车横向力系数降低、升力系数增大,使得列车倾覆力矩系数减小,高速列车横风气动性能显著提升;随气囊横向宽度增加,列车横向力系数逐渐降低,而升力系数逐渐增大,模型Ⅲ的横风气动性能较优。相较于原始列车模型,模型Ⅲ的横向力系数减小7.09%,升力系数增加12.78%,模型Ⅰ、Ⅱ、Ⅲ的倾覆力矩系数分别降低8.43%、11.05%、13.15%;改变气囊垂向宽度对高速列车横风气动特性影响较小,模型Ⅳ倾覆力矩系数降低8.78%,与模型Ⅰ的优化效果相近。

关键词：高速列车气囊结构横风安全

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