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Puncture injection of para-toluenesulfonamide combined with chemoembolization for advanced hepatocellular carcinoma

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World Journal of Gastroenterology 2012年第46期18卷 6861-6864页

作者： Qing He An-Ren Kuang Yong-Song guan yue-Qing Liu Department of Oncology West China Hospital of Sichuan University Department of Nuclear Medicine West China Hospital of Sichuan University

Hepatocellular carcinoma (HCC) is difficult to eradicate due to its resilient nature. Portal vein is often involved in tumors of large size, which exclude the patient from surgical resection and local ablative therapy, such as percutaneous ethanol injection (PEI) and radiofrequency ablation (RFA) because they were considered neither effective nor safe. Currently, there is almost no effective treatment for HCC of such condition. As a unique antitumor agent in form of lipophilic fluid for local injection, para-toluenesulfonamide (PTS) produces mild side effects while necrotizing the tumor tissues quickly and efficiently. Being largely different from both PEI and RFA therapies, PTS can disseminate itself in tumors more easily than other caustic agents, such as alcohol. So PTS may offer additional benefit to HCCs with vascular involvement. We herein describe a 70-year-old HCC patient who was treated with the combination of PTS injection and transcatheter arterial chemoembolization, resulting in a significantly improved clinical prognosis.

关键词： Hepatocellular carcinoma Para-toluenesulfonamide Antitumor agent Transcatheter arterial chemoembolization Therapy

Homodispersed B-CN/P-CN S-scheme homojunction for enhanced visible-light-driven hydrogen evolution

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Green Energy & Environment 2022年第5期7卷 1119-1127页

作者： Dashui Yuan Zongyuan Li Xueru Chen Jing Ding hui Wan Guofeng guan State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringJiangsu National Synergetic Innovation Center for Advanced MaterialsNanjing Tech UniversityNanjing210009China

Proper interface and band alignment always play essential roles in the separation of photoexcited charge of *** this work,we prepared a homodispersed S-scheme carbon nitride homojunction with local electron structure difference by a facile pre-doping and two-step calcination *** doping into heptazine created extra acceptor impurity,and phosphorus doping into heptazine created extra donor impurity,which eventually modulated the electronic structure of carbon *** heptazines with different element doping were integrated into carbon nitride by recalcination,B-CN and P-CN formed a homodispersed homojunction and thus produced a rich ***,caused by Fermi energy levels equilibrium,the band bending constructed an S-scheme homojunction,which stimulated photogenerated electrons to transfer from CB of B-CN to VB of *** homodispersed S-scheme homojunction structure led to efficient suppression of recombination of photoinduced charge and retained stronger redox ***,the photocatalytic performance was dramatically boosted to 2620 μmol g^(-1) from 60 μmol g^(-1) of pure CN in 4-h hydrogen evolution from *** novel method for electron structure engineering helped to provide a new strategy for designing homojunction photocatalysts with excellent photocatalytic performance.

关键词： dispersed scheme doping

Effects of impurity elements on SiC grain boundary stability and corrosion

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Nuclear Science and Techniques 2021年第11期32卷 77-95页

作者： Jun hui Bao-Liang Zhang Tao Liu Min Liu Wen-guan Liu Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China China Institute of Atomic Energy Beijing 102413China

Grain boundaries(GBs)have critical influences on the stability and properties of various *** this study,first-principles calculations were performed to determine the effects of four metallic impurities(Ni,Al,Bi,and Pb)and three nonmetallic impurities(H,O,and N)on the GBs of silicon carbide(SiC),using the ∑5(210)GBs as *** GB energy and segregation energy(SE)were calculated to identify the effects of impurities on the GB *** interactions considerably influenced the bonding effects of *** formation of weak bonds resulted in the corrosion and embrittlement of *** co-segregation of Bi,Pb,and O was also investigated in detail.

关键词： SiC First-principles calculation Grain boundary Impurity atom Co-segregation

Acute necrotizing pancreatitis complicated with pancreatic pseudoaneurysm of the superior mesenteric artery: A case report

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World Journal of Gastroenterology 2008年第16期14卷 2612-2614页

作者： Qing He yue-Qin Liu Yuan Liu Yong-Song guan Department of Oncology Huaxi Hospital Sichuan University Chengdu 610041 Sichuan Province China

Acute necrotizing pancreatitis complicated with pancreatic pseudoaneurysm is a rare emergency associated with high mortality that demands immediate treatment to save the patient’s life. We treated a 64-year-old man who presented with a bleeding pseudoaneurysm of the superior mesenteric artery caused by acute pancreatitis, using interventional embolizing therapy. In the present report we show that interventional treatment is an effective therapeutic modality for patients with acute necrotizing pancreatitis complicated with intra-abdominal bleeding.

关键词： Acute necrotizing pancreatitis Bleeding Complications Pseudoaneurysm Arterial embolization

PhI(OAc)2-promoted umpolung acetoxylation of enamides for the synthesis of α-acetoxy ketones

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Science China Chemistry 2017年第6期60卷 761-768页

作者： Ming Chen Wei Zhang Zhi-hui Ren Wen-Yun Gao Yao-Yu Wang Zheng-hui guan Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education Department of Chemistry & Materials Science Northwest University Xi'an 710127 China College of Life Sciences/National Engineering Research Center for Miniaturized Detection Systems Northwest University Xi 'an 710069 China

Umpolung is a fundamental concept in organic chemistry, which provides an alternative strategy for the synthesis of target compounds which were not easily accessible by conventional methods. Herein, a mild and efficient PhI(OAc)_2-promoted umpolung acetoxylation reactions of enamides was developed for the synthesis of α-acetoxy ketones. The reaction tolerates a wide range of functional groups and affords α-acetoxy ketones in good to excellent yields. PhI(OAc)_2 serves as a source of acetoxy in the reaction.

关键词： umpolung enamides acetoxylation hypervalent iodine reagents α-acetoxy ketones

BPR-UserRec:a personalized user recommendation method in social tagging systems

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The Journal of China Universities of Posts and Telecommunications 2013年第1期20卷 122-128页

作者： YANG Tan CUI Yi-dong JIN yue-hui State Key Laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications

Social tagging is one of the most important characteristics of Web 2.0 services, and social tagging systems （STS） are becoming more and more popular for users to annotate, organize and share items on the Web. Moreover, online social network has been incorporated into social tagging systems. As more and more users tend to interact with real friends on the Web, personalized user recommendation service provided in social tagging systems is very appealing. In this paper, we propose a personalized user recommendation method, and our method handles not only the users＇ interest networks, but also the social network information. We empirically show that our method outperforms a state-of-the-art method on real dataset from *** dataset and Douban.

关键词： social tagging systems user recommendation tensor factorization

Water migration in subgrade soil under seasonal freeze-thaw cycles in an alpine meadow on the Qinghai-Tibet Plateau

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Journal of Mountain Science 2022年第6期19卷 1767-1781页

作者： WU guan-qing XIE Yong-li WEI Jin yue Xia-bing School of Highway Chang'an UniversityXi'an 710064China

Highway frost heave and thawing settlement caused by water migration towards the freezing front and ice lens development is widespread in the alpine meadow area of the southeast QinghaiTibet Plateau(QTP). A laboratory experiment on a highway reconstruction and expansion project in the QTP was carried out in this work to analyze the effects of fine particle content, initial water content, and the number of freeze-thaw cycles(FTCs) on frost depth, temperature gradient(Grad T), total water intake, and water intake flux. Based on the results of the laboratory experiment, a modified model of migration potential related to fine particle content, freeze-thaw history, and freezing time was established. The results show that, with the increase of fine particle content, the frost depth of soil decreases, the curve of total water intake over time is transformed from an Sshape to an arch, and the curve of water intake flux over time is transformed from a peak shape to descending shape. The variation trend of migration potential with freezing time and the freeze-thaw history is the same as that of water intake flux with freezing time and freeze-thaw history. The variation trend of soil intake flux can be used as a reference to determine the variation trend of soil migration potential. This study provides a reference for the design and construction of highway subgrade in the alpine meadow area of the QTP.

关键词： Water migration Seasonally frozen ground Freeze-thaw cycles Laboratory experiment Migration potential model Qinghai-Tibet Plateau

Spaceflight alters the gene expression profile of cervical cancer cells

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Chinese Journal of Cancer 2011年第12期30卷 842-852页

作者： Zhi-Jie Zhang Yong-Qing Tong Jia-Jia Wang Cheng Yang Guo-Hua Zhou yue-hui Li Ping-Li Xie Jin-yue Hu guan-Cheng Li Cancer Research Inst tute Xiangya Schoo of Med c neCentral South University Changsha Hunan 410078 P. R. China

Our previous study revealed that spaceflight induced biological changes in human cervical carcinoma Caski cells. Here, we report that 48A9 cells, which were subcloned from Caski cells, experienced significant growth suppression and exhibited low tumorigenic ability after spaceflight. To further understand the potential mechanism at the transcriptional level, we compared gene expression between 48A9 cells and ground control Caski cells with suppression subtractive hybridization (SSH) and reverse Northern blotting methods, and analyzed the relative gene network and molecular functions with the Ingenuity Pathways Analysis (IPA) program. We found 5 genes, SUB1, SGEF, MALAT-1, MYL6, and MT-CO2, to be up-regulated and identified 3 new cDNAs, termed B4, B5, and C4, in 48A9 cells. In addition, we also identified the two most significant gene networks to indicate the function of these genes using the IPA program. To our knowledge, our results show for the first time that spaceflight can reduce the growth of tumor cells, and we also provide a new model for oncogenesis study.

关键词：基因表达谱航天飞行癌细胞宫颈癌 Northern 抑制性消减杂交生长抑制基因网络

Non-interference topology scheme in wireless sensor networks

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The Journal of China Universities of Posts and Telecommunications 2007年第2期14卷 7-13页

作者： MA Shu-hui JI Hong yue guang-xin School of Telecommunication Engineering Beijing University of Posts and Telecommunications Beijing 100876 China

A novel topology scheme, cell with multiple mobile sinks method （CMMSM）, is proposed in this article for the collection of information and for the environment monitoring in wireless sensor networks. The system consists of many static sensors, scattered in a large scale sensing field and multiple mobile sinks, cruising among the clusters. Conservation of energy and simplification of protocol are important design considerations in this scheme. The noninterference topology scheme largely simplifies the full-distributed communication protocol with the ability of collision avoidance and random routing. The total number of cluster heads in such a topology was analyzed, and then an approximate evaluation of the total energy consumption in one round was carded out. Simulation results show that CMMSM can save considerable energy and obtain higher throughput than low-energy adaptive clustering hierarchy （LEACH） and geographical adaptive fidelity （GAF）.

关键词： sensor networks energy consumption topology design multiple mobile sinks