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Evicting and filling attack for linking multiple network addresses of Bitcoin nodes

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Cybersecurity 2024年第3期7卷 49-68页

作者： Huashuang yang Jinqiao shi yue Gao Xuebin Wang Yanwei Sun Ruisheng shi Dongbin Wang School of Cyberspace Security Bejing University of Posts and TelecommunicationsBeijingChina Tsinghua University Bejing 100084China Institute of Information Engineering Chinese Academy of SciencesBeijingChina

Bitcoin is a decentralized P2P *** supports users to use pseudonyms instead of network addresses to send and receive transactions at the data layer,hiding users'real network *** transaction tracing attack cuts through the network layer to directly associate each transaction with the network address that issued it,thus revealing the sender's network *** this attack can be mitigated by Bitcoin's network layer privacy *** Bitcoin protects the unlinkability of Bitcoin addresses and there may be a many-to-one relation-ship between addresses and nodes,transactions sent from the same node via different addresses are seen as com-ing from different nodes because attackers can only use addresses as node *** this paper,we proposed the evicting and flling attack to expose the correlations between addresses and cluster transactions sent from different addresses of the same *** attack exploited the unisolation of Bitcoin's incoming connection processing *** particular,an attacker can utilize the shared connection pool and deterministic connection eviction strategy to infer the correlation between incoming and evicting connections,as well as the correlation between releasing and flling *** on inferred results,different addresses of the same node with these connections can be linked together,whether they are of the same or different network *** designed a multi-step attack procedure,and set reasonable attack parameters through analyzing the factors that affect the attack effciency and *** mounted this attack on both our self-run nodes and multi-address nodes in real Bitcoin network,achieving an aver-age accuracy of 96.9% and 82%,***,we found that the attack is also applicable to Zcash,Litecoin,Dogecoin,Bitcoin Cash,and *** analyzed the cost of network-wide attacks,the application scenario,and proposed countermeasures of this attack.

关键词： Security and privacy Bitcoin Address linking

Experiment of electrothermal stress for different types of end turn grading in the inverter-fed form-wound windings

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High Voltage 2024年第4期9卷 853-861页

作者： Wenhuan Zhao Peng Wang Yingwei Zhu yue Zhang Shuai yang Yan Liu yang shi Chaofan Yu Electrical Engineering Department Sichuan UniversityChengduSichuanChina D&R Dongfang Electric Machinery Co.Ltd.DeyangSichuanChina

End turn grading with resistive–capacitive coupling experiences severe electrothermal stress when subjected to pulse width modulation(PWM)*** this paper,several experiments and simulations were carried conducted for four types of end turn *** of all,the temperature rise in the end turn grading increased with a decrease in rise *** the rise time was less than 500 ns,the temperature rise at the terminal was higher owing to the increased capacitive current coupled from the main wall ***,the current in the linear region exhibited minimal variation at different fundamental frequencies resulting in synchronized the temperature rise at the terminal and ***,the jump voltage was the key factor influencing temperature rise in end turn grading,confirmed by comparing different voltage ***,the transient behaviour of the maximum field in the stress grading material was determined at rise *** experimental and simulation results indicate that balancing and interdependently addressing the electrical and thermal stress protection in end turn grading is *** study aims to provide an experimental and theoretical foundation for an insulation system of inverter-fed rotating machinery operating under PWM voltage.

关键词： stress inverter insulation

Aberrant LETM1 elevation dysregulates mitochondrial functions and energy metabolism and promotes lung metastasis in osteosarcoma

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Genes & Diseases 2024年第3期11卷 368-384页

作者： Yulu shi Quan Kang Hong Zhou Xiaohan yue yang Bi Qing Luo Stem Cell Biology and Therapy Laboratory The Children's Hospital of Chongqing Medical UniversityNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChongqing Key Laboratory of PediatricsChongqing 400014China Department of Pediatric Surgery The Children's Hospital of Chongqing Medical UniversityChongqing 400014China

Osteosarcoma is a differentiation-deficient disease,and despite the unique advan-tages and great potential of differentiation therapy,there are only a few known differentia-tion inducers,and little research has been done on their *** differentiation is associated with an increase in mitochondrial content and *** metabolism of some tu-mor cells is characterized by impaired oxidative phosphorylation,as well as up-regulation of aerobic glycolysis and pentose phosphate ***-containing zipper and EF-hand transmembrane protein 1(LETM1)is involved in the maintenance of mitochondrial morphology and is closely associated with tumorigenesis and progression,as well as cancer cell *** found that MG63 and 143B osteosarcoma cells overexpress LETM1 and exhibit abnormalities in mitochondrial structure and *** of LETM1 partially restored the mitochon-drial structure and function,inhibited the pentose phosphate pathway,promoted oxidative phosphorylation,and led to osteogenic *** also inhibited spheroid cell forma-tion,proliferation,migration,and invasion in an in vitro *** LETM1 was knocked down in vivo,there was reduced tumor formation and lung *** data suggest that mitochondria are aberrant in LETM1-overexpressing osteosarcoma cells,and knockdown of LETM1 partially restores the mitochondrial structure and function,inhibits the pentose phosphate pathway,promotes oxidative phosphorylation,and increases osteogenic differentiation,thereby reducing malignant biological behavior of the cells.

关键词： Cancer metabolism Differentiation LETM1 Osteosarcoma Stemness

Geant4 simulation of fast-electron bremsstrahlung imaging at the HL-3 tokamak

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Nuclear Science and Techniques 2024年第9期35卷 213-229页

作者： shi-Kui Cheng Yi-Po Zhang yue-Jiang shi Jie Zhang Shuai Guan Hong-Bing Xu Qiu-Lei yang College of Science Chongqing University of TechnologyChongqing 400054China Chongqing Key Laboratory of New Energy Storage Materials and Devices Chongqing 400054China Southwestern Institute of Physics Chengdu 610041China Hebei Key Laboratory of Compact Fusion Langfang 065001China ENN Science and Technology Development Co. Ltd.Langfang 065001China

To further research on high-parameter plasma,we plan to develop a two-dimensional hard X-ray(HXR)imaging system at the HL-3 tokamak to measure HXRs with energies ranging from 20 to 300 *** application of an array-structured detector ensures that this system can measure HXR-radiation spectra from the entire plasma cross ***,it is suitable for the study of fast-electron physics,such as radio-frequency wave current drives,fast electrons driving instabilities,and plasma disruptions in fusion *** this study,we develop a simulation for calculating fast-electron bremsstrahlung in the HL-3 tokamak based on the Monte Carlo simulation code Geant4,in which the plasma geometry and forward scattering of fast-electron bremsstrahlung are *** preliminary calculation results indicate that the HXR energy deposi-tion on the detector is symmetrically distributed,even though the plasma distribution is asymmetric owing to the toroidal *** simulation results are helpful in constructing the relationship between the energy deposition on the detector and parameter distribution on the plasma cross section during HL-3 *** is beneficial for the reconstruction of the fast-electron-distribution function and for optimizing the design of the HXR-imaging system.

关键词： Geant4 simulation HL-3 tokamak Fast-electron bremsstrahlung Hard X-ray imaging

Interface structure of α-Mg/14H-LPSO:First-principles prediction and experimental study

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Journal of Rare Earths 2024年第9期42卷 1792-1799,I0006页

作者： Yuan shi Xiaohua Zhang Hongyan yue Chao Li School of Materials Science and Chemical Engineering Harbin University of Science and TechnologyHarbin150040China

The interfacial structure of the α-Mg/14H-LPSO phase in rare earth-including magnesium alloy was investigated via high-angle annular dark-field scanning transmission electron microscopy(HAADFSTEM) imaging and first-principles calculations of density-functional *** possible interfacial models were constructed according to the different terminations of the LPSO phase,and the corresponding interfacial energies were calculated,from which the four most stable structures(Terl-MgY-hollow,Ter2-Zn-hollow,Ter3-MgYII-hollow and Ter4-Mg-bridge) were *** interfacial phase diagrams related to the Y chemical potentials were obtained from the calculations,and the most stable interfacial structure was ***-MgY-hollow and Ter2-Zn-hollow have the lowest interfacial energies in the range of-0.7 eV <Δμγ<-0.6 eV,where fluctuating change of state is the minimized and the interface is the most *** separation work of the two models was calculated to predict the bonding strength of the structures at both ends of the *** calculation results show that the maximum interfacial separation work is 1.45 J/m^(2) for the interface model of α-Mg and 14H-LPSO phase structure with Ter2-Zn-hollow termination.

关键词： Rare earths Magnesium alloy HAADF-STEM LPSO First-principles Interface

Establishment of a selectable marker recycling system for iterative gene editing in Fusarium fujikuroi

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Synthetic and Systems Biotechnology 2024年第1期9卷 159-164页

作者： Tian-Qiong shi Cai-Ling yang Dong-Xun Li yue-Tong Wang Zhi-Kui Nie Jiangxi New Reyphon Biochemical Co. LtdSalt&Chemical IndustryXinganJiangxi331399People’s Republic of China School of Food Science and Pharmaceutical Engineering Nanjing Normal University2 Xuelin RoadQixia DistrictNanjing210023People’s Republic of China

Gibberellic acid(GA3)is a vital plant growth hormone widely used in ***,GA3 production relies on liquid fermentation by the filamentous fungus Fusarium ***,the lack of an effective selection marker recycling system hampers the application of metabolic engineering technology in ***,as multiple-gene editing and positive-strain screening still rely on a limited number of *** this study,we developed a strategy using pyr4-blaster and CRISPR/Cas9 tools for recycling orotidine-5'-phosphate decarboxylase(Pyr4)selection *** demonstrated the effectiveness of this method for iterative gene integration and large gene-cluster *** also successfully improved GA3 titers by overexpressing geranylgeranyl pyrophosphate synthase and truncated 3-hydroxy-3-methyl glutaryl coenzyme A reductase,which rewired the GA3 biosynthesis *** results highlight the efficiency of our established system in recycling selection markers during iterative gene editing ***,the selection marker recycling system lays the foundation for further research on metabolic engineering for GA3 industrial production.

关键词： F.fujikuroi Gibberellic acid Plant growth hormone Selection marker recycling system CRISPR/Cas9 pyr4-blaster

Regulation and application of supramolecular gel with circularly polarized luminescence

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Science China Chemistry 2024年第6期67卷 1865-1880页

作者： Shen Song Yulong shi Liangliang Zhu Bingbing yue School of Materials and Chemistry&Institute of Bismuth and Rhenium University of Shanghai for Science and TechnologyShanghai200093China State Key Laboratory of Molecular Engineering of Polymers Fudan UniversityShanghai200438China

Supermolecular gel is a three-dimensional network structure assembled by small molecules or polymers in solvents through noncovalent *** emergence of system complexity occurs spontaneously during the molecular self-assembly process.A multitude of chiral molecular self-assembly systems have been engineered,facilitating the achievement of circularly polarized luminescence(CPL)through the amalgamation of chiral entities with *** bonding,π-πstacking,and noncovalent forces,such as host-guest interactions and Van der Waals'forces,confer upon supramolecular gels the capacity to react to diverse *** to the flexibility of supramolecular assembly,the CPL properties of supramolecular gels have rich controllability and can be used in various *** this review,we summarized the examples of CPL-active supramolecular gel assembly,and further summarized the assembly environment factors and external ***,the versatility of CPL applications in supramolecular gels is demonstrated,ranging from optical devices,information encryption,biosensing and chemical sensing,and other practical *** conclusion,the study provides insights into the multicultural factors influencing CPL in supramolecular gels,describes their applications in various domains,and presents future perspectives in the field.

关键词： supramolecular gels circularly polarized luminescence self-assembly chirality stimuli-response

Regulate electric double layer for one-step synthesize and modulate the morphology of(oxy)hydroxides

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Nano Research 2024年第5期17卷 3675-3683页

作者： Jiaxin Liu yue shi Yanli Gu Zheng Lv Liang Zhao Yu yang Tianrong Zhan Jianping Lai Lei Wang State Key Laboratory Base of Eco-Chemical Engineering International Science and Technology Cooperation Base of Eco-chemical Engineering and Green ManufacturingCollege of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042China Shandong Engineering Research Center for Marine Environment Corrosion and Safety Protection College of Environment and Safety EngineeringQingdao University of Science and TechnologyQingdao 266042China

FeOOH have received considerable attention due to their natural abundance and *** the significant progress achieved,the one-step synthesis of integrated FeOOH is still a major ***,the current research on FeOOH catalyst still suffers from the unclear mechanism of controlling ***,density functional theory(DFT)calculations and X-ray photoelectron spectroscopy(XPS)demonstrated the strong electron-capturing and hydrogen absorption ability of Co in FeOOH,which further promotes the formation and stabilization of *** used a one-step electrodeposition method to synthesize Co introduced FeOOH integrated electrocatalyst and propose to introduce ions with different valence states to regulate the morphology of FeOOH by precise modulation of electric double layer(EDL)composition and *** prepared Co-FeOOH-K^(+)has a larger electrochemically active surface area(ECSA)(325 cm^(2))and turnover frequency(TOF)value(0.75 s^(-1)).In the electrochemical experiments of an alkaline anion exchange membrane electrolyzer,Co-FeOOH-K^(+)shows better oxygen evolution performance than commercial RuO_(2) under industrial production conditions and has good industrial application prospects.

关键词： integrated(oxy)hydroxides electrodeposition electric double layer(EDL) oxygen evolution reaction(OER) morphology regulation

Research on the Orientated Effective Components of Huangqi in Huangqi Jianzhong Tang Against Chronic Atrophic Gastritis Based on Multi-Spectrum–Effect Correlation

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 244-253页

作者： Guo-Hong Wang Long-Fei yang shi-Wei Wang yue-Tao Liu Department of Pharmacy Shanxi Traditional Chinese Medicine HospitalTaiyuanShanxi ProvinceChina Department of Pharmacy Shijazhuang Hospital of Traditional Chinese MedicineShijiazhuangHebeiChina Modern Research Center for Traditional Chinese Medicine Key Laboratory of Chemical Biology and Molecular Engineering of the Ministry of EducationTaiyuanShanxi ProvinceChina Key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province Shanxi UniversityTaiyuanShanxi ProvinceChina

Objective: This study aimed to investigate the orientated effective components of Astragali Radix Huangqi(HQ) in HQ Jianzhong Tang(HQJZ), a classical formula of traditional Chinese medicine(TCM) used for treating chronic atrophic gastritis(CAG), using HQ as a monarch medicine. Materials and Methods: The spectra of HQJZ containing different polar parts of HQ were obtained using ultra-high-performance liquid chromatography-Q-Exactive mass spectrometry. Furthermore, the efficacy of HQJZ, which contains different polar parts of HQ, in treating rats with CAG was evaluated using traditional pharmacodynamic and nuclear magnetic resonance-based metabonomics. Grey relation analysis and partial least squares analysis were applied to analyze the spectrum–effect relationship and to screen out the orientated effective components related to HQ in the treatment of CAG. Results: Spectrum–effect relationship analysis showed that 24 compounds identified from the fingerprint spectrum were strongly correlated with efficacy. Compounds 8(calycosin-7-O-glc-6”-O-acetate), 9(3-hydroxy-9, 10-dimethoxyptercarpan), and 22(astragaloside II) were ranked among the top three. Conclusions: This study showed that integrating metabolomics and spectrum–effect relationship analysis is a powerful tool for obtaining orientated effective components of Chinese medicine in a given TCM formula.

关键词： Astragali radix chronic atrophic gastritis Huangqi Jianzhong Tang metabonomics spectrum–effect relationship