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绵羊胚胎肌源性干细胞的生物学特性

中国兽医学报 2017年第10期37卷 1973-1979页

作者：张萍马月辉关伟军中国农业科学院北京畜牧兽医研究所北京100193

为研究绵羊胚胎肌源性干细胞的生物学特性,取30日龄的绵羊胚胎,采用联合酶消化法及差速贴壁法分离培养获得均质的肌源性干细胞,并对其进行一系列生物学特性检测。结果显示,绵羊肌源性干细胞能传代培养至35代以上;免疫荧光染色和RT-PCR... 详细信息

为研究绵羊胚胎肌源性干细胞的生物学特性,取30日龄的绵羊胚胎,采用联合酶消化法及差速贴壁法分离培养获得均质的肌源性干细胞,并对其进行一系列生物学特性检测。结果显示,绵羊肌源性干细胞能传代培养至35代以上;免疫荧光染色和RT-PCR鉴定肌源性干细胞表面标记物Sca-1、CD34、CD144和Desmin呈阳性表达;生长曲线和细胞周期结果显示绵羊肌源性干细胞具有较强自我更新能力;通过不同的诱导方法可以将肌源性干细胞成功地诱导为肝样细胞和胰岛样细胞,Schiff染色和双硫腙染色均呈阳性,RT-PCR检测肝样细胞特异性标记物AFP和ALB以及胰岛样细胞特异性标记物Insulin均呈阳性表达,进一步证明了其诱导分化潜能。结果表明,本试验成功地分离培养获得了均质并具有较强自我更新潜能的绵羊肌源性干细胞,这种干细胞具有向肝样细胞和胰岛样细胞分化的潜能,这为临床治疗提供了潜在的理论基础和大量的种子细胞。

关键词：绵羊肌源性干细胞分离培养诱导分化细胞周期

Hypidone hydrochloride(YL-0919)ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation

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Neural Regeneration Research 2025年第8期20卷 2325-2336页

作者： Yafan Bai hui Ma yue Zhang Jinfeng Li Xiaojuan Hou Yixin Yang Guyan Wang Yunfeng Li Department of Anesthesiology Beijing Tongren HospitalCapital Medical UniversityBeijingChina Beijing Institute of Basic Medical Sciences BeijingChina Hebei North University ZhangjiakouHebei ProvinceChina Beijing Institute of Pharmacology and Toxicology State Key Laboratory of Toxicology and Medical CountermeasuresBeijing Key Laboratory of NeuropsychopharmacologyBeijingChina

Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary *** this study,we evaluated hypidone hydrochloride(YL-0919),a self-developed antidepressant with selective sigma-1 receptor agonist properties,and its associated mechanisms and targets in traumatic brain *** experiments to assess functional deficits were followed by assessment of neuronal damage through histological analyses and examination of blood-brain barrier permeability and brain ***,we investigated the antioxidative effects of YL-0919 by assessing the levels of traditional markers of oxidative stress in vivo in mice and in vitro in HT22 ***,the targeted action of YL-0919 was verified by employing a sigma-1 receptor antagonist(BD-1047).Our findings demonstrated that YL-0919 markedly improved deficits in motor function and spatial cognition on day 3 post traumatic brain injury,while also decreasing neuronal mortality and reversing blood-brain barrier disruption and brain ***,YL-0919 effectively combated oxidative stress both in vivo and in *** protective effects of YL-0919 were partially inhibited by *** results indicated that YL-0919 relieved impairments in motor and spatial cognition by restraining oxidative stress,a neuroprotective effect that was partially reversed by the sigma-1 receptor antagonist ***-0919 may have potential as a new treatment for traumatic brain injury.

关键词： antidepressant drug blood-brain barrier cognitive function hypidone hydrochloride(YL-0919) neurological function nuclear factor-erythroid 2 related factor 2 oxidative stress sigma-1 receptor superoxide dismutase traumatic brain injury

Microglia lactylation in relation to central nervous system diseases

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Neural Regeneration Research 2025年第1期20卷 29-40页

作者： hui Yang Nan Mo Le Tong Jianhong Dong Ziwei Fan Mengxian Jia Juanqing yue Ying Wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system ***,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of *** is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting ***,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

An Efficient Boron Source Activation Strategy for the Low‑Temperature Synthesis of Boron Nitride Nanotubes

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Nano-Micro Letters 2025年第1期17卷 548-558页

作者： Ying Wang Kai Zhang Liping Ding Liyun Wu Songfeng E Qian He Nanyang Wang hui Zuo Zhengyang Zhou Feng Ding yue Hu Jin Zhang Yagang Yao National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesJiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093People’s Republic of China School of Electronic Information and Artificial Intelligence Shaanxi University of Science&TechnologyXian 710000People’s Republic of China College of Bioresources Chemical and Materials Engineering Shaanxi University of Science&TechnologyXian 710000People’s Republic of China Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325000People’s Republic of China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518000People’s Republic of China College of Chemical and Molecular Engineering Peking UniversityBeijing 100871People’s Republic of China

Lowering the synthesis temperature of boron nitride nanotubes(BNNTs)is crucial for their *** primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid *** this study,we developed a novel approach for efficiently activating boron by introducing alkali metal compounds into the conventional MgO–B *** approach can be adopted to form various low-melting-point AM–Mg–B–O growth *** growth systems have improved catalytic capability and reactivity even under low-temperature conditions,facilitating the synthesis of BNNTs at temperatures as low as 850℃.In addition,molecular dynamics simulations based on density functional theory theoretically demonstrate that the systems maintain a liquid state at low temperatures and interact with N atoms to form BN *** findings offer novel insights into the design of boron activation and are expected to facilitate research on the low-temperature synthesis of BNNTs.

关键词： Boron nitride nanotubes Low-temperature Boron activation Density functional theory

Primary parenchymal squamous cell carcinoma of the kidney:A case report

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World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： Zhi-hui Zheng Bo Shao Chao-Min Xu Ke Wang Jia-Zhu Wen Li-Kang Luo Jia-Cheng guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

Metabolic alteration in tumorigenesis

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Science China(Life Sciences) 2013年第12期56卷 1067-1075页

作者： YANG hui XIONG yue guan KunLiang Molecular and Cell Biology Lab Institutes of Biomedical SciencesShanghai Medical College School of Life Sciences Fudan University Department of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center University of North Carolina at Chapel HillNorth Carolina 27599USA Department of Pharmacology and Moores Cancer Center University of California San DiegoLa JollaCA 92093USA

Altered metabolism in cancer was first discovered by Otto Warburg early last *** the Warburg Effect has been widely used in tumor detection,relatively little progress had been made in mechanistic understanding of cancer metabolism in the subsequent eight *** studies have recently identified mutations in human cancer targeting multiple enzymes involved in intermediate *** emerging mechanism common to these mutant enzymes is the accumulation of a metabolite that alters the epigenetic control.

关键词： metabolite epigenetic tumorigenesis

Top-K Query Framework in Wireless Sensor Networks for Smart Grid

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China Communications 2014年第6期11卷 89-98页

作者： WANG hui guan Zhitao YANG Tingting XU yue School of economics and management North China Electric Power University

The smart grid has caught great attentions in recent years, which is poised to transform a centralized, producer-controlled network to a decentralized, consumer- interactive network that＇s supported by fine-grained monitoring. Large-scale WSNs （Wireless Sensor Networks） have been considered one of the very promising technologies to support the implementation of smart grid. WSNs are applied in almost every aspect of smart grid, including power generation, power transmission, power distribution, power utilization and power dispatch, and the data query processing of ＇WSNs in power grid＇ become an hotspot issue due to the amount of data of power grid is very large and the requirement of response time is very high. To meet the demands, top-k query processing is a good choice, which performs the cooperative query by aggregating the database objects＇ degree of match for each different query predicate and returning the best k matching objects. In this paper, a framework that can effectively apply top-k query to wireless sensor network in smart grid is proposed, which is based on the cluster-topology sensor network. In the new method, local indices are used to optimize the necessary query routing and process intermediate results inside the cluster to cut down the data traffic, and the hierarchical join query is executed based on the local ***, top-k query results are verified by the clean-up process, and two schemes are taken to deal with the problem of node＇s dynamicity, which further reduce communication cost. Case studies and experimental results show that our algorithm has outperformed the current existing one with higher quality results and better efficiently.

关键词： smart grid wireless sensornetwork top-k query framework.

Challenges of Processing and Analyzing Big Data in Mesoscopic Whole-brain Imaging

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Genomics, Proteomics & Bioinformatics 2019年第4期17卷 337-343页

作者： Anan Li yue guan hui Gong Qingming Luo Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074China MOE Key Laboratory for Biomedical Photonics School of Engineering SciencesHuazhong University of Science and TechnologyWuhan 430074China HUST-Suzhou Institute for Brainsmatics JITRI Institute for BrainsmaticsSuzhou 215125China

The brain is recognized as the most complex organ on *** complex neuronal network in the human brain consists of approximately 86 billion neurons and more than one hundred trillion connections[1].Even the mouse brain,which is commonly used as a model in neuroscience studies,contains more than 71 million *** the great efforts made by the neuroscientists,our knowledge about the brain is still limited and studies on small model animals have only provided preliminary results[2–4].To improve the situation,brainsmatics studies try to accelerate neuroscience research by providing a standard whole-brain spatial coordinate system and standardized labeling tools,imaging the brain,as well as discovering new neuronal cell types,neuronal circuits,and brain vascular structures.

关键词： Whole spite coordinate

Mediating role of health literacy in the relationship between social isolation and psychological distress among pre-frail older adults

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World Journal of Psychiatry 2025年第1期15卷 137-144页

作者： Juan Fang Li-hui Li Ming-Qian He yue Ji Dong-Yan Lu Li-Bing Zhang Jin-Lan Yao School of Medicine Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina

BACKGROUND Frailty has become a significant public health *** recent increase in the number of frail older adults has led to increased attention being paid to psycho-logical care services in *** social isolation of pre-frail older adults can impact their psychological *** To explore the mediating effect of health literacy between social isolation and psychological distress among communitydwelling older adults with *** This descriptive cross-sectional study was conducted with 254 pre-frail older individuals aged 60 years and *** isolation,health literacy,and psycholo-gical distress were comprehensively measured using the Lubben Social Network Scale-6,12-item Short-Form Health Literacy Questionnaire,and the Kessler Psy-chological Distress *** were evaluated using the SPSS 27.0 package program and the PROCESS macro *** statistical analyses,correlation analyses,and bootstrap mediation tests were used to assess associations between the *** The results showed that social isolation had an effect on health literacy among pre-frail older adults(β=0.240,P<0.001),social isolation impact on psycho-logical distress pre-frail older adults(β=-0.415,P<0.001);health literacy was identified effect on psychological distress among pre-frail older persons(β=-0.307,P<0.001).Health literacy partially mediated the relationship between social isolation and psychological distress among community-dwelling older adults with pre-frailty,with a mediation effect of-0.074,accounting for 17.83%of the total effect.

关键词： Frail Ageing Psychological distress Health literacy Social isolation