检索结果-南通市图书馆

Uncommon Polycyclic Merosesquiterpenoids and Asteriscanoids from the Hainan Soft Coral Sinularia hurnesi

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2021年第9期39卷 2377-2385页

作者： Zi-Hui Chen Li-Gong Yao Qihao Wu yue-wei guo Dedicated to Dr.Guido Cimino on the occasion of his 80th birthday.0 State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of Sciences555 Zu Chong Zhi RoadZhangjiang Hi-Tech ParkShanghai 201203China University of Chinese Academy of Sciences No.19A Yuquan RoadBeijing 100049China

A rare highly fused racemic merosesquiterpenoid,9-epi-verrubenzospirolactone(1),six new asteriscane-type sesquiterpenoids,sinuhumesins A-F(4-9),and two related known ones(10 and 11)were isolated from Hainan soft coral Sinularia *** 1 was further separated by chiral HPLC resolution to one pair of enantiomers[(+)-1 and(-)-1],*** full structures of the new compounds were unambiguously determined by extensive spectroscopic analysis,chemical computation approaches,modified Mosher's method and/or X-ray diffract!on analysis,as well as comparison with previously reported data of related model compounds.

关键词： Soft coral Sinularia humesi Terpenoids X-ray diffraction Configuration determination

New Cembrane-Type Diterpenoids from the South China Sea Soft Coral Sinularia nanolobata

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2022年第1期40卷 28-38页

作者： Na Lin Heng Li Jian-Rong Wang wei Tang Ming-yue Zheng Hong Wang Cheng-Shi Jiang yue-wei guo Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals and College of Pharmaceutical Science Zhejiang University of TechnologyHangzhouZhejiang 310014China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of Sciences555 Zu Chong Zhi RoadZhangjiang Hi-Tech ParkShanghai 201203China Bohai rim Advanced Research Institute for Drug Discovery Binhai East Road198#High-tech ZoneYantaiShandong 264000China School of Biological Science and Technology University of JinanJinanShandong 250022China

In the present study,nine new cembrane-type diterpenoids,namely ximaonanolobatins A—I(1—9),together with six related known analogs(10—15)and four known tetraprenylated alkaloids malonganenones D,E,H,and K(16—19)were isolated from the soft coral Sinularia nanolobata collected off the Ximao Island in the South China *** structures of 1—9 were robustly established by a combination of detailed spectroscopic analyses,chemical reactions,quantum mechanical(QM)-NMR methods,biogenetic consideration,and the comparison with those literature *** absolute configuration of 1 was confirmed by X-ray diffraction analysis,and the absolute configuration of 2 was determined by QM-NMR calculations and chemical *** addition,the absolute configuration of 3 was determined using the modified Mosher's *** these isolates were evaluated for their anti-inflammatory and anti-tumor *** results showed that only compound 15 exhibited potential anti-inflammatory effect against LPS-induced TNF-αrelease in RAW264.7 macrophages with an IC50 value of 12.6μmol/L.

关键词： Sinularia nanolobata Cembranoids X-ray diffraction Con figuration determination Natural products

X-ray diagnosis of synchronous multiple primary carcinoma in the upper gastrointestinal tract

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2011年第14期17卷 1817-1824页

作者： Zhi-Hao Yang Jian-Bo Gao Song-wei yue Hua guo Xue-Hua Yang Department of Radiology The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052 Henan Province China

AIM:To analyze the radiological features of multiple primary carcinoma (MPC) in the upper gastrointestinal (GI) tract,study its biological characteristics and evaluate X-ray examination in its diagnosis. METHODS:Hypotonic double-contrast GI radiography was performed in 59 multiple primary carcinoma cases,pathologically proved by surgery or endoscopy biopsy. Radiological findings were analyzed. RESULTS:Of the 59 cases,esophageal MPC (EMPC) was seen in 24,esophageal and gastric MPC (EGMPC) in 27 and gastric MPC (GMPC) in 8. Of the 49 lesions found in 24 EMPC,hyperplastic type was seen in 23,medullary type in 9. The lesions were located at the upper (n = 17),middle (n = 19) or lower (n = 13) segment of the esophagus. In 27 EGMPC,the esophageal lesions were located at the middle (n = 16) or lower (n = 11) segment of the esophagus,while the gastric le-sions were located at the gastric cardia (n = 16),fundus (n = 1),body (n = 3) and antrum (n = 7). The esophageal lesions were mainly of the hyperplastic type (n = 12) or medullary type (n = 7),while the gastric lesions were mainly of the hyperplastic type (n = 18). A total of 119 lesions in the 59 patients with synchronous multiple carcinoma were proved by surgery or endoscopy biopsy,and preoperative upper radiographic examination detected 100 of them (84.03% sensitivity). Eighteen (52.94%) of the T1 lesions were found during preoperative diagnosis by radiographic examination. Moreover,only 3 (3.53%) of the T2-4 lesions were misdiagnosed. CONCLUSION:Hypotonic double-contrast upper gastrointestinal examination,providing accurate information about lesion morphology,location and size,can serve as a sensitive technique for the preoperative diagnosis of MPC.

关键词： Multiple primary carcinoma Upper gastrointestinal tract Radiography

Ocellatuspyrones A‒G,new antibacterial polypropionates from the Chinese mollusk Placobranchus ocellatus

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Marine Life Science & Technology 2023年第3期5卷 373-386页

作者： Song-wei Li Dan-Dan Yu Ming-Zhi Su Li-Gong Yao Hong Wang Xueting Liu yue-wei guo Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals College of Pharmaceutical ScienceZhejiang University of TechnologyHangzhou 310014China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai 200237China Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug DiscoveryYantai 264117China

Marine invertebrates serve as rich sources of secondary metabolites with intriguing chemical diversities and a wide spectrum of biological ***,marine shell-less sacoglossan mollusks have attracted much attentions due to the fact that mollusks apply complex metabolites as chemical defense agents against to their *** the purpose of discovering bioactive secondary metabolites to develop marine-derived medicines from the South China Sea,we have conducted a chemical study on the photosynthetic mollusk Placobranchus *** a result,seven newγ-pyrone polypropionates,namely(±)-ocellatuspyrone A(1),(±)-ocellatuspyrone B(2),and ocellatuspyrones C−G(5,9−12),along with fve known polypropionates,have been isolated and characterized from the South China Sea photosynthetic mollusk Placobranchus *** spectroscopic analysis,single crystal X-ray difraction analysis,modifed Mosher’s method,ECD comparison,CD exciton chirality method,TDDFT-ECD calculation,and chemical conversion were used to determine the structures and absolute confgurations of the new compounds and the stereochemistry of undefned known compounds 4,6 and *** these isolated polypropionates were evaluated in bioassays for their biological activities,including antibacterial,neuroprotective efect,anti-infammatory,PTP1B inhibitory,and antiviral *** 7,8 and 11 were found for the frst time to show antibacterial activity against fsh pathogenic bacteria Streptococcus parauberis(the main pathogen causing fsh streptococcal infections and acute death)with MIC values of 35.8,34.2,and 37.4μg/mL,respectively,which might be potential novel antibacterial agents for the treatment of fsh infectious diseases.

关键词： Placobranchus ocellatus γ-pyrone polypropionate Photosynthetic mollusk Antibacterial activity

Xishaglaucumins A—J,New Cembranoids with Anti-Inflammatory Activities from the South China Sea Soft Coral Sarcophyton glaucum

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2022年第1期40卷 79-90页

作者： Jin-Feng Li Yan-Bo Zeng Wang-Sheng Li Hui Luo Hai-Yan Zhang yue-wei guo Hainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-resources Institute of Tropical Bioscience and BiotechnologyChinese Academy of Tropical Agricultural SciencesHaikouHainan 571101China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of Sciences555 Zu Chong Zhi RoadZhangjiang Hi-Tech ParkShanghai 201203China Ocean College of Hebei Agricultural University QinhuangdaoHebei 066000China Key Laboratory of Zhanjiang for Research and Development Marine Microbial Resources in the Beibu Guif Rim Marine Biomedical Research InstituteGuangdong Medical UniversityZhanjiangGuangdong 524023China Bohai rim Advanced Research Institute for Drug Discovery YantaiShandong 264000China

Ten new cembrane-type diterpenoids,namely xishaglaucumins A—J(1—10),along with ten known related ones(11—20),have been isolated from the soft coral Sarcophyton glaucum collected off the Xisha Island in the South China *** structures were elucidated by extensive spectroscopic analysis,quantum mechanical nuclear magnetic resonance(QM-NMR)methods,X-ray diffraction analysis,chemical methods and comparison with the reported data in the *** absolute configuration of new compounds 1,5 and known compounds 11,12,16 and 20 were determined either by chemical methods or by X-ray diffraction analysis using Cu Kα(λ=1.5417A).In in vitro bioassay,compound 4 exhibited inhibitory effects on lipopolysaccharide(LPS)-induced inflammatory responses in BV-2 microglial cells.

关键词： Sarcophyton glaucum Cembranoids Configuration determination X-ray diffraction NMR spectroscopy

Nitrogenous Sesquiterpenoids from the South China Sea Nudibranch Hexabranchus sanguineus and Its Possible Sponge-Prey Acanthella cavernosa: Chiral Separation, Stereochemistry and Chemical Ecology

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2022年第2期40卷 235-246页

作者： Shou-Mao Shen Zai-Yong Zhang Li-Gong Yao Jian-Rong Wang yue-wei guo Xu-Wen Li State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjingJiangsu 210023China Bohai rim Advanced Research Institute for Drug Discovery 198 Binhai East RoadHigh-tech ZoneYantaiShandong 264000China

A detailed chemical investigation of the South China Sea nudibranch Hexabranchus sanguineus,as well as its possible sponge-prey Acanthella cavernosa,led to the isolation of fifteen new nitrogenous sesquiterpenoids,namely ximaocavernosins A-0,including seven cadinanes(1-7),seven spiroaxanes(12-18)and one aromadendrane(19),together with thirteen known related compounds(8-11 and 20-28).

关键词： Hexabranchus sanguineus Acanthella cavernosa Chiral separation Stereochemistry Chemical ecology

Sinucrassins A-K, Casbane-type Diterpenoids from the South China Sea Soft Coral Sinularia crassa

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2021年第9期39卷 2367-2376页

作者： Meng-Jun Wu Jiao Liu Jian-Rong Wang Juan Zhang Hong Wang Cheng-Shi Jiang yue-wei guo Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals and College of Pharmaceutical Science Zhejiang University of TechnologyHangzhouZhejiang 310014China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of Sciences555 Zu Chong Zhi RoadZhangjiang Hi-Tech ParkShanghai 201203China School of Biological Science and Technology University of JinanJinanShandong 250022China

A detailed chemical study on the Hainan soft coral Sinularia crass has resulted in the isolation and characterization of eleven cas-bane-type diterpenoids,named sinucrassins A-K(1-11),along with six known related ones(12-17).Their structures were elucidated by extensive spectroscopic analyses and comparison with the reported *** absolute configurations of new compounds were determi ned by the X-ray diffracti on analysis and computer-assisted structural elucidati on in eluding 13C NMR data calculati on and time-dependent density functional theory/electronic circular dichroism calculation.

关键词： Sinularia crassa Casbane-type diterpenoid Configuration determination X-ray diffraction NMR spectroscopy

Polyoxygenated Cembranoids from Soft Coral Lobophytum Crassum and Their Anti-tumoral Activities

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2021年第3期39卷 640-646页

作者： Fang-Zhou Yin Xia-Juan Huan Wayan Mudianta Ze-Hong Miao Hong Wang yue-wei guo Xu-Wen Li State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of Sciences555 Zu Chong Zhi RoadZhangjiang Hi-Tech ParkShanghai 201203China Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals and College of Pharmaceutical Science Zhejiang University of TechnologyHangzhouZhejiang 310014China Department of Chemistry Universitas Pendidikan GaneshaBali 81116Indonesia

Main observation and conclusion Four new cembranoids,6-oxo-cembrene-A(1),lobocrassins G-H(2-3),and 14-epi-lobophytolide B(4),along with eight known re-lated compounds(5-12),were isolated from the South China Sea soft coral Lobophytum *** structures were established by extensive spectroscopic analysis and by comparison of the spectral data with those reported in the *** absolute stere-ochemistry of 14-epi-lobophytolide B(4)was established by time-dependent density functional theory electronic circular dichroism(TDDFT-ECD)calculations,whereas that of three known metabolites(6,11 and 12)was also determined,for the first time,by using modified Mosher's method and/or X-ray diffraction *** bioassay,the cembranoids 6,7 and 12 showed significant an-ti-tumoral activity against A549,HT-29,SNU-398 and Capan-1 tumor cell lines with IC_(50) values ranging from 1.5 to 7.4μmol/L.A pre-liminary structure-activity relationship was also discussed.

关键词： Soft coral Lobophytum crassum Cembranoids Anti-tumoral activity Stereochemistry

Further New Highly Oxidative Cembranoids from the Hainan Soft Coral Sarcophyton trocheliophorum

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural Products and Bioprospecting 2016年第2期6卷 97-102页

作者： Wen-Ting Chen Lin-Fu Liang Xu-Wen Li wei Xiao yue-wei guo State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of Sciences555 Zu Chong Zhi RoadZhang Jiang High-Tech ParkShanghai 201203People’s Republic of China College of Material Science and Engineering Central South University of Forestry and Technology498 South Shaoshan RoadChangsha 410004People’s Republic of China Jiangsu Kanion Pharmaceutical Co. Ltd.Lianyungang 222001People’s Republic of China

Three new highly oxidative cembranoids,sarcophytrols D-F(1-3),were obtained from the South China Sea soft coral Sarcophyton trocheliophorum,along with two known related ones(4 and 5).Their structures were elucidated by extensive spectroscopic analyses and by comparison with literature *** discovery of these new secondary metabolites enriched the family of cembranoids deduced from the title animal.

关键词： Soft coral Sarcophyton trocheliophorum Cembranoids Sarcophytrol Structure elucidation