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Chronic infectious unilateral giant thyroid cyst related to diabetes mellitus:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1497-1503页

作者： jiang-Bo Liu Shi-Lei Zhang Wen-long jiang Hai-Kuan Sun Hao-Chen Yang Department of Thyroid and Breast Surgery The First Affiliated HospitalCollege of Clinical MedicineHenan University of Science and TechnologyLuoyang 471000Henan ProvinceChina Clinical Medicine School The First Clinical CollegeChongqing Medical UniversityChongqing 400016China

BACKGROUND Patients rarely develop complicated infections in thyroid ***,we describe a patient with chronic infected unilateral giant thyroid cyst related to diabetes mellitus(DM).CASE SUMMARY A 66-year-old male was admitted due to an evident neck lump for 5 d after approximately 40 years of gradually progressive neck mass and 7 years of *** ultrasound and computed tomography scan showed a giant lump in the left thyroid gland *** was diagnosed with a large thyroid nodule complicated by tracheal dislocation and had surgical *** exploration revealed evident inflammatory edema and exudation between the left anterior neck muscles,the nodule and glandular ***,inflammatory lesions did not affect major neck ***,a left partial thyroidectomy was *** observation showed that the cystic thyroid mass consisted of extensive cystic wall calcification and was rich in massive rough sand-like calculi content and purulent *** pathology confirmed benign thyroid cyst with chronic *** The progression of this chronic infectious unilateral giant thyroid cyst may have been related to DM,and identifying blood vessels involvement can prevent serious complications during operation.

关键词： Thyroid nodule Infection Diabetes mellitus Surgery Case report

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激光诱导透明陶瓷损伤研究进展

硅酸盐学报 2024年第3期52卷 973-992页

作者：陈跃姜本学冯涛张龙中国科学院上海光学精密机械研究所中国科学院强激光材料重点实验室上海201800 中国科学院大学北京100049

在激光诱导损伤的响应中,透明陶瓷既有与其他光学元件的相似性,也表现出损伤的特殊性因其具有晶界、微气孔等微结构缺陷。强激光对透明陶瓷诱导损伤的形貌、分析损伤的规律并揭示损伤的机理的工作被开展,这有利于完善激光陶瓷的制备工艺... 详细信息

在激光诱导损伤的响应中,透明陶瓷既有与其他光学元件的相似性,也表现出损伤的特殊性因其具有晶界、微气孔等微结构缺陷。强激光对透明陶瓷诱导损伤的形貌、分析损伤的规律并揭示损伤的机理的工作被开展,这有利于完善激光陶瓷的制备工艺,对降低高能激光系统的运行成本和提高负载能力均具有现实意义。本文综述了透明陶瓷激光诱导损伤的探究方法、损伤的影响因素和提升损伤阈值的途径3方面内容,并结合其他类光学元件较为成熟的研究思路或典型的探究方法。探讨了激光诱导透明陶瓷损伤中的几个研究重点及解决对策,对于高损伤阈值透明陶瓷的研制以及在强激光系统中的合理应用具有重要的参考价值。

关键词：透明陶瓷激光损伤表面损伤体内损伤损伤动力学

Dynamic Analysis of A Deepwater Drilling Riser with A New Hang-off System

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China Ocean Engineering 2024年第1期38卷 29-41页

作者： LI Yan-wei LIU Xiu-quan WANG Jin-long CHEN Guo-ming CHANG Yuan-jiang SHENG Lei-xiang Centre for Offshore Engineering and Safety Technology China University of PetroleumQingdao 266580China National Engineering Laboratory of Offshore Geophysical and Exploration Equipment China University of PetroleumQingdao 266580China China CNOOC Research Institute Co. Ltd.Beijing 100028China

The safety of risers in hang-off states is a vital challenge in offshore oil and gas engineering.A new hang-off system installed on top of risers is proposed for improving the security of *** approach leads to a challenging problem:coupling the dynamics of risers with a new hang-off system combined with multiple structures and complex *** accurately analyze the dynamic responses of the coupled system,a coupled dynamic model is established based on the Euler-Bernoulli beam-column theory and penalty function method.A comprehensive analysis method is proposed for coupled dynamic analysis by combining the finite element method and the Newmarkβ*** analysis program is also developed in MATLAB for dynamic *** simulation results show that the dynamic performances of the risers at the top part are significantly improved by the new hang-off system,especially the novel design,which includes the centralizer and articulation *** bending moment and lateral deformation of the risers at the top part decrease,while the hang-off joint experiences a great bending moment at the bottom of the lateral restraint area which requires particular attention in design and *** platform navigation speed range under the safety limits of risers expands with the new hang-off system in use.

关键词： deepwater drilling riser new hang-off system dynamic analysis finite element method penalty function method

In Situ High-performance Gel Polymer Electrolyte with Dual-reactive Cross-linking for Lithium Metal Batteries

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Energy & Environmental Materials 2024年第1期7卷 51-59页

作者： Fuhe Wang Honghao Liu Yaqing Guo Qigao Han Ping Lou long Li Jianjie jiang Shijie Cheng Yuancheng Cao School of Materials Science and Engineering Huazhong University Huazhong University of Science and Technology Wuhan 430074China State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic Engineering Huazhong University of Science and TechnologyWuhan 430074China State Grid Huzhou Power Supply Company Huzhou 313000China Huzhou Electric Power Design Institute Company Huzhou 311404China

Lithium metal batteries have been considered as one of the most promising next-generation power-support devices due to their high specific energy and output ***,the uncontrollable side-reaction and lithium dendrite growth lead to the limited serving life and hinder the practical application of lithium metal ***,a tri-monomer copolymerized gel polymer electrolyte(TGPE)with a cross-linked reticulation structure was prepared by introducing a cross-linker(polyurethane group)into the acrylate-based in situ polymerization *** soft segment of polyurethane in TGPE enables the far migration of lithium ions,and the-NH forms hydrogen bonds in the hard segment to build a stable cross-linked *** system hinders anion migration and leads to a high Li^(+)migration number(t_(Li^(+))=0.65),which achieves uniform lithium deposition and effectively inhibits lithium dendrite *** a result,the assembled symmetric cell shows robust reversibility over 5500 h at a current density of 1 mA cm^(-2).The LFP∷TGPE∷Li cell has a capacity retention of 89.8%after cycling 800 times at a rate of *** summary,in situ polymerization of TGPE electrolytes is expected to be a candidate material for high-energy-density lithium metal batteries.

关键词： gel polymer electrolytes hydrogen bonds in situ polymerization lithium metal batteries polyurethane

Genome editing of PAR2 through targeted delivery of CRISPR-Cas9 system for alleviating acute lung inflammation via ERK/NLRP3/IL-1β and NO/iNOS signalling

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1441-1456页

作者： Xin Zhuo yue Wu Xiujuan Fu Jianbin Li Yuxin Xiang Xiaoyu Liang Canquan Mao Yuhong jiang Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs School of Life Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China

Excessive and uncontrollable inflammatory responses in alveoli can dramatically exacerbate pulmonary disease progressions through vigorous cytokine releases,immune cell infiltration and protease-driven tissue *** is an urgent need to explore potential drug strategies for mitigating lung ***-activated receptor 2(PAR2)as a vital molecular target principally participates in various inflammatory diseases via intracellular signal ***,it has been rarely reported about the role of PAR2 in lung *** study applied CRISPR-Cas9 system encoding Cas9 and sg RNA(p Cas9-PAR2)for PAR2 knockout and fabricated an anionic human serum albuminbased nanoparticles to deliver p Cas9-PAR2 with superior inflammation-targeting efficiency and stability(TAP/p Cas9-PAR2).TAP/p Cas9-PAR2 robustly facilitated p Cas9-PAR2 to enter and transfect inflammatory cells,eliciting precise gene editing of PAR2 in vitro and in ***,PAR2 deficiency by TAP/p Cas9-PAR2 effectively and safely promoted macrophage polarization,suppressed proinflammatory cytokine releases and alleviated acute lung inflammation,uncovering a novel value of *** also revealed that PAR2-mediated pulmonary inflammation prevented by TAP/p Cas9-PAR2was mainly dependent on ERK-mediated NLRP3/IL-1β and NO/i NOS ***,this work indicated PAR2 as a novel target for lung inflammation and provided a potential nanodrug strategy for PAR2 deficiency in treating inflammatory diseases.

关键词： Protease-activated receptor 2(PAR2) CRISPR-Cas9 Gene editing Inflammation Acute lung inflammation NLRP3 Nanoparticles Drug delivery

Curation,nomenclature,and topological classification of receptor-like kinases from 528 plant species for novel domain discovery and functional inference

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Molecular Plant 2024年第4期17卷 658-671页

作者： Qian Liu Qiong Fu Yujie Yan Qian jiang longfei Mao long Wang Feng Yu Heping Zheng State Key Laboratory of Chemo/Biosensing and Chemometrics Hunan University College of BiologyChangshaHunan 410082China Bioinformatics Center Hunan University College of BiologyChangshaHunan 410082China

Receptor-like kinases(RLKs)are the most numerous signal transduction components in plants and play important roles in determining how different plants adapt to their ecological *** on RLKs has focused mainly on a small number of typical RLK members in a few model *** is an urgent need to study the composition,distribution,and evolution of RLKs at the holistic level to increase our understanding of how RLKs assist in the ecological adaptations of different plant *** this study,we collected the genome assemblies of 528 plant species and constructed an RLK *** this dataset,we identified and characterized 524948 RLK family *** member underwent systematic topological classification and was assigned a gene ID based on a unified nomenclature ***,we identified two novel extracellular domains in some RLKs,designated Xiao and *** analysis of the RLK family revealed that the RLCK-XVII and RLCK-XII-2 classes were present exclusively in dicots,suggesting that diversification of RLKs between monocots and dicots may have led to differences in downstream cytoplasmic *** also used an interaction proteome to help empower data mining for inference of new RLK functions from a global perspective,with the ultimate goal of understanding how RLKs shape the adaptation of different plants to the environments/*** assembled RLK dataset,together with annotations and analytical tools,forms an integrated foundation of multiomics data that is publicly accessible via the metaRLK web portal(http://***).

关键词： RLK RLCK domain signaling pathway receptor-protein interactions

Geant4 simulation of fast-electron bremsstrahlung imaging at the HL-3 tokamak

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Nuclear Science and Techniques 2024年第9期35卷 213-229页

作者： Shi-Kui Cheng Yi-Po Zhang yue-jiang Shi Jie Zhang Shuai Guan Hong-Bing Xu Qiu-Lei Yang College of Science Chongqing University of TechnologyChongqing 400054China Chongqing Key Laboratory of New Energy Storage Materials and Devices Chongqing 400054China Southwestern Institute of Physics Chengdu 610041China Hebei Key Laboratory of Compact Fusion Langfang 065001China ENN Science and Technology Development Co. Ltd.Langfang 065001China

To further research on high-parameter plasma,we plan to develop a two-dimensional hard X-ray(HXR)imaging system at the HL-3 tokamak to measure HXRs with energies ranging from 20 to 300 *** application of an array-structured detector ensures that this system can measure HXR-radiation spectra from the entire plasma cross ***,it is suitable for the study of fast-electron physics,such as radio-frequency wave current drives,fast electrons driving instabilities,and plasma disruptions in fusion *** this study,we develop a simulation for calculating fast-electron bremsstrahlung in the HL-3 tokamak based on the Monte Carlo simulation code Geant4,in which the plasma geometry and forward scattering of fast-electron bremsstrahlung are *** preliminary calculation results indicate that the HXR energy deposi-tion on the detector is symmetrically distributed,even though the plasma distribution is asymmetric owing to the toroidal *** simulation results are helpful in constructing the relationship between the energy deposition on the detector and parameter distribution on the plasma cross section during HL-3 *** is beneficial for the reconstruction of the fast-electron-distribution function and for optimizing the design of the HXR-imaging system.

关键词： Geant4 simulation HL-3 tokamak Fast-electron bremsstrahlung Hard X-ray imaging

Upper-Bound Limit Analysis of the Multi-Layer Slope Stability and Failure Mode Based on Generalized Horizontal Slice Method

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Journal of Earth Science 2024年第3期35卷 929-940页

作者： Huawei Zhang Changdong Li Wenqiang Chen Ni Xie Guihua Wang Wenmin Yao Xihui jiang Jingjing long Key Laboratory of Geotechnical Mechanics and Engineering of Ministry of Water Resources Changjiang River Scientific Research InstituteWuhan 430010China Faculty of Engineering China University of GeosciencesWuhan 430074China Badong National Observation and Research Station of Geohazards China University of GeosciencesWuhan 430074China School of Civil Engineering Zhengzhou UniversityZhengzhou 450001China

Multi-layer slopes are widely found in clay residue receiving fields.A generalized horizontal slice method(GHSM)for assessing the stability of multi-layer slopes that considers the energy dissipation between adjacent horizontal slices is *** view of the upper-bound limit analysis theory,the energy equation is derived and the ultimate failure mode is generated by comparing the sliding surface passing through the slope toe(mode A)with that below(mode B).In addition,the influence of the number of slices on the stability coefficients in the GHSM is studied and the stable value is *** to the original method(Chen’s method),the GHSM can acquire more precise results,which takes into account the energy dissipation in the inner sliding soil ***,the GHSM,limit equilibrium method(LEM)and numerical simulation method(NSM)are applied to analyze the stability of a multi-layer slope with different slope angles and the results of the safety factor and failure mode are very close in each *** ultimate failure modes are shown to be mode B when the slope angle is not more than 28°.It illustrates that the determination of the ultimate sliding surface requires comparison of multiple failure modes,not only mode A.

关键词： stability and failure mode slope stability generalized horizontal slice method upperbound limit analysis energy dissipation geotechnical engineering.

PACS gene family-related neurological diseases: limited genotypes and diverse phenotypes

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World Journal of Pediatrics 2024年第1期20卷 82-91页

作者： Han Zhang Kai Gao Shuang Wang yue-Hua Zhang Zhi-Xian Yang Ye Wu Yu-Wu jiang Department of Pediatrics Peking University First Hospital.No.1 Xi'an Men StreetWest DistrictBeijing 100034China Bejing Key Laboratory of Molecular Diagnosis and Study on Pediatric Genetic Diseases BeijingChina Children Epilepsy Center Peking University First HospitalBeijingChina Key Laboratory for Neuroscience Ministry of Education/National Health and Family Planning CommissionPeking UniversityBeijingChina Center of Epilepsy Beijing Institute for Brain DisordersBeijingChina

Background The PACS gene family has been demonstrated to be related to intracellular vesicular *** phenotypic manifestations caused by the pathogenic variants of PACS include epilepsy,intellectual disability/developmental delay,and malformations,such as facial *** We identified seven new cases with pathogenic or likely pathogenic PACS variants using next-generation *** information obtained from these patients was analyzed along with that obtained from previously reported *** With the inclusion of the newly diagnosed cases in this study,103 cases with PACS gene family-related neurological diseases were reported,of which 43 were PACS2-related cases and the remaining were PACSI-related *** patients had seizures,which have been reported to be effectively controlled by several types of anti-seizure medications(ASMs).The most efficacious and frequently prescribed ASMs included sodium valproate(43.3%,13/30),oxcarbazepine/carbamazepine(26.7%,8/30),and levetiracetam(20%,6/30).Almost all patients had intellectual disability/developmental *** most common pathogenic missense variants were PACSI ***203Trp and PACS2 *** addition,we report a patient carrying a likely pathogenic copy number variation(CNV)(de novo heterozygous deletion of chr14:105821380-106107443,286 kilobase,destroyed part of the furin-binding region domain and the protein structure after it)with more severe and refractory late-onset *** The clinical phenotypes of the different PACS heterozygous missense variants were *** pathogenic variant sites of PACSI and PACS2 were quite limited but located in different regions.A CNV destroying part of the PACS2 gene might also be *** findings may provide an important clue for further functional studies on the pathogenic mechanism of neurological disorders related to the PACS gene family.

关键词： Developmental delay Epilepsy Intellectual disability PACSI PACS2