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Association of tumor budding with clinicopathological features and prognostic value in stage III-IV colorectal cancer

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World Journal of Gastroenterology 2024年第2期30卷 158-169页

作者： yue-hao luo Zhe-Cheng Yan Jia-Ying Liu Xin-Yi Li Ming Yang Jun Fan Bo Huang Cheng-Gong Ma Xiao-Na Chang Xiu Nie Department of Pathology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina

BACKGROUND Tumor budding(TB)has emerged as a promising independent prognostic biomarker in colorectal cancer(CRC).The prognostic role of TB has been extensively studied and currently affects clinical decision making in patients with stage I and II ***,existing prognostic studies on TB in stage III CRC have been confined to small retrospective cohort ***,this study investigated the correlation among TB categories,clinicopathological features,and prognosis in stage III-IV CRC to further enhance the precision and individualization of treatment through refined prognostic risk *** To analyze the relationship between TB categories and clinicopathological characteristics and assess their prognostic value in stage III-IV CRC to further refine the prognostic risk stratification of stage III-IV *** The clinical data of 547 CRC patients were collected for this retrospective *** at the front edge of the tumor buds was counted according to the 2016 International Tumor Budding Consensus Conference *** Multivariate Cox proportional hazards regression analysis demonstrated that chemotherapy(P=0.004),clinical stage IV(P<0.001),≥4 regional lymph node metastases(P=0.004),left-sided colonic cancer(P=0.040),and Bd 2-3(P=0.002)were independent prognostic factors in patients with stage III-IV ***,the density of tumor infiltrating lymphocytes was higher in Bd 1 than in Bd 2-3,both in the tumor stroma and its invasive *** TB has an independent predictive prognostic value in patients with stage III-IV *** is recommended to complete the TB report of stage III-IV CRC cases in the standardized pathological report to further refine risk stratification.

关键词： Tumor budding Tumor infiltrating lymphocytes Colorectal cancer Survival analysis Prognosis

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Machine learning-assisted smart epitaxy ofⅢ-Ⅴsemiconductors

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Science China Materials 2024年第9期67卷 3041-3042页

作者： yue hao Key Laboratory of Wide Band Gap Semiconductor Technology School of MicroelectronicsXidian UniversityXi’an710071China

Semiconductor epitaxial growth is the front-end process for manufacturing microelectronic and optoelectronic *** beam epitaxy(MBE),capable of precisely controlling atomic layer deposition,has emerged as a crucial technique in chip atomic-level manufacturing[1].However,in semiconductor epitaxy,the heterogeneous nature of materials is complicated,and the growth condition fluctuations poses significant challenges in defect suppression[2],substantially impacting chip performance and yield.

关键词： optoelectronic smart semiconductors

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Adhesion Performances Between Two Orthotropic Solids Influenced by Temperature Increment

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Acta Mechanica Solida Sinica 2024年第3期37卷 430-443页

作者： Qing-Hui luo yue-Ting Zhou School of Aerospace Engineering and Applied Mechanics Tongji UniversityShanghai200092China

The classical adhesive contact models belong to isothermal adhesion theories,where the effect of temperature on adhesion was ***,a number of experimental results indicated that the adhesion behaviors can be significantly affected by *** this paper,the two-dimensional non-slipping anisothermal adhesion behaviors between two orthotropic elastic cylinders are investigated within the framework of the Johnson-Kendall-Roberts *** stated problem is reduced to the coupled singular integral equations by virtue of the Fourier integral transform,which are solved analytically with the analytical function *** closed-form solutions for the stress fields in the presence of thermoelastic effect are *** stable equilibrium state of contact system is determined by virtue of the Griffith energy *** effect of temperature difference on adhesion behaviors between orthotropic solids is *** is found that the difference between the oscillatory and non-oscillatory solutions increases with increasing the degree of anisotropy of orthotropic *** oscillatory solution cannot be well approximated by the non-oscillatory solution for the orthotropic materials with relatively high anisotropy.

关键词： Adhesive contact Non-slipping JKR model Temperature Griffith energy balance

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HetNets Under Decoupled Uplink and Downlink Access with UE Random Discontinuous Transmission: Local Delay and Energy Efficiency

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China Communications 2024年第3期21卷 205-216页

作者： Zhang yue Zheng Fuchun luo Jingjing School of Electronic and Information Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China

Due to the limited uplink capability in heterogeneousnetworks (HetNets), the decoupled uplinkand downlink access (DUDA) mode has recently beenproposed to improve the uplink performance. In thispaper, the random discontinuous transmission (DTX)at user equipment (UE) is adopted to reduce the interferencecorrelation across different time slots. By utilizingstochastic geometry, we analytically derive themean local delay and energy efficiency (EE) of an uplinkHetNet with UE random DTX scheme under theDUDA mode. These expressions are further approximatedas closed forms under reasonable *** results reveal that under the DUDA mode, there isan optimal EE with respect to mute probability underthe finite local delay constraint. In addition, with thesame finite mean local delay as under the coupled uplinkand downlink access (CUDA) mode, the HetNetsunder the DUDA mode can achieve a higher EE witha lower mute probability.

关键词： decoupled uplink and downlink access(DUDA) heterogeneous networks(HetNets) random discontinuous transmission(DTX) stochastic geometry

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Microbes in mass extinction: an accomplice or a savior?

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National Science Review 2024年第1期11卷 12-15页

作者： Genming luo Deng Liu hao Yang State Key Laboratory of Geobiology and Environmental Geology China University of Geosciences (Wuhan)

Microbes include various types of organisms that are invisible to the naked eye,e.g. bacteria, archaea and microeukaryotes. Although the precise number remains largely unknown, microbes are recognized as the unseen majority of our biosphere [1]. As a group of organisms classified by body size, microbes cover a considerable spectrum of metabolisms,

关键词： AFTERMATH

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Elevational patterns of warming effects on plant community and topsoil properties: focus on subalpine meadows ecosystem

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Journal of Mountain Science 2024年第1期21卷 146-159页

作者： hao Aihua luo Zhengming CHEN Xiaojiang Department of Geography Xinzhou Normal UniversityXinzhou 034000China Department of Biological Sciences Xinzhou Normal UniversityXinzhou 034000China

Climate warming profoundly affects plant biodiversity, community productivity, and soil properties in alpine and subalpine grassland ecosystems. However, these effects are poorly understood across elevational gradients in subalpine meadow ecosystems. To reveal the elevational patterns of warming effects on plant biodiversity, community structure, productivity, and soil properties, we conducted a warming experiment using open-top chambers from August 2019 to August 2022 at high(2764 m a. s. l.), medium(2631 m a. s. l.), and low(2544 m a. s. l.) elevational gradients on a subalpine meadow slope of Mount Wutai, Northern China. Our results showed that three years of warming significantly increased topsoil temperature but significantly decreased topsoil moisture at all elevations(P<0.05), and the percentage of increasing temperature and decreasing moisture both gradually raised with elevation lifting. Warming-induced decreasing proportions of soil organic carbon(SOC, by 19.24%), and total nitrogen(TN, by 24.56%) were the greatest at high elevational gradients. Experimental warming did not affect topsoil C: N, p H, NO_(3)^(-)-N, or NH_(4)^(+)-N at the three elevational gradients. Warming significantly increased species richness(P<0.01) and Shannon-Weiner index(P<0.05) at low elevational gradients but significantly decreased belowground biomass(P<0.05) at a depth of 0–10 cm at three elevational gradients. Warming caused significant increases in the aboveground biomass in the three elevational plots. Warming significantly increased the aboveground biomass of graminoids in medium(by 92.47%) and low(by 98.25%) elevational gradients, that of sedges in high(by 72.44%) and medium(by 57.16%) elevational plots, and that of forbs in high(by 75.88%), medium(by 34.38%), and low(by 74.95%) elevational plots. Species richness had significant linear correlations with SOC, TN, and C: N(P<0.05), but significant nonlinear responses to soil temperature and soil moisture in the warmed treatm

关键词： Warming effect Plant diversity pattern Community structure change Elevation gradient Alpine meadow ecosystem Mount Wutai

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Multi-objective Optimization of Integrated Energy Systems Considering Ladder-type Carbon Emission Trading and Refined Load Demand Response

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 828-839页

作者： Yanhong luo haowei hao Dongsheng Yang Bowen Zhou the Department of Electric Engineering Northeastern UniversityShenyang 110004China

In this paper,a novel multi-objective optimization model of integrated energy systems(IESs)is proposed based on the ladder-type carbon emission trading mechanism and refined load demand response ***,the carbon emission trading mechanism is introduced into the optimal scheduling of IESs,and a ladder-type carbon emission cost calculation model based on rewards and penalties is established to strictly control the carbon emissions of the ***,according to different response characteristics of electric load and heating load,a refined load demand response model is built based on the price elasticity matrix and substitutability of energy supply *** these basis,a multi-objective optimization model of IESs is established,which aims to minimize the total operating cost and the renewable energy source(RES)***,based on typical case studies,the simulation results show that the proposed model can effectively improve the economic benefits of IESs and the utilization efficiency of RESs.

关键词： Integrated energy system carbon emission trading load demand response renewable energy source

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Experimental Investigation and X-Ray Computed Microtomography Simulation on Thermal Physical Properties of Foundation Materials after Molten Salt Leakage in the Storage Tank

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Journal of Thermal Science 2024年第2期33卷 591-601页

作者： WANG Zhaowen ZHOU hao luo Jiawei LI Yawei FANG hao LIU Tianxiao State Key Laboratory of Clean Energy Utilization Institute for Thermal Power EngineeringZhejiang UniversityHangzhou310027China

This paper studied the thermal physical properties of foundation materials in the molten salt tank of thermal energy storage system after molten salt leakage by Transient plane source experiment and X-ray computed microtomography simulation *** microstructure,thermal properties and pressure resistance with different particle diameters were *** measured heat conductivities from Transient plane source experiment for three cases are 0.49 W/(m·K),0.48 W/(m·K),and 0.51 W/(m·K),and the porosity is 30.1%,30.7%,and 31.2% *** heat conductivity simulating results of three cases are 0.471 W/(m·K),0.482W/(m·K),and 0.513 W/(m·K).The ratio of difference between the results of simulation and Transient plane source measurement is as low as 1.2%,verifying the reliability of experimental and simulation results to a certain *** with the heat conductivity of 0.097-0.129 W/(m·K) and porosity of 71.6%-78.9% without leaking salt,the porosity is reduced by more than 50% while the heat conductivity increased by 4 to 5 times after molten salt *** significant increase in heat conductivity has a great impact on security operation,structure design,and modeling of the tank foundation for solar power plants.

关键词： heat conductivity X-ray computed microtomography foundation materials three-phase threshold algorithm molten salt leakage

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IR-YOLO: Real-Time Infrared Vehicle and Pedestrian Detection

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Computers, Materials & Continua 2024年第2期78卷 2667-2687页

作者： Xiao luo hao Zhu Zhenli Zhang Department of Electrical Engineering and Automation Jiangxi University of Science and TechnologyGanzhou341000China Jiangxi Provincial Key Laboratory of Maglev Technology Ganzhou341000China Graduate School of Information Production and SystemsWaseda UniversityKitakyushu-shiFukuoka808-0135Japan

Road traffic safety can decrease when drivers drive in a low-visibility *** application of visual perception technology to detect vehicles and pedestrians in infrared images proves to be an effective means of reducing the risk of *** tackle the challenges posed by the low recognition accuracy and the substan-tial computational burden associated with current infrared pedestrian-vehicle detection methods,an infrared pedestrian-vehicle detection method A proposal is presented,based on an enhanced version of You Only Look Once version 5(YOLOv5).First,A head specifically designed for detecting small targets has been integrated into the model to make full use of shallow feature information to enhance the accuracy in detecting small ***,the Focal Generalized Intersection over Union(GIoU)is employed as an alternative to the original loss function to address issues related to target overlap and category ***,the distribution shift convolution optimization feature extraction operator is used to alleviate the computational burden of the model without significantly compromising detection *** test results of the improved algorithm show that its average accuracy(mAP)reaches 90.1%.Specifically,the Giga Floating Point Operations Per second(GFLOPs)of the improved algorithm is only *** contrast,the improved algorithms outperformed the other algorithms on similar GFLOPs,such as YOLOv6n(11.9),YOLOv8n(8.7),YOLOv7t(13.2)and YOLOv5s(16.0).The mAPs that are 4.4%,3%,3.5%,and 1.7%greater than those of these algorithms show that the improved algorithm achieves higher accuracy in target detection tasks under similar computational resource *** the other hand,compared with other algorithms such as YOLOv8l(91.1%),YOLOv6l(89.5%),YOLOv7(90.8%),and YOLOv3(90.1%),the improved algorithm needs only 5.5%,2.3%,8.6%,and 2.3%,respectively,of the *** improved algorithm has shown significant advancements in balancing accuracy and computati

关键词： Traffic safety infrared image pedestrians and vehicles focal GIoU distributed shift convolution

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Full-domain collaborative deployment method of multiple interference sources and evaluation of its deployment effect

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Defence Technology（防务技术） 2024年第2期32卷 572-595页

作者： yue Wang Fuping Sun Xian Wang Jinming hao Kai Xiao School of Geospatial Information The PLA Information Engineering UniversityZhengzhou 450001HenanChina

This paper realizes the full-domain collaborative deployment of multiple interference sources of the global satellite navigation system(GNSS)and evaluates the deployment effect to enhance the ability to disturb the attacker and the capability to defend the GNSS during navigation *** evaluation indicators for the jamming effect of GNSS suppressive and deceptive jamming sources are first created,their evaluation models are built,and their detection procedures are sorted out,as the basis for determining the deployment *** principles for collaboratively deploying multi-jamming sources are developed to obtain the deployment structures(including the required number,structures in demand,and corresponding positions)of three single interference sources required by collaboratively ***,simulation and hardware-in-loop testing results are presented to determine a rational configuration of the collaborative deployment of multi-jamming sources in the set situation and further realize the full-domain deployment of an interference network from ground,air to *** evaluation indices for the deployment effect are finally developed to evaluate the deployment effect of the proposed configuration and further verify its reliability and rationality.

关键词： Jamming effect Multiple interference sources Collaborative deployment Effect evaluation Defense capability

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