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Casual associations between blood metabolites and colon cancer

World Journal of Gastrointestinal Oncology 2024年第5期16卷 1995-2005页

作者： Ke-yue Hu Yi-Quan Cheng Zhi-Long Shi Fu-peng Ren Gang-Feng Xiao Department of Hematology and Oncology Ningbo No.2 HospitalNingbo 315000Zhejiang ProvinceChina

BACKGROUND Limited knowledge exists regarding the casual associations linking blood metabolites and the risk of developing colorectal *** To investigate causal associations between blood metabolites and colon *** The study utilized a two-sample Mendelian randomization(MR)analysis to investigate the causal impact of 486 blood metabolites on colorectal *** primary method of analysis used was the inverse variance weighted *** further validate the results several sensitivity analyses were performed,including Cochran's Q test,MR-Egger intercept test,and MR robust adjusted profile *** additional analyses were conducted to ensure the reliability and robustness of the *** After rigorous selection for genetic variation,486 blood metabolites were included in the MR *** found Mannose[odds ratio(OR)=2.09(1.10-3.97),P=0.024],N-acetylglycine[OR=3.14(1.78-5.53),P=7.54×10^(-8)],X-11593-O-methylascorbate[OR=1.68(1.04-2.72),P=0.034],1-arachidonoylglycerophosphocholine[OR=4.23(2.51-7.12),P=6.35×10^(-8)]and 1-arachidonoylglycerophosphoethanolamine 4[OR=3.99(1.17-13.54),P=0.027]were positively causally associated with colorectal cancer,and we also found a negative causal relationship between Tyrosine[OR=0.08(0.01-0.63),P=0.014],Urate[OR=0.25(0.10-0.62),P=0.003],N-acetylglycine[0.73(0.54-0.98),P=0.033],X-12092[OR=0.89(0.81-0.99),P=0.028],Succinylcarnitine[OR=0.48(0.27-0.84),P=0.09]with colorectal cancer.A series of sensitivity analyses were performed to confirm the rigidity of the *** This study showed a causal relationship between 10 blood metabolites and colorectal cancer,of which 5 blood metabolites were found to be causal for the development of colorectal cancer and were confirmed as risk *** other five blood metabolites are protective factors.

关键词： Metabolites Colon cancer Mendelian randomization Genome-wide association studies Casual

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Optical multipath self-interference cancellation for a wideband in-band full-duplex system using a silicon photonic modulator chip

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Chinese Optics Letters 2024年第7期22卷 126-131页

作者： Xiao Yu Jia Ye Lianshan Yan Tao Zhou yue Zhu peng Li Xihua Zou Wei Pan Center for Information Photonics and Communications School of Information Science and TechnologySouthwest Jiaotong UniversityChengdu 611756China Key Laboratory of Electronic Information Control Southwest China Research Institute of Electronic EquipmentChengdu 610029China Microwave Photonics Research Laboratory School of Electrical Engineering and Computer ScienceUniversity of OttawaOttawaONK1N6N5Canada

We propose and experimentally demonstrate a photonic method for wideband multipath self-interference cancellation using a silicon photonic modulator *** chip generates phase-inverted reference signals by leveraging the opposite phase between optical *** managing amplitude and phase imbalances between self-interference and reference signals,the approach rectifies discrepancies through consistent chip manufacturing and packaging *** photonic multi-dimensional multiplexing,including wavelength and polarization,enables the acquisition of multiple reference *** results show multipath cancellation depths of 25.53 dB and 23.81 dB for bandwidths of 500 MHz and 1 GHz,achieved by superimposing 2-path reference signals.

关键词： microwave photonics multipath self-interference silicon photonics

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Pericytes protect rats and mice from sepsis-induced injuries by maintaining vascular reactivity and barrier function:implication of miRNAs and microvesicles

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Military Medical Research 2024年第1期11卷 1-18页

作者： Zi-Sen Zhang Yi-Yan Liu Shuang-Shuang He Dai-Qin Bao Hong-Chen Wang Jie Zhang Xiao-Yong peng Jia-Tao Zang Yu Zhu yue Wu Qing-Hui Li Tao Li Liang-ming Liu State Key Laboratory of Trauma Burns and Combined InjuryDepartment of Shock and TransfusionResearch Institute of SurgeryDaping HospitalArmy Medical UniversityChongqing 400042China

Background Vascular hyporeactivity and leakage are key pathophysiologic features that produce multi-organ damage upon *** hypothesized that pericytes,a group of pluripotent cells that maintain vascular integrity and tension,are protective against sepsis via regulating vascular reactivity and *** We conducted a series of in vivo experiments using wild-type(WT),platelet-derived growth factor receptor-β(PDGFR-β)-Cre+mT/mG transgenic mice and Tie2-Cre+Cx43^(flox/flox)mice to examine the relative contribution of pericytes in sepsis,either induced by cecal ligation and puncture(CLP)or lipopolysaccharide(LPS)*** a separate set of experiments with Sprague-Dawley(SD)rats,pericytes were depleted using CP-673451,a selective PDGFR-βinhibitor,at a dosage of 40 mg/(kg·d)for 7 consecutive *** pericytes,vascular endothelial cells(VECs)and vascular smooth muscle cells(VSMCs)were used for mechanistic *** effects of pericytes and pericyte-derived microvesicles(PCMVs)and candidate miRNAs on vascular reactivity and barrier function were also *** CLP and LPS induced severe injury/loss of pericytes,vascular hyporeactivity and leakage(P<0.05).Transplantation with exogenous pericytes protected vascular reactivity and barrier function via microvessel colonization(P<0.05).Cx43 knockout in either pericytes or VECs reduced pericyte colonization in microvessels(P<0.05).Additionally,PCMVs transferred miR-145 and miR-132 to VSMCs and VECs,respectively,exerting a protective effect on vascular reactivity and barrier function after sepsis(P<0.05).miR-145 primarily improved the contractile response of VSMCs by activating the sphingosine kinase 2(Sphk2)/sphingosine-1-phosphate receptor(S1PR)1/phosphorylation of myosin light chain 20 pathway,whereas miR-132 effectively improved the barrier function of VECs by activating the Sphk2/S1PR2/zonula occludens-1 and vascular endothelial-cadherin *** Pericytes are protective a

关键词： Pericyte Vascular reactivity Vascular permeability Cx43 Microvesicle

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Inducing mitochondriopathy-like damages by transformable nucleopeptide nanoparticles for targeted therapy of bladder cancer

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National Science Review 2024年第4期11卷 216-227页

作者： Da-Yong Hou Ni-Yuan Zhang Lu Wang Mei-Yu Lv Xiang-peng Li peng Zhang yue-Ze Wang Lei Shen Xiu-Hai Wu Bo Fu peng-Yu Guo Zi-Qi Wang Dong-Bing Cheng Hao Wang Wanhai Xu NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics Heilongjiang Key Laboratory of Scientific Research in Urology Harbin Medical University Department of Urology Harbin Medical University Cancer Hospital CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology(NCNST) School of Chemistry Chemical Engineering & Life Science Hubei Key Laboratory of Nanomedicine for Neurodegenerative Diseases Wuhan University of Technology

Mitochondriopathy inspired adenosine triphosphate(ATP) depletions have been recognized as a powerful way for controlling tumor growth. Nevertheless, selective sequestration or exhaustion of ATP under complex biological environments remains a prodigious challenge. Harnessing the advantages of in vivo self-assembled nanomaterials, we designed an Intracellular ATP Sequestration(IAS) system to specifically construct nanofibrous nanostructures on the surface of tumor nuclei with exposed ATP binding sites,leading to highly efficient suppression of bladder cancer by induction of mitochondriopathy-like ***, the reported transformable nucleopeptide(NLS-FF-T) self-assembled into nuclear-targeted nanoparticles with ATP binding sites encapsulated inside under aqueous conditions. By interaction with KPNA2, the NLS-FF-T transformed into a nanofibrous-based ATP trapper on the surface of tumor nuclei,which prevented the production of intracellular energy. As a result, multiple bladder tumor cell lines(T24,EJ and RT-112) revealed that the half-maximal inhibitory concentration(IC50) of NLS-FF-T was reduced by approximately 4-fold when compared to NLS-T. Following intravenous administration, NLS-FF-T was found to be dose-dependently accumulated at the tumor site of T24 xenograft mice. More significantly, this IAS system exhibited an extremely antitumor efficacy according to the deterioration of T24 tumors and simultaneously prolonged the overall survival of T24 orthotopic xenograft mice. Together, our findings clearly demonstrated the therapeutic advantages of intracellular ATP sequestration-induced mitochondriopathy-like damages, which provides a potential treatment strategy for malignancies.

关键词： self-assembly nucleopeptide nanomaterial bladder cancer mitochondriopathy

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Dynamics of iron and aluminum storages in a subtropical forest headwater stream

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Journal of Mountain Science 2024年第7期21卷 2193-2205页

作者： YI Qiumeng MA Diting peng Yan ZHAO Zemin YUAN Chaoxiang YUAN Ji NI Xiangyin WU Fuzhong yue Kai AN Nannan Key Laboratory of Humid Subtropical Eco-geographical Processes of Ministry of Education School of Geographical SciencesFujian Normal UniversityFuzhou 350117China Fujian Sanming Forest Ecosystem National Observation and Research Station Sanming 365002China

The forest headwater streams are important hubs for connecting terrestrial and aquatic ecosystems,with plant litter and sediments as the major carriers for material migrations;however,until now we knew little about the dynamics of trace elements such as iron(Fe)and aluminum(Al)in forest headwater ***,we quantitatively identified the spatiotemporal dynamics of Fe and Al storages in plant litter and sediments and their influencing factors in a subtropical forest headwater stream,and assessed the potential pollution *** results showed that:(1)the mean concentrations of Fe and Al in plant litter(sediments)were 5.48 and 8.46(7.39 and 47.47)g·kg^(-1),and the mean storages of Fe and Al in plant litter(sediments)were 0.26 and 0.43(749.04 and 5030.90)g·m^(-2),respectively;(2)the storages of Fe and Al in plant litter and sediments significantly fluctuated from January to December,and showed a decreasing pattern from the source to mouth;and(3)storages of Fe and Al had no significant correlation with riparian forest type and the present of tributary and the Fe and Al storages in plant litter were mainly affected by water temperature and water alkalinity,and their storages in sediments were mainly affected by water temperature and frequency of rainfall;and(4)there were no anthropogenic pollution in Fe and Al in the forest headwater *** study revealed the primary factors of concentrations and storages of Fe and Al in plant litter and sediments in a forest headwater stream,which will improve our understanding of the role of headwater streams in forest nutrient storage and cycling along with hydrological processes.

关键词： Plant litter Sediments Storage Forest headwater stream Stream characteristics Trace element

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Phase-Dislocation-Mediated High-Dimensional Fractional Acoustic-Vortex Communication

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Research 2024年第3期2023卷 575-584页

作者： Ruijie Cao Gepu Guo Wei yue Yang Huang Xinpeng Li Chengzhi Kai Yuzhi Li Juan Tu Dong Zhang peng Xi Qingyu Ma School of Computer and Electronic Information Nanjing Normal UniversityNanjing 210023China Department of Biomedical Engineering College of Future TechnologyPeking UniversityBeijing 100871China nstitute of Acoustics Nanjing UniversityNanjng 210093China National Biomedical Imaging Center Peking UniversityBeijing 100871China

With unlimited topological modes in mathematics,the fractional orbital angular momentum(FOAM)demonstrates the potential to infinitely increase the channel capacity in acoustic-vortex(AV)***,the accuracy and stability of FOAM recognition are still limited by the nonorthogonality and poor anti-interference of fractional AV *** popular machine learning,widely used in optics based on large datasets of images,does not work in acoustics because of the huge engineering of the 2-dimensional point-by-point ***,we report a strategy of phase-dislocation-mediated high-dimensional fractional AV communication based on pair-FOAM multiplexing,circular sparse sampling,and machine *** unique phase dislocation corresponding to the topological charge provides important physical guidance to recognize FOAMs and reduce sampling points from theory to practice.A straightforward convolutional neural network considering turbulence and misalignment is further constructed to achieve the stable and accurate communication without involving experimental *** experimentally present that the 32-point dual-ring sampling can realize the 10-bit information transmission in a limited topological charge scope from±0.6 to±2.4 with the FOAM resolution of 0.2,which greatly reduce the divergence in AV *** infinitely expanded channel capacity is further verified by the improved FOAM resolution of *** with other milestone works,our strategy reaches 3-fold OAM utilization,4-fold information level,and 5-fold OAM *** of the extra advantages of high dimension,high speed,and low divergence,this technology may shed light on the next-generation AV communication.

关键词： infinitely topological fractional

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High-density lipoprotein regulates angiogenesis by long non-coding RNA HDRACA

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Signal Transduction and Targeted Therapy 2023年第9期8卷 4320-4337页

作者： Zhi-Wei Mo yue-ming peng Yi-Xin Zhang Yan Li Bi-Ang Kang Ya-Ting Chen Le Li Mary GSorci-Thomas Yi-Jun Lin Yang Cao Si Chen Ze-Long Liu Jian-Jun Gao Zhan-peng Huang Jia-Guo Zhou Mian Wang Guang-Qi Chang Meng-Jie Deng Yu-Jia Liu Zhen-Sheng Ma Zuo-Jun Hu Yu-Gang Dong Zhi-Jun Ou Jing-Song Ou Division of Cardiac Surgery Cardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases NHC Key Laboratory of Assisted Circulation(Sun Yat-sen University)Guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular DiseasesGuangzhouChina Division of Vascular Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Division of Hypertension and Vascular Diseases Department of CardiologyHeart CenterThe First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Medical College of Wisconsin MilwaukeeWIUSA Center for Translational Medicine Institute of Precision MedicineThe First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Cardiology Heart CenterThe First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Pharmacology Cardiac and Cerebral Vascular Research CenterZhongshan School of Medicine of Sun Yat-sen UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080P.R.China

Normal high-density lipoprotein(nHDL)can induce angiogenesis in healthy ***,HDL from patients with coronary artery disease undergoes various modifications,becomes dysfunctional(dHDL),and loses its ability to promote ***,we identified a long non-coding RNA,HDRACA,that is involved in the regulation of angiogenesis by *** this study,we showed that nHDL downregulates the expression of HDRACA in endothelial cells by activating WW domain-containing E3 ubiquitin protein ligase 2,which catalyzes the ubiquitination and subsequent degradation of its transcription factor,Kruppel-like factor 5,via sphingosine 1-phosphate(S1P)receptor *** contrast,dHDL with lower levels of S1P than nHDL were much less effective in decreasing the expression of *** was able to bind to Ras-interacting protein 1(RAIN)to hinder the interaction between RAIN and vigilin,which led to an increase in the binding between the vigilin protein and proliferating cell nuclear antigen(PCNA)mRNA,resulting in a decrease in the expression of PCNA and inhibition of *** expression of human HDRACA in a hindlimb ischemia mouse model inhibited the recovery of *** together,these findings suggest that HDRACA is involved in the HDL regulation of angiogenesis,which nHDL inhibits the expression of HDRACA to induce angiogenesis,and that dHDL is much less effective in inhibiting HDRACA expression,which provides an explanation for the decreased ability of dHDL to stimulate angiogenesis.

关键词： angiogenesis lipoprotein inhibited

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Observation of spectral lines in the exceptional GRB 221009A

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 187-206页

作者： Yan-Qiu Zhang Shao-Lin Xiong Ji-Rong Mao Shuang-Nan Zhang Wang-Chen Xue Chao Zheng Jia-Cong Liu Zhen Zhang Xi-Lu Wang ming-Yu Ge Shu-Xu Yi Li-ming Song Zheng-Hua An Ce Cai Xin-Qiao Li Wen-Xi peng Wen-Jun Tan Chen-Wei Wang Xiang-Yang Wen yue Wang Shuo Xiao Fan Zhang peng Zhang Shi-Jie Zheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Yunnan Observatories Chinese Academy of SciencesKunming 650011China Center for Astronomical Mega-Science Chinese Academy of SciencesBeijing 100012China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China College of Physics and Hebei Key Laboratory of Photophysics Research and Application Hebei Normal UniversityShijiazhuang 050024China Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guizhou Normal UniversityGuiyang 550001China College of Electronic and Information Engineering Tongji UniversityShanghai 201804China

As the brightest gamma-ray burst ever observed,GRB 221009A provided a precious opportunity to explore spectral line *** this article,we performed a comprehensive spectroscopy analysis of GRB 221009A jointly with GECAM-C and Fermi/GBM data to search for emission and absorption *** the first time we investigated the line feature throughout this GRB including the most bright part where many instruments suffered problems,and identified prominent emission lines in multiple time *** central energy of the Gaussian emission line evolves from about 37 to 6 MeV,with a nearly constant ratio(about 10%)between the line width and central ***,we find that both the central energy and the energy flux of the emission line evolve with time as a power law decay with power law index of–1 and–2,*** suggest that the observed emission lines most likely origin from the blue-shifted electron positron pair annihilation 511 ke V *** find that a standard high latitude emission scenario cannot fully interpret the observation,thus we propose that the emission line comes from some dense clumps with electron positron pairs traveling together with the *** this scenario,we can use the emission line to directly,for the first time,measure the bulk Lorentz factor of the jet(Γ)and reveal its time evolution(i.e.,Γ~t^(-1))during the prompt ***,we find that the flux of the annihilation line in the co-moving frame keeps *** discoveries of the spectral line features shed new and important lights on the physics of GRB and relativistic jet.

关键词： GRB GRB 221009A emission line

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Reward Function Design Method for Long Episode Pursuit Tasks Under Polar Coordinate in Multi-Agent Reinforcement Learning

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Journal of Shanghai Jiaotong university(Science) 2024年第4期29卷 646-655页

作者： DONG Yubo CUI Tao ZHOU Yufan SONG Xun ZHU yue DONG peng School of Aeronautics and Astronautics Shanghai Jiao Tong UniversityShanghai200240China Beijing Institute of Electronic System Engineering Beijing100854China

Multi-agent reinforcement learning has recently been applied to solve pursuit ***,it suffers from a large number of time steps per training episode,thus always struggling to converge effectively,resulting in low rewards and an inability for agents to learn *** paper proposes a deep reinforcement learning(DRL)training method that employs an ensemble segmented multi-reward function design approach to address the convergence problem mentioned *** ensemble reward function combines the advantages of two reward functions,which enhances the training effect of agents in long ***,we eliminate the non-monotonic behavior in reward function introduced by the trigonometric functions in the traditional 2D polar coordinates observation *** results demonstrate that this method outperforms the traditional single reward function mechanism in the pursuit scenario by enhancing agents’policy scores of the *** ideas offer a solution to the convergence challenges faced by DRL models in long episode pursuit problems,leading to an improved model training performance.

关键词： multi-agent reinforcement learning deep reinforcement learning(DRL) long episode reward function

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Spent graphite regeneration:Exploring diverse repairing manners with impurities-catalyzing effect towards high performance and low energy consumption

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Journal of Energy Chemistry 2024年第4期91卷 656-669页

作者： Yu Dong Zihao Zeng Zhengqiao Yuan Bing Wang Hai Lei Wenqing Zhao Wuyun Ai Lingchao Kong yue Yang peng Ge School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083HunanChina Henan Institute of Advanced Technology Zhengzhou UniversityZhengzhou 450001HenanChina Shenzhen Xinmao New Energy Technology Co. LTDShenzhen 518100GuangdongChina

Spent battery recycling has received considerable attention because of its economic and environmental potential.A large amount of retired graphite has been produced as the main electrode material,accompanied by a detailed exploration of the repair ***,they still suffer from unclear repair mechanisms and physicochemical *** this study,spent graphite was repaired employing three methodologies:pickling-sintering,pyrogenic-recovery,and high-temperature *** to the catalytic effect of the metal-based impurities and temperature control,the as-obtained samples displayed an ordered transformation,including the interlayer distance,crystalline degree,and grain *** anodes of lithium ions batteries,the capacity of repaired samples reached up to 310 mA h g^(-1)above after 300loops at 1.0 C,similar to that of commercial ***,benefitting from the effective assembly of carbon atoms in internal structure of graphite at>1400℃,their initial coulombic efficiency were>87%.Even at 2.0 C,the capacity of samples remained approximately 244 mA h g^(-1)after 500 *** electrochemical and kinetic analyses revealed that a low temperature enhanced the isotropy,thereby enhancing the rate ***,economic and environmental analyses revealed that the revenue obtained through suitable pyrogenic-recovering manners was approximately the largest value(5500$t^(-1)).Thus,this study is expected to clarify the in-depth effect of different repair methods on the traits of graphite,while offering all-round evaluations of repaired graphite.

关键词： Spent graphite regeneration Repair Temperature treatment

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