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Exploring the therapeutic potential of Qi Teng Mai Ning recipe in ischemic stroke and vascular cognitive impairment

Traditional Medicine Research 2024年第10期9卷 21-35页

作者： Jia-Yan Yao yue-lan yang Wei-Jian Chen Hai-Ying Fan Department of Neurosurgery Changxing People’s HospitalChangxing 313100China Department of Ultrasound Medicine Changxing People’s HospitalChangxing 313100China Department of Orthopedics The Fifth Clinical College of Guangzhou University of Chinese MedicineGuangzhou 510095China

Background:This study aims to explore the therapeutic effects of the Qi Teng Mai Ning recipe on ischemic stroke and vascular cognitive impairment through its potential to modulate cellular autophagy,with a focus on identifying its active ingredients and their target ***:The study began with the identification of active ingredients in the Qi Teng Mai Ning *** proceeded to screen the gene expression omnibus database for ischemic stroke and vascular cognitive impairment-associated differentially expressed mRNAs and to identify cellular autophagy-related proteins via the Human Autophagy *** proteins were annotated with Gene Ontology and Kyoto Encyclopedia of Genes and Genomes functions and subjected to molecular docking with the recipe’s core active *** vitro cell experiments were conducted on hypoxic HT22 cells,involving CCK8 assay,lentiviral transfection to silence autophagy related 9B(ATG9B),immunofluorescence staining,and qPCR validation to investigate the effects of the recipe on ***:The analysis identified 104 active ingredients targeting 408 proteins and forming a complex ingredient-target *** 55 ischemic stroke-related and 909 vascular cognitive impairment-related differentially expressed mRNAs revealed 14 co-expressed *** docking showed quercetin,kaempferol,myrcene,and conferone as key ingredients targeting autophagy-related *** experiments indicated that the recipe significantly enhanced cell viability under hypoxic conditions,reduced apoptosis,and modulated the expression of autophagy-related factors,thereby decreasing apoptosis rates in HT22 ***:The Qi Teng Mai Ning recipe offers protective effects against ischemic stroke and vascular cognitive impairment by modulating autophagy-related *** efficacy highlights the potential of traditional Chinese medicine in treating these conditions,though further research is needed to fully understand its

关键词： Qi Teng Mai Ning recipe autophagy ischemic stroke vascular cognitive impairment traditional Chinese medicine

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Heterogeneous Image Knowledge Driven Visual Perception

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 255-257页

作者： lan Yan Wenbo Zheng Fei-yue Wang IEEE the College of Computer Science and Electronic Engineering Hunan UniversityChangsha 410082China the School of Computer Science and Artificial Intelligence Wuhan University of TechnologyWuhan 430070China the State Key Laboratory for Management and Control of Complex Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China

Dear Editor,This letter is concerned with visual perception closely related to heterogeneous *** the huge challenge brought by different image modalities,we propose a visual perception framework based on heterogeneous image knowledge,i.e.,the domain knowledge associated with specific vision tasks,to better address the corresponding visual perception problems.

关键词： Visual visual knowledge

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Min-norm spatial spectrum based on acoustic vector-sensor linear array

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Journal of Marine Science and Application 2006年第3期5卷 41-45页

作者： ZHANG lan-yue yang De-sen College of Underwater Acoustic Engineering Harbin Engineering University Harbin 150001 China

The high resolution of DOA（direction of arrival） estimation could be obtained by using the min-norm algorithm. In this paper, the expression of the min-norm spatial spectrum based on acoustic vector-sensor（AVS） linear arrays was presented and simulation study was carried out. Results of simulations indicated that left/right ambiguity could be removed and better performance for DOA estimation was obtainable when dealing with sources close to endfire than using pressure hydrophone linear arrays, and the interelement spacing was allowed to exceed the half-wavelength upper limit. A three-element vector hydrophone linear array with two meters interspace was designed. The AVS experiment was carried out at Songhua Lake in Jinlin Province. Experimental results show a high resolution tracking of targets can be obtained using the rain-norm algorithm.

关键词： acoustic vector-sensor linear array min-norm algorithm direction of arrival estimation

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Resource allocation for D2D-assisted haptic communications

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Digital Communications and Networks 2024年第1期10卷 63-74页

作者： Yan Wu Chao yue yang yang Liang Ao College of Telecommunication Engineering Army Engineering University of PLANanjing210000China

Haptic communications is recognized as a promising enabler of extensive services by enabling real-time haptic control and feedback in remote environments,e.g.,teleoperation and autonomous *** the strict transmission requirements on reliability and latency,Device-to-Device(D2D)communications is introduced to assist haptic *** particular,the teleoperators with poor channel quality are assisted by auxiliaries,and each auxiliary and its corresponding teleoperator constitute a D2D ***,the haptic interaction and the scarcity of radio resources pose severe challenges to the resource allocation,especially facing the sporadic packet ***,the contentionbased access scheme is applied to achieve low-latency transmission,where the resource scheduling latency is omitted and users can directly access available *** this context,we derive the reliability index of D2D pairs under the contention-based access scheme,i.e.,closed-loop packet error ***,the reliability performance is guaranteed by bidirectional power control,which aims to minimize the sum packet error probability of all D2D *** game theory is introduced to solve the problem with low ***,a distributed power control algorithm based on synchronous log-linear learning is proposed to converge to the optimal Nash *** results demonstrate the superiority of the proposed learning algorithm.

关键词： Haptic communications D2D Power control Contention-based access Potential game

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Solar evaporation for simultaneous oil-water separation and electricity generation with Janus wood-based absorbers

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Frontiers of Environmental Science & Engineering 2024年第2期18卷 13-23页

作者： yue yang Ze Fu Qi Zhang Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse School of Environmental and Biological EngineeringNanjing University of Science&TechnologyNanjing 210094China Key Laboratory of Industrial Ecology and Environmental Engineering(Ministry of Education) School of Environmental Science and TechnologyDalian University of TechnologyDalian 116024China National Laboratory of Solid State Microstructures Collaborative Innovation Center of Advanced MicrostructuresCollege of Engineering and Applied SciencesKey Laboratory of Intelligent Optical Sensing and Manipulation(Ministry of Education)Jiangsu Key Laboratory of Artificial Functional MaterialsNanjing UniversityNanjing 210093China

Oily wastewater from ocean oil spills endangers marine ecosystems and human health. Therefore, developing an effective and sustainable solution for separating oil-water mixtures is urgent. Interfacial solar photothermal evaporation is a promising approach for the complete separation of two-phase mixtures using only solar energy. Herein, we report a carbonized wood-based absorber with Janus structure of comprising a hydrophobic top-layer and an oleophobic bottom-layer for simultaneous solar-driven oil-water separation and electricity generation. Under sunlight irradiation, the rapid evaporation of seawater will induce a separation of oil-water mixtures, and cause a high salt concentration region underlying the interface, while the bottom “bulk water” maintains in a low salt concentration, thus forming a salinity gradient. Electricity can be generated by salinity gradient power. Therefore, oil-water separation efficiency of > 99% and derived extra electricity power of ~0.1 W/m2 is achieved under solar radiation, demonstrating the feasibility of oil-water separation and electricity production synchronously directly using solar energy. This work provides a green and cost-effective path for the separation of oil-water mixtures.

关键词： Oily wastewater Carbonized wood Salinity gradient Electricity generation Solar irradiation

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Bioinspired supramolecular macrocycle hybrid membranes with enhanced proton conductivity

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Nano Research 2024年第2期17卷 797-805页

作者： Pengfei yang Linlin Xu Panagiotis Trogadas Marc-Olivier Coppens yang lan Centre for Nature Inspired Engineering Department of Chemical EngineeringUniversity College LondonLondon WC1E 7JEUK

Enhancing the proton conductivity of proton exchange membranes(PEMs)is essential to expand the applications of proton exchange membrane fuel cells(PEMFCs).Inspired by the proton conduction mechanism of bacteriorhodopsin,cucurbit[n]urils(CB[n],where n is the number of glycoluril units,n=6,7,or 8)are introduced into sulfonated poly(ether ether ketone)(SPEEK)matrix to fabricate hybrid PEMs,employing a nature-inspired chemical engineering(NICE)*** carbonyl groups of CB[n]act as proton-conducting sites,while the host–guest interaction between CB[n]and water molecules offers extra protonconducting ***,the molecular size of CB[n]aids in their dispersion within the SPEEK matrix,effectively bridging the unconnected proton-conducting sulfonic group domains within the SPEEK ***,all hybrid membranes exhibit significantly enhanced proton ***,the SPEEK membrane incorporating 1 wt.%CB[8](CB[8]/SPEEK-1%)demonstrates the highest proton conductivity of 198.0 mS·cm^(−1) at 60°C and 100%relative humidity(RH),which is 228%greater than that of the pure SPEEK membrane under the same ***,hybrid membranes exhibit superior fuel cell *** CB[8]/SPEEK-1%membrane achieves a maximum power density of 214 mW·cm^(−2),representing a 140%improvement over the pure SPEEK membrane(89 mW·cm^(−2))at 50°C and 100%*** findings serve as a foundation for constructing continuous proton-conducting pathways within membranes by utilizing supramolecular macrocycles as fuel cell electrolytes and in other applications.

关键词： supramolecular macrocycle proton conductivity cucurbit[n]uril proton exchange membrane fuel cell

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Recent progress in photocatalytic NAD(P)H regeneration for photocatalytic-enzymatic-coupling system

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Frontiers of Chemical Science and Engineering 2024年第4期18卷 1-24页

作者： Wei lan Maodi Wang Huicong Dai Qihua yang Key Laboratory of the Ministry of Education for Advanced Catalysis Materials Zhejiang Key Laboratory for Reactive Chemistry on Solid SurfacesInstitute of Physical ChemistryZhejiang Normal UniversityJinhua 321004China

The enzymatic redox reactions in natural photosynthesis rely much on the participation of cofactors,with reduced nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phosphate(NADH/NADPH)or their oxidized form(NAD+/NADP+)as an important redox *** photocatalytic regeneration of expensive and unstable NADH/NADPH in vitro is an important process in enzymatic reduction and has attracted much research *** different types of photocatalysts have been developed for photocatalytic NADH/NADPH regeneration,the efficiency is still relatively *** elucidate the key factors affecting the performance of photocatalytic NADH/NADPH regeneration is helpful to rationally design the photocatalyst and improve the photocatalytic *** this paper,we overview the recent progress in photocatalytic NADH/NADPH regeneration with the focus on the strategies to improve the visible light adsorption,the charge separation and migration efficiency,as well as the surface reaction,which jointly determine the overall photocatalytic regeneration *** potential development of photocatalytic NADH/NADPH regeneration and photocatalyticenzymatic-coupling system is prospected finally.

关键词： photocatalytic-enzymatic coupling NAD(P)H regeneration photocatalysis efficiency

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Efficient oxidation of monosaccharides to sugar acids under neutral condition in flow reactors with gold-supported activated carbon catalysts

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Frontiers of Chemical Science and Engineering 2024年第9期18卷 113-123页

作者： Ziqin Gong Zengyong Li Xu Zeng Fengxia yue Wu lan Chuanfu Liu State Key Laboratory of Pulp and Paper Engineering School of Light Industry&EngineeringSouth China University of TechnologyGuangzhou 510640China Anhui Provincial Engineering Center for High Performance Biobased Nylons School of Materials and ChemistryAnhui Agricultural UniversityHefei 230036China

A significant reaction in the synthesis of biomass-based chemicals is the catalyst-based and targeted oxidation of monosaccharides into valuable sugar *** this study,an activated carbon supported gold catalyst was used to oxidize glucose and xylose to gluconic acid and xylonic acid under neutral *** of reaction conditions for the catalysts was performed using both a batch reactor and a flow-through *** a batch reactor,the yields of gluconic and xylonic acid reached 93%and 92%,respectively,at 90°C within 180 *** a flow reactor,both reactions reached a similar yield at 80°C with the weight hourly space velocity of 47.1 h^(-1).The reaction kinetics were explored in the flow *** oxidation of glucose and xylose to gluconic and xylonic acid followed a first-order kinetics and the turnover frequency was 0.195 and 0.161 s^(-1),*** activation energy was evaluated to be 60.58 and 59.30 kJ·mol^(-1),*** study presents an environmentally friendly and feasible method for the selective oxidation of monosaccharides using an activated carbon supported gold catalyst,benefiting the high-value application of carbohydrates.

关键词： monosaccharides oxidation gluconic acid xylonic acid flow reactor kinetics

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Experimental and numerical flutter analysis of a folding fin with multiple asymmetric free-plays

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Chinese Journal of Aeronautics 2024年第5期37卷 332-348页

作者： Chenyu LIU Chao AN Changchuan XIE Xin ZHANG lan yang School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China Beijing Institute of Electronic System Engineering Beijing 100854China Beijing Institute of Astronautical Systems Engineering Beijing 100076China

Experimental folding fin models with an adjustable free-play are tested in a wind *** fin structure is modeled using the free-interface component mode synthesis method,and its free-play is modeled as four independent nonlinear springs with asymmetric stiffness.A nonplanar unsteady vortex-lattice method considering compressibility is employed to address nonlinear deformation and high subsonic *** spline interpolation is improved through projection and *** aeroelastic characteristics of folding fins with different free-play magnitudes,initial conditions and elastic-axis positions are analyzed using an established time-marching method because of its relatively small computation scale and high *** results show good consistency among the presented method,the wind tunnel test and the harmonic balance *** is a negative correlation between the critical speed of divergent motion and the ratio of the initial condition to the free-play *** either the free-play magnitude or the initial condition is extreme(tiny or vast),the system nonlinearity degenerates to ***,the flutter prevention design of a linear model can be applied to a nonlinear model,such as moving the elastic-axis position *** presented fin configuration exhibits an unstable limit cycle oscillation because the orders of coupled flutter modes do not change with variations in equivalent linear stiffness.

关键词： Free-play Limit cycle oscillation Flutter Component mode synthesis Vortex-lattice method

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Alarm Log Data Augmentation Algorithm Based on a GAN Model and Apriori

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Journal of Computer Science & Technology 2024年第4期39卷 951-966页

作者： yang yang Yu-Ting Li Yong-Hua Huo Zhi-Peng Gao lan-lan Rui State Key Laboratory of Network and Switching Technology Beijing University of Posts and TelecommunicationsBeijing 100876China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

The complexity of alarm detection and diagnosis tasks often results in a lack of alarm log *** to the strong rule associations inherent in alarm log data,existing data augmentation algorithms cannot obtain good results for alarm log *** address this problem,this paper introduces a new algorithm for augmenting alarm log data,termed APRGAN,which combines a generative adversarial network(GAN)with the Apriori *** generates alarm log data under the guidance of rules mined by the rule ***,we propose a new dynamic updating mechanism to alleviate the mode collapse problem of the *** addition to updating the real reference dataset used to train the discriminator in the GAN,we dynamically update the parameters and the rule set of the Apriori algorithm according to the data generated in each *** extensive experimentation on two public datasets,it is demonstrated that APRGAN surpasses other data augmentation algorithms in the domain with respect to alarm log data augmentation,as evidenced by its superior performance on metrics such as BLEU,ROUGE,and METEOR.

关键词： data augmentation alarm log data Apriori generative adversarial network(GAN)

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