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Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder

Neural Regeneration Research 2025年第6期20卷 1541-1554页

作者： Jinmei ye Cong Duan Jiaxin Han Jinrong Chen Ning Sun Yuan Li Tifei Yuan Daihui Peng Division of Mood Disorder Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Shanghai Key Laboratory of Psychotic Disorders Brain Health InstituteNational Center for Mental DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation. This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder. Herein, we critically review the neuroinflammation theory in major depressive disorder, providing compelling evidence that mitochondrial DNA release acts as a critical biological substrate, and that it constitutes the neuroinflammatory disease pathway. After its release, mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation. Detectable exosomes render encaged mitochondrial DNA relatively stable. This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice. These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder. This review also highlights the future potential value of clinical applications combining mitochondrial DNA with a panel of other biomarkers, to improve diagnostic precision in major depressive disorder.

关键词： biomarker cytokine exosomes inflammasome major depressive disorder microglia mitochondrial DNA mitochondrial dysfunction neuroinflammation Toll-like receptor

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The DAO to MetaControl for MetaSystems in Metaverses:The System of Parallel Control Systems for Knowledge Automation and Control Intelligence in CPSS

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IEEE/CAA Journal of Automatica Sinica 2022年第11期9卷 1899-1908页

作者： Fei-yue wang The State Key Laboratory for Management and Control of Complex Systems Chinese Academy of SciencesBeijing100190Chi the Macao Institute of Systems Engineering Macao University of Science and TechnologyMacao999078China

An investigation and outline of MetaControl and DeControl in Metaverses for control intelligence and knowledge automation are *** control with prescriptive knowledge and parallel philosophy is proposed as the starting point for the new control philosophy and technology,especially for computational control of metasystems in cyberphysical-social *** argue that circular causality,the generalized feedback mechanism for complex and purposive systems,should be adapted as the fundamental principle for control and management of metasystems with metacomplexity in ***,an interdisciplinary approach is suggested for MetaControl and DeControl as a new form of intelligent control based on five control metaverses:MetaVerses,MultiVerses,InterVerses,TransVerse,and DeepVerses.

关键词： MetaControl MetaSystems Metaverses CPSS DAO DeControl Prescriptive Control Parallel Control Computational Control Knowledge Automation Control Intelligence Parallel Intelligence

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Insight of the stability and activity of platinum single atoms on ceria

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Nano Research 2019年第6期12卷 1401-1409页

作者： Xuxu ye Hengwei wang yue Lin Xinyu Liu Lina Cao Jian Gu Junling Lu Department of Chemical Physics iChEMCAS Key Laboratory of Materials for Energy ConversionUniversity of Science and Technology of ChinaHefei 230026China Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China

Single-atom catalysts (SACs) have recently attracted broad attention in the catalysis field due to their maximized atom efficiency and unique catalytic *** atomic-level understanding of the interaction between the metal atoms and support is vital for developing stable and high-performance *** this work,Pt1 single atoms with Ioadings up to 4 wt.% were fabricated on ceria nanorods using the atomic layer deposition *** understand the Pt-O-Ce bond interfacial interactions,the stability of Pt1 single atoms in the hydrogen reducing environment was extensively investigated by using in situ diffuse reflectance infrared Fourier transform spectroscopy CO chemisorption *** was found that ceria defect sites,metal Ioadings and high-temperature calcination are effective ways to tune the stability of Pt1 single atoms in the hydrogen environment.X-ray photoemission spectroscopy further showed that Pt1 single atoms on ceria are dominantly at a +2 valence state at the defect and step edge sites,while those on terrace sites are at a +4 *** above tailored stability and electronic properties of Pt1 single atoms are found to be strongly correlated with the catalytic activity in the dry and water-mediated CO oxidation reactions.

关键词： single atom catalyst Pt1/CeO2 metal-support interaction stabilitywater-mediated CO oxidation

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Preparation and applications of calcium ferrite as a functional material:A review

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 292-310页

作者： Xiuli Han Bowen Duan Lei Liu Shilong Fang Weiwei wang College of Mining Engineering North China University of Science and TechnologyTangshan 063210China Collaborative Innovation Center of Green Development and Ecological Restoration of Mineral Resources of Hebei Province Tangshan 063210China Key Laboratory of Mining Development and Security Technology of Hebei Province Tangshan 063210China

Calcium ferrite(CF)is recognized as a potential green and efficient functional material because of its advantages of magnetism,electrochemistry,catalysis,and biocompatibility in the fields of materials chemistry,environmental engineering,and ***-fore,the obtained research results need to be systematically summarized,and new perspectives on CF and its composite materials need to be *** on the presented studies of CF and its composite materials,the types and structures of the crystal are *** addition,the current application technologies and theoretical mechanisms with various properties in different fields are ***,the various preparation methods of CF and its composite materials are elaborated in *** importantly,the advantages and disadvantages of the synthesis methods of CF and its composite materials are discussed,and the existing problems and emerging challenges in practical production are ***,the key future research directions of CF and its composite materials have been prospected from the potential application technologies to provide references for its synthesis and efficient utilization.

关键词： calcium ferrite mineral functional materials preparation application perspectives

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Spatio-temporal variation of landfill gas in pilot-scale semi-aerobic and anaerobic landfills over 5 years

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Journal of Environmental Sciences 2017年第4期29卷 288-297页

作者： Xiaohui Wu Bo yue Qifei Huang Qi wang ye Lin Wei Zhang Zhuoyi Yan State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental Sciences College of Water Sciences Beijing Normal University

Variation of CH4, CO2, and O2 concentrations in layers of different depths in semi-aerobic and anaerobic landfills was analyzed over a period of 5 years. The results showed that most of the municipal solid waste became basically stable after 5 years of landfill disposal. In the upper and middle layer, the concentration of CH4 in the semi-aerobic landfill was significantly lower than that in the anaerobic landfill in different landfill periods, while in the lower layer, there was little difference in the CH4 concentration between the semi-aerobic and anaerobic landfills. The average concentration of CH4 and CO2in the anaerobic landfill was always higher than that in the semi-aerobic landfill, while the O2 concentration showed an opposite variation in different landfill periods. This was related to the aerobic reaction of landfill waste around the perforated pipe in the semi-aerobic landfill,which inhibited effective landfill gas generation.

关键词： Landfill gas Semi-aerobic landfill Anaerobic landfill Municipal solid waste

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Intelligent hydrogels for treating malignant melanoma

Engineered Regeneration

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Engineered Regeneration 2024年第3期5卷 295-305页

作者： Guopu Chen Xiyu wang Jiaye Li ye Xu yue Lin Fengyuan wang Department of Burns and Plastic Surgery Nanjing Drum Tower HospitalSchool of MedicineSoutheast UniversityNanjing 210009China Department of Dermatology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210009China

Malignant melanoma(MM)is an extremely aggressive and fatal form of skin cancer that primarily affects the bottom layer of the epidermis and is associated with poor clinical ***-stage MM is typically treated through surgical removal,while chemotherapy and radiotherapy are common conventional treatment options that come with harmful side *** therapies such as immunotherapy,photodynamic therapy,biologic therapy,and photothermal therapy present hopeful options for treatment due to their effective and secure drug delivery *** address the limitations of current treatment options,advanced methods of drug delivery for subcutaneous MM are being developed,with hydrogels emerging as a promising *** date,significant advancements have been made in the treatment of MM through the use of hydrogels-based drug delivery systems through focal plastering,injection,implantation,and *** research on hydrogel-based drug delivery systems that integrate multiple therapies for the treatment of subcutaneous MM is discussed in this review.

关键词： Intelligent Hydrogel Microneedle Drug delivery system Malignant melanoma

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Recent Progress Using High-throughput Sequencing Technologies in Plant Molecular Breeding

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Journal of Integrative Plant Biology 2012年第4期54卷 215-227页

作者： Qiang Gao Guidong yue Wenqi Li Junyi wang Jiaohui Xu ye Yin Beijing Genomics Institute-Shenzhen Shenzhen 518083China

High-throughput sequencing is a revolutionary technological in- novation in DNA sequencing. This technology has an ultra-low cost per base of sequencing and an overwhelmingly high data output. High-throughput sequencing has brought novel research methods and solutions to the research fields of genomics and post-genomics. Furthermore, this technology is leading to a new molecular breeding revolution that has landmark significance for scientific research and enables us to launch multi-level, multi- faceted, and multi-extent studies in the fields of crop genetics, genomics, and crop breeding. In this paper, we review progress in the application of high-throughput sequencing technologies to plant molecular breeding studies.

关键词： High-throughput sequencing genomics molecular breeding.

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电动拖拉机双电源并联控制研究

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农机化研究 2025年第1期47卷 234-238页

作者：初香港王宝超陈叶青岛农业大学机电工程学院山东青岛266109

电动拖拉机具有结构简单和节能减排等优点,但现有电动拖拉机作业时采用单一动力电池能源,存在续航时间短的问题。为了提高电动拖拉机长续航供电能力,提出了一种基于下垂控制的直流双电源并联均流联合供电方案,利用MatLab/Simulink搭建... 详细信息

电动拖拉机具有结构简单和节能减排等优点,但现有电动拖拉机作业时采用单一动力电池能源,存在续航时间短的问题。为了提高电动拖拉机长续航供电能力,提出了一种基于下垂控制的直流双电源并联均流联合供电方案,利用MatLab/Simulink搭建了系统模型。仿真试验表明:单电源可以实现升压稳压控制;基于下垂控制的双电源并联均流能够实现双电源的电流均流;当切换不同功率负载时,系统电压随功率增加按比例下调,验证了该方案的可行性。

关键词：电动拖拉机双电源并联下垂控制动态仿真

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Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia Jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu Lian Xin Hua Jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing yue Minyu Zhu Ying wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

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A C_(54)B_(2) Polycyclic π-System with Bilayer Assembly and Multi-Redox Activity

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CCS Chemistry 2023年第4期5卷 876-884页

作者： Liuzhong Yuan Jiaxiang Guo yue Yang Kaiqi ye Chuandong Dou yue wang State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012

Doping heteroatoms into polycyclic aromatic hydrocarbons(PAHs)is an efficient strategy to achieve fascinating electronic structures and ***,nanoscale B-doped PAHs remain very challenging because of the intrinsic instability of the boron atom and the lack of suitable *** this study,we report a C_(54)B_(2) polycyclicπ-system with one embedded 1,4-diboron-substituted benzene subunit,which was successfully synthesized from doubly B-doped *** represents not only the largest B-doped PAH by far but also an unprecedented B-doped *** fully zigzag-armchair-edged structure creates a planar conformation,thus leading to its unique bilayer assembly *** importantly,it possesses intriguing electronic structure and optoelectronic properties,such as very broad light absorption that covers 350–750 nm,sharp near-infrared fluorescence with a band width of only 26 nm,and reversible five-step redox capability,all of which are rarely observed for other B-doped *** addition,this molecule displays distinctive local aromaticity that cannot be reproduced via the reductive manipulation of an allcarbon congener.

关键词： boron polycyclic aromatic hydrocarbons near-infrared fluorescence redox aromaticity

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