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Mechanism of action of Zhuyu Annao pill in mice with cerebral intrahemorrhage based on TLR4

Asian Pacific Journal of Tropical Medicine 2016年第11期9卷 1072-1077页

作者： Wei Chen yue-qiang hu Ling-Fei Jiang Lin Wu First Cerebropathy Unit.First Affiliated Hospital of Guangxi University of Chinese Medicine Key Laboratory of Guangxi Basic Chinese Medicine Postgraduate Department Guangxi University of Chinese Medicine Science Experiment Center Guangxi University of Chinese Medicine

Objective:To explore the protective effect and possible mechanism of action of Zhuyu Annao pill in mice with intracerebral hemorrhage(ICH).Methods:Sixty mice were divided into the control group,hemorrhage group,drug-treated group(after hemorrhage),TLR4-knockout hemorrhage group and TLR4-knockout hemorrhage + drug-treated group(after hemorrhage) with 12 in each *** of autologous ICH was established in all *** drilling and 12 h of fasting,models in the control group hemorrhage group and TLR4-knockout hemorrhage group were all drenched with 10 mL/kg distilled water by intragastric *** in the drug-treated group and TLR4-knockout hemorrhage + drugtreated group were drenched with 6.25 g/kg of Zhuyu Annao *** groups were treated for 7 *** scoring method was used to measure the neurological defect scores and determine the brain water contents of all groups;ELISA was employed to detect the inflammatory factor interleukin(IL)-6,tumor necrosis factor- α(TNF- α) and IL-1β in brain tissues;and Western blot was applied to test the expression quantities of apoptotic protein Bax and anti-apoptotic protein Bcl-2 in brain ***:At day 3 and7,compared with the hemorrhage group,the neurological defect scores of the drug-treated group,TLR4-knockout hemorrhage group and TLR4-knockout hemorrhage + drug-treated group decreased significantly(P<0.05) Compared with the hemorrhage group,the brain water contents of the drug-treated group,TLR4-knockout hemorrhage group and TLR4-knockout hemorrhage + drug-treated group reduced significantly(P<0.05) Compared with the hemorrhage group,the inflammatory factor IL-6,TNF-α and IL-1β of the drug-treated group,TLR4-knockout hemorrhage group and TLR4-knockout hemorrhage + drug-treated group decreased significantly(P<0.05).Compared with the hemorrhage group,the expression of apoptotic protein Bax of the drug-treated group,TLR4-knockout hemorrhage group and TLR4-knockout hemorrhage+ drug-treated group de

关键词： Zhuyu Annao pill Intacerebral hemorrhage TLR4 Gene knockout Mechanism

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Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation

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Neural Regeneration Research 2025年第2期20卷 326-342页

作者： Yi Ji Chaoyi Yang Xuerui Pang Yibing Yan yue Wu Zhi Geng Wenjie hu Panpan hu Xingqi Wu Kai Wang Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhui ProvinceChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina Department of Psychology and Sleep Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and *** Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients *** transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological *** the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and *** has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological ***,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of *** study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated *** review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s *** mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also ***,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.

关键词： Alzheimer’s disease amyloid deposition apoptotic mechanisms biomarker neural regeneration neurodegeneration repetitive transcranial magnetic stimulation synaptic plasticity

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Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min Qin Zhongliang Li Wen‑Xia Su Jia‑Min hu Hanqin Zou Zhixuan Wu Zhiqin Ruan yue‑Peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

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An Efficient Boron Source Activation Strategy for the Low‑Temperature Synthesis of Boron Nitride Nanotubes

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Nano-Micro Letters 2025年第1期17卷 548-558页

作者： Ying Wang Kai Zhang Liping Ding Liyun Wu Songfeng E Qian He Nanyang Wang hui Zuo Zhengyang Zhou Feng Ding yue hu Jin Zhang Yagang Yao National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesJiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093People’s Republic of China School of Electronic Information and Artificial Intelligence Shaanxi University of Science&TechnologyXian 710000People’s Republic of China College of Bioresources Chemical and Materials Engineering Shaanxi University of Science&TechnologyXian 710000People’s Republic of China Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325000People’s Republic of China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518000People’s Republic of China College of Chemical and Molecular Engineering Peking UniversityBeijing 100871People’s Republic of China

Lowering the synthesis temperature of boron nitride nanotubes(BNNTs)is crucial for their *** primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid *** this study,we developed a novel approach for efficiently activating boron by introducing alkali metal compounds into the conventional MgO–B *** approach can be adopted to form various low-melting-point AM–Mg–B–O growth *** growth systems have improved catalytic capability and reactivity even under low-temperature conditions,facilitating the synthesis of BNNTs at temperatures as low as 850℃.In addition,molecular dynamics simulations based on density functional theory theoretically demonstrate that the systems maintain a liquid state at low temperatures and interact with N atoms to form BN *** findings offer novel insights into the design of boron activation and are expected to facilitate research on the low-temperature synthesis of BNNTs.

关键词： Boron nitride nanotubes Low-temperature Boron activation Density functional theory

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The Grad-Shafranov reconstruction in twenty years: 1996–2016

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Science China Earth Sciences 2017年第8期60卷 1466-1494页

作者： hu qiang Department of Space Science and CSPAR University of Alabama in Huntsville

We review and summarize the applications of the Grad-Shafranov(GS) reconstruction technique to space plasma structures in the Earth's magnetosphere and in the interplanetary space. We organize our presentations following the branches of the "academic family tree" rooted on Prof. Bengt U. ? Sonnerup, the inventor of the GS method. Special attentions are paid to validations of the GS reconstruction results via(1) the direct validation by co-spatial in-situ measurements among multiple spacecraft, and(2) indirect validation by implications and interpretations of the physical connection between the structures reconstructed and other related processes. For the latter, the inter-comparison and interconnection between the large-scale magnetic flux ropes(i.e., Magnetic Clouds) in the solar wind and their solar source properties are presented. In addition, we also summarize various GS-type(or-like) reconstruction and an extension of the GS technique to toroidal geometry. In particular,we point to a possible advancement with added complexity of "helical symmetry" and mixed helicity, in the hope of stimulating interest in future development. We close by offering some thoughts on appreciating the scientific merit of GS reconstruction in general.

关键词： Grad-Shafranov equation Magnetohydrodynamics Magnetic clouds Magnetic flux ropes Magnetopause Current sheets Flux transfer events Plasmoids Solar flare Coronal mass ejections

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Visualization of collision and aggregation behavior of particles simulating movement of inclusions in molten steel

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Journal of Iron and Steel Research International 2018年第2期25卷 173-180页

作者： qiang yue Zeng hu Zhao-yang Wu Hong-ming Long Qing-min Meng Key Laboratory of Metallurgical Emission Reductionand Resources Recycling (Anhui University of Technology) Ministry of Education Ma'anshan 243002 Anhui China The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081 Hubei China School of Metallurgical Engineering Anhui Universityof Technology Ma'anshan 243002 Anhui China

Inclusions with sizes less than 1 μm in molten steel are difficult to float up to the molten steel and slag interface owing to their slow terminal velocity. Thus, increasing the size of inclusion is essential for accelerating the removal of inclusions. Polystyrene particles simulating inclusions in molten steel were quantified by direct observation of the particle collision behavior in a turbulent flow in a water model. The box-counting fractal dimension of particles was calculated by processing the binary images of aggregated particles. The fractal dimension of the outer contours of the single plastic particles was smaller than that of the aggregated particles. The fractal dimension was varied from 1.14 to 1.35. When two or more monomer particles collide, the aggregates are separated more easily, as the temperature increases from 40 to 80 ℃. The aggregated particles were loose and easy to separate in the high-temperature aqueous solution. The effect of temperature on the surface tension of liquid and the interracial tension of solid and liquid is obvious. The particles are wetting in the water solution at a temperature more than 60 ℃. The relationship between the velocity of the particles and the fractal dimension of the solid particles with the equivalent diameter was discussed.

关键词： Non-metallic inclusion Fractal Box-counting dimension Visualization Collision. Aggregation

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Luojia-HSSR:A high spatial-spectral resolution remote sensing dataset for land-cover classification with a new 3D-HRNet

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Geo-Spatial Information Science 2023年第3期26卷 289-301页

作者： yue Xu Jianya Gong Xin huang Xiangyun hu Jiayi Li qiang Li Min Peng School of Remote Sensing and Information Engineering Wuhan UniversityWuhanChina State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhanChina hubei Luojia Laboratory WuhanChina Institute of Artificial Intelligence in Geomatics Wuhan UniversityWuhanChina Data Center Shenyang Surveying and Mapping Institute Co.LtdShenyangChina

High Spatial and Spectral Resolution(HSSR)remote-sensing images can provide rich spectral bands and detailed ground information,but there is a relative lack of research on this new type of remote-sensing *** there are already some HSSR datasets for deep learning model training and testing,the data volume of these datasets is small,resulting in low classification accuracy and weak generalization ability of the trained *** this paper,an HSSR dataset Luojia-HSSR is constructed based on aerial hyperspectral imagery of southern Shenyang City of Liaoning Province in *** our knowledge,it is the largest HSSR dataset to date,with 6438 pairs of 256×256 sized samples(including 3480 pairs in the training set,2209 pairs in the test set,and 749 pairs in the validation set),covering area of 161 km2 with spatial resolution 0.75 m,249 Visible and Near-Infrared(VNIR)spectral bands,and corresponding to 23 classes of field-validated ground *** is an ideal experimental data for spatial-spectral feature ***,a new deep learning model 3D-HRNet for interpreting HSSR images is *** conv-neck in HRNet is modified to better mine the spatial information of the ***,a 3D convolution module with attention mechanism is designed to capture the global-local fine spectral information ***,the 3D convolution is inserted into the HRNet to optimize the *** experiments show that the 3D-HRNet model has good interpreting ability for the Luojia-HSSR dataset with the Frequency Weighted Intersection over Union(FWIoU)reaching 80.54%,indicating that the Luojia-HSSR dataset constructed in this paper and the proposed 3D-HRnet model have good applicable prospects for processing HSSR remote sensing images.

关键词： High Spatial and Spectral Resolution(HSSR) remotesensing image classification deep learning Convolutional Neural Network(CNN)

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Room-Temperature Magnetism of Ceria Nanocubes by Inductively Transferring Electrons to Ce Atoms from Nearby Oxygen Vacancy

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Nano-Micro Letters 2016年第1期8卷 13-19页

作者： yue Kang qiang Leng Donglin Guo Dezhi Yang Yanping Pu Chenguo hu Department of Applied Physics Chongqing University School of Public Affairs Chongqing University

Ceria(CeO_2) nanocubes were synthesized by a hydrothermal method and weak ferromagnetism was observed in room temperature. After ultraviolet irradiation, the saturation magnetization was significantly enhanced from*3.18×10^(-3) to *1.89×10^(-2) emug^(-1). This is due to the increase of oxygen vacancies in CeO_2 structure which was confirmed by X-ray photoelectron spectra. The first-principle calculation with Vienna ab-initio simulation package was used to illustrate the enhanced ferromagnetism mechanism after calculating the density of states(DOSs) and partial density of states(PDOSs) of CeO_2 without and with different oxygen vacancies. It was found that the increase of oxygen vacancies will enlarge the PDOSs of Ce 4f orbital and DOSs. Two electrons in one oxygen vacancy are respectively excited to 4f orbital of two Ce atoms neighboring the vacancy, making these electron spin directions on 4f orbitals of these two Ce atoms parallel. This superexchange interaction leads to the formation of ferromagnetism in CeO_2 at room temperature. Our work indicates that ultraviolet irradiation is an effective method to enhance the magnetism of CeO_2 nanocube, and the firstprinciple calculation can understand well the enhanced magnetism.

关键词： UV irradiation Oxygen vacancies Saturation magnetism Spin direction Superexchange interaction

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Simulating coupled dynamics of a rigid-flexible multibody system and compressible fluid

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Science China(Physics,Mechanics & Astronomy) 2018年第4期61卷 54-68页

作者： Wei hu qiang Tian HaiYan hu Ministry of Education Key Laboratory of Dynamics and Control of Flight Vehicle School of Aerospace Engineering Beijing Institute of Technology

As a subsequent work of previous studies of authors, a new parallel computation approach is proposed to simulate the coupled dynamics of a rigid-flexible multibody system and compressible fluid. In this approach, the smoothed particle hydrodynamics(SPH) method is used to model the compressible fluid, the natural coordinate formulation(NCF) and absolute nodal coordinate formulation(ANCF) are used to model the rigid and flexible bodies, respectively. In order to model the compressible fluid properly and efficiently via SPH method, three measures are taken as follows. The first is to use the Riemann solver to cope with the fluid compressibility, the second is to define virtual particles of SPH to model the dynamic interaction between the fluid and the multibody system, and the third is to impose the boundary conditions of periodical inflow and outflow to reduce the number of SPH particles involved in the computation process. Afterwards, a parallel computation strategy is proposed based on the graphics processing unit(GPU) to detect the neighboring SPH particles and to solve the dynamic equations of SPH particles in order to improve the computation efficiency. Meanwhile, the generalized-alpha algorithm is used to solve the dynamic equations of the multibody system. Finally, four case studies are given to validate the proposed parallel computation approach.

关键词： smoothed particle hydrodynamics(SPH) compressible flow Riemann solver absolute nodal coordinate formulation(ANCF) graphics processing unit(GPU)

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Effects of Ti_(0.5)Al_(0.5)N coatings on the protecting against oxidation for titanium alloys

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Rare Metals 2010年第2期29卷 154-161页

作者： RU qiang hu Shejun Laboratory of Quantum Information Technology School of Physics and Telecommunication Engineering South China Normal University Guangzhou 510006 China Department of Mathematics and Physics Wuyi University Jiangmen 529020 China

Ti0.5Al0.5N coatings were deposited on TC11（Ti-6.5Al-3.5Mo-1.5Zr-0.3Si） and silicon substrates using a cathode arc ion-plating *** microstructure, composition, phase structure, and oxidation-resistance of the alloys and nitride coatings were investigated by scanning electron microscopy, X-ray diffraction, transmission electron microscopy, Auger electron spectroscopy, and thermal *** results show that the oxidation resistance of the titanium alloy is relatively limited;the compound structures of Ti mixed with Al oxides are formed during the heating *** phases of the Ti0.5Al0.5N coatings are composed of a TiN solid solution *** oxidation kinetics obeys the parabolic *** the oxidation process, the selective oxidation of Al occurs, thus protecting the underlying coating and substrate.

关键词： titanium alloy TiAlN oxidation resistance ion plating

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