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治疗特应性皮炎的选择性Janus激酶抑制剂的量化评估

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中国新药与临床杂志 2024年第5期43卷 374-379页

作者：赵越杨浩天薛朝军李宵鞠晓宇赵倩董占军河北省人民医院药学部河北石家庄050057 河北省中医院药学部河北石家庄050011 河北省临床药学重点实验室河北石家庄050051

目的对治疗特应性皮炎的选择性Janus激酶抑制剂进行量化评估,为临床合理用药方案决策提供科学的依据。方法根据《中国医疗机构药品评价与遴选快速指南(第二版)》,从药学特性、有效性、安全性、经济性与其他属性五个方面对乌帕替尼和阿... 详细信息

目的对治疗特应性皮炎的选择性Janus激酶抑制剂进行量化评估,为临床合理用药方案决策提供科学的依据。方法根据《中国医疗机构药品评价与遴选快速指南(第二版)》,从药学特性、有效性、安全性、经济性与其他属性五个方面对乌帕替尼和阿布昔替尼进行综合评价并量化评估。结果乌帕替尼与阿布昔替尼的总分分别为80.5分和80.2分。乌帕替尼与阿布昔替尼在瘙痒缓解及皮损清除方面疗效确切,但在联合外用糖皮质激素等药物时,阿布昔替尼疗效提高幅度优于乌帕替尼。乌帕替尼在适用人群方面较阿布昔替尼范围更广,而阿布昔替尼血液系统不良反应发生率低于乌帕替尼。对于医疗机构药品遴选,两者均可推荐入选。结论阿布昔替尼适用于追求迅速见效、建立信心的患者,以及需要根据病情灵活调整治疗方案的患者。对于12岁以上青少年、严重肾功能不全或合并类风湿关节炎、溃疡性结肠炎等疾病的患者优选乌帕替尼。

关键词：乌帕替尼阿布昔替尼 Janus激酶抑制剂皮炎,特应性药物评价

SS-拟正规子群对有限群p-超可解性的影响

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西北师范大学学报（自然科学版） 2024年第2期60卷 1-5页

作者：高建玲毛月梅曹陈辰山西大同大学数学与统计学院山西大同037009 宁波大学数学与统计学院浙江宁波315211

设G为有限群,若存在B≤G使得G=hB,且对任意p∈π(B),P∈Sy1_( p)(B),都有hP=Ph,则称子群h在G中SS-拟正规.利用极小阶反例法,讨论某些p-子群SS-拟正规的有限群结构,得到p-超可解群的若干充分条件,推广了p-超可解性的部分结果.

关键词： p-子群 SS-拟正规子群 p-超可解群极小阶反例

仅知需求区间信息下具有二次订货机会的损失厌恶报童鲁棒优化模型

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管理工程学报 2022年第2期36卷 182-194页

作者：邱若臻曹沙沙孙月东北大学工商管理学院辽宁沈阳110169

在仅知需求区间信息条件下,本文研究了具有二次订货机会(追索权)的损失厌恶报童鲁棒库存决策问题。在构建不确定需求下的报童支付函数基础上,根据前景理论给出了考虑二次订货的损失厌恶报童期望值函数,本文针对随机优化方法难以处理需... 详细信息

在仅知需求区间信息条件下,本文研究了具有二次订货机会(追索权)的损失厌恶报童鲁棒库存决策问题。在构建不确定需求下的报童支付函数基础上,根据前景理论给出了考虑二次订货的损失厌恶报童期望值函数,本文针对随机优化方法难以处理需求信息缺失情况和传统最大最小鲁棒建模准则过于保守问题,在仅知需求区间信息下,建立了基于最小最大后悔值准则的鲁棒优化模型。在此基础上,本文分别给出了风险中性和损失厌恶下具有封闭形式的报童鲁棒订货量决策和后悔值绩效;分析了损失厌恶系数、初次订货单位成本、二次订货单位成本、剩余产品单位残值以及需求区间范围等系统参数对报童鲁棒订货量和后悔值的影响,并给出了相应的管理启示。结果表明,同风险中性情况相比,损失厌恶下的报童订货量更低,而对应的后悔值却更高。此外,虽然各系统参数对报童订货量决策和后悔值的影响机制不同,但无论是风险中性还是损失厌恶情况下,该影响机制并无本质区别,表明即使决策者具有不同风险态度,依据文中方法制定的订货策略在管理意义上具有一致性。进一步,通过对比不同决策准则下的报童运作绩效发现,基于文中最小最大后悔值方法得到的订货量决策能够确保较小的绩效损失,具有更好的鲁棒性。

关键词：报童模型损失厌恶二次订货最小最大后悔值准则鲁棒优化

The Comparison Between Finite Element Analysis and Experimental Results of the Cooling of Injection Moulds with hot Runner System

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厦门大学学报（自然科学版） 2002年第S1期41卷 110-111页

作者： Y F sun K S Lee C h Tan A Y C Nee Department of Mechanical Engineering National University of Singap oreDepartment of Mechanical Engineering National University of Singap oreSchool of Mechanical & Manufacturing EngineeringDepartment of Mechanical Engineering National University of Singapore SingaporeSingaporeSingapore Polytechnic Singapore Singapore

In an injection moulding process, the mould cooling s ystem is very important as an efficient and uniform cooling effect can improve b oth the productivity and part quality. Due to the complexity of the process, muc h research on the mould cooling analysis and cooling design optimization has bee n focused on the core and the cavity, excluding other systems of injection mould s. however, the runner system introduces a considerable amount of h.at into the mould. In recent years, more and more hot runner systems are being applied in th e moulding industry to save material and decrease losses of injection pressure. This raises the need to include the hot runner system in the cooling analysis. I n this paper, a photo frame part was studied. The mould was built with.a hot run ner system. Two thermal sensors were installed: one measures the temperature of lateral surface of hot runner nozzle; the other measures the plastic temperature from the core side. A pressure sensor was also installed to measure the pressur e of the core impression. Cooling analysis was performed using ABAQUS, ananalysi s software based on the Finite Element Method (FEM). The assembly including core , cavity and plastic part was modeled. h.at conduction from hot runner to cavity and from polymer melt to the mould and force convection on the cooling channel surfaces were studied. The natural convection between the ambient air and the ex terior mould surface was ignored. The simulations were adjusted with the experim ental results to find out the h.at input from hot runner and its influence on mo uld cooling. Finally, the optimal cooling design and optimal injection condition were obtained.

关键词： injection moulding cooling injection mould cool ing finite element method hot runner

The effect of Pickering emulsion adjuvants on the immune efficacy of the COVID-19 polypeptide vaccine

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ChemPhysMater 2023年第3期2卷 259-266页

作者： Zh.anqing h.ang Qi sun haoyuan Shi Sen Yang Yuanyuan Li yue Ma Fei Yang Zhenwei Shi Yalong Yang Ying Zhang hui Gong Fengh.a Xu Pharmaceutical Sciences Research Division Department of PharmacyMedical Supplies CentrePLA General HospitalBeijing 100853China Medical School of Chinese PLA Beijing 100853China Chinese People’s Armed Police Force hospital of Beijing Beijing 100600China

Pickering emulsions were prepared by phacoemulsification in an ice water bath with squalene as the oil phase and an aluminum adjuvant as the particle *** effects of formulation and process conditions on the size and distribution of the Pickering emulsions were *** emulsions prepared under the optimal prescription and process conditions were mixed with.a peptide antigen to obtain a peptide *** optimal prescription and process condition of the Pickering emulsion is as follows:squalene as the oil phase,ultra-pure water as the water phase with 5 mg/mL aluminum adjuvant,and an ultrasonication time of 4 min at 200 W ***/c mice were immunized with the peptide vaccine,and the ability of the Pickering emulsion as an immunological adjuvant to improve the efficacy of the peptide vaccine was *** optimal conditions,a Pickering emulsion with.a small particle size(430.8 nm),uniform distribution(polydispersion index of 16.9%),and zeta potential of 31.5 mV,was *** results showed that the serum specific antibody level in the vaccinated group reached 1×104 after three *** proportion of CD4+T cells and CD4/CD8 cells was significantly higher(Phe vaccinated groups than the blank control ***,cytokine(TNF-𝛼)secretion decreased in the aluminum adjuvant and Pickering emulsion groups but increased in the Freund’s adjuvant *** three vaccinated groups of mice exhibited low but detectable levels of IFN-𝛾secretion.

关键词： Pickering emulsions Ultrasonic emulsification Immunologic adjuvant COVID-19 Polypeptide vaccine

Lead-Free hybrid Indium Perovskites with highly Efficient and Stable Green Light Emissions

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CCS Chemistry 2022年第9期4卷 3106-3121页

作者： Chen sun Jin-Peng Zang Yu-Qing Liu Qian-Qian Zhong Xin-Xin Xing Jia-Peng Li Cheng-Yang yue Xiao-Wu Lei School of Chemistry Chemical Engineer and MaterialsJining UniversityQufuShandong273155

Lead halide perovskite nanocrystals(PNCs)have emerged as new-generation light-emitting materials with important potentials in optoelectronic ***,the toxicity of lead metal and the instabilities of PNCs overwhelmingly hinder their device engineering;thus,it is still urgent to construct new single crystalline lead-free perovskites with high-performance luminescent properties.

关键词： zero-dimensional indium perovskites green light-emitting Sb-doping strategy high photoluminescence quantum yield

Meningeal carcinomatosis: a retrospective analysis of seventy-seven cases

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Neuroimmunology and Neuroinflammation 2017年第1期4卷 1-5页

作者： Feng-Na Chu yue Lang Xiao-Min sun Li Cui Neuroscience Center the First Hospital of Jilin UniversityJilin UniversityChangchun 130021JilinChina

Aim:Meningeal carcinomatosis is a special type of malignant tumor characterized by short survival and poor *** the present study,the authors aim to analyze the clinical,laboratory data and prognosis of meningeal carcinomatosis ***:The authors enrolled 77 cases of meningeal carcinomatosis from 2003 to 2013 in the First hospital of Jilin *** clinical data including age,gender,symptoms at onset,clinical manifestations,primary tumors and the laboratory data including cerebrospinal fluid (CSF),tumor markers as well as the imaging data were *** interval between the onset of primary tumor and the onset of central nervous symptoms,treatments and survival time were also ***:The onset of meningeal carcinomatosis was usually acute (46.2%) or subacute (39.0%).The most frequent symptom at onset was intracranial hypertension (70.1%).Symptoms such.as h.adache,vomit and high lumbar puncture intracranial pressure was observed in 56% of cases during the course of the *** abnormalities such.as higher protein concentration (73.4%),more CSF pleocitosis (57.1%) and lower glucose levels (48.4%) were found in 95.3% of meningeal carcinomatosis ***-contrast enhanced cerebral magnetic resonance imaging (MRI) showed that 13.2% patients had abnormal meningeal changes while in the enhancement scan 35.3% patients showed *** serum tumor markers increased in 84% of the *** were no differences regarding the mean survival between patients who received intrathecal chemotherapy and those who received brain radiotherapy or supportive ***:The most common clinical manifestation of meningeal carcinomatosis is intracranial *** most common primary tumor is lung cancer,followed by gastric cancer and breast *** linear enhancement of meningeal on the MRI scan is of great importance for the diagnosis of meningeal carcinomatosis.

关键词： Meningeal carcinomatosis cerebrospinal fluid magnetic resonance imaging therapy

基于因果模型的复杂工业过程数据驱动软传感器自动特征选择方法

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Engineering 2023年第3期22卷 82-93页

作者： Yan-Ning sun 秦威 Jin-h.a hu hong-Wei Xu Poly Z.h.sun School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Institute of Artificial Intelligence Shanghai Jiao Tong UniversityShanghai 200240China

关键绩效指标(KPI)的软感知在复杂工业过程的决策中起着至关重要的作用。许多研究人员已经使用尖端的机器学习(ML)或深度学习(DL)模型开发出了数据驱动的软传感器。此外,特征选择是一个关键的问题,因为一个原始的工业数据集通常是高维的... 详细信息

关键绩效指标(KPI)的软感知在复杂工业过程的决策中起着至关重要的作用。许多研究人员已经使用尖端的机器学习(ML)或深度学习(DL)模型开发出了数据驱动的软传感器。此外,特征选择是一个关键的问题,因为一个原始的工业数据集通常是高维的,并不是所有的特征都有利于软传感器的发展。一个完美的特征选择方法不应该依赖于超参数和后续的ML或DL模型。相反,它应该能够自动选择一个特征子集进行软传感器建模,其中每个特征对工业KPI都有独特的因果影响。因此,本研究提出了一种受因果模型启发的自动特征选择方法,用于工业KPI的软感知。首先,受后非线性因果模型的启发,本研究将该方法与信息论相结合,以量化原始工业数据集中每个特征和KPI之间的因果效应。然后,提出了一种新的特征选择方法,即自动选择具有非零因果效应的特征来构造特征的子集。最后,利用所构造的子集,通过AdaBoost集成策略开发KPI的软传感器。通过对两个实际工业应用的实验证实了该方法的有效性。在未来,该方法也可以应用于其他工业过程,以帮助开发更先进的数据驱动的软传感器。

关键词： Big data analytics Machine intelligence Quality prediction Soft sensors Intelligent manufacturing

Intestinal organoid as an in vitro model in studying host-microbial interactions

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Frontiers in Biology 2017年第2期12卷 94-102页

作者： Jun sun Division of Gastroenterology and hepatology Department of Medicine University of Illinois at Chicago 840 S Wood Street Chicago IL 60612 USA

BACKGROUND： Organoid is an in vitro three-dimensional organ-bud that shows realistic microanatomy and physiological relevance. The progress in generating organoids that faithfully recapitulate human in vivo tissue composition has extended organoid applications from being just a basic research tool to a translational platform with.a wide range of uses. Study of host- microbial interactions relies on model systems to mimic the in vivo infection. Researchers have developed various experimental models in vitro and in vivo to examine the dynamic host-microbial interactions. For some infectious pathogens, model systems are lacking whereas some of the used systems are far from optimal. OBJECTIVE： In the present work, we will review the brief history and recent findings using organoids for studying host- microbial interactions. METhODS： A systematic literature search was performed using the PubMed search engine. We also shared our data and research contribution to the field. RESULTS： we summarize the brief history of 3D organoids. We discuss the feasibility of using organoids in studying host- microbial interactions, focusing on the development of intestinal organoids and gastric organoids. We highlight the advantage and challenges of the new experimental models. Further, we discuss the future direction in using organoids in studying host- microbial interactions and its potential application in biomedical studies. CONCLUSION： In combination with genetic, transcriptome and proteomic profiling, both murine- and human-derived organoids have revealed crucial aspects of development, homeostasis and diseases. Specifically, human organoids from susceptible host will be used to test their responses to pathogens, probiotics, and drugs. Organoid system is an exciting tool for studying infectious disease, microbiome, and therapy.

关键词： bacteria colonoids enteroids gastric organoids host-microbial interactions h. pylori inflammation intestinalorganoids microbiome organoids tight junctions Salmonella stem-cell differentiation ZO-1