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Age-specific distribution of oculometric parameters and myopia in children aged 8-12y

International Journal of Ophthalmology(English edition) 2024年第10期17卷 1887-1897页

作者： Tao tang Si-Tong Chen Heng zhao Kai Wang Ming-Wei zhao Department of Ophthalmology&Clinical Centre of Optometry Peking University People’s HospitalBeijing 100044China Institute of Medical Technology Peking University Health Science CenterBeijing 100083China College of Optometry Peking University Health Science CenterBeijing 100083China Eye Disease and Optometry Institute Peking University People’s HospitalBeijing 100044China Beijing Key Laboratory of the Diagnosis and Therapy of Retinal and Choroid Diseases Beijing 100044China National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To describe the distribution of ocular biometrics and to evaluate its associations with refractive error and to assess the contribution from ocular parameters to refractive error among Chinese myopic ***:This cross-sectional study evaluated subjects aged ***,ocular biometry,and cycloplegic autorefraction were performed on each *** equivalent refraction(SER)and ocular biometrics were assessed as a function of age and *** Pearson correlation analysis between SER and ocular biometrics was carried *** linear regression was performed to analyze the association between SER and ocular ***:A total of 689 out of 735 participants(321 boys,48.1%)were analyzed,with a mean SER of-2.98±1.47 diopter(D).Axial length(AL),anterior chamber depth(ACD),corneal radius of curvature(CR),horizontal visible iris diameter(HVID),central corneal thickness(CCT)and lens power(LP)showed normal *** AL,AL/CR ratio,ACD and CR increased from 8 to 12y of age,while SER and LP decreased,HVID and CCT remained *** was no difference in *** decreased by 0.929 D for every 1 mm increase in AL and decreased by 1.144 D for every 0.1 increase in AL/CR *** Pearson correlation coefficient between SER and AL was-0.538(P<0.01)and-0.747(P<0.01)between SER and AL/CR *** the SER variance,AL explained 29.0%,AL/CR ratio explained 55.7%,while AL,CR,ACD and LP explained 99.3%after adjusting for age and ***:The AL,CR,ACD and LP are the most important determinants of myopic refractive error during myopia progression.

关键词： myopia ocular biometry refractive error population-based study

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Application of CFD and FEA Coupling to Predict Structural Dynamic Responses of A Trimaran in Uni-and Bi-Directional Waves

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China Ocean Engineering 2024年第1期38卷 81-92页

作者： LIAO Xi-yu XIA Jin-song CHEN Zhan-yang tang Qin zhao Nan zhao Wei-dong GUI Hong-bin Marine Design&Research Institute of China Shanghai 200011China Ship Structure Division China Ship Scientific Research CenterWuxi 214082China College of Ocean Engineering Harbin Institute of TechnologyWeihaiWeihai 264209China State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentDalian University of TechnologyDalian 116024China School of Foreign Studies Jiangnan UniversityWuxi 214122China

To predict the wave loads of a flexible trimaran in different wave fields,a one-way interaction numerical simulation method is proposed by integrating the fluid solver(Star-CCM+)and structural solver(Abaqus).Differing from the existing coupled CFD-FEA method for monohull ships in head waves,the presented method equates the mass and stiffness of the whole ship to the hull shell so that any transverse and longitudinal section stress of the hull in oblique waves can be ***,verification study and sensitivity analysis are carried out by comparing the trimaran motions using different mesh sizes and time step *** on the wave elevation of uni-and bi-directional waves is also carried *** a comprehensive analysis on the structural responses of the trimaran in different uni-directional regular wave and bi-directional cross sea conditions is carried out,***,the differences in structural response characteristics of trimaran in different wave fields are *** results show that the present method can reduce the computational burden of the two-way fluid-structure interaction simulations.

关键词： CFD-FEA fluid-structure coupling structural responses trimaran bi-directional cross sea

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Investigation of stress distribution and damage behavior caused by forced installation of a composite bolted joint with a hole-location error

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Chinese Journal of Aeronautics 2024年第1期37卷 201-217页

作者： Chinan LIU Yuan LI Yi CHENG An’an zhao Kunpeng DU yue SHI Ximing LI Hui CHENG School of Mechanical Engineering Northwestern Polytechnical UniversityXi’an 710072China AVIC Xi’an Aircraft Industry Group Company LTD Xi’an 710089China

In this paper,the influence of forced installation caused by a hole-location error on the 3D stress distribution and damage of a composite bolted joint is *** analytical model of stress distributed on composite holes is promoted,in view of non-uniform extrusion caused by forced *** first,non-uniform extrusion of the hole edge caused by forced installation is *** to the contact state,expression of hole deformation is ***,based on Hertz theory,the maximum extrusion load is obtained with help of deformation *** constructing an elastic foundation beam model,3D stress distributed on a hole could be analyzed according to the extrusion ***,stress distribution predicted by the above analytical method is compared with that provided by FE considering composite ***,a forced installation experiment is carried out to analyze the damage distribution of the *** show that a central-symmetrically distributed stress is introduced by the hole-location *** an increment of the error,strength of composite decreases due to extrusion ***,stress presents a concave distribution on the *** the hole-location error exceeding 3%,stress decreases gradually due to failure of *** of holes does not exhibit a centrosymmetric *** damage is mainly distributed on the entrance of the hole at the lower sheet.

关键词： Hole-location error Composite joint Forced installation Stress distribution Damage

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The effects of various factors on spontaneous imbibition in tight oil reservoirs

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Petroleum Science 2024年第1期21卷 315-326页

作者： Cheng Liu Tian-Ru Wang Qing You yue-Chun Du Guang zhao Cai-Li Dai School of Energy Resources China University of GeosciencesBeijing100083PR China School of Petroleum Engineering China University of PetroleumQingdao266580ShandongPR China

Slickwater fracturing fluids have gained widespread application in the development of tight oil reservoirs. After the fracturing process, the active components present in slickwater can directly induce spontaneous imbibition within the reservoir. Several variables influence the eventual recovery rate within this procedure, including slickwater composition, formation temperature, degree of reservoir fracture development, and the reservoir characteristics. Nonetheless, the underlying mechanisms governing these influences remain relatively understudied. In this investigation, using the Chang-7 block of the Changqing Oilfield as the study site, we employ EM-30 slickwater fracturing fluid to explore the effects of the drag-reducing agent concentration, imbibition temperature, core permeability, and core fracture development on spontaneous imbibition. An elevated drag-reducing agent concentration is observed to diminish the degree of medium and small pore utilization. Furthermore, higher temperatures and an augmented permeability enhance the fluid flow properties, thereby contributing to an increased utilization rate across all pore sizes. Reduced fracture development results in a lower fluid utilization across diverse pore types. This study deepens our understanding of the pivotal factors affecting spontaneous imbibition in tight reservoirs following fracturing. The findings act as theoretical, technical, and scientific foundations for optimizing fracturing strategies in tight oil reservoir transformations.

关键词： Tight oil reservoir Spontaneous imbibition Nuclear magnetic resonance Slickwater fracturing fluid Fluid utilization degree

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Towards experimental studying the airborne sound insulation of light frame walls with staggered studs

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Science China(Technological Sciences) 2024年第7期67卷 2230-2243页

作者： ZHANG YuCai yue Kong XIE YiFan CHENG XiangYu SHI XinLei WU Peng zhao Hui College of Civil Engineering Nanjing Tech UniversityNanjing 211800China Key Laboratory of Architectural Acoustic Environment of Anhui Higher Education Institutes Hefei 230601China Nanjing Gongda Construction Technology Co.Ltd. Nanjing 211800China

Light frame walls(LFWs) serve as common partition walls in prefabricated buildings due to their lightweight nature, costeffectiveness, energy efficiency, and adaptability for rapid on-site assembly. However, their acoustic insulation capability is hindered by issues such as sound bridges, resonance, and coincidence dips, resulting in inadequate sound insulation. This study aims to propose LFW designs with superior acoustic insulation suitable for practical engineering while meeting prevailing national standards. Nine full-scale LFW configurations were subjected to laboratory testing to evaluate the impact of staggered stud arrangements, stud types, and incorporation of compounded materials. The tests were performed between 100 and 5000 Hz,and the sound pressure level and reverberation time at 1/3 octave band were measured and used to calculate the weighted sound insulation index(Rw). Results demonstrated that the outlined design modifications significantly enhanced the sound insulation of the LFW. These modifications effectively mitigate the influence of sound bridges while addressing resonance and coincidence dips inherent in the wall system. Particularly noteworthy was the superior sound insulation achieved by staggered-stud LFWs with compounded materials, surpassing that of autoclaved lightweight concrete walls commonly used in prefabricated constructions despite having lesser thickness and surface density. Rwvalues increased from 43 to 54 dB compared to conventional LFWs, translating to a notable elevation in airborne sound insulation level from 4 to 7 as an internal separation component,meeting the requisite standards for most applications.

关键词： light frame wall staggered stud airborne sound insulation weighted sound insulation index

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Lath-like phases formed at an extremely high temperature in a Mg-RE(RE=rare earth)-Al alloy

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Rare Metals 2024年第8期43卷 3937-3945页

作者： Bo Deng Shu-Hui Lv Qiang Yang Dong-yue zhao Jun-Yuan Fan Xin Qiu School of Materials Science and Engineering Changchun University of Science and TechnologyChangchun 130022China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Chongqing Research Institute Changchun University of Science and TechnologyChongqing 401135China

Thermal stable intermetallic particles are important for the heat resistance of magnesium(Mg)*** this work,many lath-like particles formed in α-Mg grains of a Mg-8Gd-3Sm-0.7Al casting alloy when heat-treated at 873 ***-resolution high-angle annular dark field scanning transmission electron microscopy(HAADF-STEM) characterizations indicate that most of them are Mg-containing Al_(2)(Gd,Sm),with the atomic ratio of Mg:Al:(Gd,Sm) being ~1:1:1;a small part of them with relatively wider thickness are long-period stacking ordered(LPSO) phases simultaneously containing both 14H and 18R *** followed common orientation relationships with Mg matrix as those reported in previous *** addition,many Mg laths were observed in the primary blocky Al_(2)(Gd,Sm) phase at grain boundaries,where the atomic ratio of Al:(Gd,Sm) in the Al_(2)(Gd,Sm) matrix was 2:***,density functional theory(DFT) calculations illustrated the detail structure of the re-constructed Mg/Al_(2)RE interface and simultaneously deduced the underlying reason for the re-dissolution of the newly formed Mg-containing Al_(2)(Gd,Sm) plates in α-Mg matrix.

关键词： Magnesium alloy HAADF-STEM Microstructures Intermetallic particles Orientation relationships Interfaces

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Tim4 deficiency reduces CD301b+macrophage and aggravates periodontitis bone loss

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International Journal of Oral Science 2024年第2期16卷 280-292页

作者： Ziming Wang Hao Zeng Can Wang Jiaolong Wang Jing Zhang Shuyuan Qu yue Han Liu Yang yueqi Ni Wenan Peng Huan Liu Hua tang Qin zhao Yufeng Zhang State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool&Hospital of StomatologyTaikang Center for Life and Medical SciencesWuhan UniversityWuhanChina School of Stomatology Nanchang UniversityNanchangChina Institute of Infection and Immunity Science and Technology Innovation CenterShandong First Medical University&Shandong Academy of Medical SciencesJinanChina Medical Research Institute School of MedicineWuhan UniversityWuhanChina

Periodontitis is a common chronic inflammatory disease that causes the periodontal bone destruction and may ultimately result in tooth *** the progression of periodontitis,the osteoimmunology microenvironment in periodontitis is damaged and leads to the formation of pathological alveolar bone ***301b^(+)macrophages are specific to the osteoimmunology microenvironment,and are emerging as vital booster for conducting bone ***,the key upstream targets of CD301b^(+)macrophages and their potential mechanism in periodontitis remain *** this study,we concentrated on the role of Tim4,a latent upstream regulator of CD301b^(+)*** first demonstrated that the transcription level of Timd4(gene name of Tim4)in CD301b^(+)macrophages was significantly upregulated compared to CD301b^(-) macrophages via high-throughput RNA ***,several Tim4-related functions such as apoptotic cell clearance,phagocytosis and engulfment were positively regulated by CD301b^(+)*** single-cell RNA sequencing analysis subsequently discovered that Cd301b and Timd4 were specifically co-expressed in *** following flow cytometric analysis indicated that Tim4 positive expression rates in total macrophages shared highly synchronized dynamic changes with the proportions of CD301b^(+)macrophages as periodontitis ***,the deficiency of Tim4 in mice decreased CD301b^(+)macrophages and eventually magnified alveolar bone resorption in ***,Tim4 controlled the p38 MAPK signaling pathway to ultimately mediate CD301b^(+)macrophages *** a word,Tim4 might regulate CD301b^(+)macrophages through p38 MAPK signaling pathway in periodontitis,which provided new insights into periodontitis immunoregulation as well as help to develop innovative therapeutic targets and treatment strategies for periodontitis.

关键词： period upstream eventually

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A multifunctional shear apparatus for rocks subjected to true triaxial stress and high temperature in real-time

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第9期16卷 3524-3543页

作者： Jun zhao Xia-Ting Feng Jia-Rong Wang Liang Hu yue Guo Key Laboratory of Ministry of Education on Safe Mining of Deep Metal Mines Northeastern UniversityShenyang110819China Key Laboratory of Liaoning Province on Deep Engineering and Intelligent Technology Northeastern UniversityShenyang110819China

Deep engineering disasters,such as rockbursts and collapses,are more related to the shear slip of rock joints.A novel multifunctional device was developed to study the shear failure mechanism in *** this device,the complete shearedeformation process and long-term shear creep tests could be performed on rocks under constant normal stiffness(CNS)or constant normal loading(CNL)conditions in real-time at high temperature and true-triaxial *** the research and development process,five key technologies were successfully broken through:(1)the ability to perform true-triaxial compressioneshear loading tests on rock samples with high stiffness;(2)a shear box with ultra-low friction throughout the entire stress space of the rock sample during loading;(3)a control system capable of maintaining high stress for a long time and responding rapidly to the brittle fracture of a rock sample as well;(4)a refined ability to measure the volumetric deformation of rock samples subjected to true triaxial shearing;and(5)a heating system capable of maintaining uniform heating of the rock sample over a long *** developing these technologies,loading under high true triaxial stress conditions was *** apparatus has a maximum normal stiffness of 1000 GPa/m and a maximum operating temperature of 300*** differences in the surface temperature of the sample are constant to within5*** types of true triaxial shear tests were conducted on homogeneous sandstone to verify that the apparatus has good performance and *** results show that temperature,lateral stress,normal stress and time influence the shear deformation,failure mode and strength of the *** novel apparatus can be reliably used to conduct true-triaxial shear tests on rocks subjected to high temperatures and stress.

关键词： True-triaxial shear apparatus Rocks Complete shear stressedeformation process Creep Real-time high-temperature

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Food poisoning due to money tree seeds:a case report of toxic encephalopathy

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Emergency and Critical Care Medicine 2024年第3期4卷 126-129页

作者： yue zhao Xiaojiao Quan Tao Wang Department of Emergency Medicine Hainan Hospital of Chinese PLA General HospitalSanyaHainanChina The Center of Heat Stroke Prevention and Treatment of Peoples’Liberation Army SanyaHainanChina

Background:The money tree is a favored indoor potted plant in *** seeds resemble chestnuts in both shape and flavor when cooked,which are generally considered non-toxic and safe for *** presentation:This report presents the first published case of food poisoning due to the ingestion of large amounts of money tree seeds.A 67-year-old man exhibited toxic encephalopathy symptoms and dyspnea after consuming the seeds for approximately 6 *** empirical mechanical ventilation,therapeutic plasma exchange,and other medical interventions,the patient’s clinical status improved *** was subsequently discharged from the ***:Consuming a substantial quantity of money tree seeds within a limited timeframe can lead to poisoning,resulting in adverse outcomes,particularly toxic ***,plasma exchange may have some therapeutic effect.

关键词： Case report Money tree Pachira macrocarpa Respiratory failure Toxic encephalopathy

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Feasible Synthesis of N,O-Bidentate Difluoroboron Chromophores through Direct Functionalization of Quinoxalin-2(1H)-ones with Ketones in One Shot

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Chinese Journal of Chemistry 2024年第13期42卷 1481-1486页

作者： Shuaichen Zhang Jing Zhang Xiang Ling Yifan zhao yue Ma Peng Sun State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Center and Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China Department of Pharmaceutics School of PharmacyChina Pharmaceutical UniversityState Key Laboratory of Natural MedicinesNanjingJiangsu 210009China

Organic difluoroboron complexes are a kind of potential platforms for a wide range of applications owing to their excellent photophysical ***,we have explored a simple and direct synthesis methodology for a library of N,O-bidentate difluoroboron complexes from quinoxalin-2(1H)-ones and ketones in one *** photophysical properties of the generated complexes were evaluated and the application potential of these compounds on subcellular imaging was also explored.

关键词： N,O-Bidentate difluoroboron Chromophores Quinoxalin-2(1H)-ones Ketones/Green chemistry Synthetic method C-CcouplingI Boron

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