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Enamel matrix proteins in promoting saliva lubrication

Friction 2024年第10期12卷 2298-2312页

作者： hujun WANG yue TANG Haonan QIU Jingyang hu Yuan SU Jing ZHENG Zhongrong zhou Tribology Research Institute School of Mechanical Engineering and Key Laboratory of Advanced Technologies of Materials(Ministry of Education)Southwest Jiaotong UniversityChengdu 610031China

Anti-wear performance of human enamel in the mouth is closely related to the lubrication of salivary *** is well known that the inorganic hydroxyapatite(HA)of the enamel plays an important role in the adsorption and pellicle-forming of salivary proteins on the enamel,but the role of enamel matrix proteins remains *** this study,the adsorption and lubrication behavior of salivary proteins on original,heated,and deproteinated enamel surfaces was comparatively investigated using an atomic force microscopy and nano-indentation/scratch *** with that on the original enamel surface,the adsorption and lubrication behavior of salivary proteins remains almost unchanged on the heated enamel surface(where the enamel matrix proteins are denatured but the size of HA crystalline nanoparticles keeps constant)but exhibits an obvious compromise on the deproteinated enamel surface(where the enamel matrix proteins are removed and agglomeration of HA crystallites occurs).The HA agglomeration weakens the electrostatic interaction of enamel surfaces with salivary proteins to cause a distinct negative influence on the adsorption and pellicle-forming of salivary ***,the negative effect is confirmed with a quartz crystal microbalance with *** summary,by regulating enamel nanostructure for appropriate electrostatic interactions between salivary proteins and enamel surfaces,the enamel matrix proteins play an essential role in the adsorption and pellicle-forming of salivary proteins on human enamel,and then contribute to saliva lubrication,which provides the enamel with an anti-wear *** findings will promote and assist the design of enamel-inspired anti-wear materials.

关键词： enamel matrix proteins hydroxyapatite(HA)crystalline nanoparticles salivary proteins adsorption lubrication

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Booming Forward

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Beijing Review 2009年第36期52卷 34-35页

作者： hu yue & zhou JIANXIONG

A homegrown story of state-owned trading companies Rome was not built in one day-nor was China’s foreign trade infrastructure.

关键词： Booming Forward

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Green trading and ecological sustainability under macroeconomic policy framework

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Geoscience Frontiers 2024年第3期15卷 50-66页

作者： yue hu Binhui Li Munir Ahmad College of Science&Technology Ningbo UniversityNingbo 315300ZhejiangChina Donghai Academy Ningbo UniversityNingbo 315211ZhejiangChina Research Center for County Industry Digitization College of Science&TechnologyNingbo UniversityNingbo 315300ZhejiangChina College of International Economics&Trade Ningbo University of Finance and EconomicsNingbo 315175ZhejiangChina “Belt and Road”Bulk Commodity Research Center Ningbo University of Finance and EconomicsNingbo 315175ZhejiangChina

When confronted with ecological challenges,trading ecologically friendly products involving renewable technologies,green management practices,and effluent treatment methods could alleviate ecological degradation on a global scale while considering the macroeconomic policy ***,this study determines the effectiveness of fiscal and monetary policy instruments in moderating the relationship between green trade openness(i.e.,trade in environmentally related products)and ecological *** panel quantile regression on data from 20 OECD members from 2003 to 2016,we found that green trade openness supports ecological sustainability through a gains-from-trade *** moderation effects,expenditure-driven fiscal expansion reinforces the favorable influence of green trade openness on ecological sustainability across ecologically less/moderately efficient economies,while it does the reverse for ecologically more efficient ***-driven fiscal contraction promotes ecological sustainability amelioration impact of green trade openness for economies with belowaverage ecological quality and remains neutral for those with average/above-average ecological ***,interest rate-driven monetary contraction proliferates the ecological sustainability enhancement effect of green *** suggest that the fiscal and monetary policies demand unambiguous coordination with the OECD’s trade policy structure for optimal environmental outcomes of trading in environmental *** insights would help OECD’s green trade policies gain momentum to facilitate the attainment of the Climate Action agenda of the United Nations’Sustainable Development Goals.

关键词： Fiscal policy Monetary policy Green trade openness Ecological sustainability OECD

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Water resource utilization characteristics and driving factors in the Hainan Island

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Journal of Groundwater Science and Engineering 2023年第2期11卷 191-206页

作者： Dun Wang Li-xin Pei Li-zhong Zhang Xi-wen Li Ze-heng Chen yue-hu zhou Haikou Marine Geological Survey Center China Geological SurveyHaikou 571100China Comprehensive Survey and Management Center for Natural Resources China Geological SurveyBeijing 100055China Chinese Academy of Geological Sciences Beijing 100037China

The scarcity of water resources caused by the unique topography and uneven rainfall distribution in Hainan Island has become a major factor restricting local development. In order to provide effective and scientific reference basis for the overall water resource utilization status and solving this problem, this study calculated the water resource utilization situation of Hainan Island from 2017 to 2021 in detail using methods including water resource ecological footprint analysis. Furthermore, a spatial correlation analysis was conducted to examine the island's water resource utilization characteristics, and the driving factors behind the changes in water resource utilization over the past five years were analyzed using the LMDI model. The results show that:(1) During the study period, the water resource ecological footprint in Hainan Island exhibited a slow growth trend, while the ecological carrying capacity showed a downward *** per capita ecological deficit of water resources remains relatively high, and the water consumption per 10 000 yuan GDP in the whole land continues to decrease, indicating that the overall pressure on water resource demand remains high with significant regional differences accompanied by the efficiency of water resource utilization steadily improving at the same time;(2) Agricultural water use accounts for the highest proportion in the entire water use structure, while ecological water use represents the smallest share, with a year-on-year increase, indicating that Hainan Island highlights the agricultural development and is increasingly conscious of the ecological environment;(3) Significant spatial differentiation in water resource utilization characteristics exists in Hainan Island, with the western region being a hot spot aggregation area for per capita water resource ecological footprint, per capita ecological carrying capacity of water resources, water consumption per 10 000 yuan GDP, while it is a cold spot cluster area fo

关键词： Ecological footprint Ecological carrying capacity Water consumption Moran'sⅠindex Cold/hot spot analysis LMDI model

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Superior compound coatings prepared by low-temperature vanadium-nitrocarburizing duplex treatment

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Rare Metals 2024年第4期43卷 1828-1835页

作者： Gen Jin Fang-Fang Xu Xun-Xun hu yue Xu School of Chemistry Beihang UniversityBeijing100191China Guobiao(Beijing)Testing and Certification Co. LtdBeijing100088China School of Materials Science and Engineering Beihang UniversityBeijing100191China

Superior compound coatings were prepared on CK45 steel surface by vanadium-nitrocarburizing duplex treatment in low-temperature salt *** this study,the microhardness,the phase constitution and the compositional distribution in the coatings prepared under different conditions were systematically *** results indicated that the reactions among activated vanadium,carbon and nitrogen atoms occurred on the steel surface,leading to the formation of compound coatings composed of outermost and compound *** mechanism for the formation of compound layer as well as the growth kinetics of the layer was also *** the duplex treatment,the wear and corrosion resistances of steel surface were significantly *** was found that the growth kinetics of compound layer obeyed the parabolic law,with the activation energy of 122.82 kJ·moL^(-1).

关键词： Vanadium-nitrocarburizing duplex treatment Compound coatings Microstructure Formation mechanism Growth kinetics

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New perspectives in prognostication of hepatocellular carcinoma:The role and clinical implications of transient receptor potential family genes

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2862-2864页

作者： Shi-Hao Guan Wen-Jing hu Xin-Yu Wang yue-Xia Gu De-hua zhou Department of Plastic Surgery Qingpu Branch of Zhongshan Hospital Affiliated to Fudan UniversityShanghai 201700China Department of Nursing Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China Department of Thyroid Breast and Vascular SurgeryShanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China Department of Gastrointestinal Surgery Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China

The study titled“Transient receptor potential-related risk model predicts prognosis of hepatocellular carcinoma patients”is a significant contribution to hepatocellular carcinoma(HCC)research,highlighting the role of transient receptor potential(TRP)family genes in the disease’s progression and *** data from The Cancer Genome Atlas database,it establishes a new risk assessment model,emphasizing the interaction of TRP genes with tumor proliferation pathways,key metabolic reactions like retinol metabolism,and the tumor immune ***,the overexpression of the TRPC1 gene in HCC correlates with poorer patient survival outcomes,suggesting its potential as a prognostic biomarker and a target for personalized therapy,particularly in strategies combining immunotherapy and anti-TRP agents.

关键词： Hepatocellular carcinoma Transient receptor potential channels TRPC1 gene Tumor immune microenvironment Cancer prognosis Bioinformatics in cancer research

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A two-pronged strategy utilizing exosomes extracted from antigenpresenting cells to combat hepatitis B

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Nano Research 2024年第10期17卷 9084-9094页

作者： Fumin hu Dangyang Wang Ting Lu Guanghui Ma hua yue State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing 100190China

Chronic hepatitis B(CHB)is consistently challenging to conquer with numerous complications and *** the effectiveness of antiviral therapies in suppressing hepatitis B virus(HBV)replication,there is an urgent need for novel and more effective treatment *** strategies predominantly emphasize immune activation but still face challenges in sufficiently eliciting T cell *** into account the targeted delivery of nanoparticles to the liver and spleen via intravenous injection,we have proposed a dual-pronged therapeutic strategy based on antigen-presenting cells(APCs)-derived ***,exosomes targeted to the spleen can activate specific immune responses,while those targeted to the liver can modulate or reverse the liver’s immunosuppressive *** immunization,exosome formulations exhibit the remarkable ability to effectively activate APCs,thereby triggering the proliferation of CD8^(+)T ***,they also play an immunoregulatory role by converting M2 macrophages into M1 *** two-pronged therapeutic strategy precisely addresses the issues of T cell dysfunction and immune suppression,both characteristic features of CHB *** combined with Aluminum(Alum)-adjuvanted vaccine,these exosome formulations not only demonstrate a high level of cellular immune response but also secrete specific antibodies comparable to those induced by Alum *** combined approach effectively enhances both cellular and humoral immunity,offering a promising avenue for the development of therapeutic hepatitis B vaccines based on exosome formulations.

关键词： chronic hepatitis B antigen-presenting cells(APCs)-derived exosomes immunoregulatory role two-pronged therapeutic strategy

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Ramsey Numbers of Trees Versus Multiple Copies of Books

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 600-612页

作者： Xiao-bing GUO Si-nan hu yue-jian PENG School of Mathematical Sciences Luoyang Normal UniversityLuoyang 471934China School of Mathematics Hunan UniversityChangsha 410082China

Given two graphs G and H,the Ramsey number R(G,H) is the minimum integer N such that any two-coloring of the edges of K_(N) in red or blue yields a red G or a blue *** v(G) be the number of vertices of G and χ(G) be the chromatic number of *** s(G) denote the chromatic surplus of G,the number of vertices in a minimum color class among all proper χ(G)-colorings of *** showed that R(G,H)≥(v(G)-1)(χ(H)-1)+s(H) if G is connected and v(G)≥s(H).A connected graph G is H-good if R(G,H)=(v(G)-1)(χ(H)-1)+s(H).Let tH denote the disjoint union of t copies of graph H,and let G∨H denote the join of G and *** a complete graph on n vertices by K_(n),and a tree on n vertices by T_(n).Denote a book with n pages by B_(n),i.e.,the join K_(2) ∨■.Erd?s,Faudree,Rousseau and Schelp proved that T_(n) is B_(m)-good if n≥*** this paper,we obtain the exact Ramsey number of T_(n) versus 2B_(2).Our result implies that T_(n) is 2B_(2)-good if n≥5.

关键词： ramsey number ramsey goodness tree book

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Bio-soft matter derived from traditional Chinese medicine:Characterizations of hierarchical structure,assembly mechanism,and beyond

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Journal of Pharmaceutical Analysis 2024年第6期14卷 823-839页

作者： Guiya Yang yue Liu Yuying hu yue Yuan Yunan Qin Quan Li Shuangcheng Ma School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China Institute for Control of Chinese Traditional Medicine and Ethnic Medicine National Institutes for Food and Drug ControlBeijing100050China Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine School of Chinese Materia MedicaTianjin University of Traditional Chinese MedicineTianjin301617China Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional MoleculesCollege of Chemistry and Chemical EngineeringHubei UniversityWuhan430062China

Structural and functional explorations on bio-soft matter such as micelles,vesicles,nanoparticles,aggregates or polymers derived from traditional Chinese medicine(TCM)has emerged as a new topic in the field of *** discovery of such cross-scaled bio-soft matter may provide a unique perspective for unraveling the new effective material basis of TCM as well as developing innovative medicine and *** the rapid rise of TCM-derived bio-soft matter,their hierarchical structure and assembly mechanism must be unambiguously probed for a further in-depth understanding of their pharmacological *** this review,the current emerged TCM-derived bio-soft matter assembled from either small molecules or macromolecules is introduced,and particularly the unambiguous elucidation of their hierarchical structure and assembly mechanism with combined electron microscopic and spectroscopic techniques is *** pros and cons of each technique are also *** future challenges and perspective of TCM-derived bio-soft matter are outlined,particularly the requirement for their precise in situ structural determination is highlighted.

关键词： Electron microscopy Spectroscopy Traditional Chinese medicine Bio-soft matter Structural characterization

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Significant improvement after sensory tricks and trunk strength training for Parkinson’s disease with antecollis and camptocormia:A case report

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World Journal of Clinical Cases 2024年第2期12卷 443-450页

作者： Jia-Ren Wang yue hu Department of Neurology and Neurological Rehabilitation Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)Shanghai 201619China

BACKGROUND Patients with Parkinson's disease(PD)exhibit symptoms such as antecollis(AC)and camptocormia(CC).The pathology of these two conditions is ***,standard treatment methods have not been *** article reports the case of a 65-year-old female patient with AC and CC who was treated with central and peripheral interventions to alleviate *** SUMMARY We present the case of a 65-year-old female PD patient with AC and *** course of the disease was 5 *** was treated with rehabilitation strategies such as sensory tricks and trunk strength *** the inpatient period,we compared and analyzed the patient's gait,rehabilitation assessment scale score,and angles of her abnormal trunk posture in the first week,the third week,and the fifth *** patient's stride length increased,indicating that the patient's walking ability was *** Unified Parkinson's Disease Scale Part Three score and CC severity score ***,the score of the other scale *** addition,the patient showed significant improvements in AC,upper CC,and lower CC *** This case study suggested that sensory tricks and trunk strength training are beneficial and safe for patients with AC and CC.

关键词： Antecollis Camptocormia Parkinson's disease Sensory tricks Trunk strength training Case report

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